Reposted by Dominika Borek
Happy birthday to Charles Darwin,
patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.
patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.
February 12, 2026 at 6:58 PM
Happy birthday to Charles Darwin,
patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.
patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.
Reposted by Dominika Borek
Reposted by Dominika Borek
Reposted by Dominika Borek
Some cool E3 ligase structures here with calmodulin-mediated oligomerisation. Also interesting collection/processing to deal with preferred orientation.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 11, 2026 at 1:50 PM
Some cool E3 ligase structures here with calmodulin-mediated oligomerisation. Also interesting collection/processing to deal with preferred orientation.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Dominika Borek
Reposted by Dominika Borek
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
February 3, 2026 at 8:41 PM
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
Co-chairing IUCr 2026 MS-012 “Next-generation validation metrics for macromolecular structures” with Deborah Harrus (@deborah83.bsky.social)! Focus: new validation concepts/methods/best practices across all methods. Submit abstracts by Feb 15; early-bird reg by Mar 31. www.iucr2026.org
IUCr2026
www.iucr2026.org
February 3, 2026 at 12:38 AM
Co-chairing IUCr 2026 MS-012 “Next-generation validation metrics for macromolecular structures” with Deborah Harrus (@deborah83.bsky.social)! Focus: new validation concepts/methods/best practices across all methods. Submit abstracts by Feb 15; early-bird reg by Mar 31. www.iucr2026.org
Reposted by Dominika Borek
Reposted by Dominika Borek
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
cryoetdataportal.czscience.com/depositions/...
January 27, 2026 at 7:59 PM
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
cryoetdataportal.czscience.com/depositions/...
Reposted by Dominika Borek
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
January 27, 2026 at 10:29 PM
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
Reposted by Dominika Borek
🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2
Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p
academic.oup.com
January 27, 2026 at 10:03 PM
🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
Reposted by Dominika Borek
Reposted by Dominika Borek
Reposted by Dominika Borek
#teamtomo gets another quantitative cell biology tool!
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...
#CryoET
#CryoET
January 6, 2026 at 1:51 AM
#teamtomo gets another quantitative cell biology tool!
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
Reposted by Dominika Borek
Larissa Lopes Cavalcante et al.: Crystal structure of diacetylene unveiled by X-ray and neutron diffraction, Raman spectroscopy and periodic DFT ##IntermolecularInteractions##MolecularCrystals... ##IUCrhttps://journals.iucr.org/paper?S2052252525010486
Crystal structure of diacetylene unveiled by X-ray and neutron diffraction, Raman spectroscopy and periodic DFT
The crystal structure and thermal expansion behaviour of diacetylene were determined via diffraction methods and supplemented by spectroscopic techniques. The similarities to the structure of acetylene and implications for Titan in situ exploration are discussed.
journals.iucr.org
December 23, 2025 at 1:01 AM
Larissa Lopes Cavalcante et al.: Crystal structure of diacetylene unveiled by X-ray and neutron diffraction, Raman spectroscopy and periodic DFT ##IntermolecularInteractions##MolecularCrystals... ##IUCrhttps://journals.iucr.org/paper?S2052252525010486
Reposted by Dominika Borek
Reposted by Dominika Borek
The atomic ensemble time scale at the NIST Boulder campus has failed.
December 20, 2025 at 10:53 PM
The atomic ensemble time scale at the NIST Boulder campus has failed.
Reposted by Dominika Borek
While stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪
Explainer🧵👇1/n
Explainer🧵👇1/n
Evaluating the effects of archaic protein-altering variants in living human adults
Promise and pitfalls of using large biobanks to study impacts of archaic protein-coding variants in living humans.
www.science.org
December 18, 2025 at 1:51 PM
While stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪
Explainer🧵👇1/n
Explainer🧵👇1/n
Reposted by Dominika Borek
Reposted by Dominika Borek
Reposted by Dominika Borek
Reposted by Dominika Borek
Justin Bergmann et al.: Linear-scaling aspherical crystallographic refinement of proteins: a case study for crambin and rubredoxin ##HirshfeldAtomRefinement##QuantumCrystallography@lundsuni@RWTH...##IUCrhttps://journals.iucr.org/paper?S2052252525010188
Linear-scaling aspherical crystallographic refinement of proteins: a case study for crambin and rubredoxin
Linear-scaling fragment Hirshfeld atom refinement has been implemented in Olex2 within the NoSpherA2 interface, which also solved previous issues with hydrogen bonds. This allowed the refinement of two small proteins, crambin and rubredoxin (the latter including a metal site), with quantum mechanical aspherical atomic form factors.
journals.iucr.org
December 13, 2025 at 1:00 AM
Justin Bergmann et al.: Linear-scaling aspherical crystallographic refinement of proteins: a case study for crambin and rubredoxin ##HirshfeldAtomRefinement##QuantumCrystallography@lundsuni@RWTH...##IUCrhttps://journals.iucr.org/paper?S2052252525010188
Reposted by Dominika Borek
Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
December 12, 2025 at 3:53 PM
Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Reposted by Dominika Borek
Reposted by Dominika Borek
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
December 8, 2025 at 5:20 PM
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!