Emily Addington
@emilyaddington.bsky.social
Postdoc in the Roe Lab, Glasgow, working on the genotoxin colibactin. Interested in pathogenic E. coli, the gut microbiome, and CRC. She/Her. 🇧🇲 🏴 🏳️🌈
Reposted by Emily Addington
For those of you who approached me at @microbiologysociety.org #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
April 4, 2025 at 9:46 AM
For those of you who approached me at @microbiologysociety.org #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!
Reposted by Emily Addington
If you're still at #MircoBio25, head down to poster 89 and catch up with all the work that @phoebecrossley.bsky.social is up to as part of her PhD in my lab #microsky #vaginalmicrobiome
April 2, 2025 at 1:52 PM
If you're still at #MircoBio25, head down to poster 89 and catch up with all the work that @phoebecrossley.bsky.social is up to as part of her PhD in my lab #microsky #vaginalmicrobiome
Reposted by Emily Addington
New paper from the group - here we show that aurodox prevents shiga toxin mediated damage in a murine model. Interesting changes to the microbiota too. Amazing work by @rebeccamchugh.bsky.social and the group.
Paper here- rdcu.be/efW0K
Paper here- rdcu.be/efW0K
April 1, 2025 at 11:31 AM
New paper from the group - here we show that aurodox prevents shiga toxin mediated damage in a murine model. Interesting changes to the microbiota too. Amazing work by @rebeccamchugh.bsky.social and the group.
Paper here- rdcu.be/efW0K
Paper here- rdcu.be/efW0K
Reposted by Emily Addington
The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer
bsky.app/profile/them...
bsky.app/profile/them...
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
www.sciencedirect.com
February 13, 2025 at 2:29 PM
The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer
bsky.app/profile/them...
bsky.app/profile/them...
Reposted by Emily Addington
🚨 #PhD opportunity! 🚨
Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬
Details here: www.strath.ac.uk/studywithus/...
Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬
Details here: www.strath.ac.uk/studywithus/...
February 8, 2025 at 10:41 AM
🚨 #PhD opportunity! 🚨
Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬
Details here: www.strath.ac.uk/studywithus/...
Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬
Details here: www.strath.ac.uk/studywithus/...
Reposted by Emily Addington
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
January 24, 2025 at 12:07 PM
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
Reposted by Emily Addington
New Scientist (@newscientist.bsky.social) wrote a feature on our work! 🧪✨🔬
We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing.
newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/
We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing.
newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/
January 10, 2025 at 8:20 PM
New Scientist (@newscientist.bsky.social) wrote a feature on our work! 🧪✨🔬
We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing.
newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/
We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing.
newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/
go.bsky.app/CJyjtir
A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼
A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼
December 12, 2024 at 3:18 PM
go.bsky.app/CJyjtir
A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼
A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼
Reposted by Emily Addington
New paper from the group. Very proud to share our recent work for the first time here on Bluesky- give me 50 likes and it’s a permanent move!🤣.
doi.org/10.1098/rsob...
doi.org/10.1098/rsob...
November 29, 2024 at 9:15 PM
New paper from the group. Very proud to share our recent work for the first time here on Bluesky- give me 50 likes and it’s a permanent move!🤣.
doi.org/10.1098/rsob...
doi.org/10.1098/rsob...
Reposted by Emily Addington
Our second paper on the bacterial toxin colibactin is now out on mBio, this time we critically evaluated the claim that colibactin toxicity necessitates cell-cell contact 🧪🦠🧵(1/9)
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
December 2, 2024 at 4:44 PM
Our second paper on the bacterial toxin colibactin is now out on mBio, this time we critically evaluated the claim that colibactin toxicity necessitates cell-cell contact 🧪🦠🧵(1/9)
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Emily Addington
Colibactin-producing E. coli 🦠 uses adhesin proteins to bind to colon cells, driving DNA damage 🧬 and tumor growth in #CRC. Blocking this binding with targeted inhibitors could open paths to anti-cancer therapies! 🌟! #Microbiome #ColorectalCancer #GutHealth #ImmunoSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding - Nature
The oncogenic potential of pks+ Escherichia coli depends critically on bacterial adhesion to host epithelial cells mediated by the type 1 pilus adhesin FimH and the F9 pilus adhesin FmlH.
www.nature.com
November 7, 2024 at 4:39 PM
Colibactin-producing E. coli 🦠 uses adhesin proteins to bind to colon cells, driving DNA damage 🧬 and tumor growth in #CRC. Blocking this binding with targeted inhibitors could open paths to anti-cancer therapies! 🌟! #Microbiome #ColorectalCancer #GutHealth #ImmunoSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Emily Addington
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
www.sciencedirect.com
December 5, 2024 at 9:04 AM
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
I wrote a short blog post for the Microbiology Society regarding our recent colibactin regulation review. Available here. @sofiasandalli.bsky.social @drandyjroe.bsky.social
Regulation of a carcinogenic genotoxin
<span style="font-family:"Calibri",sans-serif; font-size:11.0pt; mso-ansi-language:EN-GB; mso-ascii-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-language:AR-SA; mso-bidi-them...
microbiologysociety.org
February 6, 2024 at 3:09 PM
I wrote a short blog post for the Microbiology Society regarding our recent colibactin regulation review. Available here. @sofiasandalli.bsky.social @drandyjroe.bsky.social
Reposted by Emily Addington
Really pleased to share Curtis Cottam’s first paper from his PhD, where he discovered a new Arabinose transporter in pathogenic E.coli and investigated the impact of Arabinose utilisation on virulence gene regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Metabolism of ʟ -arabinose converges with virulence regulation to promote enteric pathogen fitness
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
December 23, 2023 at 11:22 AM
Really pleased to share Curtis Cottam’s first paper from his PhD, where he discovered a new Arabinose transporter in pathogenic E.coli and investigated the impact of Arabinose utilisation on virulence gene regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
@sofiasandalli.bsky.social @drandyjroe.bsky.social and I wrote a little review about colibactin, with a brilliant graphical abstract by Iris Floria. You can read it here: go.shr.lc/42t0SCb
Current understandings of colibactin regulation
The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA – S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a pote...
go.shr.lc
February 5, 2024 at 11:42 AM
@sofiasandalli.bsky.social @drandyjroe.bsky.social and I wrote a little review about colibactin, with a brilliant graphical abstract by Iris Floria. You can read it here: go.shr.lc/42t0SCb
Reposted by Emily Addington
BBSRC NorthWest Bio Fully Funded Doctoral Training Programme #Studentship with me & @lore-fermar.bsky.social on understanding how antibiotic producing #Streptomyces bacteria adapt to their environment & how reproducible mutations are-Pls share-Details here www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Bio - Our Pr...
www.gla.ac.uk
November 28, 2023 at 2:31 PM
BBSRC NorthWest Bio Fully Funded Doctoral Training Programme #Studentship with me & @lore-fermar.bsky.social on understanding how antibiotic producing #Streptomyces bacteria adapt to their environment & how reproducible mutations are-Pls share-Details here www.gla.ac.uk/postgraduate...