Izabela Zakrocka
@izabelazakrocka.bsky.social
Internist, nephrologist, transplantologist, Assistant Professor at Medical University of Lublin, #Glomcon 2021-2022 Fellow, ERA YNP Representative of Poland 🇵🇱, Board of Polish Young Transplantologists #NephSky #KidneyOmics #PharmKidney
Reposted by Izabela Zakrocka
BK nephropathy
Clues:
- Heavy but focal tubulointerstitial inflammation
- Increased plasma cells
- Viral cytopathic change
- Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here)
-SV40 IHC confirmatory
#renalpath #pathsky #nephsky
Clues:
- Heavy but focal tubulointerstitial inflammation
- Increased plasma cells
- Viral cytopathic change
- Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here)
-SV40 IHC confirmatory
#renalpath #pathsky #nephsky
November 19, 2025 at 3:35 PM
BK nephropathy
Clues:
- Heavy but focal tubulointerstitial inflammation
- Increased plasma cells
- Viral cytopathic change
- Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here)
-SV40 IHC confirmatory
#renalpath #pathsky #nephsky
Clues:
- Heavy but focal tubulointerstitial inflammation
- Increased plasma cells
- Viral cytopathic change
- Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here)
-SV40 IHC confirmatory
#renalpath #pathsky #nephsky
Reposted by Izabela Zakrocka
Urine crystals in a patient with Crohn’s
Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social
#NephSky
Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social
#NephSky
November 19, 2025 at 5:40 PM
Urine crystals in a patient with Crohn’s
Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social
#NephSky
Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social
#NephSky
Reposted by Izabela Zakrocka
In the last #KidneyKompass @brendonneuen.bsky.social chats with Sophia Zoungas podcasts.apple.com/ca/podcast/k... on the SURPASS data
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
Understanding Renal Outcomes in SURPASS-CVOT, With Sophia Zoungas, MBBS, PhD
Podcast Episode · Kidney Compass: Navigating Clinical Trials · 2025-11-13 · 17m
podcasts.apple.com
November 19, 2025 at 2:58 PM
In the last #KidneyKompass @brendonneuen.bsky.social chats with Sophia Zoungas podcasts.apple.com/ca/podcast/k... on the SURPASS data
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
Reposted by Izabela Zakrocka
Should nephrologists further implement genetic testing in patients with CKD? In this #ASNJASN study of adult CKD management, genetic testing showed diagnostic and clinical utility in the year following the reporting of test results. Read more: kidney.pub/JASN0913
November 15, 2025 at 6:00 PM
Should nephrologists further implement genetic testing in patients with CKD? In this #ASNJASN study of adult CKD management, genetic testing showed diagnostic and clinical utility in the year following the reporting of test results. Read more: kidney.pub/JASN0913
Reposted by Izabela Zakrocka
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease
Chronic kidney disease (CKD) affects 9.1% globally and is associated with significant morbidity and mortality. While up to 10% of CKD cases yield a genetic diagnosis with hundreds of implicated genes ...
www.medrxiv.org
November 14, 2025 at 2:54 AM
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Reposted by Izabela Zakrocka
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease
Chronic kidney disease (CKD) affects 9.1% globally and is associated with significant morbidity and mortality. While up to 10% of CKD cases yield a genetic diagnosis with hundreds of implicated genes ...
www.medrxiv.org
November 14, 2025 at 4:33 PM
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Reposted by Izabela Zakrocka
How'd I miss this one? Phase 1b results for mezagitamab, an anti-CD38 monoclonal antibody. (All meds should come with a pronunciation guide.) #NephSky #KidneyWk #IgAN #IgANephropathy
Mezagitamab Stablized eGFR 18 Months After Treatment in IgAN
Phase 1b IgAN data: mezagitamab (TAK‑079) stabilized eGFR, reduced proteinuria and serum Gd-IgA1, no serious AEs through Week 96; Phase 3 trials enrolling.
