GW Gant Luxton
@gwgl.bsky.social
I’m Gant. My lab studies how the structure of cells affects disease progression. Allen Distinguished Investigator in Molecular and Celular Biology at @UCDavis.
https://luxton.faculty.ucdavis.edu
https://luxton.faculty.ucdavis.edu
Reposted by GW Gant Luxton
TaoChongBao: A Large-Scale Caenorhabditis elegans Mutagenesis and Missense Variant Database Bridging Worm and Human Genomes https://www.biorxiv.org/content/10.64898/2025.12.03.692224v1
December 12, 2025 at 10:46 AM
TaoChongBao: A Large-Scale Caenorhabditis elegans Mutagenesis and Missense Variant Database Bridging Worm and Human Genomes https://www.biorxiv.org/content/10.64898/2025.12.03.692224v1
Reposted by GW Gant Luxton
Reposted by GW Gant Luxton
So excited to post my first official #zebrafish paper in my new gig at UC Berkeley with my amazing co-authors @swinburnelab.bsky.social @alinetschanz.bsky.social
The TL;DR is that monomeric StayGolds are game changers for in vivo imaging in zebrafish 1/7
micropublication.org/journals/bio...
The TL;DR is that monomeric StayGolds are game changers for in vivo imaging in zebrafish 1/7
micropublication.org/journals/bio...
Systematic comparison of mStayGold and mGold2 variants for live imaging in zebrafish | microPublication
micropublication.org
December 5, 2025 at 9:20 PM
So excited to post my first official #zebrafish paper in my new gig at UC Berkeley with my amazing co-authors @swinburnelab.bsky.social @alinetschanz.bsky.social
The TL;DR is that monomeric StayGolds are game changers for in vivo imaging in zebrafish 1/7
micropublication.org/journals/bio...
The TL;DR is that monomeric StayGolds are game changers for in vivo imaging in zebrafish 1/7
micropublication.org/journals/bio...
Reposted by GW Gant Luxton
WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1
December 5, 2025 at 9:32 PM
WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1
Grateful to be featured in Nature Methods discussing how @danstarrucdavis.bsky.social and I run the joint Starr-Luxton Lab @ucdavis.bsky.social together. Thanks to Vivien Marx for the thoughtful interview - she really captured what makes this model work. www.nature.com/articles/s41...
Two as one: when scientists run a lab together - Nature Methods
Leading a lab is both a venture and an adventure. It’s double that for these researchers.
www.nature.com
December 5, 2025 at 12:56 AM
Grateful to be featured in Nature Methods discussing how @danstarrucdavis.bsky.social and I run the joint Starr-Luxton Lab @ucdavis.bsky.social together. Thanks to Vivien Marx for the thoughtful interview - she really captured what makes this model work. www.nature.com/articles/s41...
Reposted by GW Gant Luxton
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
scim.ag
October 6, 2025 at 1:45 PM
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Reposted by GW Gant Luxton
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/48QDdAJ
go.nature.com/48QDdAJ
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 3:56 PM
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/48QDdAJ
go.nature.com/48QDdAJ
Reposted by GW Gant Luxton
Write your program officer and grants management official TODAY and thank them! It takes 30 seconds and its really appreciated. The only reason they're remotely this close is because those folks are working 60 hour weeks under immense pressure
Here are data on the percentage of FY2024 appropriation committed to date in FY2025. Most ICs are well on track, but four ICs (NIMHD, NINR, NHLBI, NHGRI) still appear to be under 80%.
Note that values >100% reflect either a higher appropriation for FY25 or an increased % devoted to grants.
Note that values >100% reflect either a higher appropriation for FY25 or an increased % devoted to grants.
