GW Gant Luxton
@gwgl.bsky.social
I’m Gant. My lab studies how the structure of cells affects disease progression. Allen Distinguished Investigator in Molecular and Celular Biology at @UCDavis.
https://luxton.faculty.ucdavis.edu
https://luxton.faculty.ucdavis.edu
Therapeutic implications: target ribosome production pathways, not just nuclear proteins.
@danstarrucdavis.bsky.social (6/6)
#CellBiology #MuscularDystrophy #FrontierScience
@danstarrucdavis.bsky.social (6/6)
#CellBiology #MuscularDystrophy #FrontierScience
September 23, 2025 at 6:26 PM
Therapeutic implications: target ribosome production pathways, not just nuclear proteins.
@danstarrucdavis.bsky.social (6/6)
#CellBiology #MuscularDystrophy #FrontierScience
@danstarrucdavis.bsky.social (6/6)
#CellBiology #MuscularDystrophy #FrontierScience
This changes how we think about laminopathies. It's not just nuclear mechanics or gene regulation - it's fundamental cellular biophysics being rewired by ribosome depletion. (5/6)
September 23, 2025 at 6:26 PM
This changes how we think about laminopathies. It's not just nuclear mechanics or gene regulation - it's fundamental cellular biophysics being rewired by ribosome depletion. (5/6)
Lamin mutations → disrupted nucleolus → fewer ribosomes → altered cytoplasmic crowding → cellular chaos
We call this the "nucleolar-ribosomal axis" and it explains the widespread cellular defects in EDMD. (4/6)
We call this the "nucleolar-ribosomal axis" and it explains the widespread cellular defects in EDMD. (4/6)
September 23, 2025 at 6:26 PM
Lamin mutations → disrupted nucleolus → fewer ribosomes → altered cytoplasmic crowding → cellular chaos
We call this the "nucleolar-ribosomal axis" and it explains the widespread cellular defects in EDMD. (4/6)
We call this the "nucleolar-ribosomal axis" and it explains the widespread cellular defects in EDMD. (4/6)
Using nanoparticle tracking in living C. elegans, we discovered that lamin mutations do not just break nuclear mechanics, they trigger a cascade that reorganizes the entire cytoplasm. (3/6)
September 23, 2025 at 6:26 PM
Using nanoparticle tracking in living C. elegans, we discovered that lamin mutations do not just break nuclear mechanics, they trigger a cascade that reorganizes the entire cytoplasm. (3/6)
Emery-Dreifuss muscular dystrophy is caused by mutations in nuclear proteins (lamins/emerin). But patients show problems way beyond the nucleus: misplaced organelles, disrupted cell structure, etc. Current models couldn't fully explain this. (2/6)
September 23, 2025 at 6:26 PM
Emery-Dreifuss muscular dystrophy is caused by mutations in nuclear proteins (lamins/emerin). But patients show problems way beyond the nucleus: misplaced organelles, disrupted cell structure, etc. Current models couldn't fully explain this. (2/6)
Many thanks to Liana Wait for this fabulous write up!
September 10, 2025 at 7:20 PM
Many thanks to Liana Wait for this fabulous write up!
Worms Reveal Just How Cramped Cells Really Are
In a new study published in Science Advances on September 10, a team of UC Davis researchers tracked the movement of fluorescent particles inside the cells of microscopic worms, providing unprecedente...
biology.ucdavis.edu
September 10, 2025 at 7:20 PM
Congrats to first authors
@xiangyiding.bsky.social, Hongyan Hao, and Daniel Elnatan! This was a fantastic collaboration with
Liam Holt at NYU and the Starr
@danstarrucdavis.bsky.social
-Luxton lab. Many thanks to
@alleninstitute.org nstitute
and @NIGMS for funding this work. #Frontierscience
@xiangyiding.bsky.social, Hongyan Hao, and Daniel Elnatan! This was a fantastic collaboration with
Liam Holt at NYU and the Starr
@danstarrucdavis.bsky.social
-Luxton lab. Many thanks to
@alleninstitute.org nstitute
and @NIGMS for funding this work. #Frontierscience
September 10, 2025 at 7:18 PM
Congrats to first authors
@xiangyiding.bsky.social, Hongyan Hao, and Daniel Elnatan! This was a fantastic collaboration with
Liam Holt at NYU and the Starr
@danstarrucdavis.bsky.social
-Luxton lab. Many thanks to
@alleninstitute.org nstitute
and @NIGMS for funding this work. #Frontierscience
@xiangyiding.bsky.social, Hongyan Hao, and Daniel Elnatan! This was a fantastic collaboration with
Liam Holt at NYU and the Starr
@danstarrucdavis.bsky.social
-Luxton lab. Many thanks to
@alleninstitute.org nstitute
and @NIGMS for funding this work. #Frontierscience
September 9, 2025 at 9:58 PM
Thank you so much! It was such a joy to see Xiangyi's transformation through the MBL program. Looking forward to the blog post - and thanks for highlighting how these summer courses shape the next generation of scientists!
June 28, 2025 at 4:54 AM
Thank you so much! It was such a joy to see Xiangyi's transformation through the MBL program. Looking forward to the blog post - and thanks for highlighting how these summer courses shape the next generation of scientists!
Reposted by GW Gant Luxton
So nice that you encouraged her to apply. Oh and she is also in this teeny-tiny blog post. Still in the works. communities.springernature.com/posts/when-s...
When summertime courses transform a science journey
Summer courses can shape one's science and change one's life, too.
communities.springernature.com
June 27, 2025 at 4:04 PM
So nice that you encouraged her to apply. Oh and she is also in this teeny-tiny blog post. Still in the works. communities.springernature.com/posts/when-s...