Ilaria Panzeri
@ilariapanzeri.bsky.social
Research scientist @ Van Andel Institute | Research focus: the developmental origin of cancer susceptibility | Epigenetics, physiology, metabolism | Proud mom | In love with science, travel, art, nature | She/her/hers.
Pinned
Ilaria Panzeri
@ilariapanzeri.bsky.social
· Jan 27
Excited to share our work from the @andrewpospisilik.bsky.social, now in @naturecancer.bsky.social!
#epigenetic heterogeneity via Trim28, arising early in #development, shapes long-term #cancer risk.
Check it out: www.nature.com/articles/s43...
#epigenetic heterogeneity via Trim28, arising early in #development, shapes long-term #cancer risk.
Check it out: www.nature.com/articles/s43...
Reposted by Ilaria Panzeri
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
November 19, 2025 at 3:17 PM
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
Reposted by Ilaria Panzeri
Cuts to NIH grants don’t just affect clinicians and researchers– they affect patients, too. A new study shows that cancelled NIH funding led to the termination of 383 clinical trials, affecting more than 74,000 participants. Learn more: https://bit.ly/411zjk0
#Fight4Hematology
#Fight4Hematology
November 19, 2025 at 6:32 PM
Cuts to NIH grants don’t just affect clinicians and researchers– they affect patients, too. A new study shows that cancelled NIH funding led to the termination of 383 clinical trials, affecting more than 74,000 participants. Learn more: https://bit.ly/411zjk0
#Fight4Hematology
#Fight4Hematology
Reposted by Ilaria Panzeri
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature Communications
KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealin...
www.nature.com
November 6, 2025 at 9:40 AM
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Reposted by Ilaria Panzeri
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Reposted by Ilaria Panzeri
Van Andel Institute PhD program- App Deadline soon
Innovative curriculum/personalized academic support/generous financial support: $44,635 stipend, tuition waiver, health insurance coverage, laptop computer, $2,500/year for scientific conferences, relocation allowance.
www.vai.org/graduate-sch...
Innovative curriculum/personalized academic support/generous financial support: $44,635 stipend, tuition waiver, health insurance coverage, laptop computer, $2,500/year for scientific conferences, relocation allowance.
www.vai.org/graduate-sch...
Graduate School
Learn more about at Van Andel Institute. Explore our in-depth resources and latest articles.
www.vai.org
November 3, 2025 at 1:03 PM
Van Andel Institute PhD program- App Deadline soon
Innovative curriculum/personalized academic support/generous financial support: $44,635 stipend, tuition waiver, health insurance coverage, laptop computer, $2,500/year for scientific conferences, relocation allowance.
www.vai.org/graduate-sch...
Innovative curriculum/personalized academic support/generous financial support: $44,635 stipend, tuition waiver, health insurance coverage, laptop computer, $2,500/year for scientific conferences, relocation allowance.
www.vai.org/graduate-sch...
Reposted by Ilaria Panzeri
One of the neatest pieces of Science I've seen in a while.
Incredibly cool biology (no spoilers, go read it), a question tackled from every angle, 3 (three!) models, and paper that reads better than a novel
Incredibly cool biology (no spoilers, go read it), a question tackled from every angle, 3 (three!) models, and paper that reads better than a novel
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:56 PM
One of the neatest pieces of Science I've seen in a while.
Incredibly cool biology (no spoilers, go read it), a question tackled from every angle, 3 (three!) models, and paper that reads better than a novel
Incredibly cool biology (no spoilers, go read it), a question tackled from every angle, 3 (three!) models, and paper that reads better than a novel
Reposted by Ilaria Panzeri
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements | PNAS
The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich
regions of DNA with a higher-than-expected occurrence of CpG din...
www.pnas.org
October 26, 2025 at 5:51 PM
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Ilaria Panzeri
Programmable promoter editing for precise control of transgene expression - @mitcheme.bsky.social @mitdeptofbe.bsky.social go.nature.com/4h9wlR1
October 13, 2025 at 7:11 PM
Programmable promoter editing for precise control of transgene expression - @mitcheme.bsky.social @mitdeptofbe.bsky.social go.nature.com/4h9wlR1
Reposted by Ilaria Panzeri
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
October 9, 2025 at 8:08 PM
(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
Very interesting and elegant paper:
McSCs undergo seno-differentiation in response to DNA DSBs resulting in hair greying, and effectively protecting against melanoma. Conversely, carcinogens can suppress McSC seno-differentiation promoting self-renewal.
www.nature.com/articles/s41...
McSCs undergo seno-differentiation in response to DNA DSBs resulting in hair greying, and effectively protecting against melanoma. Conversely, carcinogens can suppress McSC seno-differentiation promoting self-renewal.
www.nature.com/articles/s41...
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma - Nature Cell Biology
Mohri et al. show that, in response to genotoxic stress, melanocyte stem cells undergo senescence-associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by carcinogens.
www.nature.com
October 7, 2025 at 7:33 PM
Very interesting and elegant paper:
McSCs undergo seno-differentiation in response to DNA DSBs resulting in hair greying, and effectively protecting against melanoma. Conversely, carcinogens can suppress McSC seno-differentiation promoting self-renewal.
www.nature.com/articles/s41...
McSCs undergo seno-differentiation in response to DNA DSBs resulting in hair greying, and effectively protecting against melanoma. Conversely, carcinogens can suppress McSC seno-differentiation promoting self-renewal.
www.nature.com/articles/s41...
Reposted by Ilaria Panzeri
A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪
October 3, 2025 at 1:29 AM
A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪
Reposted by Ilaria Panzeri
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
September 22, 2025 at 2:22 PM
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Reposted by Ilaria Panzeri
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Reposted by Ilaria Panzeri
Lab-grown organoids reproduce some of a kidney’s internal structure and function. https://scim.ag/4n0YH26
Scientists make most authentic kidney replicas so far
Lab-grown organoids reproduce some of a kidney’s internal structure and function
www.science.org
September 17, 2025 at 10:37 PM
Lab-grown organoids reproduce some of a kidney’s internal structure and function. https://scim.ag/4n0YH26
Surprising?
There isn't a single college major where women (who outnumber men in college) earn more than men. Examples:
Social Work: 9.5%
Nursing: 14.6%
Elementary Ed 16.0%
Comp Sci: 20.4%
Sociology: 20.7%
Business: 26.0%
Criminal Justice: 27.1%
Engineering: 26.3%
www.forbes.com/sites/eriksh...
Social Work: 9.5%
Nursing: 14.6%
Elementary Ed 16.0%
Comp Sci: 20.4%
Sociology: 20.7%
Business: 26.0%
Criminal Justice: 27.1%
Engineering: 26.3%
www.forbes.com/sites/eriksh...
Surprising Data On College Majors, Poverty Rates, And Gender Pay Gaps
No matter the major, there is a significant gap between male and female wages, and one of three majors with the lowest poverty rate has a twist.
www.forbes.com
September 18, 2025 at 1:21 PM
Surprising?
Reposted by Ilaria Panzeri
"We are so very late that many students will not be able to apply this year."
My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org
www.science.org/content/arti...
My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org
www.science.org/content/arti...
Delays, uncertainty plague NSF fellowship for graduate students
After an unusual award process this year, applicants for next year are waiting for overdue guidelines
www.science.org
September 17, 2025 at 10:31 PM
"We are so very late that many students will not be able to apply this year."
My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org
www.science.org/content/arti...
My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org
www.science.org/content/arti...
Reposted by Ilaria Panzeri
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
September 16, 2025 at 4:01 PM
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Reposted by Ilaria Panzeri
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
www.nature.com
September 16, 2025 at 1:33 PM
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Reposted by Ilaria Panzeri
Unmasked: transposable elements as drivers and targets in cancer. #TransposableElements #TEs #CancerDrivers @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
September 15, 2025 at 4:32 PM
Unmasked: transposable elements as drivers and targets in cancer. #TransposableElements #TEs #CancerDrivers @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Reposted by Ilaria Panzeri
Survey the landscape of healthy human immune cells from childhood to adulthood with the Human Immune Health Atlas!
This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc...
#OpenScienceWeek
This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc...
#OpenScienceWeek
September 15, 2025 at 8:18 PM
Survey the landscape of healthy human immune cells from childhood to adulthood with the Human Immune Health Atlas!
This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc...
#OpenScienceWeek
This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc...
#OpenScienceWeek
Reposted by Ilaria Panzeri
Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...
September 15, 2025 at 5:24 PM
Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...
Reposted by Ilaria Panzeri
Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 6:58 AM
Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...
Reposted by Ilaria Panzeri
🚀 WE'RE BACK! "The Many Faces of Cancer Evolution" is coming back to Rimini on May 27-29, 2026! meetings.embo.org/event/26-can... Join me, Luca @magnanilab.bsky.social , Celine Vallot, and Samra @turajliclab.bsky.social for 3 days of amazing science on the beach! @embo.org meeting #cancer 👇👇
The Many Faces of Cancer Evolution
Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to an…
meetings.embo.org
September 9, 2025 at 12:17 PM
🚀 WE'RE BACK! "The Many Faces of Cancer Evolution" is coming back to Rimini on May 27-29, 2026! meetings.embo.org/event/26-can... Join me, Luca @magnanilab.bsky.social , Celine Vallot, and Samra @turajliclab.bsky.social for 3 days of amazing science on the beach! @embo.org meeting #cancer 👇👇
Reposted by Ilaria Panzeri
Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth
go.nature.com/4lZtawb
go.nature.com/4lZtawb
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.
go.nature.com
September 4, 2025 at 5:08 PM
Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth
go.nature.com/4lZtawb
go.nature.com/4lZtawb
Reposted by Ilaria Panzeri
(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer
The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...
www.biorxiv.org
September 4, 2025 at 7:11 PM
(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...