Janel Le Belle
@janellebelle.bsky.social
UCLA Associate Professor, PhD Researcher of brains 🧠 (development, stem cells, neuroinflammation, autism, sensory processing, brain injury & repair)
Teacher of Neuroanatomy, Neurophilosophy (consciousness, cognitive science), & Stem Cell Biology
Teacher of Neuroanatomy, Neurophilosophy (consciousness, cognitive science), & Stem Cell Biology
Reposted by Janel Le Belle
Beta frequency shifts in decision making: Spectral fingerprints or communication channels?
arxiv.org/abs/2511.03503
#neuroscience
arxiv.org/abs/2511.03503
#neuroscience
Beta frequency shifts in decision making: Spectral fingerprints or communication channels?
Recent evidence suggests that beta-band activity plays a key role in decision-making. Here we review our recent work in humans and non-human primates showing that beta-band frequency shifts in frontal...
arxiv.org
November 10, 2025 at 5:12 PM
Beta frequency shifts in decision making: Spectral fingerprints or communication channels?
arxiv.org/abs/2511.03503
#neuroscience
arxiv.org/abs/2511.03503
#neuroscience
Reposted by Janel Le Belle
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
November 10, 2025 at 6:14 PM
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
Reposted by Janel Le Belle
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
November 9, 2025 at 3:03 PM
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Reposted by Janel Le Belle
Andrew, who is a contemporary of mine in the theoretical-cosmologist game, has a new book out, The Random Universe: How Models and Probability Help Us Make Sense of the Cosmos.
yalebooks.yale.edu/book/9780300...
yalebooks.yale.edu/book/9780300...
The Random Universe
An award-winning astrophysicist looks at how the understanding of uncertainty and randomness has led to breakthroughs in our knowledge of the cosmos All o...
yalebooks.yale.edu
November 10, 2025 at 12:16 PM
Andrew, who is a contemporary of mine in the theoretical-cosmologist game, has a new book out, The Random Universe: How Models and Probability Help Us Make Sense of the Cosmos.
yalebooks.yale.edu/book/9780300...
yalebooks.yale.edu/book/9780300...
Reposted by Janel Le Belle
More evidence of continuous flash suppression / binocular rivalry under anesthesia (in mice): www.biorxiv.org/content/10.1...
Continuous Flash Suppression responses in mouse visual cortex: stimulus laterality and anesthesia effects
We investigated whether binocularly conflicting stimuli adapted from primate binocular rivalry studies could induce binocular response suppression in mouse visual cortex. We presented binocularly conf...
www.biorxiv.org
November 10, 2025 at 2:34 PM
More evidence of continuous flash suppression / binocular rivalry under anesthesia (in mice): www.biorxiv.org/content/10.1...
Reposted by Janel Le Belle
Ultrasound pulses to the brain could boost survival after a stroke by mopping up brain debris.
Ultrasound may boost survival after a stroke by clearing brain debris
www.newscientist.com
November 10, 2025 at 5:43 PM
Ultrasound pulses to the brain could boost survival after a stroke by mopping up brain debris.
Reposted by Janel Le Belle
Neuroscientist Matthew Sacchet is revealing how mastering meditation can not only enable transcendental states of bliss, but also reshape how we experience pain and emotion
What we’re learning about consciousness from master meditators’ brains
www.newscientist.com
November 10, 2025 at 12:24 PM
Neuroscientist Matthew Sacchet is revealing how mastering meditation can not only enable transcendental states of bliss, but also reshape how we experience pain and emotion
Reposted by Janel Le Belle
"Cognition all the way down". Great to see this fine new paper from @robertchisciure.bsky.social & @drmichaellevin.bsky.social out now in Synthese - introducing a new metric to quantify biological intelligence as search efficiency in multidimensional problem spaces link.springer.com/article/10.1...
November 10, 2025 at 2:46 PM
"Cognition all the way down". Great to see this fine new paper from @robertchisciure.bsky.social & @drmichaellevin.bsky.social out now in Synthese - introducing a new metric to quantify biological intelligence as search efficiency in multidimensional problem spaces link.springer.com/article/10.1...
Reposted by Janel Le Belle
Brain activity from more than 1000 people shows a rapid transition from being awake to being asleep, rather than a slow transition between the two states
Falling asleep isn’t a gradual process – it happens all of a sudden
Brain activity from more than 1000 people shows a rapid transition from being awake to being asleep, rather than a slow transition between the two states
www.newscientist.com
November 10, 2025 at 4:48 PM
Brain activity from more than 1000 people shows a rapid transition from being awake to being asleep, rather than a slow transition between the two states
Reposted by Janel Le Belle
Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning
doi.org/10.5607/en25...
#neuroscience
doi.org/10.5607/en25...
#neuroscience
Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning
Hahyeon Park, Haseong Kim, Eunyoung Yeo and Alan Jung Park. Exp Neurobiol -0001;0:. https://doi.org/10.5607/en25034
doi.org
November 10, 2025 at 4:56 PM
Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning
doi.org/10.5607/en25...
