Peter Hsu
@hsuuperman.bsky.social
Animal lover, PNWer (currently Bay Area), structural biologist @ Genentech
Reposted by Peter Hsu
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology
Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...
www.nature.com
November 14, 2025 at 8:51 PM
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Peter Hsu
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
prospect.org
June 29, 2025 at 3:17 AM
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Reposted by Peter Hsu
ATTENTION: NSF GRANT RECIPIENTS
We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years.
1/n
We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years.
1/n
a cartoon of a man holding a frying pan and a spoon with red alert written above him
ALT: a cartoon of a man holding a frying pan and a spoon with red alert written above him
media.tenor.com
April 24, 2025 at 9:09 PM
ATTENTION: NSF GRANT RECIPIENTS
We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years.
1/n
We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years.
1/n
Reposted by Peter Hsu
Everyone please read and act! 👇
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 9:00 PM
Everyone please read and act! 👇
Reposted by Peter Hsu
Reposted by Peter Hsu
This is such an incredible explainer of Indirect Funding!
💡 Some takeaways:
🧬 The federal science funding landscape in America was created after the US economy, security, and health by partnering with universities that would conduct research for the government.
🧵
💡 Some takeaways:
🧬 The federal science funding landscape in America was created after the US economy, security, and health by partnering with universities that would conduct research for the government.
🧵
Still wondering how Indirect Funding (F&A) works, and why it's so important for research institutions? Check out this great video from the Association of American Universities:
#standwithscience #standupforscience2025 @standupforscience.bsky.social
🧪 🤝 🧬 🐟🎸 🍎
#standwithscience #standupforscience2025 @standupforscience.bsky.social
🧪 🤝 🧬 🐟🎸 🍎
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
youtu.be
February 18, 2025 at 3:40 PM
This is such an incredible explainer of Indirect Funding!
💡 Some takeaways:
🧬 The federal science funding landscape in America was created after the US economy, security, and health by partnering with universities that would conduct research for the government.
🧵
💡 Some takeaways:
🧬 The federal science funding landscape in America was created after the US economy, security, and health by partnering with universities that would conduct research for the government.
🧵
Reposted by Peter Hsu
The House Science Committee is now adopting its rules, authorization, and oversight plan, and introducing their new staffers. Immediately following, there will be a hearing on the future of U.S. science with the president of AAAS and two former Trump officials in academia and Trump operative.
Adoption of Committee Rules & Approval of Authorization & Oversight Plan
YouTube video by House Science, Space, and Technology Committee
www.youtube.com
February 5, 2025 at 3:20 PM
The House Science Committee is now adopting its rules, authorization, and oversight plan, and introducing their new staffers. Immediately following, there will be a hearing on the future of U.S. science with the president of AAAS and two former Trump officials in academia and Trump operative.
Reposted by Peter Hsu
Reposted by Peter Hsu
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Reposted by Peter Hsu
So many people added to pack 1 this weekend we had to make pack 2. Makes sure you refresh for followers on pack one to see them all!
🧶🧬
go.bsky.app/DDetSBp
🧶🧬
go.bsky.app/DDetSBp
November 17, 2024 at 11:37 AM
So many people added to pack 1 this weekend we had to make pack 2. Makes sure you refresh for followers on pack one to see them all!
🧶🧬
go.bsky.app/DDetSBp
🧶🧬
go.bsky.app/DDetSBp
Reposted by Peter Hsu
US should be leading this charge. We are not. How sad is that?
November 17, 2024 at 4:14 PM
US should be leading this charge. We are not. How sad is that?