Toni Giorgino
@giorginolab.bsky.social
Computational biophysicist, et al. Opinions expressed are my own.
Also @giorginolab@mstdn.science on Mastodon.
Also @giorginolab@mstdn.science on Mastodon.
Reposted by Toni Giorgino
Our work presented today at the #PhysicsOfBiomolecules workshop in Bressanone sites.unimi.it/bressanone/! @sdimarco.bsky.social will show our attempts to make replica exchange molecular dynamics simulations more effective for sampling #RNA conformations
Bressanone Workshop – 9th Workshop
9th Workshop
sites.unimi.it
February 12, 2026 at 8:39 AM
Our work presented today at the #PhysicsOfBiomolecules workshop in Bressanone sites.unimi.it/bressanone/! @sdimarco.bsky.social will show our attempts to make replica exchange molecular dynamics simulations more effective for sampling #RNA conformations
Reposted by Toni Giorgino
On this International Day of Women and Girls in Science I (as in previous years) take an Implicit Association Test to remind myself of my potential biases and with the goal of remembering to take them into account
You too can do this at:
implicit.harvard.edu/implicit/
You too can do this at:
implicit.harvard.edu/implicit/
February 11, 2026 at 7:11 PM
On this International Day of Women and Girls in Science I (as in previous years) take an Implicit Association Test to remind myself of my potential biases and with the goal of remembering to take them into account
You too can do this at:
implicit.harvard.edu/implicit/
You too can do this at:
implicit.harvard.edu/implicit/
Reposted by Toni Giorgino
![Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreihwhjblp5lyiwp63ouar7ocfea7evmckytoeo7rkfuoo4gw5rnrra@jpeg)
November 26, 2025 at 10:32 PM
Reposted by Toni Giorgino
As some of you may know, I draw coloring books in my spare time for kids and adults. Last year, I did a series on Chemistry Nobel Prizes. ALL 117 of them :D
Now, for a series of very good reasons: F**k Amazon !!!
You can now buy them from Lulu bookstores: www.lulu.com/search?sortB...
Now, for a series of very good reasons: F**k Amazon !!!
You can now buy them from Lulu bookstores: www.lulu.com/search?sortB...
February 11, 2026 at 12:42 PM
As some of you may know, I draw coloring books in my spare time for kids and adults. Last year, I did a series on Chemistry Nobel Prizes. ALL 117 of them :D
Now, for a series of very good reasons: F**k Amazon !!!
You can now buy them from Lulu bookstores: www.lulu.com/search?sortB...
Now, for a series of very good reasons: F**k Amazon !!!
You can now buy them from Lulu bookstores: www.lulu.com/search?sortB...
Reposted by Toni Giorgino
📢 We are #hiring!
▫️Head, Advanced #Genomics Technologies Core Facility
▫️Head, #Histopathology Core Facility
▫️Research Associate on #genAI applied to #DrugDiscovery
▫️ Senior Spatial #Omics Technician
...& many more!
➡️ https://bit.ly/irbjobs
#IRBJobs #ScienceJobs #JobOffer #OncoSky #AcademicSky
▫️Head, Advanced #Genomics Technologies Core Facility
▫️Head, #Histopathology Core Facility
▫️Research Associate on #genAI applied to #DrugDiscovery
▫️ Senior Spatial #Omics Technician
...& many more!
➡️ https://bit.ly/irbjobs
#IRBJobs #ScienceJobs #JobOffer #OncoSky #AcademicSky
February 10, 2026 at 10:02 AM
📢 We are #hiring!
▫️Head, Advanced #Genomics Technologies Core Facility
▫️Head, #Histopathology Core Facility
▫️Research Associate on #genAI applied to #DrugDiscovery
▫️ Senior Spatial #Omics Technician
...& many more!
