Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome
journals.lww.com/jasn/fulltex...
journals.lww.com/jasn/fulltex...
Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy... : Journal of the American Society of Nephrology
sociated with good kidney outcomes at 10 years.Monogenic nephrotic syndrome cases had very high proteinuria and rapid progression to kidney failure with little response to current treatments.
Backgro...
journals.lww.com
July 3, 2025 at 7:55 AM
Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome
journals.lww.com/jasn/fulltex...
journals.lww.com/jasn/fulltex...
Reposted
A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024
#ERA25 🇦🇹 #Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/39211339/
#ERA25 🇦🇹 #Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/39211339/
June 8, 2025 at 6:54 PM
A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024
#ERA25 🇦🇹 #Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/39211339/
#ERA25 🇦🇹 #Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/39211339/
Reposted
Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month
@ndt-era.bsky.social
The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease
academic.oup.com/ndt/article/...
@ndt-era.bsky.social
The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease
academic.oup.com/ndt/article/...
Disease-modifying anti-nephropathic drugs (DMANDs)—a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA)
ABSTRACT. A definition of ‘disease modification’ for kidney disease is long overdue. Here, we propose three key criteria for disease modification in immune
academic.oup.com
June 3, 2025 at 5:23 AM
Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month
@ndt-era.bsky.social
The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease
academic.oup.com/ndt/article/...
@ndt-era.bsky.social
The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease
academic.oup.com/ndt/article/...
Reposted
Foundational therapies in ESRD for heart failure
Dr Matt Graham-Brown from Leicester presents at #NephGR
www.youtube.com/watch?v=Ar11...
(Rounds from Feb, late share!)
Dr Matt Graham-Brown from Leicester presents at #NephGR
www.youtube.com/watch?v=Ar11...
(Rounds from Feb, late share!)
Foundation therapies for heart failure in end stage kidney disease with Dr Matt Graham-Brown
YouTube video by Ottawa Nephrology
www.youtube.com
June 2, 2025 at 1:08 PM
Foundational therapies in ESRD for heart failure
Dr Matt Graham-Brown from Leicester presents at #NephGR
www.youtube.com/watch?v=Ar11...
(Rounds from Feb, late share!)
Dr Matt Graham-Brown from Leicester presents at #NephGR
www.youtube.com/watch?v=Ar11...
(Rounds from Feb, late share!)
Reposted
May 27, 2025 at 11:08 PM
Reposted
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients
doi.org/10.1016/j.kint.2025.04.023
#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx
doi.org/10.1016/j.kint.2025.04.023
#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx
May 27, 2025 at 1:14 PM
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients
doi.org/10.1016/j.kint.2025.04.023
#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx
doi.org/10.1016/j.kint.2025.04.023
#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx
Reposted
Discontinuing aspirin during surgery for chronic subdural hematoma did not lower recurrence rates compared to continuous treatment.
by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky
👉 get more here
📖 read the article:
by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky
👉 get more here
📖 read the article:
Aspirin Continuation or Discontinuation in Surgically Treated Chronic Subdural Hematoma
The SECA randomized clinical trial assesses the risk of recurrence of chronic subdural hematoma (cSDH) and cardiovascular events in patients undergoing surgical treatment for cSDH with continuous vs discontinuous low-dose acetylsalicylic acid treatment.
jamanetwork.com
May 6, 2025 at 2:14 AM
Reposted
#archive30 #day24
It's very hard to choose 😵💫
But this is a pretty #popularitem - an original X ray tube
Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️
@arascot.bsky.social
It's very hard to choose 😵💫
But this is a pretty #popularitem - an original X ray tube
Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️
@arascot.bsky.social
April 24, 2025 at 6:01 AM
#archive30 #day24
It's very hard to choose 😵💫
But this is a pretty #popularitem - an original X ray tube
Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️
@arascot.bsky.social
It's very hard to choose 😵💫
But this is a pretty #popularitem - an original X ray tube
Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️
@arascot.bsky.social
Reposted
This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece
I will argue we need less guidelines
They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)
I will argue we need less guidelines
They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)
Why Health Guidelines Should Be Waged Like War
Updated Here's a modest proposal: we need fewer and shorter guidelines. In fact, I'd like to propose that guidelines, like war, should be waged only when there is absolute consensus and overwhelming e...
www.forbes.com
April 16, 2025 at 3:32 PM
This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece
I will argue we need less guidelines
They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)
I will argue we need less guidelines
They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)
Reposted
Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmM
Longest human transplant of pig kidney fails
In latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months
scim.ag
April 11, 2025 at 12:12 PM
Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmM
Reposted
Overall they sleep poorly
Median ~ 6.5 hours - and look at the spread
2/
Median ~ 6.5 hours - and look at the spread
2/
April 10, 2025 at 2:13 AM
Overall they sleep poorly
Median ~ 6.5 hours - and look at the spread
2/
Median ~ 6.5 hours - and look at the spread
2/
Reposted
Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social
Renal Denervation in .....loin pain hematuria syndrome!
www.ajkd.org/article/S027...
