Siobhan Mitchell, PhD
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esiobhanmitchell.bsky.social
Siobhan Mitchell, PhD
@esiobhanmitchell.bsky.social
850 followers 1.1K following 140 posts
I'm a neuroscientist with a special focus on nutrition, metabolism and mitochondria. Always happy to chat about brain aging (or any kind of aging), great books to read, travel, food and writing.

https://sciprofiles.com/user/publications/865800
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Reposted by Siobhan Mitchell, PhD
sadie.moe
For what its worth, the blue plaque crediting Watson and Crick was replaced a few years back with one that gives proper credit because people kept adding Franklin's name to it.

newn.cam.ac.uk/newnham-news...
Revised plaque acknowledges Franklin’s DNA role
A blue plaque which commemorates the celebration by Francis Crick and James Watson of the discovery of the structure of DNA in 1953 has been updated to acknowledge the contribution of Newnham alumna R...
newn.cam.ac.uk
November 9, 2025 at 10:00 AM
esiobhanmitchell.bsky.social
🧪 Wearing your heart (and your age) on your wrist

Cool new study shows that an Apple watch can act as a biological aging clock.

This study predicted cardiovascular, diabetes, and other diseases of aging all through that pulsing green light on your wrist.
www.nature.com/articles/s41...
A wearable-based aging clock associates with disease and behavior - Nature Communications
Biomarkers of aging play a vital role in understanding human longevity, but can be inconvenient or invasive to collect. Here, the authors develop an aging clock using consumer wearable photoplethysmog...
www.nature.com
November 5, 2025 at 3:39 AM
esiobhanmitchell.bsky.social
Younger adults are reporting higher levels of memory problems.

The authors state that economic hardship may be a cause

I wonder if growing rates of obesity at younger ages might play a role (I recently published how losing just 5% of body weight can improve cognition).
dx.doi.org/10.1212/WNL....
Rising Cognitive Disability as a Public Health Concern Among US Adults | Neurology
Background and ObjectivesCognitive disability—defined by the Behavioral Risk Factor Surveillance System (BRFSS) as serious difficulty concentrating, remembering, or making decisions because of a physi...
dx.doi.org
November 3, 2025 at 2:04 AM
Reposted by Siobhan Mitchell, PhD
cbartman.bsky.social
excited to read this preprint from rabinowitz lab- how does the body decide which nutrients are burned, and how can this go wrong in T2 diabetes?
www.biorxiv.org/content/10.1...
Competitive catabolism in systemic metabolic homeostasis
Systemic metabolic homeostasis maintains circulating nutrient concentrations within physiological ranges. Insulin is central to this process, lowering circulating levels of glucose, free fatty acids, ...
www.biorxiv.org
October 31, 2025 at 7:40 PM
esiobhanmitchell.bsky.social
Huge paradigm shift!

The brain does use fat, this is big news in the neuroscience world, since for decades it was thought that the brain used exclusively glucose or ketones.

Why did this take so long to figure out? Because neurons don't use this fuel all the time
www.nature.com/articles/s42...
Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism
Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.
www.nature.com
October 27, 2025 at 8:37 PM
Reposted by Siobhan Mitchell, PhD
hellengreenblat.bsky.social
A tale of two organelles: #Mitochondria and #lysosomes
Activated cell states → ↑ mitochondria vs. resting cell states. These mitochondria have more dense cristae, suggesting they are an important part of regulatory T cell activation during #inflammation. bit.ly/4qLclsH bit.ly/3LdvLWx
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells
Mitochondrial and lysosomal signaling orchestrates Treg cell metabolic states and functional fitness.
bit.ly
October 27, 2025 at 7:27 PM
Reposted by Siobhan Mitchell, PhD
drtanakabluesky.bsky.social
🧠💥 #Depression, #PTSD & #Alzheimer’s may share a #Tryptophan storm!😱 KAT2 knockout mice reveal #Brain-region rewiring in #Trp– #kynurenine metabolism🔄🔥 @mdpiopenaccess.bsky.social #Neuroscience #Depression #PTSD #Tryptophan #Kynurenine
👉
www.preprints.org/manuscript/2...
October 14, 2025 at 5:50 AM
Reposted by Siobhan Mitchell, PhD
jennanewman.bsky.social
Community science! Input from over TEN THOUSAND PEOPLE! From Mexico to Canada! In a natural experiment!

