Bornberglab
@bornberglab.bsky.social
Molecular evolution and bioinformatics at Uni Muenster, Germany. Protein evolution | domains | de novo genes | comparative evolutionary genomics
http://bornberglab.org/
http://bornberglab.org/
Reposted by Bornberglab
🧩 Thrilled to share our new paper in @genomebiolevol.bsky.social !
We present a comprehensive review of de novo gene emergence — providing a classification of current detection methods and a roadmap for addressing major challenges in the field of gene birth from non-genic sequences.
We present a comprehensive review of de novo gene emergence — providing a classification of current detection methods and a roadmap for addressing major challenges in the field of gene birth from non-genic sequences.
November 12, 2025 at 3:42 PM
🧩 Thrilled to share our new paper in @genomebiolevol.bsky.social !
We present a comprehensive review of de novo gene emergence — providing a classification of current detection methods and a roadmap for addressing major challenges in the field of gene birth from non-genic sequences.
We present a comprehensive review of de novo gene emergence — providing a classification of current detection methods and a roadmap for addressing major challenges in the field of gene birth from non-genic sequences.
Reposted by Bornberglab
🚀We’re excited to share our new paper in Bioinformatics!
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
November 12, 2025 at 12:41 PM
🚀We’re excited to share our new paper in Bioinformatics!
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
Reposted by Bornberglab
🎉We are happy to announce that our wonderful GEvol SPP will be funded by @dfg.de for another 3 years. Included are 17 great projects all over Germany with amazing people. You want to be part of this fantastic community? Soon you can find new PhD/Post-Doc positions here & on our website. Stay tuned🎉
November 10, 2025 at 11:39 AM
🎉We are happy to announce that our wonderful GEvol SPP will be funded by @dfg.de for another 3 years. Included are 17 great projects all over Germany with amazing people. You want to be part of this fantastic community? Soon you can find new PhD/Post-Doc positions here & on our website. Stay tuned🎉
Reposted by Bornberglab
The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp!
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
November 3, 2025 at 7:47 PM
The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp!
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
Reposted by Bornberglab
📢 Check out our GEvol inspired Special Issue in JEZ-B:
onlinelibrary.wiley.com/toc/15525015... 🚨
onlinelibrary.wiley.com/toc/15525015... 🚨
Genomic Basis of Evolutionary Innovations in Insects: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution: Vol 344, No 7
The Journal of Experimental Zoology – B (JEZ-B): Molecular and Developmental Evolution covers the structure & evolution of animal & non-animal organisms.
onlinelibrary.wiley.com
November 3, 2025 at 7:41 AM
📢 Check out our GEvol inspired Special Issue in JEZ-B:
onlinelibrary.wiley.com/toc/15525015... 🚨
onlinelibrary.wiley.com/toc/15525015... 🚨
Reposted by Bornberglab
We are in Bluesky and we are happy to share our two last consortium publications: the DrosEU expanded DEST dataset and a Continent-wide study of phenotypic differentiation among European #Drosophila melanogaster populations (1/7)
October 19, 2025 at 9:35 AM
We are in Bluesky and we are happy to share our two last consortium publications: the DrosEU expanded DEST dataset and a Continent-wide study of phenotypic differentiation among European #Drosophila melanogaster populations (1/7)
Reposted by Bornberglab
The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
October 6, 2025 at 7:22 AM
The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
New Paper Alert! Our group member Matthew Merski published a paper about new potential therapeutic leads against the parasite Trypanosoma brucei, causing the African Sleeping sickness. They used molecular docking on known, approved (FDA) drugs to find (1/2)
journals.plos.org/plosntds/art...
journals.plos.org/plosntds/art...
Molecular docking to homology models of human and Trypanosoma brucei ERK8 that identified ortholog-specific inhibitors
Author summary The discovery and production of safe and effective therapeutics for treating people suffering from neglected tropical diseases, such as sleeping sickness caused by the pathogen Trypanos...
journals.plos.org
September 16, 2025 at 12:57 PM
New Paper Alert! Our group member Matthew Merski published a paper about new potential therapeutic leads against the parasite Trypanosoma brucei, causing the African Sleeping sickness. They used molecular docking on known, approved (FDA) drugs to find (1/2)
journals.plos.org/plosntds/art...
journals.plos.org/plosntds/art...
We had a great time at the Long Night of Insects at the LWL Museum of Natural History in Münster! From watching a cockroach race to exploring and ant farm and info booths there was much to discover. Marie even joined the science slam. What a great way to wrap up our @gevol.bsky.social meeting!🐜✨🪰🪳
September 9, 2025 at 11:09 AM
We had a great time at the Long Night of Insects at the LWL Museum of Natural History in Münster! From watching a cockroach race to exploring and ant farm and info booths there was much to discover. Marie even joined the science slam. What a great way to wrap up our @gevol.bsky.social meeting!🐜✨🪰🪳
Reposted by Bornberglab
Many thanks to all GEvol members for a truly wonderful annual meeting. It was really great to catch up with you all again.
