Jun Ishigohoka
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junishigohoka.bsky.social
Jun Ishigohoka
@junishigohoka.bsky.social
180 followers 230 following 39 posts
Evolutionary biologist

Tübingen < Plön < Kiel < Sapporo < Tokyo
https://junishigohoka.github.io/
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junishigohoka.bsky.social
Jun Ishigohoka @junishigohoka.bsky.social · Jan 27
Happy to share our new paper OA in Genetics. We show that population genomic methods based on ARGs (ancestral recombination graphs i.e. genetic ancestry along chromosomes) for demography inference can be biased when applied to genomes with wide high-recombining regions. doi.org/10.1093/gene...
High-recombining genomic regions affect demography inference based on ancestral recombination graphs
Abstract. Multiple methods of demography inference are based on the ancestral recombination graph. This powerful approach uses observed mutations to model
doi.org
Reposted by Jun Ishigohoka
evoldir.bsky.social
Postdoc position available at Max Planck Institute, Germany, focusing on the genetic basis of polygenic traits in Drosophila. Applications due by Dec 22, 2025. More info: barghi@evolbio.mpg.de. #postdoc
November 11, 2025 at 4:44 PM
junishigohoka.bsky.social
Next year Ig Nobel

Electrostatics facilitate midair host attachment in parasitic jumping nematodes | PNAS www.pnas.org/doi/10.1073/...
Electrostatics facilitate midair host attachment in parasitic jumping nematodes | PNAS
Jumping can be hazardous for entomopathogenic nematodes (EPNs) as those that fail to attach to an insect host face death by predation or starvation...
www.pnas.org
October 22, 2025 at 6:28 AM
junishigohoka.bsky.social
elifesciences.org/articles/105...
The general version of Hamilton’s rule
The flexibility of the general version of Hamilton's rule allows the rule to match the complexity of the model of social behaviour, or the complexity implied by the data.
elifesciences.org
October 17, 2025 at 10:05 PM
junishigohoka.bsky.social
A mosaic of modular variation at a single gene underpins convergent plumage coloration | Science www.science.org/doi/10.1126/...
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
www.science.org
October 17, 2025 at 7:24 PM
Reposted by Jun Ishigohoka
plosbiology.org
Winter-active #herbivores struggle to get #nitrogen in winter, when dietary #protein is scarce. This study shows that winter protein restriction drives gut #microbiome remodeling in the #pika, increasing microbiome N recycling & helping maintain protein balance @plosbiology.org 🧪 plos.io/4nZ86I6
Left: A pika (almost certainly the wrong species!), photo credit Pixabay user mikieni777. Right: Proposed mechanism for urea nitrogen salvaging and relative changes during winter protein restriction. Urea endogenously produced by the liver is transported by epithelial urea transporters (UT-B) from blood into the cecal lumen where it is hydrolyzed to yield CO2 and NH3 by microbial urease. CO2 is excreted by the host and/or fixed by microbes. NH3 is absorbed by the host and converted into amino acids (AAs) and/or urea in the liver, or it used by microbes to synthesize AAs (green balls) that are incorporated into the microbial proteome or potentially absorbed by the host through amino-acid transporters (brown squares). Ultimately, the AAs are used to synthesize protein (green circles) in host tissues, thus recycling the urea nitrogen.
October 17, 2025 at 4:30 PM
Reposted by Jun Ishigohoka
mpiforbi.bsky.social
What is the genetic basis of bird migration? Find out in our next keynote lecture by Miriam Liedvogel @genmig.bsky.social, Professor of Ornithology at the Uni Oldenburg and Director of the Institute of Avian Research!

