James Ross
@jamesrossneuro.bsky.social
I’m interested in central nervous system immunity in high-grade brain tumors and chronic viral infection. Assistant prof at Univ. of Virginia🧠 rossbrainlab.com
Checkout this comprehensive review paper written by Jiabo Li of the Daniel Brat lab on the immunopathology of glioblastoma! 👏🏼
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Immunopathology of Glioblastoma
Glioblastoma (GBM), the most frequent and malignant primary brain tumor, is characterized by a highly diverse and profoundly immunosuppressive tumor microenvironment (TME) that provides an unconstrain...
www.annualreviews.org
October 9, 2025 at 10:27 PM
Checkout this comprehensive review paper written by Jiabo Li of the Daniel Brat lab on the immunopathology of glioblastoma! 👏🏼
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by James Ross
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...
Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
October 4, 2025 at 10:49 AM
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...
Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
Reposted by James Ross
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Oxidized phospholipid damage signals as modulators of immunity | Open Biology
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during
tissue damage that influence immune responses. Phospholipids, essential to cell membranes
and lung surfactants, ...
royalsocietypublishing.org
July 30, 2025 at 1:28 PM
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Reposted by James Ross
I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:
and 🧵below:
June 30, 2025 at 6:26 PM
I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:
and 🧵below:
Reposted by James Ross
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @nature.com today! Congrats to Brian Andersen and Camilo Faust Akl!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature
Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...
www.nature.com
June 25, 2025 at 8:44 PM
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @nature.com today! Congrats to Brian Andersen and Camilo Faust Akl!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by James Ross
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
June 9, 2025 at 9:13 PM
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
Reposted by James Ross
Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...
June 3, 2025 at 4:00 PM
Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...
Reposted by James Ross
Abstract deadline extended to May 23rd! Join us in NYC in Sept 2025 for the Cell Symposium "The Neuro-immune Axis: Charting the periphery" #CSNeuroimmune25 #neuroimmunology Organized by
@cp-neuron.bsky.social, @kavithascranton.bsky.social, Brian Kim & David Artis hubs.ly/Q03gmh5w0
@cp-neuron.bsky.social, @kavithascranton.bsky.social, Brian Kim & David Artis hubs.ly/Q03gmh5w0
May 16, 2025 at 9:49 PM
Abstract deadline extended to May 23rd! Join us in NYC in Sept 2025 for the Cell Symposium "The Neuro-immune Axis: Charting the periphery" #CSNeuroimmune25 #neuroimmunology Organized by
@cp-neuron.bsky.social, @kavithascranton.bsky.social, Brian Kim & David Artis hubs.ly/Q03gmh5w0
@cp-neuron.bsky.social, @kavithascranton.bsky.social, Brian Kim & David Artis hubs.ly/Q03gmh5w0
Reposted by James Ross
The Venkatesh Lab is looking for a Sr. Lab Technician to help support ongoing projects focused on the peripheral nervous system & its interactions with cancers. Check out the posting below!
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Senior Lab Technician RESEARCH NEUROLOGY V Lab
Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts t...
massgeneralbrigham.wd1.myworkdayjobs.com
May 16, 2025 at 6:15 PM
The Venkatesh Lab is looking for a Sr. Lab Technician to help support ongoing projects focused on the peripheral nervous system & its interactions with cancers. Check out the posting below!
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Reposted by James Ross
Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025
May 5, 2025 at 9:42 PM
Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025
Reposted by James Ross
We are excited to share our new study @cp-cancercell.bsky.social identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by Fadi Sheban, Truong San Phan, Kai Kun Xie & @florianingelfinger.bsky.social. (1/20)
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
ZEB2 is a master switch controlling the tumor-associated macrophage program
Sheban et al. present a single-cell CRISPR screen to dissect macrophage gene regulation
in a pan-cancer tumor-associated macrophage (TAM) atlas. Using a generative model,
they identify ZEB2 as a key d...
www.cell.com
April 10, 2025 at 7:05 PM
We are excited to share our new study @cp-cancercell.bsky.social identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by Fadi Sheban, Truong San Phan, Kai Kun Xie & @florianingelfinger.bsky.social. (1/20)
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Reposted by James Ross
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications
Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...
www.nature.com
February 11, 2025 at 11:29 AM
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
Know anyone looking for a lab specialist/technician job? The Ross lab is hiring! This position will help the lab with our research on anti-tumor immunity in high-grade glioma. Incredible training environment!!
🐭🔬🧪🦠🧠
jobs.virginia.edu/us/en/job/R0...
🐭🔬🧪🦠🧠
jobs.virginia.edu/us/en/job/R0...
Lab Tech/Specialist Varying Levels - Neuroscience in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Lab Tech/Specialist Varying Levels - Neuroscience job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia
jobs.virginia.edu
April 17, 2025 at 10:52 PM
Know anyone looking for a lab specialist/technician job? The Ross lab is hiring! This position will help the lab with our research on anti-tumor immunity in high-grade glioma. Incredible training environment!!
🐭🔬🧪🦠🧠
jobs.virginia.edu/us/en/job/R0...
🐭🔬🧪🦠🧠
jobs.virginia.edu/us/en/job/R0...
Fantastic lineup of speakers. Looking forward to this!
‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/
ReThink - The Gene Lay Institute
genelayinstitute.org
April 16, 2025 at 10:25 AM
Fantastic lineup of speakers. Looking forward to this!
Reposted by James Ross
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
March 31, 2025 at 12:20 PM
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Reposted by James Ross
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...
March 25, 2025 at 5:40 PM
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...
Excited to see two brilliant brain tumor neuroscientists win this award. Their work has inspired much of the field, and certainly my own work.
Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
March 6, 2025 at 12:02 AM
Excited to see two brilliant brain tumor neuroscientists win this award. Their work has inspired much of the field, and certainly my own work.
Very cool to see this manuscript by Dan Brat’s lab on inducing photothrombosis in live glioblastoma bearing mice utilizing two photon microscopy to study the events of necrosis on tumor progression. I started this project as a first year grad student and his current student “wrapped” this up. 🔬⚡️🧠
February 13, 2025 at 10:32 PM
Very cool to see this manuscript by Dan Brat’s lab on inducing photothrombosis in live glioblastoma bearing mice utilizing two photon microscopy to study the events of necrosis on tumor progression. I started this project as a first year grad student and his current student “wrapped” this up. 🔬⚡️🧠
Reposted by James Ross
Hi Y’all-this paper out in print now sheds new light on how nutrients can affect histone acetylation in a locus-specific manner…in other words “you are what you eat”!
ICYMI by First Release - now officially in print @science.org
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
February 10, 2025 at 3:02 PM
Hi Y’all-this paper out in print now sheds new light on how nutrients can affect histone acetylation in a locus-specific manner…in other words “you are what you eat”!
Reposted by James Ross
Excited to share a new paper from our lab 😀
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
February 10, 2025 at 2:03 PM
Excited to share a new paper from our lab 😀
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...