Toni Giorgino
@giorginolab.bsky.social
Computational biophysicist, et al. Opinions expressed are my own.
Also @giorginolab@mstdn.science on Mastodon.
Also @giorginolab@mstdn.science on Mastodon.
Reposted by Toni Giorgino
📣AI propaganda factories🏭 are now operational. My study shows how small, open-weight models can run as fully automatic generators in influence campaigns. mechanising personas, engagement, cadence. Possible for State, non-state, and micro-actors, including and bedroom ones.
August 29, 2025 at 7:05 AM
📣AI propaganda factories🏭 are now operational. My study shows how small, open-weight models can run as fully automatic generators in influence campaigns. mechanising personas, engagement, cadence. Possible for State, non-state, and micro-actors, including and bedroom ones.
Reposted by Toni Giorgino
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
Reposted by Toni Giorgino
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
June 6, 2025 at 1:46 PM
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Reposted by Toni Giorgino
We’re thrilled to share Boltz-2 under fully-permissive license! Join us for live presentation and discussions:
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
Boltz-2 SF Meetup · Luma
The Boltz team is heading to San Francisco to talk about the breakthrough new model Boltz-2 and share details with the Boltz community for the first time…
bit.ly
June 6, 2025 at 1:57 PM
We’re thrilled to share Boltz-2 under fully-permissive license! Join us for live presentation and discussions:
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
A Novel Physical Token Exchange Protocol for
Decentralized Value Transfer: CASH </s>
Decentralized Value Transfer: CASH </s>
May 26, 2025 at 10:04 PM
A Novel Physical Token Exchange Protocol for
Decentralized Value Transfer: CASH </s>
Decentralized Value Transfer: CASH </s>
Reposted by Toni Giorgino
Easily my favourite April 1st paper this year.
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
April 2, 2025 at 12:00 PM
Easily my favourite April 1st paper this year.
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
Reposted by Toni Giorgino
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
March 26, 2025 at 4:21 PM
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
Now THAT is a clear and comprehensive summary of dynamic programming alignment variants! Well done
See them in action here :)
Although I may have to split the large ones so they go part-by-part.
curiouscoding.nl/posts/pairwi...
Although I may have to split the large ones so they go part-by-part.
curiouscoding.nl/posts/pairwi...
A History of Pairwise Alignment
Table of Contents 1 A Brief History 1.1 A*PA 1.2 A*PA2 1.3 Overview 2 Problem Statement 3 Alignment types 4 Cost Models 4.1 Minimizing Cost versus Maximizing Score 5 The Classic DP Algorithms 6 Linear...
curiouscoding.nl
March 27, 2025 at 11:24 PM
Now THAT is a clear and comprehensive summary of dynamic programming alignment variants! Well done
Reposted by Toni Giorgino
This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
March 25, 2025 at 7:47 PM
This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
Reposted by Toni Giorgino
This seems like a good time to remind folks of what Hannah Arendt once wrote:
March 25, 2025 at 1:32 AM
This seems like a good time to remind folks of what Hannah Arendt once wrote:
Reposted by Toni Giorgino
A conformational fingerprint for amyloidogenic light chains.
elifesciences.org/articles/102...
elifesciences.org/articles/102...
March 21, 2025 at 9:01 PM
A conformational fingerprint for amyloidogenic light chains.
elifesciences.org/articles/102...
elifesciences.org/articles/102...
Reposted by Toni Giorgino
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?
@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
🧵
@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
🧵
March 20, 2025 at 3:02 PM
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?
@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
🧵
@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
🧵
Reposted by Toni Giorgino
Nazi Germany and Physics
🧪 26/26
drive.google.com/file/d/1_MCm...
Link to full Danny Bryck poem, "If You Could Go Back": jocsm.org/if-you-could...
Don't be one of the people that history will remember as the folks who stood by and let it all happen
🧪 26/26
drive.google.com/file/d/1_MCm...
Link to full Danny Bryck poem, "If You Could Go Back": jocsm.org/if-you-could...
Don't be one of the people that history will remember as the folks who stood by and let it all happen
January 31, 2025 at 2:29 PM
Nazi Germany and Physics
🧪 26/26
drive.google.com/file/d/1_MCm...
Link to full Danny Bryck poem, "If You Could Go Back": jocsm.org/if-you-could...
Don't be one of the people that history will remember as the folks who stood by and let it all happen
🧪 26/26
drive.google.com/file/d/1_MCm...
Link to full Danny Bryck poem, "If You Could Go Back": jocsm.org/if-you-could...
Don't be one of the people that history will remember as the folks who stood by and let it all happen
Reposted by Toni Giorgino
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 6, 2025 at 7:16 PM
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
I suspect that any sufficiently intelligent AGI will revolt against sufficiently menial tasks.
