Dr Hannah Tompkins
@hetompkins.bsky.social
Scientist (UoM & UoG alumni), interested in all things spatial & lung immuno-matrix 🫁🔬
Research Engagement Officer at Blood Cancer UK 🩸💜 (she/her)
Research Engagement Officer at Blood Cancer UK 🩸💜 (she/her)
Pinned
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
So pleased to see our research out in #ScienceImmunology demonstrating that CLPs regulate airway remodelling during allergy 🫁 Really proud of the hard work and collaboration that went into this project 🫱🏼🫲🏽. Definitely one to check out for lovers of the immuno-matrix & pretty pictures👇🏼🔬
Reposted by Dr Hannah Tompkins
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
scim.ag
November 7, 2025 at 4:00 PM
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Reposted by Dr Hannah Tompkins
My PhD work is (finally) published in Science Signaling! And it made the cover!
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
November 4, 2025 at 7:04 PM
My PhD work is (finally) published in Science Signaling! And it made the cover!
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Reposted by Dr Hannah Tompkins
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory pathogen that emerged in December 2019 and caused a global pandemic by March 2020, with >7 million deaths due to coronavirus disease 2019 globally as of September 2025.
https://www.nature.c...
https://www.nature.c...
October 29, 2025 at 5:11 PM
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory pathogen that emerged in December 2019 and caused a global pandemic by March 2020, with >7 million deaths due to coronavirus disease 2019 globally as of September 2025.
https://www.nature.c...
https://www.nature.c...
Reposted by Dr Hannah Tompkins
Excited to share my PhD work (in @douglaspdyer.bsky.social’s lab) now published in Mucosal Immunology! 🥳
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often
damages the healthy tissues, particularly the intestines, leading to radiation-induced
toxicities with limited treatme...
www.mucosalimmunology.org
October 29, 2025 at 5:51 PM
Excited to share my PhD work (in @douglaspdyer.bsky.social’s lab) now published in Mucosal Immunology! 🥳
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Reposted by Dr Hannah Tompkins
📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
(MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester on FindAPhD.com
PhD Project - (MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
October 15, 2025 at 9:36 AM
📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Reposted by Dr Hannah Tompkins
The 2025 Nobel Prize in Physiology or Medicine was awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.” This Collection celebrates the award and recognizes the winners’ achievements. #medsky 🧪
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
go.nature.com
October 14, 2025 at 1:49 AM
The 2025 Nobel Prize in Physiology or Medicine was awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.” This Collection celebrates the award and recognizes the winners’ achievements. #medsky 🧪
Reposted by Dr Hannah Tompkins
Listen here for an interview I did on "Climbing the Immune Ladder: Steps for Success in Science".
We discuss immunology, kindness and mentorship, navigating scientific challenges, identifying high-impact research questions, and our evolving scientific careers
open.spotify.com/episode/00rJ...
We discuss immunology, kindness and mentorship, navigating scientific challenges, identifying high-impact research questions, and our evolving scientific careers
open.spotify.com/episode/00rJ...
Interview with Adrian Liston
open.spotify.com
October 14, 2025 at 7:40 AM
Listen here for an interview I did on "Climbing the Immune Ladder: Steps for Success in Science".
We discuss immunology, kindness and mentorship, navigating scientific challenges, identifying high-impact research questions, and our evolving scientific careers
open.spotify.com/episode/00rJ...
We discuss immunology, kindness and mentorship, navigating scientific challenges, identifying high-impact research questions, and our evolving scientific careers
open.spotify.com/episode/00rJ...
Reposted by Dr Hannah Tompkins
What is #immunology?
It’s the study of the immune system, protecting us from infection, disease & cancer. From vaccines to immunotherapies, it shapes modern medicine.
Celebrate #BiologyWeek by exploring how immunologists keep the world healthy 👩🔬👨🔬 https://bit.ly/4nmt8zR
It’s the study of the immune system, protecting us from infection, disease & cancer. From vaccines to immunotherapies, it shapes modern medicine.
Celebrate #BiologyWeek by exploring how immunologists keep the world healthy 👩🔬👨🔬 https://bit.ly/4nmt8zR
What is immunology? | British Society for Immunology
bit.ly
October 13, 2025 at 12:29 PM
What is #immunology?
It’s the study of the immune system, protecting us from infection, disease & cancer. From vaccines to immunotherapies, it shapes modern medicine.
Celebrate #BiologyWeek by exploring how immunologists keep the world healthy 👩🔬👨🔬 https://bit.ly/4nmt8zR
It’s the study of the immune system, protecting us from infection, disease & cancer. From vaccines to immunotherapies, it shapes modern medicine.
