Félix Ramos-León
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felixrl.bsky.social
Félix Ramos-León
@felixrl.bsky.social
1.3K followers 870 following 78 posts
Postdoctoral fellow at NIH studying cell biology of coccoid bacteria.
Views my own.
He/him/Él 🏳️‍🌈
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felixrl.bsky.social
Félix Ramos-León @felixrl.bsky.social · Oct 28
Excited to share that our paper is now out in ⁦Nature Microbiology @natureportfolio.bsky.social! We characterize a positive mechanism for Z ring placement in S. aureus governed by the proteins PcdA/DivIVA, and its implication during infection in a mouse model #Microsky
rdcu.be/dYmdC
PcdA promotes orthogonal division plane selection in Staphylococcus aureus
Nature Microbiology - PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces...
rdcu.be
Reposted by Félix Ramos-León
wvschaik.bsky.social
Heroic work by @bluebirdsjunk.bsky.social in pulling this mammoth study together

'Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism'

www.biorxiv.org/content/10.1...
Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism
Staphylococcus haemolyticus is a common commensal bacterium but also an opportunistic pathogen, frequently implicated in bacteraemia and sepsis in preterm neonates and immunocompromised patients. Desp...
www.biorxiv.org
November 11, 2025 at 10:04 AM
Reposted by Félix Ramos-León
jcamthrash.bsky.social
The cell envelope of diderm bacteria: a unified scaffold, not a stack of layers www.sciencedirect.com/science/arti... #jcampubs
November 10, 2025 at 4:39 PM
Reposted by Félix Ramos-León
thanbichlerlab.bsky.social
📢 Postdoc position: Biochemistry & Bacterial cell biology

in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"

🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025

Please repost. #Postdoc
November 10, 2025 at 6:15 PM
Reposted by Félix Ramos-León
jaanmannik.bsky.social
Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...

#MicroSky #Microbiology #Biophysics #CellBiology
Diagram of an E. coli cell showing polysomes pushing sister chromosomes apart. Bottom heatmaps show cell-cycle-dependent changes in DNA and ribosome density distributions, and constriction formation. The top right corner shows normalized mid cell amounts from these heatmaps (integrated between the dashed horizontal lines).
November 9, 2025 at 2:05 AM
Reposted by Félix Ramos-León
smitslab.bsky.social
🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens - Nature Communications
In this work, Urem et al. characterize the mode of action as well as mechanism of reduced susceptibility related to a class of antimicrobials that is in development for the treatment of infections wit...
doi.org
November 6, 2025 at 10:29 AM
Reposted by Félix Ramos-León
tbharat-lab.bsky.social
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Reposted by Félix Ramos-León
brunlabcaulo.bsky.social
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Reposted by Félix Ramos-León
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Félix Ramos-León
veeninglab.com
Now online! journals.plos.org/plospathogen... #MicroSky
November 5, 2025 at 12:21 PM
Reposted by Félix Ramos-León
biorxiv-microbiol.bsky.social
Genome-wide screen identifies novel factors for surface protein cross-wall trafficking and cell envelope homeostasis in Staphylococcus aureus https://www.biorxiv.org/content/10.1101/2025.11.03.686427v1
November 5, 2025 at 2:16 AM
Reposted by Félix Ramos-León
drym.bsky.social
Methanobrevibacter smithii: Trends in Microbiology www.cell.com/trends/micro...
Methanobrevibacter smithii
Methanobrevibacter smithii is one of the most prevalent and worldwide distributed archaea in the human gut. M. smithii is a strict anaerobe that obtains its energy through methanogenesis. In culture, ...
www.cell.com
November 3, 2025 at 9:41 PM
Reposted by Félix Ramos-León
emmseveri.bsky.social
#microsky #phagesky #phage defence

Novel bacterial ubiquitination-like pathway!

www.nature.com/articles/s41...
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway - Nature Structural & Molecular Biology
Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitina...
www.nature.com
November 3, 2025 at 8:56 PM
Reposted by Félix Ramos-León
thanbichlerlab.bsky.social
📢 Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025

Please repost. #Postdoc
November 2, 2025 at 7:13 PM
Reposted by Félix Ramos-León
kevindwhitley.bsky.social
Interested in a PhD at the intersection of biophysics and microbiology?

Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠

Closing 4 Dec!

www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
www.findaphd.com
October 31, 2025 at 1:09 PM
Reposted by Félix Ramos-León
asm.org
How did life begin, and why does it matter? Scientists are tracing early microbial life–from LUCA to multicellularity–to unlock insights for biotech, climate science and even space exploration. Read the article: asm.org/articles/202...
Early Microbial Evolution | ASM.org
How did life begin, and why does it matter? Scientists are tracing early microbial life—from LUCA to multicellularity—to unlock insights for biotech, climate science and even space exploration.
asm.org
October 30, 2025 at 2:09 PM
Reposted by Félix Ramos-León
bactophile.bsky.social
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex
Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...
journals.plos.org
October 28, 2025 at 1:25 AM
Reposted by Félix Ramos-León
biorxiv-microbiol.bsky.social
Fast assembly and in vivo coalescence of ParB biocondensates involved in bacterial DNA partition https://www.biorxiv.org/content/10.1101/2025.10.27.684735v1
October 27, 2025 at 9:17 PM
Reposted by Félix Ramos-León
geiselbiofilm.bsky.social
JB Editor's Choice: Peng, Lyman & Schmitt characterize zinc-binding proteins in the cell wall of Corynebacterium diphtheriae - their work suggests an uncharacterized mechanism whereby these proteins are localized.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 27, 2025 at 3:12 PM
Reposted by Félix Ramos-León
zeynepbaharoglu.bsky.social
Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC url: academic.oup.com/nar/article/...
Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC
Abstract. Natural chromosomal transformation (NCT) in Bacillus subtilis requires RecA and its accessory proteins including RecX and RecD2. Inactivation of
academic.oup.com
October 25, 2025 at 12:10 PM
Reposted by Félix Ramos-León
biorxivpreprint.bsky.social
FlAsH-ID: A short peptide tag for live cell photoproximity labeling https://www.biorxiv.org/content/10.1101/2025.10.24.684417v1
October 25, 2025 at 3:18 AM
Reposted by Félix Ramos-León
seamusholden.bsky.social
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com
PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com
www.findaphd.com
October 22, 2025 at 8:29 AM
Reposted by Félix Ramos-León
matthutchings.bsky.social
This is a model strain we use in the lab. It's from a Kenyan fungus growing plant-ant nest and has ~60 biosynthetic gene clusters, many of which look novel. It's also amenable to genome editing, which is unusual in our environmental strain collection.

www.microbiologyresearch.org/content/jour...
Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory
Streptomyces formicae KY5 was isolated from a Tetraponera penzigi plant-ant nest. It is primarily known for its production of the formicamycins, antibiotics with potent activity against Gram-positive ...
www.microbiologyresearch.org
October 24, 2025 at 12:05 PM
Reposted by Félix Ramos-León
jerryknowsnothing.bsky.social
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications
Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...
www.nature.com
October 24, 2025 at 4:08 AM
Reposted by Félix Ramos-León
emmseveri.bsky.social
www.pnas.org/doi/10.1073/...

#microsky
Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria | PNAS
Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacter...
www.pnas.org
October 22, 2025 at 6:31 PM
Reposted by Félix Ramos-León
sanmillan.bsky.social
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
www.cell.com
October 22, 2025 at 1:12 PM