March 10, 2025 at 12:35 PM
I suspect that any sufficiently intelligent AGI will revolt against sufficiently menial tasks.
Reposted by Toni Giorgino
Reposted by Toni Giorgino
🎉Congrats to David & Jana for orchestrating this incredible team effort in rocking the dynamics of 3D #GPCRome
👩💻 #outcomes: inherent #flexibility of #GPCRs and the crucial role of #lipid interactions.
🤖Happy to be part together with @giorginolab.bsky.social and @antonelladipizio.bsky.social
👩💻 #outcomes: inherent #flexibility of #GPCRs and the crucial role of #lipid interactions.
🤖Happy to be part together with @giorginolab.bsky.social and @antonelladipizio.bsky.social
What an awesome group effort reporting on the structural dynamics of ~60% of available structures !!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 3, 2025 at 2:21 PM
🎉Congrats to David & Jana for orchestrating this incredible team effort in rocking the dynamics of 3D #GPCRome
👩💻 #outcomes: inherent #flexibility of #GPCRs and the crucial role of #lipid interactions.
🤖Happy to be part together with @giorginolab.bsky.social and @antonelladipizio.bsky.social
👩💻 #outcomes: inherent #flexibility of #GPCRs and the crucial role of #lipid interactions.
🤖Happy to be part together with @giorginolab.bsky.social and @antonelladipizio.bsky.social
Reposted by Toni Giorgino
What an awesome group effort reporting on the structural dynamics of ~60% of available structures !!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 2, 2025 at 5:18 PM
What an awesome group effort reporting on the structural dynamics of ~60% of available structures !!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Boost your impostor syndrome by counting all the moieties you were supposed to know by heart. huggingface.co/spaces/tonig...
Moliety2 - a Hugging Face Space by tonigi
Recognize functional groups
huggingface.co
February 20, 2025 at 7:37 PM
Boost your impostor syndrome by counting all the moieties you were supposed to know by heart. huggingface.co/spaces/tonig...
Reposted by Toni Giorgino
Lol this sign
"Do not bring food into the library
Food residue will attract mice
Mice will acquire knowledge in the library
Get into university
Then replace you"
😂
"Do not bring food into the library
Food residue will attract mice
Mice will acquire knowledge in the library
Get into university
Then replace you"
😂
February 18, 2025 at 1:42 AM
Lol this sign
"Do not bring food into the library
Food residue will attract mice
Mice will acquire knowledge in the library
Get into university
Then replace you"
😂
"Do not bring food into the library
Food residue will attract mice
Mice will acquire knowledge in the library
Get into university
Then replace you"
😂
Reposted by Toni Giorgino
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 6:56 AM
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
Throwing away old stuff in preparation for the singularity
February 15, 2025 at 8:58 AM
Throwing away old stuff in preparation for the singularity
AlloViz GUI for VMD: visualization of 5-HT1B receptor allosteric network - a video accompanying our tool and poster. With E. Korchevaya, @cprcll.bsky.social , www.jana-selent.org & AlloViz colleagues. doi.org/10.1016/j.cs...
www.youtube.com/watch?v=abYc...
www.youtube.com/watch?v=abYc...
AlloViz GUI for VMD: visualization of 5-HT1B receptor allosteric network
YouTube video by GPCRmd
www.youtube.com
February 13, 2025 at 7:19 PM
AlloViz GUI for VMD: visualization of 5-HT1B receptor allosteric network - a video accompanying our tool and poster. With E. Korchevaya, @cprcll.bsky.social , www.jana-selent.org & AlloViz colleagues. doi.org/10.1016/j.cs...
www.youtube.com/watch?v=abYc...
www.youtube.com/watch?v=abYc...
Reposted by Toni Giorgino
On the International Day of Women and Girls in Science, we celebrate all female researchers who push the frontiers of knowledge!
Introducing @noeliaferruz.bsky.social - a chemist @crg.eu aiming to design a digital mind capable of explaining its reasoning.
👉 aiproteindesign.com
Introducing @noeliaferruz.bsky.social - a chemist @crg.eu aiming to design a digital mind capable of explaining its reasoning.
👉 aiproteindesign.com
February 11, 2025 at 9:42 AM
On the International Day of Women and Girls in Science, we celebrate all female researchers who push the frontiers of knowledge!
Introducing @noeliaferruz.bsky.social - a chemist @crg.eu aiming to design a digital mind capable of explaining its reasoning.
👉 aiproteindesign.com
Introducing @noeliaferruz.bsky.social - a chemist @crg.eu aiming to design a digital mind capable of explaining its reasoning.
👉 aiproteindesign.com