#neuroscience
doi.org/10.5607/en25...
#neuroscience
Reposted by Janel Le Belle
yesssss
Democrat’s Win May Upend a Conservative Push in Virginia Universities
www.nytimes.com
November 10, 2025 at 5:12 PM
yesssss
Reposted by Janel Le Belle
Very well done story on 60 Minutes about the harms of grant terminations and freezes at Harvard with Joan Brugge, Don Engbar, David Liu, and a very compelling young cancer patient, now cured with Liu's technology.
Transcript and video here
www.cbsnews.com/news/researc...
Transcript and video here
www.cbsnews.com/news/researc...
Battle between Trump and universities hurting scientific research in need of federal funding
Federal research funding to universities has fueled breakthroughs for years. The White House is pressuring universities to align with the president's political agenda, or risk losing their funding.
www.cbsnews.com
November 10, 2025 at 1:03 AM
Very well done story on 60 Minutes about the harms of grant terminations and freezes at Harvard with Joan Brugge, Don Engbar, David Liu, and a very compelling young cancer patient, now cured with Liu's technology.
Transcript and video here
www.cbsnews.com/news/researc...
Transcript and video here
www.cbsnews.com/news/researc...
LA morning hike & the Atwater Village bakery & cat rescue for some kitty therapy
November 9, 2025 at 10:03 PM
LA morning hike & the Atwater Village bakery & cat rescue for some kitty therapy
Reposted by Janel Le Belle
Neat that my review of Zhang et al.'s "Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI" was quoted in this Research Briefing. It was one of my favorite papers I reviewed in 2024! rdcu.be/eOlTT by Jiahe Zhang, @lisafeldmanbarrett.com and others
Evidence from 7 Tesla fMRI of intrinsic network supporting allostasis in the human brain
Nature Neuroscience - Functional connectivity analyses using ultra-high precision 7 Tesla functional MRI identified a unified system for allostasis and interoception that included more than 96% of...
rdcu.be
November 7, 2025 at 10:28 PM
Neat that my review of Zhang et al.'s "Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI" was quoted in this Research Briefing. It was one of my favorite papers I reviewed in 2024! rdcu.be/eOlTT by Jiahe Zhang, @lisafeldmanbarrett.com and others
Reposted by Janel Le Belle
UC of all institutions, should not be caving in to Stephen Miller's regressive agenda. Encouraging diversity in public post-graduate education is still necessary, alas, and diversity itself is a feature, not a bug—and to hell with thin-skinned white trustees who have everything, yet feel otherwise.
A devastating set of decisions on the part of UC leadership to withdraw support from our nationally recognized postdoc program that prioritizes research excellence combined with addressing our university public service mission. www.insidehighered.com/news/faculty...
UC to Stop Funding Systemwide Postdoc Program
Established in 1984 to encourage women and minority Ph.D.s to pursue academia, the program has attracted right-wing criticism for prioritizing diverse candidates.
www.insidehighered.com
November 5, 2025 at 9:58 PM
UC of all institutions, should not be caving in to Stephen Miller's regressive agenda. Encouraging diversity in public post-graduate education is still necessary, alas, and diversity itself is a feature, not a bug—and to hell with thin-skinned white trustees who have everything, yet feel otherwise.
Reposted by Janel Le Belle
A set of 12 papers published in Nature journals offers new atlases of brain development and hints at the varied evolutionary origins of different cell types.
By Holly Barker
#neuroskyence
www.thetransmitter.org/spectrum/con...
By Holly Barker
#neuroskyence
www.thetransmitter.org/spectrum/con...
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
www.thetransmitter.org
November 5, 2025 at 6:26 PM
A set of 12 papers published in Nature journals offers new atlases of brain development and hints at the varied evolutionary origins of different cell types.
By Holly Barker
#neuroskyence
www.thetransmitter.org/spectrum/con...
By Holly Barker
#neuroskyence
www.thetransmitter.org/spectrum/con...
Reposted by Janel Le Belle
New in @nature.com, @labnowakowski.bsky.social uses barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. www.nature.com/articles/s41... #studyBRAIN 🧠🟦
November 5, 2025 at 8:28 PM
New in @nature.com, @labnowakowski.bsky.social uses barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. www.nature.com/articles/s41... #studyBRAIN 🧠🟦
Reposted by Janel Le Belle
Online Now: Sensory processing sensitivity: theory, evidence, and directions
Sensory processing sensitivity: theory, evidence, and directions
In recent years, scientific interest in sensory processing sensitivity (SPS), a personality trait reflecting increased sensitivity, reactivity, and deeper processing of stimuli, has grown exponentially. Building on this momentum, we synthesise recent SPS literature to discuss several central themes, including SPS assessment, relations to other personality traits and diverse positive and negative outcomes. We propose a novel account of SPS grounded in predictive processing, that bridges cognitive, neural, and computational domains. Specifically, we posit that brains of high-SPS individuals consistently assign high precision to incoming sensory signals. This account offers a unified explanation for the phenotypic consequences of heightened sensory sensitivity. We review behavioural and neural evidence that indirectly supports this account, and delineate important avenues for future research.
dlvr.it
November 4, 2025 at 1:40 PM
Online Now: Sensory processing sensitivity: theory, evidence, and directions
Reposted by Janel Le Belle
A brain injury was reported in a trial using ultrasound, framed as low-intensity TUS. Kim Butts Pauly and I reviewed the case and disagreed with how it's presented. Key acoustic data are missing.