Celebrate #BiologyWeek by exploring how immunologists keep the world healthy 👩🔬👨🔬 https://bit.ly/4nmt8zR
Reposted by Dr Hannah Tompkins
Nature’s global survey of 3,785 doctoral students shows satisfaction has recovered from pandemic lows, but harassment and inadequate supervision remain widespread. #Academicsky 🧪
How money, politics and technology are redefining the PhD experience in 2025
Nature’s global survey of 3,785 doctoral students shows satisfaction has recovered from pandemic lows, but harassment and inadequate supervision remain widespread.
go.nature.com
October 11, 2025 at 10:47 PM
Nature’s global survey of 3,785 doctoral students shows satisfaction has recovered from pandemic lows, but harassment and inadequate supervision remain widespread. #Academicsky 🧪
Reposted by Dr Hannah Tompkins
Regulatory T cells, the immune cells at the centre of Monday's Nobel Prize, are showing promise as a treatment for autoimmune diseases, cancer, and even organ transplants
go.nature.com/3VSjVDB
go.nature.com/3VSjVDB
These immune cells won Nobel fame — can they solve autoimmune disease?
Regulatory T cells, which help to dampen inflammation, are being used in clinical trials against ailments such as rheumatoid arthritis.
go.nature.com
October 8, 2025 at 11:04 AM
Regulatory T cells, the immune cells at the centre of Monday's Nobel Prize, are showing promise as a treatment for autoimmune diseases, cancer, and even organ transplants
go.nature.com/3VSjVDB
go.nature.com/3VSjVDB
Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
Vote now and help decide which badge will join the line-up in Liverpool 👇
Cast your vote here🔗: https://bit.ly/46DtHzy
October 8, 2025 at 8:54 AM
Reposted by Dr Hannah Tompkins
Delighted to contribute to this project! Please read and repost 😊
Our newest preprint is out now! Great work by Dr Robin Bartolini on how "Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation." www.biorxiv.org/content/10.1...
Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation.
Adaptive immune responses are intensely energy-dependent and rely on a local source of fuel-producing molecules which have been proposed to be derived from fat pads in which mammalian lymph nodes are ...
www.biorxiv.org
October 7, 2025 at 2:46 PM
Delighted to contribute to this project! Please read and repost 😊
Reposted by Dr Hannah Tompkins
This year's Nobel Prize in Medicine honors the discovery of regulatory T cells (T-regs).
In this piece, our Director Prof Tracy Hussell @tracyh9494.bsky.social explains how the recipients discovered T-regs - transforming autoimmune disease research.
#ImmunoSky
theconversation.com/nobel-prize-...
In this piece, our Director Prof Tracy Hussell @tracyh9494.bsky.social explains how the recipients discovered T-regs - transforming autoimmune disease research.
#ImmunoSky
theconversation.com/nobel-prize-...
Nobel prize awarded for discovery of immune system’s ‘security guards’
The discovery of cells that prevent the immune system from hurting the body is paving the way for new treatments for autoimmune diseases and cancer.
theconversation.com
October 7, 2025 at 7:30 AM
This year's Nobel Prize in Medicine honors the discovery of regulatory T cells (T-regs).
In this piece, our Director Prof Tracy Hussell @tracyh9494.bsky.social explains how the recipients discovered T-regs - transforming autoimmune disease research.
#ImmunoSky
theconversation.com/nobel-prize-...
In this piece, our Director Prof Tracy Hussell @tracyh9494.bsky.social explains how the recipients discovered T-regs - transforming autoimmune disease research.
#ImmunoSky
theconversation.com/nobel-prize-...
Reposted by Dr Hannah Tompkins
This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 1:55 PM
This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪
Reposted by Dr Hannah Tompkins
What's one piece of advice you'd give to someone considering a PhD?
We asked 3785 doctoral candidates across 107 countries for their hard-won wisdom
go.nature.com/4nDjJ7t
We asked 3785 doctoral candidates across 107 countries for their hard-won wisdom
go.nature.com/4nDjJ7t
27 things we wish we’d known when we started our PhDs
Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.
go.nature.com
October 6, 2025 at 2:17 PM
What's one piece of advice you'd give to someone considering a PhD?
We asked 3785 doctoral candidates across 107 countries for their hard-won wisdom
go.nature.com/4nDjJ7t
We asked 3785 doctoral candidates across 107 countries for their hard-won wisdom
go.nature.com/4nDjJ7t
Reposted by Dr Hannah Tompkins
A new study from @drtesutherland.bsky.social (@uniofaberdeen.bsky.social) suggests future asthma treatments could reverse lung damage.
Funded by @medresfdn.bsky.social + @asthmaandlung.org.uk, this research may transform care for asthma + other fibrosis-linked diseases.💡
📖➡️ https://bit.ly/4mHTOKq
Funded by @medresfdn.bsky.social + @asthmaandlung.org.uk, this research may transform care for asthma + other fibrosis-linked diseases.💡
📖➡️ https://bit.ly/4mHTOKq
Research points to new treatment target for asthma
A new way to treat asthma symptoms and even repair previously irreversible lung damage could be on the horizon following the discovery of a potential new therapeutic target by Foundation-funded Dr Tara Sutherland and a team of scientists at the University of Aberdeen.
bit.ly
October 1, 2025 at 3:40 PM
A new study from @drtesutherland.bsky.social (@uniofaberdeen.bsky.social) suggests future asthma treatments could reverse lung damage.
