Dirk Metzler
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dirkmetzler.bsky.social
Dirk Metzler
@dirkmetzler.bsky.social
stochastic modelling in biology, evolutionary bioinformatics, theoretical population genetics, evolutionary (epi)genomics and transcriptomics
Pinned
Reposted by Dirk Metzler
PhD position available in evolutionary genomics/bioinformatics (hoehnalab.github.io/job_adverts/...). Topic: analyzing gene expression evolution across several firefly species and linking expression changes to genomic architecture. The position is jointly supervised with @anaevolcatalan.bsky.social
hoehnalab.github.io
November 11, 2025 at 9:00 AM
Reposted by Dirk Metzler
@jochenwolflab.bsky.social Check out the latest paper spearheaded by @chyiyin.bsky.social. She explored different methods for target enrichment of DNA extracted from thousands of years old crow bones. Long live ancient DNA!

doi.org/10.1111/1755...
Performance of Two Custom Probe Kits for In‐Solution Enrichment of Ancient Avian DNA
Ancient DNA (aDNA) analysis remains challenging due to low endogenous DNA content of degraded samples. Hybridisation-based in-solution enrichment has emerged as an effective tool for targeting genomi...
doi.org
November 10, 2025 at 4:47 PM
Reposted by Dirk Metzler
🎉We are happy to announce that our wonderful GEvol SPP will be funded by @dfg.de for another 3 years. Included are 17 great projects all over Germany with amazing people. You want to be part of this fantastic community? Soon you can find new PhD/Post-Doc positions here & on our website. Stay tuned🎉
November 10, 2025 at 11:39 AM
Reposted by Dirk Metzler
Our new @science.org paper is out! Cuckoos and hosts are locked in a coevolutionary arms race over egg mimicry.

But how are these egg types inherited, and could this drive speciation? We sequenced hundreds of genomes to find out!

doi.org/10.1126/scie...

🧵1/6
Genomic architecture of egg mimicry and its consequences for speciation in parasitic cuckoos
Host-parasite arms races facilitate rapid evolution and can fuel speciation. Cuculus cuckoos are deceptive egg mimics that exhibit a broad diversity of counterfeit egg phenotypes, representing host-ad...
doi.org
October 30, 2025 at 7:15 PM
Reposted by Dirk Metzler
AKW-Kühltürme sind wie 1500 Jahre alte Buddha-Statuen

Die Wärmepumpe ist “die letzte Entfremdung des Menschen vom Feuer”

E-Autos “haben keine Seele”

Aber die Fanatiker, die “Sekte”, die “Ideologen”, die mit der “Klima-Religion”
- das sind die anderen! #Welt

1/2
October 25, 2025 at 3:38 PM
Reposted by Dirk Metzler
This month is my turn to bust science myths in our institute's mini-videos series. This month's topic: fruit flies and evolution! 🪰🧬

@mpi-bio-fml.bsky.social
Fruit flies are more than pests! Humans share 60% of their genome with them. @luisapallares.bsky.social busts myths about how these tiny creatures can tell us about human diseases. Watch Luisa's full video here: www.fml.tuebingen.mpg.de/71433/videos #BiologyMyths #Drosophila #Genomics
October 23, 2025 at 6:58 PM
Reposted by Dirk Metzler
Fruit flies are more than pests! Humans share 60% of their genome with them. @luisapallares.bsky.social busts myths about how these tiny creatures can tell us about human diseases. Watch Luisa's full video here: www.fml.tuebingen.mpg.de/71433/videos #BiologyMyths #Drosophila #Genomics
October 22, 2025 at 12:18 PM
Reposted by Dirk Metzler
Just out! Andre Amaral´s latest paper "First fossil mosquito larva in 99-million-year-old amber with a modern type of morphology sheds light on the evolutionary history of mosquitoes" is now published 🎉
Read here: www.sciencedirect.com/science/arti...
October 17, 2025 at 3:19 PM
Reposted by Dirk Metzler
We have put together a comprehensive eQTL map for D. melanogaster using thousands of genetically diverse flies 🪰🪰🪰🪰🪰 We hope this helps -as similar resources have done in yeast and humans- to understand how genetic variation 🧬 regulates complex traits variation 🪰 via transcriptional regulation ⬆️⬇️
Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Pallares et al. collect over a thousand RNA-seq and DNA samples from Drosophila melanogaster flies to investigate the genetic basis of gene expression variation. They find eQTLs for 98% of the genes a...
www.cell.com
October 14, 2025 at 12:55 PM
Reposted by Dirk Metzler
Family life in burying beetles. New paper out on the importance of direct and indirect care. Congrats to Madlen and Daniela!
link.springer.com/article/10.1...
From constructing nests to nutritional provisioning: the impact of direct and indirect parental care in the burying beetle, Nicrophorus orbicollis - Behavioral Ecology and Sociobiology
Abstract Parental care has evolved multiple times in the animal kingdom and includes all parental traits that enhance offspring fitness. The evolution of care can lead to prolonged associations between parents and their offspring. This, in turn, can drive parent–offspring coevolution, creating systems in which multiple care behaviors are exhibited and potentially resulting in offspring becoming more dependent on parental care. Parental care often takes indirect forms, such as nest building, while direct care behaviors, like feeding, which involve physical interaction with offspring, are generally less frequent. However, in species where both types of care occur, the extent to which offspring rely on indirect versus direct care is often unknown. In this study, we investigated the roles and relative importance of direct and indirect care in a system where offspring are highly dependent on parental care. We conducted an experiment in which we manipulated the duration and composition of direct and indirect post-hatching care in the burying beetle Nicrophorus orbicollis. Burying beetles reproduce by exploiting small vertebrate carcasses, which they bury and convert into a nutritious nursery for their offspring. In addition to modifying the food resource, parents actively feed their offspring. We found that direct care had a greater effect on offspring growth and survival than indirect care, although indirect care also enhanced fitness. The greater reliance on feeding over indirect care is likely the result of sibling competition for food. Our study underscores the complexity and multi-layered nature of parental care strategies and their effects on offspring performance. Significance Statement Parental care enhances offspring fitness and can include both indirect care, like nest building, and direct care, like feeding. In systems where both care types occur, it is often unclear how much offspring rely on each type. As a model, we used Nicrophorus orbicollis burying beetles, which prepare a carcass as a nursery and regurgitate food to their offspring, to experimentally manipulate the duration and composition of direct and indirect care and assess their relative contributions to offspring survival and growth in this species. Our results show that while direct care has a stronger effect on offspring survival and growth, indirect care also provides measurable benefits. This study highlights the adaptive value of multi-component parental care strategies and the complex interactions between parents and offspring in species that depend heavily on parental care.
link.springer.com
October 12, 2025 at 7:46 AM
Reposted by Dirk Metzler
You. Do. Not. Try. To. Prove. Your. Hypothesis.

