Gabriel Ortega
@gabolab.bsky.social
Research lab at CIC bioGUNE (Bilbao, Spain).
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Biosensors, biomolecular engineering and protein biophysics.
www.cicbiogune.es/people/gortega
Wavelength AND lifetime multiplexed imaging, cool!
By @ciqus.bsky.social
onlinelibrary.wiley.com/doi/full/10....
By @ciqus.bsky.social
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
January 29, 2026 at 12:07 PM
Wavelength AND lifetime multiplexed imaging, cool!
By @ciqus.bsky.social
onlinelibrary.wiley.com/doi/full/10....
By @ciqus.bsky.social
onlinelibrary.wiley.com/doi/full/10....
Reposted by Gabriel Ortega
This is how we first teach chirality to our undergrads !
Loved this from @simonmaechling.bsky.social - chemistry FTW…
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
January 19, 2026 at 5:54 PM
This is how we first teach chirality to our undergrads !
Very interesting study on the cardiac toxicity of doxorubicin chemotherapy.
By researchers from CNIC, Spain:
academic.oup.com/eurheartj/ad...
By researchers from CNIC, Spain:
academic.oup.com/eurheartj/ad...
Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload
AbstractBackground and Aims. Hypertension and valvular heart disease, both associated with left ventricular (LV) pressure overload, increase the risk of an
academic.oup.com
January 14, 2026 at 3:00 PM
Very interesting study on the cardiac toxicity of doxorubicin chemotherapy.
By researchers from CNIC, Spain:
academic.oup.com/eurheartj/ad...
By researchers from CNIC, Spain:
academic.oup.com/eurheartj/ad...
I knew it!
Those Fuckers Were Making It Up This Whole Time: An Exposé of “Electrochemistry"
PDF: www.immaterialscience.org/2025/electro...
PDF: www.immaterialscience.org/2025/electro...
December 29, 2025 at 8:35 AM
I knew it!
Reposted by Gabriel Ortega
New preprint🚨
Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design?
What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be?
Why to be wary🧵👇
Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design?
What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be?
Why to be wary🧵👇
December 16, 2025 at 3:15 PM
New preprint🚨
Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design?
What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be?
Why to be wary🧵👇
Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design?
What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be?
Why to be wary🧵👇
Reposted by Gabriel Ortega
We are proud to introduce the Program Planning Committee for the 40th Anniversary Symposium of The Protein Society!
This outstanding team will curate an unforgettable scientific program for our 2026 meeting.
Stay tuned for more info!
#PS40 #TheProteinSociety #ProteinScience #TPS2026
This outstanding team will curate an unforgettable scientific program for our 2026 meeting.
Stay tuned for more info!
#PS40 #TheProteinSociety #ProteinScience #TPS2026
December 8, 2025 at 9:21 PM
We are proud to introduce the Program Planning Committee for the 40th Anniversary Symposium of The Protein Society!
This outstanding team will curate an unforgettable scientific program for our 2026 meeting.
Stay tuned for more info!
#PS40 #TheProteinSociety #ProteinScience #TPS2026
This outstanding team will curate an unforgettable scientific program for our 2026 meeting.
Stay tuned for more info!
#PS40 #TheProteinSociety #ProteinScience #TPS2026
They are going down the folding funnel
I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:
November 30, 2025 at 9:05 AM
They are going down the folding funnel
Reposted by Gabriel Ortega
Reposted by Gabriel Ortega
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
We are all mosaics: vast genetic diversity found between cells in a single person
Technical advances allow researchers to trace the genetic changes that occur over time.
go.nature.com
November 26, 2025 at 9:28 AM
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
Reposted by Gabriel Ortega
#bioGUNE_Outreach | 🎨 La ciencia y el arte vuelven a encontrarse en #CICbioGUNE @brtaeus.bsky.social
Recibimos al alumnado de #ArgiArte en una nueva edición de #CICbioArte para explorar el metabolismo a través del #Pointillismo
🙏 Eskerrik asko!
🔗 www.cicbiogune.es/news/cic-bio...
Recibimos al alumnado de #ArgiArte en una nueva edición de #CICbioArte para explorar el metabolismo a través del #Pointillismo
🙏 Eskerrik asko!
🔗 www.cicbiogune.es/news/cic-bio...
November 27, 2025 at 8:16 AM
#bioGUNE_Outreach | 🎨 La ciencia y el arte vuelven a encontrarse en #CICbioGUNE @brtaeus.bsky.social
Recibimos al alumnado de #ArgiArte en una nueva edición de #CICbioArte para explorar el metabolismo a través del #Pointillismo
🙏 Eskerrik asko!
🔗 www.cicbiogune.es/news/cic-bio...
Recibimos al alumnado de #ArgiArte en una nueva edición de #CICbioArte para explorar el metabolismo a través del #Pointillismo
🙏 Eskerrik asko!
🔗 www.cicbiogune.es/news/cic-bio...