“Bc a total solar eclipse occurs in the same location once every 3 or4 centuries, most free-living birds, like most ppl, have never seen day turn quickly to pm, only to return again mins later”🧪
October 10, 2025 at 2:00 AM
esiobhanmitchell.bsky.social
I was recently on @hackmyage.bsky.social,
a podcast about #biohacking and #longevity, to talk about how protecting your #mitochondria may be the best thing you can to delay #aging

You can find links to the episode below:
open.spotify.com/embed/episod...
October 4, 2025 at 9:01 PM
esiobhanmitchell.bsky.social
Sequential versus Co-treatment of MitoQ and NMN to Enhance Autophagy, NAD⁺ Metabolism, and Mitochondrial Function in Cellular Senescence, with Exploratory Uncoupler–NMN Synergy in Vascular Aging www.researchhub.com/fund/4365/se...
Sequential versus Co-treatment of MitoQ and NMN to Enhanc...
Sequential versus Co-treatment of MitoQ and NMN to Enhance Aut...
www.researchhub.com
August 31, 2025 at 9:44 PM
Reposted by Siobhan Mitchell, PhD
natashaloder.bsky.social
This finding is mindblowing to me (and probably anyone who lives in a country with universal healthcare).

www.cbsnews.com/news/over-th...
Nearly a third of people using over-the-counter birth control pills previously used nothing, study finds
Two years ago, the first over-the-counter birth control pill was approved. Now, new research looks at who's switching to it and why.
www.cbsnews.com
August 20, 2025 at 6:16 AM
Reposted by Siobhan Mitchell, PhD
timsargeant.bsky.social
Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people:

www.tandfonline.com/doi/full/10.... @sahmri.bsky.social
Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction
Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a ...
www.tandfonline.com
August 18, 2025 at 5:50 AM
esiobhanmitchell.bsky.social
White matter in the brain gets broken down in high energy need situations, and might affect later cognitive decline

Brain myelin as a deficient energy source in aging and disease: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
Brain myelin as a deficient energy source in aging and disease
Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at main...
www.cell.com
August 18, 2025 at 8:17 PM
esiobhanmitchell.bsky.social
Insightful review of how mitochondria are behind the very early causes of cardiovascular disease and diabetes.

www.mdpi.com/2077-0383/14...
www.mdpi.com
August 17, 2025 at 2:44 AM
esiobhanmitchell.bsky.social
Happy to share that I'll be speaking at Functional Medicine is Longevity Medicine: A Masterclass for Clinicians! Make sure to attend it on September 18. www.linkedin.com/events/funct...
Functional Medicine is Longevity Medicine: A Masterclass for Clinicians | LinkedIn
Join me for the Functional Medicine IS Longevity Medicine Masterclass, a free online event September 17-19 that acknowledges, unites, and elevates the role of functional medicine in longevity medicine...
www.linkedin.com
August 9, 2025 at 11:08 PM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 27, 2025 at 6:36 PM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 22, 2025 at 7:17 PM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 16, 2025 at 2:55 AM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 14, 2025 at 3:01 AM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 14, 2025 at 2:59 AM
esiobhanmitchell.bsky.social
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.

#Books
#BookSky 💙📚
#BookChallenge
July 8, 2025 at 12:45 PM
Reposted by Siobhan Mitchell, PhD
karagavin.bsky.social
Wow - an important read for #academicsky #scisky #medsky, about a study on professional social media activity by female scientists vs male, performed using @altmetric.com data from 2013-2018 (so, pre-Bluesky)

Summary: news.umich.edu/fewer-women-...
Paper: www.nature.com/articles/s41...
Fewer women amplify their scientific voices online
A new University of Michigan study finds that women are about 28% less likely than men to promote their scientific papers on X (formerly Twitter)—a seemingly minor digital decision that could have big...
news.umich.edu
July 7, 2025 at 5:48 PM
Reposted by Siobhan Mitchell, PhD
danieljdrucker.bsky.social
Here inflammation-related pathways are identified as associated with and possibly relevant for the response to depression treatment in people with type 1 diabetes or type 2 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Biomarkers of inflammation and improvement in depressive symptoms in type 1 and type 2 diabetes: differential associations with depressive symptom clusters - Diabetologia
Aims/hypothesis People with diabetes and depression show large heterogeneity in their response to depression treatment. This study aimed to identify biomarkers of subclinical inflammation that were as...
link.springer.com
July 8, 2025 at 9:52 AM
esiobhanmitchell.bsky.social
Check out the interview I had on Modern Healthspan YouTube/podcast, where I talk about how MitoQ reverses 15-20 years of #vascular #aging, as well as the latest clinical study results on #menopause and #exercise

www.youtube.com/watch?v=lSFu...
Mitochondria Expert: This Supplement Reversed Vascular Aging by 20 Years
YouTube video by Modern Healthspan
www.youtube.com
July 7, 2025 at 2:37 PM