September 23, 2025 at 11:11 PM
Write your program officer and grants management official TODAY and thank them! It takes 30 seconds and its really appreciated. The only reason they're remotely this close is because those folks are working 60 hour weeks under immense pressure
Reposted by GW Gant Luxton
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 7:52 PM
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 6:26 PM
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
Reposted by GW Gant Luxton
Centrosomes might look tough, but they are actually big softies - see the latest work from the Dammermann lab now on BioRxiv:
1/6 Extremely happy to share my PhD work is out on bioRxiv! We discovered that microtubules deform mitotic centrosomes. When we removed them, the SPD-5 scaffold became denser but didn't lose material. This suggests it's an elastically deformable solid! This only happens in mitosis.
September 19, 2025 at 4:29 PM
Centrosomes might look tough, but they are actually big softies - see the latest work from the Dammermann lab now on BioRxiv:
Reposted by GW Gant Luxton
Congrats to @xiangyiding.bsky.social et al. on their new study on the intense cellular dance happening in worm cells! 🕺
Dive into the #FrontierScience of organelle crowd control. 👇
Dive into the #FrontierScience of organelle crowd control. 👇
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
September 11, 2025 at 6:58 PM
Congrats to @xiangyiding.bsky.social et al. on their new study on the intense cellular dance happening in worm cells! 🕺
Dive into the #FrontierScience of organelle crowd control. 👇
Dive into the #FrontierScience of organelle crowd control. 👇
🧬Want the full story of our paper without the science jargon? Our @ucdavis.bsky.social department broke down our "cells are crowded AND constrained" findings in plain English! Perfect explanation of why worm cells are nothing like cultured cells 🪱🌠
September 10, 2025 at 7:20 PM
🧬Want the full story of our paper without the science jargon? Our @ucdavis.bsky.social department broke down our "cells are crowded AND constrained" findings in plain English! Perfect explanation of why worm cells are nothing like cultured cells 🪱🌠
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
September 10, 2025 at 7:18 PM
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration
Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kines…
www.sciencedirect.com
September 9, 2025 at 9:58 PM
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by GW Gant Luxton
Reposted by GW Gant Luxton
Our review is out! Such an honor to publish with Ryoko and Michael-early midbody leaders!
The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential
www.molbiolcell.org/doi/full/10....
The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential
www.molbiolcell.org/doi/full/10....
The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential | Molecular Biology of the Cell
The midbody (MB), a transient structure formed during cytokinesis, has evolved from a mere structural component to a complex signaling organelle with diverse functions beyond cell division. Recent stu...
www.molbiolcell.org
July 2, 2025 at 4:12 PM
Our review is out! Such an honor to publish with Ryoko and Michael-early midbody leaders!
The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential
www.molbiolcell.org/doi/full/10....
The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential
www.molbiolcell.org/doi/full/10....
Congratulations to Dr. Gümüşderelioğlum from the Starr-Luxton Lab @ucdavis.bsky.social! 🎓 Fresh off her recent PhD defense, she gave an excellent talk this morning at the Cell Biology session of #Worm2025 on UNC-83 molecular switches in nuclear migration. So proud! 👏 #NewPhD #CellBiology
June 30, 2025 at 4:10 PM
Congratulations to Dr. Gümüşderelioğlum from the Starr-Luxton Lab @ucdavis.bsky.social! 🎓 Fresh off her recent PhD defense, she gave an excellent talk this morning at the Cell Biology session of #Worm2025 on UNC-83 molecular switches in nuclear migration. So proud! 👏 #NewPhD #CellBiology
Incredible plenary presentation by Starr-Luxton Lab student @xiangyiding.bsky.social at the International Worm Meeting! Who knew C. elegans cytoplasm has the viscosity of strawberry jam? 🍓 So proud! #Worm2025 #frontierscience @danstarrucdavis.bsky.social
June 30, 2025 at 6:10 AM
Incredible plenary presentation by Starr-Luxton Lab student @xiangyiding.bsky.social at the International Worm Meeting! Who knew C. elegans cytoplasm has the viscosity of strawberry jam? 🍓 So proud! #Worm2025 #frontierscience @danstarrucdavis.bsky.social
Reposted by GW Gant Luxton
So nice that you encouraged her to apply. Oh and she is also in this teeny-tiny blog post. Still in the works. communities.springernature.com/posts/when-s...