www.takeda.com
November 11, 2025 at 3:25 PM
How'd I miss this one? Phase 1b results for mezagitamab, an anti-CD38 monoclonal antibody. (All meds should come with a pronunciation guide.) #NephSky #KidneyWk #IgAN #IgANephropathy
Reposted by Izabela Zakrocka
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 8:27 PM
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
Great start of ‚Hot topics in lupus nephritis’ session chaired by @saynanorouzi.bsky.social and Juan M. Mejia-Vilet, with an excellent lecture of @kronbichlerlab.bsky.social on 25’ treatment targets #KidneyWk @asnkidney.bsky.social
November 7, 2025 at 11:44 PM
Great start of ‚Hot topics in lupus nephritis’ session chaired by @saynanorouzi.bsky.social and Juan M. Mejia-Vilet, with an excellent lecture of @kronbichlerlab.bsky.social on 25’ treatment targets #KidneyWk @asnkidney.bsky.social
Reposted by Izabela Zakrocka
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
November 7, 2025 at 6:07 PM
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
Reposted by Izabela Zakrocka
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.
jamanetwork.com
November 7, 2025 at 6:50 PM
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
@ninagoerlich.bsky.social wonderful talk on novel GSH-sensitive biosensors in kidney transplant recipients monitoring 🧪 #KidneyWk @asnkidney.bsky.social
November 7, 2025 at 11:36 PM
@ninagoerlich.bsky.social wonderful talk on novel GSH-sensitive biosensors in kidney transplant recipients monitoring 🧪 #KidneyWk @asnkidney.bsky.social
Reposted by Izabela Zakrocka
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
November 5, 2025 at 10:37 PM
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
Reposted by Izabela Zakrocka
This was one of the most interesting parts of the podcast. It is a discussion of intention to treat versus per protocol and Michael Walsh shocked then owned me.
I think he is right but it's possible that I just got played
pca.st/episode/ba27...
I think he is right but it's possible that I just got played
pca.st/episode/ba27...
FF 84 ACHIEVE. Spironolactone in dialysis
pca.st
November 4, 2025 at 4:32 PM
This was one of the most interesting parts of the podcast. It is a discussion of intention to treat versus per protocol and Michael Walsh shocked then owned me.
I think he is right but it's possible that I just got played
pca.st/episode/ba27...
I think he is right but it's possible that I just got played
pca.st/episode/ba27...
Reposted by Izabela Zakrocka
Katalin Susztak will be presented the Homer W. Smith Award on Friday, November 7. Join us at #KidneyWk and read more in #ASNKidneyNews: kidney.pub/KN1710-34
November 4, 2025 at 7:00 PM
Katalin Susztak will be presented the Homer W. Smith Award on Friday, November 7. Join us at #KidneyWk and read more in #ASNKidneyNews: kidney.pub/KN1710-34
Reposted by Izabela Zakrocka
Freely Filtered dives into ACHIEVE with Mike Walsh. This was a great episode. Also with show notes, chapters, and key images (if your podcast client supports it) www.nephjc.com/freelyfilter...
November 2, 2025 at 2:01 PM
Freely Filtered dives into ACHIEVE with Mike Walsh. This was a great episode. Also with show notes, chapters, and key images (if your podcast client supports it) www.nephjc.com/freelyfilter...
Reposted by Izabela Zakrocka
With plenty of bad puns but a great discussion on MRAs, RCTs in dialysis and trials and tribulations of a Trialist
And yes @kidneyboy.bsky.social went with the @murderbotbot.bsky.social theme (since I am stalking @marthawells.com with my tubular secretions….which sounds oddly naughty 😳)
#NephSky
And yes @kidneyboy.bsky.social went with the @murderbotbot.bsky.social theme (since I am stalking @marthawells.com with my tubular secretions….which sounds oddly naughty 😳)
#NephSky
November 2, 2025 at 4:09 PM
With plenty of bad puns but a great discussion on MRAs, RCTs in dialysis and trials and tribulations of a Trialist
And yes @kidneyboy.bsky.social went with the @murderbotbot.bsky.social theme (since I am stalking @marthawells.com with my tubular secretions….which sounds oddly naughty 😳)
#NephSky
And yes @kidneyboy.bsky.social went with the @murderbotbot.bsky.social theme (since I am stalking @marthawells.com with my tubular secretions….which sounds oddly naughty 😳)
#NephSky
Reposted by Izabela Zakrocka
We achieved pushing out the ACHIEVE podcast before #KidneyWk
@lastwalsh.bsky.social with @kidneyboy.bsky.social @medpeedskidneys.bsky.social @sophiakidney.bsky.social
www.nephjc.com/freelyfilter...
