Xiangyi Ding
@xiangyiding.bsky.social
PhD Candidate @ucdavis | Starr–Luxton Lab | Cell biology & biophysics
Pinned
Xiangyi Ding
@xiangyiding.bsky.social
· Sep 10
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 7:52 PM
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
Reposted by Xiangyi Ding
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
September 10, 2025 at 7:18 PM
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
September 10, 2025 at 7:10 PM
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Xiangyi Ding
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration
Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kines…
www.sciencedirect.com
September 9, 2025 at 9:58 PM
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Xiangyi Ding
Ellen Gregory, @gwgl.bsky.social, & @danstarrucdavis.bsky.social show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX
June 25, 2025 at 6:03 PM
Ellen Gregory, @gwgl.bsky.social, & @danstarrucdavis.bsky.social show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX
It was great to gave a plenary talk to the worm community 🪱 Received great questions and comments. Thanks to both of my PIs @gwgl.bsky.social and @danstarrucdavis.bsky.social for the co-mentorship and thanks to the organizers @genetics-gsa for bringing us together.
Amazing talk (and videos) in plenary 2 from Xiangyi Ding ( @danstarrucdavis.bsky.social ) about biophys constraints in cytoplasm. #Celegans cytoplasm is more like jelly than honey (human cells), plus found gene that constrains this mess particle diffusion. #worm25
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo
Understanding how cells control their biophysical properties during development remains a fundamental challenge. While cytoplasmic macromolecular crowding affects multiple cellular processes in single...
www.biorxiv.org
June 30, 2025 at 2:23 AM
It was great to gave a plenary talk to the worm community 🪱 Received great questions and comments. Thanks to both of my PIs @gwgl.bsky.social and @danstarrucdavis.bsky.social for the co-mentorship and thanks to the organizers @genetics-gsa for bringing us together.