Brian Johnston
@drbwbri.bsky.social
Anaesthetist | Intensive Care Medicine | PhD 🫀 🩺 researcher (Liverpool Centre for Cardiovascular Sciences) | Artificial Intelligence/ML/Digital Twins | (lazy) 🏃♂️🚴🏼♂️ | probably too political | cat person 🐱| my own views 🇬🇧🇮🇪☘️🇪🇺
https://linktr.ee/drbwbri
https://linktr.ee/drbwbri
Pinned
Brian Johnston
@drbwbri.bsky.social
· Dec 13
🚨 Seeking stakeholders to participate in the Development of a Core Outcome Set for Trials on the Management of Atrial Fibrillation 🚨
Please consider joining our international stakeholder group by scanning the QR code below:
Please consider joining our international stakeholder group by scanning the QR code below:
New publication out in Intensive Care Medicine! We review the challenges & advances in managing atrial fibrillation in critical illness, and outline key gaps for future research.
Read it here: doi.org/10.1007/s001...
#ICU #AFib #CriticalCare
Read it here: doi.org/10.1007/s001...
#ICU #AFib #CriticalCare
May 6, 2025 at 1:45 PM
New publication out in Intensive Care Medicine! We review the challenges & advances in managing atrial fibrillation in critical illness, and outline key gaps for future research.
Read it here: doi.org/10.1007/s001...
#ICU #AFib #CriticalCare
Read it here: doi.org/10.1007/s001...
#ICU #AFib #CriticalCare
In Lund, Sweden 🇸🇪 for the TARGET meeting — advancing AI-driven virtual twins 🤖 to fight AF ❤️ and stroke 🧠 across Europe 🇪🇺
#TARGETproject #DigitalHealth #AF #EUresearch
@nhsuhlg-ri.bsky.social @target-horizoneu.bsky.social @liverpooluni.bsky.social
#TARGETproject #DigitalHealth #AF #EUresearch
@nhsuhlg-ri.bsky.social @target-horizoneu.bsky.social @liverpooluni.bsky.social
April 7, 2025 at 2:06 PM
In Lund, Sweden 🇸🇪 for the TARGET meeting — advancing AI-driven virtual twins 🤖 to fight AF ❤️ and stroke 🧠 across Europe 🇪🇺
#TARGETproject #DigitalHealth #AF #EUresearch
@nhsuhlg-ri.bsky.social @target-horizoneu.bsky.social @liverpooluni.bsky.social
#TARGETproject #DigitalHealth #AF #EUresearch
@nhsuhlg-ri.bsky.social @target-horizoneu.bsky.social @liverpooluni.bsky.social
Reposted by Brian Johnston
Prof Xavier Monnet addresses the HD effects of prone positioning.
Great take homes about the risk of the waterfall effect and the use of Trendelenburg position in the prone patient to predict fluid responsiveness.
Linked paper below
#ISICEM25
#EMIMCC
ccforum.biomedcentral.com/articles/10....
Great take homes about the risk of the waterfall effect and the use of Trendelenburg position in the prone patient to predict fluid responsiveness.
Linked paper below
#ISICEM25
#EMIMCC
ccforum.biomedcentral.com/articles/10....
March 18, 2025 at 5:54 PM
Prof Xavier Monnet addresses the HD effects of prone positioning.
Great take homes about the risk of the waterfall effect and the use of Trendelenburg position in the prone patient to predict fluid responsiveness.
Linked paper below
#ISICEM25
#EMIMCC
ccforum.biomedcentral.com/articles/10....
Great take homes about the risk of the waterfall effect and the use of Trendelenburg position in the prone patient to predict fluid responsiveness.
Linked paper below
#ISICEM25
#EMIMCC
ccforum.biomedcentral.com/articles/10....