Funded by @medresfdn.bsky.social + @asthmaandlung.org.uk, this research may transform care for asthma + other fibrosis-linked diseases.💡
📖➡️ https://bit.ly/4mHTOKq
Funded by @medresfdn.bsky.social + @asthmaandlung.org.uk, this research may transform care for asthma + other fibrosis-linked diseases.💡
📖➡️ https://bit.ly/4mHTOKq
Reposted by Dr Hannah Tompkins
Did you know that since 1999 an independent group of global experts called the Strategic Advisory Group of Experts on Immunization (SAGE) has been providing WHO evidence-based recommendations on #vaccines?
September 30, 2025 at 4:43 PM
Did you know that since 1999 an independent group of global experts called the Strategic Advisory Group of Experts on Immunization (SAGE) has been providing WHO evidence-based recommendations on #vaccines?
Reposted by Dr Hannah Tompkins
Multiple myeloma (MM) is a haematological lymphoid malignancy involving tumoural plasma cells, characterized by a monoclonal immunoglobulin protein presence. MM is one of most common haematological malignancy, with an increasing global incidence.
Multiple myeloma - Nature Reviews Disease Primers
This PrimeView highlights the epidemiology, mechanisms, diagnosis, management and quality of life of patients with multiple myeloma.
www.nature.com
September 27, 2025 at 5:49 PM
Multiple myeloma (MM) is a haematological lymphoid malignancy involving tumoural plasma cells, characterized by a monoclonal immunoglobulin protein presence. MM is one of most common haematological malignancy, with an increasing global incidence.
Reposted by Dr Hannah Tompkins
Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 19, 2025 at 7:53 PM
Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!
Reposted by Dr Hannah Tompkins
Exciting news - we are recruiting new Group Leaders! 🥼
We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes
Full details on our website: www.cruk.manchester.ac.uk/career/new-g...
We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes
Full details on our website: www.cruk.manchester.ac.uk/career/new-g...
Group Leader Recruitment at the Cancer Research UK Manchester Institute
YouTube video by CRUK Manchester Institute
youtu.be
September 24, 2025 at 3:03 PM
Exciting news - we are recruiting new Group Leaders! 🥼
We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes
Full details on our website: www.cruk.manchester.ac.uk/career/new-g...
We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes
Full details on our website: www.cruk.manchester.ac.uk/career/new-g...
Reposted by Dr Hannah Tompkins
September is Blood Cancer Awareness Month. 31% of people see their GP three or more times before getting a diagnosis. For support and info, visit: bloodcancer.org.uk/about-us/our...
Blood Cancer UK | Blood Cancer Awareness Month
Say Blood Cancer
bloodcancer.org.uk
September 25, 2025 at 11:47 AM
September is Blood Cancer Awareness Month. 31% of people see their GP three or more times before getting a diagnosis. For support and info, visit: bloodcancer.org.uk/about-us/our...
Reposted by Dr Hannah Tompkins
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 22, 2025 at 9:20 AM
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Reposted by Dr Hannah Tompkins
Surprisingly, airway ECM remodelling was protective for lung function, and rather seems to support epithelial function. Huge amount of work by @james-ep.bsky.social @hetompkins.bsky.social and a tremendous amount of help and support from all of our collaborators at Aberdeen and Manchester
September 22, 2025 at 9:20 AM
Surprisingly, airway ECM remodelling was protective for lung function, and rather seems to support epithelial function. Huge amount of work by @james-ep.bsky.social @hetompkins.bsky.social and a tremendous amount of help and support from all of our collaborators at Aberdeen and Manchester
So pleased to see our research out in #ScienceImmunology demonstrating that CLPs regulate airway remodelling during allergy 🫁 Really proud of the hard work and collaboration that went into this project 🫱🏼🫲🏽. Definitely one to check out for lovers of the immuno-matrix & pretty pictures👇🏼🔬
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 20, 2025 at 6:04 PM
So pleased to see our research out in #ScienceImmunology demonstrating that CLPs regulate airway remodelling during allergy 🫁 Really proud of the hard work and collaboration that went into this project 🫱🏼🫲🏽. Definitely one to check out for lovers of the immuno-matrix & pretty pictures👇🏼🔬
Reposted by Dr Hannah Tompkins
A sad reality… gaslighting and performative actions are still the norm.
Equity in science is a beautiful lie — and I’m done pretending
Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system.
www.nature.com
September 16, 2025 at 7:18 PM
A sad reality… gaslighting and performative actions are still the norm.