That is completely backwards.

The proper way to do science is to form a hypothesis, and then do everything you can to try and tear that hypothesis apart.

Any other way is scientifically unsound at the least, and malpractice or outright lies at worst
RFK Jr on Tylenol and autism: "It is not proof. We're doing the studies to make the proof."
October 9, 2025 at 5:14 PM
Reposted by Dirk Metzler
Does bird migration 

increase bird speciation? 

The methods decides. 

                                                   Calabrese et al. (2025) Syst Biol
academic.oup.com/sysbio/advan...
No Consistent Effect of Migration on Speciation Rates in Two Avian Superfamilies: A Check on the Robustness of Trait-Dependent Diversification Methods
Abstract. Seasonal migration is performed by taxonomically diverse groups across the planet’s oceans and continents. Migration has been hypothesized to pro
academic.oup.com
October 8, 2025 at 4:27 PM
Reposted by Dirk Metzler
Die EU-Kommission will Messenger-Dienste zwingen, ALLE privaten Nachrichten und Fotos in Echtzeit zu scannen. Die #Chatkontrolle bedeutet das Ende von verschlüsselter Kommunikation. Das verstößt gegen unsere Grundrechte. Jetzt dagegen unterzeichnen: 👇
Chatkontrolle stoppen!
Die EU-Kommission will Messenger-Dienste wie WhatsApp und Signal zwingen, alle privaten Nachrichten und Fotos in Echtzeit zu scannen. Angeblich zum Kinderschutz. In Wahrheit bedeutet die Chatkontrolle...
weact.campact.de
October 7, 2025 at 10:53 AM
Reposted by Dirk Metzler
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Reposted by Dirk Metzler
SINGER, our ARG inference method, is finally published and freely available online:

doi.org/10.1038/s415...

It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics
SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.
doi.org
September 11, 2025 at 3:50 AM
Reposted by Dirk Metzler
Many thanks to all GEvol members for a truly wonderful annual meeting. It was really great to catch up with you all again.
September 5, 2025 at 2:05 PM
Reposted by Dirk Metzler
Congrats Dr. @roriwijnhorst.bsky.social @lmumuenchen.bsky.social for an impressive PhD-presentation and defence. Thanks partner in crime @cdegroot.bsky.social and collaborators @ali--wilson.bsky.social, Henrik Jensen & Jon Wright and @dfg.de for funding his project on social evolution in sparrows
July 18, 2025 at 3:24 PM
Reposted by Dirk Metzler
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Reposted by Dirk Metzler
Two #LMU projects receive ERC #ProofOfConcept Grants!
🌿 Silke Robatzek is pursuing a novel approach in plant protection strategies.
🧠 @tobiasstaudigl.bsky.social optimizes deep brain stimulation with functional markers.
#LMU #ERC #ResearchInThePractice Read more here: www.lmu.de/en/newsroom/...
July 15, 2025 at 2:29 PM
Also here:

This tropical plant builds isolated ‘apartments’ to prevent battles among the aggressive ant tenants it relies on for survival theconversation.com/this-tropica...
This tropical plant builds isolated ‘apartments’ to prevent battles among the aggressive ant tenants it relies on for survival
Squamellaria plants grow special structures to host the ants they symbiotically rely on for nutrients. Distinct compartments help different ant colonies live peacefully side by side.
theconversation.com
July 14, 2025 at 9:44 PM
We are quite delighted by the media coverage of our paper:

This Jungle Plant Is a Good Landlord to Its Tenant Ants www.nytimes.com/2025/07/10/s...
This Jungle Plant Is a Good Landlord to Its Tenant Ants
www.nytimes.com
July 14, 2025 at 9:43 PM
Reposted by Dirk Metzler
🧬 Shift between specialized & generalized diets in #bees is associated with evolutionary changes in their sensory genes. Generalists lose odorant receptors (ORs) and gain gustatory receptors (GRs), while specialists diversify existing genes 🌸🐝 #genomics #pollinators
academic.oup.com/g3journal/ad...
Shifts in bee diet breadths are associated with gene gains and losses and positive selection across olfactory receptors
Abstract. Bees are palynivorous insects that vary widely in the number of plant families from which they collect pollen. Their evolutionary history has bee
academic.oup.com
July 11, 2025 at 5:55 PM
Compartmentalization reduces conflict in multipartner plant-insect symbioses | Science www.science.org/doi/10.1126/...
Compartmentalization reduces conflict in multipartner plant-insect symbioses
Many symbioses involve one host species having several mutualist partners, yet theory predicts that unrelated symbionts lead to destabilizing conflict through competition for host resources. We combin...
www.science.org
July 12, 2025 at 4:20 PM