📍October 21 at 11am in House 4 in Seewiesen
Art by @somedonkey.bsky.social
October 16, 2025 at 3:29 PM
junishigohoka.bsky.social
www.biorxiv.org/content/10.1...
The demographic history, genomic variation, and transcontinental genotype-phenotype-environment map of mungbean
The breeding of mungbean, a crucial Asian legume, has been hampered by the lack of genomic resources. The International Mungbean Improvement Network (IMIN) aims to ensure global access to diverse germ...
www.biorxiv.org
October 16, 2025 at 9:03 PM
junishigohoka.bsky.social
journals.plos.org/plosbiology/...
A large-scale study across the avian clade identifies ecological drivers of neophobia
Neophobia (the aversive response to novelty) varies considerably across species and individuals, and can impact adaptability and survival. This study assesses neophobia in 1400 subjects from 136 bird ...
journals.plos.org
October 15, 2025 at 3:02 PM
Reposted by Jun Ishigohoka
luisapallares.bsky.social
We have put together a comprehensive eQTL map for D. melanogaster using thousands of genetically diverse flies 🪰🪰🪰🪰🪰 We hope this helps -as similar resources have done in yeast and humans- to understand how genetic variation 🧬 regulates complex traits variation 🪰 via transcriptional regulation ⬆️⬇️
Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Pallares et al. collect over a thousand RNA-seq and DNA samples from Drosophila melanogaster flies to investigate the genetic basis of gene expression variation. They find eQTLs for 98% of the genes a...
www.cell.com
October 14, 2025 at 12:55 PM
junishigohoka.bsky.social
www.nature.com/articles/s41...
Learned use of an innate sound-meaning association in birds - Nature Ecology & Evolution
Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experimen...
www.nature.com
October 15, 2025 at 2:57 PM
Reposted by Jun Ishigohoka
plosbiology.org
Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT
Heritability and target size underlie differences between trait architectures: examples for three traits. Top: Height (blue) and platelet crit (red) have the same heritability per site h2/L, but height has a much higher mutational target size L. This results in many more hits for height (1533) than for platelet crit (648) (2 left panels). However, the marginal distributions of effect sizes, MAFs, and z-scores of hits are nearly identical for the two traits (3 right panels). Middle: Height (blue) and FEV1 (gold) differ in h2/L, but have similar L. Consequently, the joint distribution of z-scores and MAFs of their hits are markedly different (2 left panels), as are the marginal distributions of hit effect sizes, MAFs and z-scores (right). Bottom: After scaling by their respective , and imposing the more stringent scaled significance threshold (corresponding to FEV1) for both traits, the joint distribution of z-scores and MAFs of their hits (2 left panels) and the corresponding marginal distributions (3 right panels) are highly similar.
October 13, 2025 at 6:20 PM
Reposted by Jun Ishigohoka
biorxiv-evobio.bsky.social
An empirical long-term competition among natural yeast isolates reveals that short-term fitness largely but not entirely predicts long-term outcomes https://www.biorxiv.org/content/10.1101/2025.10.09.681448v1
October 10, 2025 at 9:32 PM
Reposted by Jun Ishigohoka
clocksevolution.bsky.social
How can larval #competition for space, adult #reproductive #timing and the #tides interact to produce different timing strains, aka #chronotypes, of the marine insect #Clunio?

See our latest preprint with Alec Jacobsen & @gokhalecs.bsky.social

#evolution #ecology #chronobiology #circalunar #clock
How competition can drive allochronic divergence: a case study in the marine midge, Clunio marinus
Synchronizing mating to extrinsic environmental cycles can increase the chance of successful reproduction. However, the resulting temporally-assorted mating may precipitate speciation if coupled with ...
www.biorxiv.org
September 17, 2025 at 8:12 AM
Reposted by Jun Ishigohoka
biorxiv-genomic.bsky.social
Read mismapping from segmental duplications drives spurious trans associations https://www.biorxiv.org/content/10.1101/2025.10.08.681258v1
October 10, 2025 at 3:33 AM
Reposted by Jun Ishigohoka
clocksevolution.bsky.social
WE ARE HIRING!
Please spread widely!