When summertime courses transform a science journey
Summer courses can shape one's science and change one's life, too.
communities.springernature.com
June 27, 2025 at 4:04 PM
So nice that you encouraged her to apply. Oh and she is also in this teeny-tiny blog post. Still in the works. communities.springernature.com/posts/when-s...
Amazing to see our student @xiangyiding.bsky.social featured in Nature Methods discussing how the Marine Biological Laboratory Physiology course transformed her approach to research! So proud of her experience and growth. #Frontierscience 🪱💎
A sweet summer of science - Nature Methods
Some graduate students, postdoctoral fellows and senior researchers choose a special kind of science-focused summer.
www.nature.com
June 26, 2025 at 4:52 AM
Amazing to see our student @xiangyiding.bsky.social featured in Nature Methods discussing how the Marine Biological Laboratory Physiology course transformed her approach to research! So proud of her experience and growth. #Frontierscience 🪱💎
Reposted by GW Gant Luxton
Ellen Gregory, @gwgl.bsky.social, & @danstarrucdavis.bsky.social show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX
June 25, 2025 at 6:03 PM
Ellen Gregory, @gwgl.bsky.social, & @danstarrucdavis.bsky.social show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX
🧵 1/8: Excited to share our new paper on how heterochromatin (tightly packed DNA) helps cell nuclei migrate through tight spaces in #Celegans! Published in @genetics_asa #CellBiology #NuclearMigration pubmed.ncbi.nlm.nih.gov/40335054/ Congrats @danstarrucdavis.bsky.social and 1st author Ellen!
Nuclear deformability depends on H3K9-methylated heterochromatin anchorage to the nuclear periphery in Caenorhabditis elegans - PubMed
Nuclei adjust their deformability while migrating through constrictions to enable structural changes and maintain nuclear integrity. The effect of heterochromatin anchored at the nucleoplasmic face of...
pubmed.ncbi.nlm.nih.gov
May 9, 2025 at 6:55 PM
🧵 1/8: Excited to share our new paper on how heterochromatin (tightly packed DNA) helps cell nuclei migrate through tight spaces in #Celegans! Published in @genetics_asa #CellBiology #NuclearMigration pubmed.ncbi.nlm.nih.gov/40335054/ Congrats @danstarrucdavis.bsky.social and 1st author Ellen!
Reposted by GW Gant Luxton
8:30 pm PST.
MARKET CRISIS DEEPENING.
Hang Seng falls 9.96% while HSI Volatility Index surges 43.63%.
Nikkei stabilized at -6.48% after earlier -7.56% drop.
What began as Japanese banking stress has become full regional contagion.
Asian markets now facing their worst session since March 2020.
MARKET CRISIS DEEPENING.
Hang Seng falls 9.96% while HSI Volatility Index surges 43.63%.
Nikkei stabilized at -6.48% after earlier -7.56% drop.
What began as Japanese banking stress has become full regional contagion.
Asian markets now facing their worst session since March 2020.
April 7, 2025 at 3:29 AM
8:30 pm PST.
MARKET CRISIS DEEPENING.
Hang Seng falls 9.96% while HSI Volatility Index surges 43.63%.
Nikkei stabilized at -6.48% after earlier -7.56% drop.
What began as Japanese banking stress has become full regional contagion.
Asian markets now facing their worst session since March 2020.
MARKET CRISIS DEEPENING.
Hang Seng falls 9.96% while HSI Volatility Index surges 43.63%.
Nikkei stabilized at -6.48% after earlier -7.56% drop.
What began as Japanese banking stress has become full regional contagion.
Asian markets now facing their worst session since March 2020.