➡️ https://bit.ly/irbjobs
#IRBJobs #ScienceJobs #JobOffer #OncoSky #AcademicSky
▫️Head, Advanced #Genomics Technologies Core Facility
▫️Head, #Histopathology Core Facility
▫️Research Associate on #genAI applied to #DrugDiscovery
▫️ Senior Spatial #Omics Technician
...& many more!
➡️ https://bit.ly/irbjobs
#IRBJobs #ScienceJobs #JobOffer #OncoSky #AcademicSky
The deluge - or even the possibility - of LLM-written papers, written in plausible prose but actually unfounded, is definitely eroding my trust in what is published.
Will it be worth reading papers any more? Even assuming it is physically possible to pre-screen them.
Will it be worth reading papers any more? Even assuming it is physically possible to pre-screen them.
February 10, 2026 at 2:19 PM
The deluge - or even the possibility - of LLM-written papers, written in plausible prose but actually unfounded, is definitely eroding my trust in what is published.
Will it be worth reading papers any more? Even assuming it is physically possible to pre-screen them.
Will it be worth reading papers any more? Even assuming it is physically possible to pre-screen them.
Reposted by Toni Giorgino
I made a map of 3.4 million Bluesky users - see if you can find yourself!
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
Bluesky Map
Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.
bluesky-map.theo.io
February 8, 2026 at 10:59 PM
I made a map of 3.4 million Bluesky users - see if you can find yourself!
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
Reposted by Toni Giorgino
🧐 You are a physicist or chemist who wants to reveal how life works at the molecular level?
🤓 You know how to combine computer power and theory to solve biological problems?
❤️ You just love doing science?
👉 Send us your application!
🔗 Current job adverts www.mpinat.mpg.de/grubmueller
🤓 You know how to combine computer power and theory to solve biological problems?
❤️ You just love doing science?
👉 Send us your application!
🔗 Current job adverts www.mpinat.mpg.de/grubmueller
February 6, 2026 at 3:09 PM
🧐 You are a physicist or chemist who wants to reveal how life works at the molecular level?
🤓 You know how to combine computer power and theory to solve biological problems?
❤️ You just love doing science?
👉 Send us your application!
🔗 Current job adverts www.mpinat.mpg.de/grubmueller
🤓 You know how to combine computer power and theory to solve biological problems?
❤️ You just love doing science?
👉 Send us your application!
🔗 Current job adverts www.mpinat.mpg.de/grubmueller
My humble contribution to the slop-calypse: a visualizer of historical SMART (HDD monitoring) data logs.
giorginolab.github.io/smartmontool...
It was surprisingly missing. Made in one hour or so.
giorginolab.github.io/smartmontool...
It was surprisingly missing. Made in one hour or so.
February 6, 2026 at 6:45 PM
My humble contribution to the slop-calypse: a visualizer of historical SMART (HDD monitoring) data logs.
giorginolab.github.io/smartmontool...
It was surprisingly missing. Made in one hour or so.
giorginolab.github.io/smartmontool...
It was surprisingly missing. Made in one hour or so.
Reposted by Toni Giorgino
Incredible article which points out that it often collectively costs more to apply for scarce research funding than the funds awarded to the successful proposals.
What an absurd system we've built in the service of efficiency and competition.
www.nature.com/articles/d41...
What an absurd system we've built in the service of efficiency and competition.
www.nature.com/articles/d41...
January 13, 2026 at 8:55 PM
Incredible article which points out that it often collectively costs more to apply for scarce research funding than the funds awarded to the successful proposals.
What an absurd system we've built in the service of efficiency and competition.
www.nature.com/articles/d41...
What an absurd system we've built in the service of efficiency and competition.
www.nature.com/articles/d41...
Reposted by Toni Giorgino
Just making sure that 2025 is definitely over
January 1, 2026 at 4:43 AM
Just making sure that 2025 is definitely over
December 26, 2025 at 8:26 AM
Reposted by Toni Giorgino
Cover art to 'Look and Learn,' December 1976
December 24, 2025 at 10:03 PM
Cover art to 'Look and Learn,' December 1976
Reposted by Toni Giorgino
Andromeda and Sprites over Australia apod.nasa.gov/apod/ap25121...