Reposted by Gabriel Ortega
#bioGUNE_Seminars | 👥 Yesterday we held a new #OncoSeminar session at #CICbioGUNE @brtaeus.bsky.social under #PreMetaCan, where researchers shared recent advances and challenges. A participatory format that fostered synergies, collaboration, and new connections
@contracancerinv.bsky.social
@contracancerinv.bsky.social
November 21, 2025 at 7:43 AM
#bioGUNE_Seminars | 👥 Yesterday we held a new #OncoSeminar session at #CICbioGUNE @brtaeus.bsky.social under #PreMetaCan, where researchers shared recent advances and challenges. A participatory format that fostered synergies, collaboration, and new connections
@contracancerinv.bsky.social
@contracancerinv.bsky.social
Not only an impressive high-throughput characterization of protein stability, but so many interesting take away messages...
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 20, 2025 at 11:54 AM
Not only an impressive high-throughput characterization of protein stability, but so many interesting take away messages...
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Arginines bad for solubility
Solubility predictors not great
Anti-correlation between aggregation and folding stability
...
Amazing work!
Reposted by Gabriel Ortega
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Gabriel Ortega
#bioGUNE_Research | The @caixaresearch.bsky.social funds nearly €1M for #GlycoTARGET, led by June Ereño-Orbea #CICbioGUNE #Ikerbasque @brtaeus.bsky.social, to boost cancer immunotherapy with partners from Spain & Portugal
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
November 20, 2025 at 8:24 AM
#bioGUNE_Research | The @caixaresearch.bsky.social funds nearly €1M for #GlycoTARGET, led by June Ereño-Orbea #CICbioGUNE #Ikerbasque @brtaeus.bsky.social, to boost cancer immunotherapy with partners from Spain & Portugal
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
🔗 cicbiogune.es/news/la-caix...
@urv.cat @champalimaudr.bsky.social
Reposted by Gabriel Ortega
Giant telescope project, long planned for Hawaii, gets cozy with Spain | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Giant telescope project, long planned for Hawaii, gets cozy with Spain
Spain’s €400 million offer could induce Thirty Meter Telescope to switch sites
www.science.org
November 17, 2025 at 5:50 PM
Giant telescope project, long planned for Hawaii, gets cozy with Spain | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Reposted by Gabriel Ortega
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Saw this on the other site by @smead2.bsky.social
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
November 12, 2025 at 10:14 PM
Saw this on the other site by @smead2.bsky.social
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Synuclein spreading as prions… great news for all researchers ever working with synuclein!
Reposted by Gabriel Ortega
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Chemical Tools for Complex Biological Systems IV
Organizers Luke Lavis, HHMI/Janelia Research Campus Matthew Bogyo, Stanford University Zev Gartner, University of California, San Francisco Jennifer Prescher, University of California, Irvine
www.janelia.org
November 11, 2025 at 6:03 PM
ahem, ONE of THE chemical biology conferences of 2026:) www.janelia.org/you-janelia/...
Reposted by Gabriel Ortega
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Reposted by Gabriel Ortega
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by Gabriel Ortega
#bioGUNE_News | 💡 The European project #RGNcestry, awarded an #ERCSyG, brings together #CICbioGUNE and Instituto Biofisika to study CRISPR evolution and develop next-gen gene-editing and diagnostic tools
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
November 6, 2025 at 11:55 AM
#bioGUNE_News | 💡 The European project #RGNcestry, awarded an #ERCSyG, brings together #CICbioGUNE and Instituto Biofisika to study CRISPR evolution and develop next-gen gene-editing and diagnostic tools
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
🔗 www.cicbiogune.es/news/cic-bio...
@erc.europa.eu
Reposted by Gabriel Ortega
Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
go.nature.com/47qdigV
go.nature.com/47qdigV
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkhals snakes.
go.nature.com
October 29, 2025 at 6:30 PM
Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
go.nature.com/47qdigV
go.nature.com/47qdigV
Reposted by Gabriel Ortega
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
Cancer immunotherapy by γδ T cells
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and i...
scim.ag
October 24, 2025 at 7:56 PM
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
¿Qué son y para qué sirven los biosensores?
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
#bioGUNE_Outreach | 🎙️ Biosensores, el cuerpo habla y la ciencia escucha
➡️ ¿Y si la tecnología pudiera avisarte antes de que aparezcan los síntomas? Descúbrelo con @gabolab.bsky.social #Ikerbasque en #BioEnredados #CICbioGUNE @brtaeus.bsky.social
🔗 ow.ly/TJYO50XeLy0
➡️ ¿Y si la tecnología pudiera avisarte antes de que aparezcan los síntomas? Descúbrelo con @gabolab.bsky.social #Ikerbasque en #BioEnredados #CICbioGUNE @brtaeus.bsky.social
🔗 ow.ly/TJYO50XeLy0
October 21, 2025 at 9:40 AM
¿Qué son y para qué sirven los biosensores?
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Aquí hablo de ello en #BioEnredados el podcast de divulgación científica de @cicbiogune.bsky.social
Enjoy!
Reposted by Gabriel Ortega
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