IGFL
LightNews LightNews
banner
igflyon.bsky.social
IGFL
@igflyon.bsky.social
630 followers 85 following 30 posts
A strong focus on integrative, organism-level research at the interfaces of evolution, development & integrative physiology studied in lots of model systems
igfl.ens-lyon.fr
Posts Replies Media Videos
Reposted by IGFL
michalis-averof.bsky.social
What are these?

You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social

see doi.org/10.1101/2024... 🧵
October 26, 2025 at 8:55 AM
igflyon.bsky.social
When the clock’s feedback loop breaks, chromatin keeps ticking 🕒
Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control.
🔗 nature.com/articles/s41467-025-64045-2
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback - Nature Communications
Rhythms in chromatin state guide circadian gene expression. Here, the authors show that histone H3.3 coordinates BMAL1 activity along with cBAF/PBAF remodelers. Circadian disruption promotes remodeler...
nature.com
October 18, 2025 at 1:15 PM
Reposted by IGFL
yghavi.bsky.social
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Reposted by IGFL
brownalgaedev.bsky.social
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
Developping Fucus embryo labelled with the orange fluorescent probe SBIS (autofluorescent chloroplasts in red).
October 11, 2025 at 9:28 AM
Reposted by IGFL
filipedevadder.bsky.social
Our new study, just accepted in the Journal of the Endocrine Society
👉 doi.org/10.1210/jend...
We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.
pendingpublications
Pending Publication
doi.org
October 9, 2025 at 4:09 PM
Reposted by IGFL
michalis-averof.bsky.social
Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale

apply here: www.averof-lab.org/pages/tracman

1/3
michalis-averof.bsky.social Michalis Averof @michalis-averof.bsky.social · Jul 13
We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3
October 3, 2025 at 10:47 AM
igflyon.bsky.social
Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux!

www.ens-lyon.fr/indexation/a...
Fête de la science 2025 | École normale supérieure de Lyon
Consultez les prochains événements organisés à l'ENS de Lyon en lien avec la formation.
www.ens-lyon.fr
September 26, 2025 at 1:29 PM
Reposted by IGFL
cnrs-rhoneauvergne.bsky.social
Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏
September 22, 2025 at 6:50 AM
Reposted by IGFL
zaycha.bsky.social
So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!
September 4, 2025 at 10:26 AM
Reposted by IGFL
michalis-averof.bsky.social
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
August 8, 2025 at 5:39 PM
Reposted by IGFL
cnrs-rhoneauvergne.bsky.social
Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏

cc @ensdelyon.bsky.social
July 28, 2025 at 2:07 PM
Reposted by IGFL
yghavi.bsky.social
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
July 23, 2025 at 7:44 AM
igflyon.bsky.social
Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨
Flyer announcing a seminar by Jean Livet from the Institut de la Vision, hosted by Jonathan Enriquez at IGFL Lyon on June 30th, 2025. The talk is titled “Topography and topology in a central sensory neuronal projection.” The abstract explains that in the vertebrate brain, sensory pathways connect neuronal relays with high precision over long distances. To study these circuits, dense single-neuron tracing and large-volume microscopy are used. Jean Livet will discuss their efforts in connectomic mapping using multicolor labeling, focusing on an auditory relay to reveal its topographical and topological organization. The flyer also includes a short bio: Jean Livet completed his PhD on motor neuron development at IBDM Marseille, developed the Brainbow labeling method during his postdoc with Jeff W. Lichtman in the USA, and has led the “neurogenesis and circuit development” team at the Institut de la Vision since 2008.
June 23, 2025 at 1:38 PM
igflyon.bsky.social
🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics
Cartoon of Steven Van Belleghem riding a giant beetle over green islands, holding a camera and flying scientific papers. A hawk and butterfly accompany him, symbolizing his evolutionary genomics research on butterflies, Daphnia, and beetles.
June 2, 2025 at 9:15 AM
igflyon.bsky.social
🧬 From genomes to pangenomes to adaptation!
Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐
May 16, 2025 at 1:40 PM
igflyon.bsky.social
Live now at IGFL: Laure Bally-Cuif (Institut Pasteur) is sharing her fascinating work on the heterogeneity of adult neural stem cells. A deep dive into brain plasticity in action! #Neuroscience #IGFL #StemCells
@zenlabpasteur.bsky.social
May 5, 2025 at 9:10 AM
igflyon.bsky.social
Congrats to Dr. Laurie Nemoz Billet for earning an Accessit 2025 from @sfbd.bsky.social for her thesis on the role of the ECM in motor nerve development and regeneration in zebrafish! A brilliant contribution to the field. Read more: www.pnas.org/doi/10.1073/... 🎉
Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons | PNAS
During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose ident...
www.pnas.org
April 28, 2025 at 3:05 PM
igflyon.bsky.social
🧠 Seminar alert! Laure Bally-Cuif (Pasteur Institute) will present:
"Individual cell heterogeneities and population dynamics for adult neural stem cell maintenance"
She will show how neural stem cell sub-populations sustain neurogenesis in zebrafish.
📅 05/05/25, 11am, Salle Condorcet ENS Lyon
April 25, 2025 at 12:17 PM
igflyon.bsky.social
Time to go mad! Thank you @zaycha.bsky.social for inviting @mads100tist.bsky.social for exciting science on somatosensory neuron diversity.
April 7, 2025 at 9:06 AM
igflyon.bsky.social
IGFL will be going mad next Monday, when we host @mads100tist.bsky.social, directly from Basel! We are looking forward to hearing an exciting talk!
April 1, 2025 at 9:51 PM
Reposted by IGFL
francoisleulier.bsky.social
Today BioSymposium of the 4 research units at @ensdelyon.bsky.social
Great mix of PI and Doc/Postdoc presentations and posters with some live musics tonight
@igflyon.bsky.social
@lbmcinlyon.bsky.social
@ciri-lyon.bsky.social
and RDP (not yet on Bluesky I think)
March 27, 2025 at 8:13 AM
Reposted by IGFL
zaycha.bsky.social
Very excited to host the one and only @mads100tist.bsky.social at @igflyon.bsky.social in Lyon on April 7th! Don't hesitate to pass by for his talk if you're in the city, it promises to be a real treat!
March 25, 2025 at 7:12 AM
igflyon.bsky.social
Guest lecture today on Drosophila brain metabolism. Exciting results by Prof. Stefanie Schirmeier from TU Dresden.
The drosophila brain
March 17, 2025 at 10:10 AM
igflyon.bsky.social
Seminar alert! 🧠🔬 Prof. Stefanie Schirmeier (TU Dresden) presents "Metabolic flexibility of the Drosophila nervous system" on March 17th, 11 am at Salle Condorcet. Explore glial cells & adaptive metabolism! #Neuroscience #Metabolism
Title of the presentation Metabolic flexibility of the Drosophila nervous system Short abstract Neuronal function consumes large amounts of energy. This energy needs to be provided in order to maintain homeostasis. To deal with this disproportionate demand, glial cells support neurons metabolically. Like their mammalian counterparts, Drosophila glial cells are very glycolytically active and provide lactate to the neurons under optimal conditions. Upon suboptimal conditions, several aspects of brain metabolism can be adapted. On the one hand, nutrient uptake into the nervous system is regulated to ensure nervous system function. On the other hand, glial cellular metabolism can adapt to changing conditions. E.g. when carbohydrate supply is not sufficient to meet the metabolic needs of the neurons, the glial cells switch to ß-oxidation of fatty acids and produce ketone bodies as an alternate fuel that they supply to neurons. It turns out that glial metabolism can be adapted to different conditions, like starvation or cold exposure, in different ways to ensure neuronal function. Short CV Stefanie Schirmeier graduated from the University of Bayreuth (Germany) and joined Dominique Ferrandon’s team at the University of Strasbourg (France), where she studied host-pathogen interactions using Drosophila melanogaster as a model. She contributed to a genome-wide genetic screen and discovered the compensatory proliferation of intestinal stem cells in response to gut infection, as well as identifying a bacterial virulence factor required to counteract the cellular immune response. She then moved to the University of Münster (Germany) for a postdoctoral position, joining Christian Klämbt’s team and later establishing her own research group there. Stefanie focused on investigating the physiology and metabolism of glial cells and uncovered their role in neuronal nutritional support via the astrocyte-neuron lactate shuttle. Since 2021, Stefanie has been a professor at Dresden Technic…
March 13, 2025 at 2:58 PM
Reposted by IGFL
cnrs-rhoneauvergne.bsky.social
‪
#TalentsCNRS 🥈 | Découvrez le portrait vidéo de François Leulier, médaille d'argent 2024 du @cnrs.fr, chercheur en biologie et directeur de @igflyon.bsky.social

@cnrsbiologie.bsky.social @ensdelyon.bsky.social @francoisleulier.bsky.social
🎬👇
www.youtube.com/watch?v=QKOk...
François Leulier, du microbiote aux mécanismes de croissance l TalentsCNRS
YouTube video by CNRS
www.youtube.com
February 24, 2025 at 12:15 PM