Reposted by Brian Johnston
#ISICEM25 | Always fascinating to hear @MichardFrederic discuss the future of bedside screens 🖥️🔍
📊 Evolution to visual decision support tools
🔹 Turning data into knowledge
⚡ Faster & more accurate detection of abnormalities
🧠 Improving situation awareness & reducing cognitive workload
📊 Evolution to visual decision support tools
🔹 Turning data into knowledge
⚡ Faster & more accurate detection of abnormalities
🧠 Improving situation awareness & reducing cognitive workload
March 20, 2025 at 5:56 PM
#ISICEM25 | Always fascinating to hear @MichardFrederic discuss the future of bedside screens 🖥️🔍
📊 Evolution to visual decision support tools
🔹 Turning data into knowledge
⚡ Faster & more accurate detection of abnormalities
🧠 Improving situation awareness & reducing cognitive workload
📊 Evolution to visual decision support tools
🔹 Turning data into knowledge
⚡ Faster & more accurate detection of abnormalities
🧠 Improving situation awareness & reducing cognitive workload
Absolutely thrilled that @liverpooluni.bsky.social 4th year medical student Jessica who undertook her MRes with us at NHS University Hospitals of Liverpool Group has won an award for her poster at #isicem25 #isicem ISICEM. Absolutely bossing it! 👊🏻🤗 well done Jessica! 👊🏻
@nhsuhlg-ri.bsky.social
@nhsuhlg-ri.bsky.social
March 21, 2025 at 12:46 PM
Absolutely thrilled that @liverpooluni.bsky.social 4th year medical student Jessica who undertook her MRes with us at NHS University Hospitals of Liverpool Group has won an award for her poster at #isicem25 #isicem ISICEM. Absolutely bossing it! 👊🏻🤗 well done Jessica! 👊🏻
@nhsuhlg-ri.bsky.social
@nhsuhlg-ri.bsky.social
Reposted by Brian Johnston
Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. https://ja.ma/4kxDZGm #ISICEM25
March 18, 2025 at 7:50 AM
Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. https://ja.ma/4kxDZGm #ISICEM25
Reposted by Brian Johnston
Now @pirracchior presenting the OVISS Reinforcement Learning Study: Optimal Vasopressin Initiation in Septic
Shock
@ISICEM.bsky.social #ISICEM25
Shock
@ISICEM.bsky.social #ISICEM25
March 18, 2025 at 8:40 AM
Now @pirracchior presenting the OVISS Reinforcement Learning Study: Optimal Vasopressin Initiation in Septic
Shock
@ISICEM.bsky.social #ISICEM25
Shock
@ISICEM.bsky.social #ISICEM25
Reposted by Brian Johnston
Results of the #SESARtrial:
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
March 18, 2025 at 8:38 AM
Results of the #SESARtrial:
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Reposted by Brian Johnston
At #ISICEM
Fodder for the evening run is gathering.
Not least the OVISS study looking at a reinforcement learning tool for the optimal timing of vasopressin introduction.
jamanetwork.com/journals/jam...
Fodder for the evening run is gathering.
Not least the OVISS study looking at a reinforcement learning tool for the optimal timing of vasopressin introduction.
jamanetwork.com/journals/jam...
Optimal Vasopressin Initiation in Septic Shock
This multicenter study uses reinforcement learning to examine the treatment implications of a vasopressin initiation rule developed to improve short-term and hospital outcomes in critically ill adults...
jamanetwork.com
March 18, 2025 at 10:00 AM
At #ISICEM
Fodder for the evening run is gathering.
Not least the OVISS study looking at a reinforcement learning tool for the optimal timing of vasopressin introduction.
jamanetwork.com/journals/jam...
Fodder for the evening run is gathering.
Not least the OVISS study looking at a reinforcement learning tool for the optimal timing of vasopressin introduction.
jamanetwork.com/journals/jam...
Reposted by Brian Johnston
@isicem.bsky.social is renowned for its full, high-quality scientific program.
Watch now Prof. Fabio Taccone's recommendations & start crafting your personalized learning journey today!
More sessions on isicem.org/1/ProgrammeI...
#criticalcare #intensivecare #emergencymedicine
Watch now Prof. Fabio Taccone's recommendations & start crafting your personalized learning journey today!
More sessions on isicem.org/1/ProgrammeI...
#criticalcare #intensivecare #emergencymedicine
March 6, 2025 at 12:36 PM
@isicem.bsky.social is renowned for its full, high-quality scientific program.
Watch now Prof. Fabio Taccone's recommendations & start crafting your personalized learning journey today!
More sessions on isicem.org/1/ProgrammeI...
#criticalcare #intensivecare #emergencymedicine
Watch now Prof. Fabio Taccone's recommendations & start crafting your personalized learning journey today!
More sessions on isicem.org/1/ProgrammeI...
#criticalcare #intensivecare #emergencymedicine
Reposted by Brian Johnston
"The sparseness of formal regulation contrasts starkly with AI’s potential to cause harm." This Viewpoint examines prospects for populating the regulatory landscape for health and health care AI in the coming years. https://ja.ma/429LY54
March 17, 2025 at 3:45 PM
"The sparseness of formal regulation contrasts starkly with AI’s potential to cause harm." This Viewpoint examines prospects for populating the regulatory landscape for health and health care AI in the coming years. https://ja.ma/429LY54
Reposted by Brian Johnston
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
March 15, 2025 at 5:32 PM
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
Reposted by Brian Johnston
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
buff.ly
February 21, 2025 at 7:41 PM
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
🩺🫀 Exciting news! 🫀🩺
Thank you, Isansys Lifecare, for delivering our next batch of wireless patient monitoring systems for the WARD 24/7 substudy!
We’re using AI & wireless monitoring to improve patient care & save lives.
#AIinHealthcare #WirelessMonitoring #Research #AI
@nhsuhlg-ri.bsky.social
Thank you, Isansys Lifecare, for delivering our next batch of wireless patient monitoring systems for the WARD 24/7 substudy!
We’re using AI & wireless monitoring to improve patient care & save lives.
#AIinHealthcare #WirelessMonitoring #Research #AI
@nhsuhlg-ri.bsky.social
February 17, 2025 at 9:06 PM
🩺🫀 Exciting news! 🫀🩺
Thank you, Isansys Lifecare, for delivering our next batch of wireless patient monitoring systems for the WARD 24/7 substudy!
We’re using AI & wireless monitoring to improve patient care & save lives.
#AIinHealthcare #WirelessMonitoring #Research #AI
@nhsuhlg-ri.bsky.social
Thank you, Isansys Lifecare, for delivering our next batch of wireless patient monitoring systems for the WARD 24/7 substudy!
We’re using AI & wireless monitoring to improve patient care & save lives.
#AIinHealthcare #WirelessMonitoring #Research #AI
@nhsuhlg-ri.bsky.social
Reposted by Brian Johnston
Disappointing decision whatever the underlying reasons, given that Liverpool's future economic growth is centred on Health and Life Sciences development.
How and why did a £450m deal for a major vaccine hub in Liverpool fall apart and what does it mean for the city and it’s prospects?
The inside story from me and @danhaygarth1.bsky.social
www.liverpoolecho.co.uk/news/liverpo...
The inside story from me and @danhaygarth1.bsky.social
www.liverpoolecho.co.uk/news/liverpo...
A ‘text message’ deal, a £450m blow and a city region left hanging
The inside story of how a massive Liverpool vaccine project fell to pieces and what happens next
www.liverpoolecho.co.uk
February 9, 2025 at 2:00 PM
Disappointing decision whatever the underlying reasons, given that Liverpool's future economic growth is centred on Health and Life Sciences development.
Reposted by Brian Johnston
It's World Cancer Day and 10 years ago this year I was diagnosed with breast cancer. I can't believe it was a decade ago
This is me in hospital waiting to have a mastectomy. I'm smiling but god I was so anxious, so worried I wouldn't wake up from the anaesthetic
🧵
This is me in hospital waiting to have a mastectomy. I'm smiling but god I was so anxious, so worried I wouldn't wake up from the anaesthetic
🧵
February 4, 2025 at 10:41 AM
It's World Cancer Day and 10 years ago this year I was diagnosed with breast cancer. I can't believe it was a decade ago
This is me in hospital waiting to have a mastectomy. I'm smiling but god I was so anxious, so worried I wouldn't wake up from the anaesthetic
🧵
This is me in hospital waiting to have a mastectomy. I'm smiling but god I was so anxious, so worried I wouldn't wake up from the anaesthetic
🧵
Reposted by Brian Johnston
#Medsky🧪 #IDSky #Immunosky #pharmasky #publichealth This Review discusses management of safety issues for #CARTcell therapies : #cytokine release syndrome, as well as druggable targets & cellular engineering strategies to develop safer #CART cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 4, 2025 at 10:15 PM
#Medsky🧪 #IDSky #Immunosky #pharmasky #publichealth This Review discusses management of safety issues for #CARTcell therapies : #cytokine release syndrome, as well as druggable targets & cellular engineering strategies to develop safer #CART cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Brian Johnston
🚨🚨We’re so excited to be back podding today!!
Listen now to the first episode in our new Guidelines Series. We’re starting with the Asthma GINA guidelines and today talking about diagnosis, assessment, and phenotyping
www.pulmpeeps.com/2025/02/04/9...
Listen now to the first episode in our new Guidelines Series. We’re starting with the Asthma GINA guidelines and today talking about diagnosis, assessment, and phenotyping
www.pulmpeeps.com/2025/02/04/9...
February 4, 2025 at 9:38 PM
🚨🚨We’re so excited to be back podding today!!
Listen now to the first episode in our new Guidelines Series. We’re starting with the Asthma GINA guidelines and today talking about diagnosis, assessment, and phenotyping
www.pulmpeeps.com/2025/02/04/9...
Listen now to the first episode in our new Guidelines Series. We’re starting with the Asthma GINA guidelines and today talking about diagnosis, assessment, and phenotyping
www.pulmpeeps.com/2025/02/04/9...
Reposted by Brian Johnston
And submental muscle recruitment increases during expiratory loading tasks
pubmed.ncbi.nlm.nih.gov/17294298/
Although post extubation dysphagia is clearly multi factorial, could training of the submental muscles after extubation improve swallowing?
pubmed.ncbi.nlm.nih.gov/17294298/
Although post extubation dysphagia is clearly multi factorial, could training of the submental muscles after extubation improve swallowing?
February 4, 2025 at 8:15 AM
And submental muscle recruitment increases during expiratory loading tasks
pubmed.ncbi.nlm.nih.gov/17294298/
Although post extubation dysphagia is clearly multi factorial, could training of the submental muscles after extubation improve swallowing?
pubmed.ncbi.nlm.nih.gov/17294298/
Although post extubation dysphagia is clearly multi factorial, could training of the submental muscles after extubation improve swallowing?
Reposted by Brian Johnston
Expiratory muscle strength training (EMST) has some evidence for improving swallowing in several disease states
But what about after extubation in intensive care? Can EMST improve post extubation dysphagia?
Our SR protocol, published today #critcare
onlinelibrary.wiley.com/doi/full/10....
But what about after extubation in intensive care? Can EMST improve post extubation dysphagia?
Our SR protocol, published today #critcare
onlinelibrary.wiley.com/doi/full/10....
Effects of Expiratory Muscle Strength Training on Swallowing in Survivors of Critical Illness: A Protocol for a Systematic Review and Meta‐Analysis
Background and Aims Post Extubation Dysphagia (PED) is a common consequence of mechanical ventilation. Muscular weakness and atrophy are potential causes. Expiratory Muscle Strength Training (EMST) ...
onlinelibrary.wiley.com
February 4, 2025 at 8:02 AM
Expiratory muscle strength training (EMST) has some evidence for improving swallowing in several disease states
But what about after extubation in intensive care? Can EMST improve post extubation dysphagia?
Our SR protocol, published today #critcare
onlinelibrary.wiley.com/doi/full/10....
But what about after extubation in intensive care? Can EMST improve post extubation dysphagia?
Our SR protocol, published today #critcare
onlinelibrary.wiley.com/doi/full/10....
🫁 Can breathing training help ICU patients swallow again?
💡 41% of ICU patients struggle with swallowing after ventilation. This review explores Expiratory Muscle Strength Training (EMST)—a technique that strengthens breathing muscles 💪 to aid recovery.
#medsky #icu #criticalcare #recovery
💡 41% of ICU patients struggle with swallowing after ventilation. This review explores Expiratory Muscle Strength Training (EMST)—a technique that strengthens breathing muscles 💪 to aid recovery.
#medsky #icu #criticalcare #recovery
Effects of Expiratory Muscle Strength Training on Swallowing in Survivors of Critical Illness: A Protocol for a Systematic Review and Meta‐Analysis
Background and Aims Post Extubation Dysphagia (PED) is a common consequence of mechanical ventilation. Muscular weakness and atrophy are potential causes. Expiratory Muscle Strength Training (EMST) ...
onlinelibrary.wiley.com
February 4, 2025 at 9:36 AM
🫁 Can breathing training help ICU patients swallow again?
💡 41% of ICU patients struggle with swallowing after ventilation. This review explores Expiratory Muscle Strength Training (EMST)—a technique that strengthens breathing muscles 💪 to aid recovery.
#medsky #icu #criticalcare #recovery
💡 41% of ICU patients struggle with swallowing after ventilation. This review explores Expiratory Muscle Strength Training (EMST)—a technique that strengthens breathing muscles 💪 to aid recovery.
#medsky #icu #criticalcare #recovery
Reposted by Brian Johnston
New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
Screening performance and characteristics of breast cancer detected in the Mammography Screening with Artificial Intelligence trial (MASAI): a randomised, controlled, parallel-group, non-inferiority, ...
The findings suggest that AI contributes to the early detection of clinically relevant
breast cancer and reduces screen-reading workload without increasing false positives.
thelancet.com
February 4, 2025 at 3:00 AM
New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...
Reposted by Brian Johnston
🚑 Can AI predict pneumonia severity? A study finds ML models show promise but need better validation. Some outperform CURB-65, but practical barriers remain. Future focus: clinical validation, integration & transparency. AI in healthcare is evolving—will it transform pneumonia care? #AI #Healthcare
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
February 3, 2025 at 5:21 PM
🚑 Can AI predict pneumonia severity? A study finds ML models show promise but need better validation. Some outperform CURB-65, but practical barriers remain. Future focus: clinical validation, integration & transparency. AI in healthcare is evolving—will it transform pneumonia care? #AI #Healthcare