Simon Grelet
greletlab.bsky.social
Simon Grelet
@greletlab.bsky.social
Cancersgetnervous.com
Reposted by Simon Grelet
Identification of optimal fluorophores for use in the Drosophila embryo https://www.biorxiv.org/content/10.1101/2025.09.29.678560v1
September 30, 2025 at 11:31 AM
Our work on intercellular transfer of mitochondria and cancer metastasis has been featured in Cancer Discovery, a journal of the American Association for Cancer Research @theaacr.bsky.social

📖 Read it here: aacrjournals.org/cdnews/news/...
Neurons Can Transfer Mitochondria to Cancer Cells
Cancer-associated neurons can transfer their mitochondria to cancer cells, boosting their metabolism and function. Mitochondria might also serve as a measure of risk of metastases. Future therapies co...
aacrjournals.org
July 28, 2025 at 1:38 PM
🎉 NIH-MERIT Award (R37): I have received the NOA for my first R01 grant from the NIH. I am honored that it has been selected for conversion into an R37 MERIT Award, which allows funding for up to seven years! Learn more: grants.nih.gov/funding/acti...
July 22, 2025 at 6:09 AM
🧠⚡ Check out this article about our work on mitochondrial transfers from nerves to cancer cells, recently featured in New Scientist.

www.newscientist.com/article/2485...
Cancer cells steal mitochondria from nerve cells to fuel their spread
Cancer cells can acquire energy-generating structures called mitochondria from nearby nerve cells, which seems to aid their spread, a discovery that could lead to new treatments
www.newscientist.com
July 3, 2025 at 3:06 PM
Reposted by Simon Grelet
The @greletlab.bsky.social show enhanced metastatic capabilities of cancer cells that receive mitochondria from neurons in primary tumors, shedding new light on how the nervous system supports cancer metabolism and metastatic dissemination.
Nerve-to-cancer transfer of mitochondria during cancer metastasis
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
www.nature.com
June 30, 2025 at 8:00 PM
Reposted by Simon Grelet
Did you know that sea slugs steal chloroplasts from algae as portable snacks?! Neither did I, but a new Cell paper demonstrates that they do. 🐌🧪

My favorite part is the researchers called the storage for these stolen hors d’oeuvres “kleptosomes” 😂🥰

Summary from Nature & Cell paper linked below.
‘Wildest thing’: solar-powered slug steals chloroplasts and stores them for emergencies
Marine creatures house contraband structures in special organelles, which the animal raids for food in times of need.
www.nature.com
June 27, 2025 at 8:53 PM
Reposted by Simon Grelet
Center of Rho ophiuchi cloud complex, 7.5h LRGB. #astrophotography
June 27, 2025 at 5:04 PM
Here is an interesting and detailed highlight of our work.
"Neuronal transfer of mitochondria to tumour cells promotes cancer spread"
- News and views - section of Nature.
www.nature.com/articles/d41...
Neuronal transfer of mitochondria to tumour cells promotes cancer spread
Neurons often receive organelles called mitochondria from other cells. It emerges that neurons donate mitochondria that support cancer-cell spread.
www.nature.com
June 27, 2025 at 12:10 AM
Check out our work highlight in the "News" section of Nature.
"Cancer cells get power boost by stealing mitochondria from nerves"
www.nature.com/articles/d41...
Cancer cells get power boost by stealing mitochondria from nerves
The theft probably helps the cells to spread around the body, and preventing it could provide a path to treatment, researchers say.
www.nature.com
June 27, 2025 at 12:08 AM
Reposted by Simon Grelet
When I began studying mitochondria transfer during my master's internship in 2016, a committee member dismissed it as artificial and irrelevant to (patho)physiology. It's great to see growing evidence from recent studies proving otherwise 😊
June 26, 2025 at 7:38 AM
Happy to share our latest study is now out in Nature!

Cancer cells steal mitochondria from neurons to boost metabolism, resist stress & spread.

www.nature.com/articles/s41...

#CancerGetsNervous #Metastasis #Mitochondria #Neuron #CancerResearch #Nature
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...
www.nature.com
June 26, 2025 at 10:38 AM
Reposted by Simon Grelet
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 4:31 PM
Reposted by Simon Grelet
June 25, 2025 at 4:38 PM