#NephSky
Renal Denervation in .....loin pain hematuria syndrome!
www.ajkd.org/article/S027...
#NephSky
Renal Denervation in Loin Pain Hematuria Syndrome: A Pilot Randomized Controlled Trial
Loin pain hematuria syndrome (LPHS) is a rare disease characterized by severe, unrelenting
unilateral or bilateral loin pain localized to the kidney but not caused by any identifiable
urinary tract di...
www.ajkd.org
April 10, 2025 at 2:25 PM
Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social
Renal Denervation in .....loin pain hematuria syndrome!
www.ajkd.org/article/S027...
#NephSky
Renal Denervation in .....loin pain hematuria syndrome!
www.ajkd.org/article/S027...
#NephSky
Reposted
hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there
April 5, 2025 at 1:55 PM
hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there
Reposted
#archive30 #day3 #soundandvision
#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.
The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs
#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.
The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs
April 3, 2025 at 6:01 AM
#archive30 #day3 #soundandvision
#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.
The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs
#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.
The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs
Reposted
Anti-Nephrin Antibodies in Adult Chinese Patients with Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis
doi.org/10.1016/j.kint.2025.02.028
#NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis
doi.org/10.1016/j.kint.2025.02.028
#NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis
March 27, 2025 at 2:14 PM
Anti-Nephrin Antibodies in Adult Chinese Patients with Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis
doi.org/10.1016/j.kint.2025.02.028
#NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis
doi.org/10.1016/j.kint.2025.02.028
#NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis
Delivering a trial with adequate power to answer the question of anticoagulation and AF should now be a priority for the nephrology community. journals.lww.com/jasn/abstrac...
Anticoagulation for Patients with Atrial Fibrillation... : Journal of the American Society of Nephrology
agulation (n=48).Despite coronavirus disease–related pauses, recruitment was completed in 30 months, with 83% of participants completing follow-up in their assigned treatment arm.
Background
Atrial...
journals.lww.com
March 27, 2025 at 8:24 AM
Delivering a trial with adequate power to answer the question of anticoagulation and AF should now be a priority for the nephrology community. journals.lww.com/jasn/abstrac...
Haven’t entered for #nephmadness for couple of years as Twitter toxic. Really enjoyed entering for 2025. Excellent CME. Great work as ever from all involved. mild dismay at infiltration of “… up to x%” instead of “approximately x%” from general journalism in to nephrologist prose. up to x = 0 to x 🫣
March 26, 2025 at 7:20 PM
Haven’t entered for #nephmadness for couple of years as Twitter toxic. Really enjoyed entering for 2025. Excellent CME. Great work as ever from all involved. mild dismay at infiltration of “… up to x%” instead of “approximately x%” from general journalism in to nephrologist prose. up to x = 0 to x 🫣
Reposted
5 minute resting + 60 seconds between measurements is the current standard for Blood Pressure
Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
March 25, 2025 at 2:04 PM
5 minute resting + 60 seconds between measurements is the current standard for Blood Pressure
Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
Reposted
So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything!
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
March 19, 2025 at 11:22 AM
So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything!
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
Reposted
ACEi and ARBs are not “nephrotoxic.”
We all know about their long term renal protective benefits…
But even in the short term, they improve renal blood flow!
They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI.
But bad for kidneys? No
We all know about their long term renal protective benefits…
But even in the short term, they improve renal blood flow!
They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI.
But bad for kidneys? No
Good morning to everyone except the Walgreen pharmacist telling my patients that lisinopril is bad for the kidneys.
March 18, 2025 at 4:15 PM
ACEi and ARBs are not “nephrotoxic.”
We all know about their long term renal protective benefits…
But even in the short term, they improve renal blood flow!
They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI.
But bad for kidneys? No
We all know about their long term renal protective benefits…
But even in the short term, they improve renal blood flow!
They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI.
But bad for kidneys? No
More evidence that DDAVP is not useful to reduce the risk of kidney biopsy bleeding
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
Effect of Desmopressin in Post Kidney Biopsy Bleeding... : Kidney360
journals.lww.com
March 12, 2025 at 1:26 PM
More evidence that DDAVP is not useful to reduce the risk of kidney biopsy bleeding
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
Reposted
I've never been to an M&M about kidney injury attributable to iodinated contrast.
I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost
I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost
So without a randomized clinical trial this is what we are left with. The highest quality epidemiology studies are unable to detect any increase in AKI, so those bumps in creatinine following contrast are almost certainly run of the mill AKI and not contrast induced AKI.
March 11, 2025 at 2:35 PM
I've never been to an M&M about kidney injury attributable to iodinated contrast.
I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost
I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost