Jorge Domínguez Andrés
@dominjor.bsky.social
👨🏼🔬 Ass Prof at Radboudumc 🇳🇱
🦠 Trained immunity | Vaccines | Infectious diseases | Evolution
📺@TEDx → http://youtu.be/5FvbTs3L8FI
🦠 Trained immunity | Vaccines | Infectious diseases | Evolution
📺@TEDx → http://youtu.be/5FvbTs3L8FI
Pinned
The impact of disease on human evolution | Dr. Jorge Domínguez Andrés | TEDxHotelschoolTheHague
YouTube video by TEDx Talks
www.youtube.com
Throwback to my TEDx talk on February 28, 2020, where I discussed the impact of disease on human evolution. Just weeks later, the world faced a strong reminder of this topic’s relevance with the onset of the pandemic:
www.youtube.com/watch?v=5Fvb...
www.youtube.com/watch?v=5Fvb...
Reposted by Jorge Domínguez Andrés
Off-target beneficial effect of live-attenuated herpes zoster (shingles) vaccine (Zostavax).
#IDSky #vaccination
#IDSky #vaccination
Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia
https://go.nature.com/3XHRhq5
https://go.nature.com/3XHRhq5
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.
go.nature.com
April 4, 2025 at 4:18 AM
Off-target beneficial effect of live-attenuated herpes zoster (shingles) vaccine (Zostavax).
#IDSky #vaccination
#IDSky #vaccination
Today, I dropped my phone on the street while cycling to work. Luckily, a kind soul found it and took it with her to her workplace so I could pick it up. That kind soul turned out to be my department director, @middeldorps.bsky.social. What were the chances? Many thanks!
February 20, 2025 at 3:20 PM
Today, I dropped my phone on the street while cycling to work. Luckily, a kind soul found it and took it with her to her workplace so I could pick it up. That kind soul turned out to be my department director, @middeldorps.bsky.social. What were the chances? Many thanks!
This. We need to stop the fever of needing lots of preliminary data in grant applications.
Grant reviewers, do not say there needs to be more preliminary data without actually specifying what data are required. If you are unable to do so the comment is facile and negative for the sake of negativity. There are many grants that do not need any preliminary data.
January 14, 2025 at 6:46 AM
This. We need to stop the fever of needing lots of preliminary data in grant applications.
Reposted by Jorge Domínguez Andrés
📃Friday publication alert!
Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social
Brief paper tutorial below 👇
@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...
Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social
Brief paper tutorial below 👇
@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...
Friends to remember: innate immune memory regulation by the microbiota
Innate immune memory (IIM) is the process by which, upon a primary challenge, innate immune cells alter their epigenetic, transcriptional, and immunom…
www.sciencedirect.com
January 10, 2025 at 3:06 PM
📃Friday publication alert!
Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social
Brief paper tutorial below 👇
@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...
Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social
Brief paper tutorial below 👇
@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Jorge Domínguez Andrés
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...
www.biorxiv.org
January 6, 2025 at 9:34 AM
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jorge Domínguez Andrés
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
January 4, 2025 at 1:26 PM
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Jorge Domínguez Andrés
Pls RT. The organizers of #GDTcellclub webinar series are looking to welcome new #GDTcell scientists to join the team. Pls comment below to be added to the upcoming informational meeting. Looking for driven grads/postdocs/faculty to join us in keeping this platform alive. @forum-gd.bsky.social
December 22, 2024 at 7:07 PM
Pls RT. The organizers of #GDTcellclub webinar series are looking to welcome new #GDTcell scientists to join the team. Pls comment below to be added to the upcoming informational meeting. Looking for driven grads/postdocs/faculty to join us in keeping this platform alive. @forum-gd.bsky.social
Reposted by Jorge Domínguez Andrés
Attended a beautiful talk by @dominjor.bsky.social at the @cnb-csic.bsky.social workshop for young scientists abroad. We think of Earth as the only place in Universe with life, but... did you know astronauts left 96 bags of 💩 on the Moon? Who knows what 🦠 are there now!
www.vox.com/science-and-...
www.vox.com/science-and-...
Apollo astronauts left their poop on the moon. We gotta go back for that shit.
What 50-year-old dirty diapers can teach us about the potential origins of life on Earth.
www.vox.com
December 19, 2024 at 1:54 PM
Attended a beautiful talk by @dominjor.bsky.social at the @cnb-csic.bsky.social workshop for young scientists abroad. We think of Earth as the only place in Universe with life, but... did you know astronauts left 96 bags of 💩 on the Moon? Who knows what 🦠 are there now!
www.vox.com/science-and-...
www.vox.com/science-and-...
Reposted by Jorge Domínguez Andrés
There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky 🧪
We're hiring! 3 year post-doc position available in the lab on fungal adaptation to the host. Funded by Wellcome Trust, working closely with the group of Becky Hall at Kent. Informal enquiries welcome - further details in link below. #immunosky 🧪🍄
uk.indeed.com/m/viewjob?jk...
uk.indeed.com/m/viewjob?jk...