#Postdoc in #Evolutionary #Genomics
-> www.mpg.de/25524526/

#Postdoc in #Molecular #Biology & #Cell #Signalling
-> www.mpg.de/25524509/

@mpi-evolbio.bsky.social @maxplanck.de

#ScienceJobs #EvoBio #MolBio #Ecology #Chronobiology #Marine #EntoSky #Biodiversity
October 9, 2025 at 6:56 AM
Reposted by Jun Ishigohoka
nature.com
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/48QDdAJ
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 3:56 PM
junishigohoka.bsky.social
www.biorxiv.org/content/10.1...
Predator induced phenotypes are inherited over four generations in genetically identical Daphnia lumholtzi
Environmental variation can induce phenotypic changes through adaptation of populations and acclimation of individuals. Whereas adaptation can lead to persistent changes within a population via allele...
www.biorxiv.org
October 1, 2025 at 8:54 AM
Reposted by Jun Ishigohoka
plosbiology.org
How are #circadian rhythms established during development? This study shows that maternal metabolic signals oscillate in the fetal #SCN before the endogenous #clock becomes functional, offering a plausible mechanism for maternal entrainment of the developing clock @plosbiology.org 🧪 plos.io/3VD45fZ
Rhythmic metabolites in the E19 SCN peak during the day. Majority of rhythmic lipids and polar metabolites in the E19 SCN peak during the day, while there are more diverse phase clusters in the developed P28 SCN postweaning. Polar metabolites and lipids identified as rhythmic in E19 SCN (E19 clusters 1, top, and 2, bottom) were divided into subgroups based on hierarchical K-means clustering. Line plots on the left show traces of the normalized level of each rhythmic compound in each corresponding cluster. Bar plots on the right represent the lipid classes and polar metabolites in each rhythmic cluster.
September 29, 2025 at 4:58 PM
Reposted by Jun Ishigohoka
oikosjournal.bsky.social
📜Forum: A trait-based framework for adaptive phenotypic plasticity under global change

vist.ly/48kss

#BehavioralPlasticity #ClimateChange #ExtremeEvents #GeneByEnvironmentInteractions #IntraspecificVariation #MorphologicalPlasticity #PhysiologicalPlasticity #Stochasticity #Variability

September 29, 2025 at 5:06 PM
Reposted by Jun Ishigohoka
biorxiv-evobio.bsky.social
Evolution of the rate, spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.09.24.678306v1
September 26, 2025 at 7:32 PM
junishigohoka.bsky.social
Categorical and semantic perception of the meaning of call types in zebra finches | Science www.science.org/doi/10.1126/...
Categorical and semantic perception of the meaning of call types in zebra finches
Vocal communication in social animals involves the production and perception of various calls that ethologists categorize into call types based on their acoustical structure and behavioral context. Wh...
www.science.org
September 24, 2025 at 5:59 AM
Reposted by Jun Ishigohoka
luisapallares.bsky.social
Jun @junishigohoka.bsky.social is the first postdoc of the lab. Today, during #postdocappreciationweek, I just want to let you all know that Jun is t h e b e s t! 🤓 I'm very happy he decided to join us here at @mpi-bio-fml.bsky.social. Looking forward to our papers together, Jun! 💻🧬🪰🔢
September 19, 2025 at 11:43 AM
Reposted by Jun Ishigohoka
plosbiology.org
How do your #linguistic, #economic & #gender backgrounds impact your #scientific productivity? @tatsuya-amano.bsky.social & co reveal that being a woman, a non-native English speaker, and from a low-income country is associated with a 70% reduction in productivity @plosbiology.org 🧪 plos.io/4n3RLRQ
Scientific productivity gap based on English-language peer-reviewed papers. Shown are the maximum % differences in the number of peer-reviewed papers published by female native English speakers from a high-income country (-45%), female non-native English speakers from a high-income country (-60%), and female non-native English speakers from a lower-middle income country (-70%), compared to male native English speakers from a high-income country (red flag). Credit: Tatsuya Amano
September 19, 2025 at 5:14 PM
junishigohoka.bsky.social
academic.oup.com/jeb/article/...
Distribution theories for genetic line of least resistance and evolvability measures
Abstract. Quantitative genetic theory on multivariate character evolution predicts that a population’s response to directional selection is biased towards
academic.oup.com
September 17, 2025 at 5:20 AM
junishigohoka.bsky.social
www.biorxiv.org/content/10.1...
A model-free method for genealogical inference without phasing and its application for topology weighting
Recent advances in methods to infer and analyse ancestral recombination graphs (ARGs) are providing powerful new insights in evolutionary biology and beyond. Existing inference approaches tend to be d...
www.biorxiv.org
September 15, 2025 at 9:33 PM