What’s happening over that tree? Two very different things. On the left is the Andromeda galaxy, an object that is older than humanity and will last billions of years into the future.
What’s happening over that tree? Two very different things. On the left is the Andromeda galaxy, an object that is older than humanity and will last billions of years into the future.
December 20, 2025 at 12:56 AM
Andromeda and Sprites over Australia apod.nasa.gov/apod/ap25121...
What’s happening over that tree? Two very different things. On the left is the Andromeda galaxy, an object that is older than humanity and will last billions of years into the future.
What’s happening over that tree? Two very different things. On the left is the Andromeda galaxy, an object that is older than humanity and will last billions of years into the future.
Reposted by Toni Giorgino
Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
December 19, 2025 at 9:38 AM
Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
Reposted by Toni Giorgino
We all need to be far more skeptical about the "promises" of AI in academia.
This hands a terrifying amount of power to AI companies.
And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.
This hands a terrifying amount of power to AI companies.
And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.
December 16, 2025 at 7:30 PM
We all need to be far more skeptical about the "promises" of AI in academia.
This hands a terrifying amount of power to AI companies.
And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.
This hands a terrifying amount of power to AI companies.
And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.
Reposted by Toni Giorgino
My amazing joint grad student (with Ami Bhatt) Danica Schmidtke, gave me a ceramic phage she made as a gift. It makes me very happy indeed.
December 16, 2025 at 1:28 AM
My amazing joint grad student (with Ami Bhatt) Danica Schmidtke, gave me a ceramic phage she made as a gift. It makes me very happy indeed.
Reposted by Toni Giorgino
“One of the misconceptions about autistic people is we take things literally” #KiwiPyCon
November 22, 2025 at 8:18 PM
“One of the misconceptions about autistic people is we take things literally” #KiwiPyCon
Reposted by Toni Giorgino
📣AI propaganda factories🏭 are now operational. My study shows how small, open-weight models can run as fully automatic generators in influence campaigns. mechanising personas, engagement, cadence. Possible for State, non-state, and micro-actors, including and bedroom ones.
August 29, 2025 at 7:05 AM
📣AI propaganda factories🏭 are now operational. My study shows how small, open-weight models can run as fully automatic generators in influence campaigns. mechanising personas, engagement, cadence. Possible for State, non-state, and micro-actors, including and bedroom ones.
Reposted by Toni Giorgino
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
Reposted by Toni Giorgino
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
June 6, 2025 at 1:46 PM
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Reposted by Toni Giorgino
We’re thrilled to share Boltz-2 under fully-permissive license! Join us for live presentation and discussions:
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
Boltz-2 SF Meetup · Luma
The Boltz team is heading to San Francisco to talk about the breakthrough new model Boltz-2 and share details with the Boltz community for the first time…
bit.ly
June 6, 2025 at 1:57 PM
We’re thrilled to share Boltz-2 under fully-permissive license! Join us for live presentation and discussions:
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
• MIT (Cambridge) – Monday June 9 bit.ly/boltz2-mit
• San Francisco – Wednesday June 11 bit.ly/boltz2-sf • • NVIDIA #GTC25 (Paris) – Wednesday June 11
• MoML (Montreal) – Tuesday June 17
A Novel Physical Token Exchange Protocol for
Decentralized Value Transfer: CASH </s>
Decentralized Value Transfer: CASH </s>
May 26, 2025 at 10:04 PM
A Novel Physical Token Exchange Protocol for
Decentralized Value Transfer: CASH </s>
Decentralized Value Transfer: CASH </s>
Reposted by Toni Giorgino
Easily my favourite April 1st paper this year.
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
April 2, 2025 at 12:00 PM
Easily my favourite April 1st paper this year.
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com
Brave and terrifying. #TeXLaTeX
paper: arxiv.org/abs/2503.24187
homepage: neuralatex.com