Research Fellow - Department of Immunology and Immunotherapy - 104822 - Grade 7 - Birmingham - Indeed.com
University of Birmingham
uk.indeed.com
December 16, 2024 at 11:03 AM
There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky 🧪
On Thursday 19th, I will be back to @cnb-csic.bsky.social 7,5 years later to give a talk about the work we have been conducting since I left. If you are around and want to talk about evolution, metabolites and space... don't miss it!🚀
📢 Next Thursday, we will host the “Advances in Molecular Biology by Young Researchers Abroad” workshop, where we welcome postdoctoral scientists working abroad to present their work at #CNB_CSIC.
🗓️ December 19th
🕘 9:00 AM
📍 #CNB Lecture Hall
@cbm-csic-uam.bsky.social
ℹ️👇
bit.ly/Workshop_YRA
🗓️ December 19th
🕘 9:00 AM
📍 #CNB Lecture Hall
@cbm-csic-uam.bsky.social
ℹ️👇
bit.ly/Workshop_YRA
December 16, 2024 at 8:00 PM
On Thursday 19th, I will be back to @cnb-csic.bsky.social 7,5 years later to give a talk about the work we have been conducting since I left. If you are around and want to talk about evolution, metabolites and space... don't miss it!🚀
Reposted by Jorge Domínguez Andrés
Breaking news: Enterococcus faecalis just got promoted from 'gut squatter' to 'immune system personal trainer.' Turns out this bacteria can journey to the bone marrow and whip your immune cells into shape. Gut bugs: sometimes freeloaders, sometimes coaches. 🦠💪 #MicrobiomeMagic
What is the effect of increased bacterial dissemination in distant organs?
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we ex...
www.biorxiv.org
December 13, 2024 at 6:16 PM
Breaking news: Enterococcus faecalis just got promoted from 'gut squatter' to 'immune system personal trainer.' Turns out this bacteria can journey to the bone marrow and whip your immune cells into shape. Gut bugs: sometimes freeloaders, sometimes coaches. 🦠💪 #MicrobiomeMagic
Reposted by Jorge Domínguez Andrés
What is the effect of increased bacterial dissemination in distant organs?
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we ex...
www.biorxiv.org
December 13, 2024 at 2:08 PM
What is the effect of increased bacterial dissemination in distant organs?
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
Check our www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors
2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
A couple of weeks ago, I wrote written a letter published in @natureportfolio.bsky.social
discussing the disparities in the ERC's parental leave policies for fathers across Europe. We must address these issues to promote equality in research careers:
www.nature.com/articles/d41...
discussing the disparities in the ERC's parental leave policies for fathers across Europe. We must address these issues to promote equality in research careers:
www.nature.com/articles/d41...
Fathers disadvantaged by European research-grant policy
Letter to the Editor
www.nature.com
December 6, 2024 at 5:14 PM
A couple of weeks ago, I wrote written a letter published in @natureportfolio.bsky.social
discussing the disparities in the ERC's parental leave policies for fathers across Europe. We must address these issues to promote equality in research careers:
www.nature.com/articles/d41...
discussing the disparities in the ERC's parental leave policies for fathers across Europe. We must address these issues to promote equality in research careers:
www.nature.com/articles/d41...
Reposted by Jorge Domínguez Andrés
Very excited for this story to be out!! Check out our dissection of how type I IFN promotes NET release, which contributes to Mtb pathogenesis and is associated with granuloma necrosis. Congratulations to all authors!! www.cell.com/cell-host-mi...
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
www.cell.com
December 5, 2024 at 1:30 AM
Very excited for this story to be out!! Check out our dissection of how type I IFN promotes NET release, which contributes to Mtb pathogenesis and is associated with granuloma necrosis. Congratulations to all authors!! www.cell.com/cell-host-mi...
Remember you have until February 28th to join the call for papers for our special Trained Immunity issue on @elife.bsky.social!
elifesciences.org/inside-elife...
elifesciences.org/inside-elife...
Focus Issue: Call for papers in Trained Immunity
After a decade of research into innate immune memory, we are pleased to launch a call for papers in trained immunity addressing what we have learned and what’s next for the field.
elifesciences.org
December 5, 2024 at 6:46 AM
Remember you have until February 28th to join the call for papers for our special Trained Immunity issue on @elife.bsky.social!
elifesciences.org/inside-elife...
elifesciences.org/inside-elife...
Reposted by Jorge Domínguez Andrés
As the community grows fast, here is an updated Metabolism Starter Pack 2 with loads of exciting scientists
go.bsky.app/CH1MctZ
go.bsky.app/CH1MctZ
December 4, 2024 at 5:43 AM
As the community grows fast, here is an updated Metabolism Starter Pack 2 with loads of exciting scientists
go.bsky.app/CH1MctZ
go.bsky.app/CH1MctZ
Throwback to my TEDx talk on February 28, 2020, where I discussed the impact of disease on human evolution. Just weeks later, the world faced a strong reminder of this topic’s relevance with the onset of the pandemic:
www.youtube.com/watch?v=5Fvb...
www.youtube.com/watch?v=5Fvb...
The impact of disease on human evolution | Dr. Jorge Domínguez Andrés | TEDxHotelschoolTheHague
YouTube video by TEDx Talks
www.youtube.com
December 4, 2024 at 9:23 AM
Throwback to my TEDx talk on February 28, 2020, where I discussed the impact of disease on human evolution. Just weeks later, the world faced a strong reminder of this topic’s relevance with the onset of the pandemic:
www.youtube.com/watch?v=5Fvb...
www.youtube.com/watch?v=5Fvb...