@lastwalsh.bsky.social with @kidneyboy.bsky.social @medpeedskidneys.bsky.social @sophiakidney.bsky.social
www.nephjc.com/freelyfilter...
FF 84 ACHIEVE: Spironolactone flops in dialysis — NephJC
FF 84 ACHIEVE: Spiro in dialysis….uhmm maybe no
www.nephjc.com
November 2, 2025 at 4:09 PM
We achieved pushing out the ACHIEVE podcast before #KidneyWk
@lastwalsh.bsky.social with @kidneyboy.bsky.social @medpeedskidneys.bsky.social @sophiakidney.bsky.social
www.nephjc.com/freelyfilter...
@lastwalsh.bsky.social with @kidneyboy.bsky.social @medpeedskidneys.bsky.social @sophiakidney.bsky.social
www.nephjc.com/freelyfilter...
Reposted by Izabela Zakrocka
C’mon - hydration really?
@nytgames.bsky.social
You know what pure hydration during running gives you?
Hyponatremia
#NephSky
@nytgames.bsky.social
You know what pure hydration during running gives you?
Hyponatremia
#NephSky
November 2, 2025 at 4:17 PM
C’mon - hydration really?
@nytgames.bsky.social
You know what pure hydration during running gives you?
Hyponatremia
#NephSky
@nytgames.bsky.social
You know what pure hydration during running gives you?
Hyponatremia
#NephSky
Reposted by Izabela Zakrocka
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025
Abstract. ADPKD is the most common monogenic cause of kidney failure globally and a significant cause of morbidity and mortality. It is now recognized that
academic.oup.com
November 1, 2025 at 11:02 AM
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Reposted by Izabela Zakrocka
Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection
#nephsky
#nephsky
Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection
Chronic active antibody-mediated rejection (CAMR) is a leading cause of late kidney allograft dysfunction, characterized by transplant glomerulopathy involving glomerular endothelial cells (GEC),…
buff.ly
November 1, 2025 at 3:00 PM
Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection
#nephsky
#nephsky
Reposted by Izabela Zakrocka
Renal tubular epithelial cell cast (Sternheimer-Malbin stain) under 1000x bright field. Pt with nephrotic range proteinuria, suspected GN. Note small lipid droplets on most inferior cell in the cast.
November 1, 2025 at 6:42 PM
Renal tubular epithelial cell cast (Sternheimer-Malbin stain) under 1000x bright field. Pt with nephrotic range proteinuria, suspected GN. Note small lipid droplets on most inferior cell in the cast.
Reposted by Izabela Zakrocka
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
November 1, 2025 at 7:53 PM
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
Reposted by Izabela Zakrocka
Stream it now! Our webinar in cooperation with NDT:
IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan
@ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social
youtu.be/l0g9_lkW5_w?...
IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan
@ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social
youtu.be/l0g9_lkW5_w?...
IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan
YouTube video by MARKUS at HOMe
youtu.be
October 31, 2025 at 6:21 PM
Stream it now! Our webinar in cooperation with NDT:
IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan
@ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social
youtu.be/l0g9_lkW5_w?...
IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan
@ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social
youtu.be/l0g9_lkW5_w?...
Reposted by Izabela Zakrocka
Our hospital does reverse trick or treating where the staff dress up and deliver candy to the admitted kiddies
#HospitalLife
#HospitalLife
October 31, 2025 at 10:16 PM
Our hospital does reverse trick or treating where the staff dress up and deliver candy to the admitted kiddies
#HospitalLife
#HospitalLife