Case: doi.org/10.1016/j.br...
Letters: www.elsa-fouragnan.com/blog | web.stanford.edu/~kimbutts/Le...
Case: doi.org/10.1016/j.br...
Letters: www.elsa-fouragnan.com/blog | web.stanford.edu/~kimbutts/Le...
Brain Injury During Focused Ultrasound Neuromodulation for Substance Use Disorder
www.sciencedirect.com
November 3, 2025 at 11:39 AM
A brain injury was reported in a trial using ultrasound, framed as low-intensity TUS. Kim Butts Pauly and I reviewed the case and disagreed with how it's presented. Key acoustic data are missing.
Case: doi.org/10.1016/j.br...
Letters: www.elsa-fouragnan.com/blog | web.stanford.edu/~kimbutts/Le...
Case: doi.org/10.1016/j.br...
Letters: www.elsa-fouragnan.com/blog | web.stanford.edu/~kimbutts/Le...
Reposted by Janel Le Belle
How do people flexibly integrate visual & textual information to draw mental inferences about agents we've never met?
In a new paper led by @lanceying.bsky.social, we introduce a cognitive model that achieves this by synthesizing rational agent models on-the-fly -- presented at #EMNLP2025!
In a new paper led by @lanceying.bsky.social, we introduce a cognitive model that achieves this by synthesizing rational agent models on-the-fly -- presented at #EMNLP2025!
November 5, 2025 at 3:55 PM
How do people flexibly integrate visual & textual information to draw mental inferences about agents we've never met?
In a new paper led by @lanceying.bsky.social, we introduce a cognitive model that achieves this by synthesizing rational agent models on-the-fly -- presented at #EMNLP2025!
In a new paper led by @lanceying.bsky.social, we introduce a cognitive model that achieves this by synthesizing rational agent models on-the-fly -- presented at #EMNLP2025!
Reposted by Janel Le Belle
Fun fact: When an #LLM writes confident-sounding nonsense, it's not 'broken', it's doing exactly what it was designed to do. It's not a bug. It's math with no concept of truth.
Our new white paper explains why, plus the actual engineering under the hood: www.tag1.com/white-paper/... #TechEthics
Our new white paper explains why, plus the actual engineering under the hood: www.tag1.com/white-paper/... #TechEthics
Beyond the Magic: How LLMs Actually Work
White Paper Beyond the Magic: How LLMs Actually Work Jeremy Andrews - Founding Partner/CEO October 27, 2025 Table of Contents IntroductionThe...
www.tag1.com
November 4, 2025 at 7:23 PM
Reposted by Janel Le Belle
Norton author Richard B. Ivry's new co-written research suggests the cerebellum can adapt movements without storing context 🧠 🤯 #Neuroscience #Cerebellum #BrainFunction #AcademicBluesky #BlueskyScience www.science.org/doi/full/10....
Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model
A cerebellar-inspired model describes the impact of state uncertainty and context changes on implicit sensorimotor adaptation.
www.science.org
November 4, 2025 at 4:52 PM
Norton author Richard B. Ivry's new co-written research suggests the cerebellum can adapt movements without storing context 🧠 🤯 #Neuroscience #Cerebellum #BrainFunction #AcademicBluesky #BlueskyScience www.science.org/doi/full/10....
Reposted by Janel Le Belle
JS: Hope and hype for stem cell interventions for autism spectrum disorder Despite considerable research, there is little evidence to support stem cell interventions as a treatment for autism spectrum disorder. Cites article by @stemcells.bsky.social #TMM2025
Why hype for autism stem cell therapies continues despite dead ends
After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.
www.thetransmitter.org
November 4, 2025 at 2:29 PM
JS: Hope and hype for stem cell interventions for autism spectrum disorder Despite considerable research, there is little evidence to support stem cell interventions as a treatment for autism spectrum disorder. Cites article by @stemcells.bsky.social #TMM2025
Reposted by Janel Le Belle
Reposted by Janel Le Belle
YES! "to explain all human cognition, we inherently must include development".
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy - Ward - Topics in Cognitive Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy - Ward - Topics in Cognitive Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy
In this paper, we argue that Predictive Processing cannot be a unifying account of cognition until it can explain infant development. We show why development is crucial for understanding human cognit...
onlinelibrary.wiley.com
November 2, 2025 at 11:54 AM
YES! "to explain all human cognition, we inherently must include development".
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy - Ward - Topics in Cognitive Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy - Ward - Topics in Cognitive Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....