September 5, 2025 at 2:05 PM
Many thanks to all GEvol members for a truly wonderful annual meeting. It was really great to catch up with you all again.
Erich and Marie travelled to Barcelona for #ESEB2025. Erich gave two talks: one exploring de novo and random proteins, and another discussing gene family losses in slave-maker ants. Marie presented her work on neORF emergence in Drosophila at Symposium 29, organised by @gevol.bsky.social. 🧬🪰🐜
August 25, 2025 at 7:49 AM
Erich and Marie travelled to Barcelona for #ESEB2025. Erich gave two talks: one exploring de novo and random proteins, and another discussing gene family losses in slave-maker ants. Marie presented her work on neORF emergence in Drosophila at Symposium 29, organised by @gevol.bsky.social. 🧬🪰🐜
Reposted by Bornberglab
Lots of inspiring talks & posters at our GEvol symposium at #ESEB2025 yesterday!
Thanks to everyone who presented, especially our invited speakers @ahuylmans.bsky.social & @rmwaterhouse.bsky.social. From GEvol, Marie Lebherz, Elisa Israel and Barbara Feldmeyer gave talks about their work. (1/2)
Thanks to everyone who presented, especially our invited speakers @ahuylmans.bsky.social & @rmwaterhouse.bsky.social. From GEvol, Marie Lebherz, Elisa Israel and Barbara Feldmeyer gave talks about their work. (1/2)
August 20, 2025 at 12:32 PM
Lots of inspiring talks & posters at our GEvol symposium at #ESEB2025 yesterday!
Thanks to everyone who presented, especially our invited speakers @ahuylmans.bsky.social & @rmwaterhouse.bsky.social. From GEvol, Marie Lebherz, Elisa Israel and Barbara Feldmeyer gave talks about their work. (1/2)
Thanks to everyone who presented, especially our invited speakers @ahuylmans.bsky.social & @rmwaterhouse.bsky.social. From GEvol, Marie Lebherz, Elisa Israel and Barbara Feldmeyer gave talks about their work. (1/2)
Erich travelled to Marseilles this week and visited former postdocs, now PIs, Anna Grandchamp and Nicolas Terrapon. Great to catch up with both of them! ☀️
August 17, 2025 at 6:50 AM
Erich travelled to Marseilles this week and visited former postdocs, now PIs, Anna Grandchamp and Nicolas Terrapon. Great to catch up with both of them! ☀️
Reposted by Bornberglab
A night full of fun, science and insects: We invite you to join our “Lange Nacht der Insekten” on Sept. 5th, 6pm until midnight, at LWL Museum of Natural History in Münster. Bring your family and friends and explore an ant farm, watch a science slam and visit the planetarium! Entrance is free.
August 13, 2025 at 11:37 AM
A night full of fun, science and insects: We invite you to join our “Lange Nacht der Insekten” on Sept. 5th, 6pm until midnight, at LWL Museum of Natural History in Münster. Bring your family and friends and explore an ant farm, watch a science slam and visit the planetarium! Entrance is free.
We are proud of our master student Brenda who did a research module at the Earth-Life Science Institute (ELSI) in Tokyo, working on enzymatic nucleotide phosphorylation focusing on the PPK2 Class III enzyme MAN (1/2).
July 22, 2025 at 1:48 PM
We are proud of our master student Brenda who did a research module at the Earth-Life Science Institute (ELSI) in Tokyo, working on enzymatic nucleotide phosphorylation focusing on the PPK2 Class III enzyme MAN (1/2).
Excited for the upcoming @gevol.bsky.social symposium at @eseb2025.bsky.social ! ☀️Marie give a talk there, while Erich will give two talks at symposium 46 on synthetic biology, evolution, and the origin of life and symposium 25 on gene content across genomes. Hope to see you there! 🙌
@eseb2025.bsky.social We are looking forward to welcome four GEvol members presenting Tuesday 19.8. in S29 "Genomic Basis of evolutionary innovation": Invited Speaker @ahuylmans.bsky.social, Marie Lebherz @bornberglab.bsky.social, Elisa Israel (Prohaska Lab) and Barbara Feldmeyer @sgn.one. 🌞
July 16, 2025 at 11:22 AM
Excited for the upcoming @gevol.bsky.social symposium at @eseb2025.bsky.social ! ☀️Marie give a talk there, while Erich will give two talks at symposium 46 on synthetic biology, evolution, and the origin of life and symposium 25 on gene content across genomes. Hope to see you there! 🙌
Looking to detect newly expressed ORFs (neORFs) in your transcriptomes? Check out the DESwoMAN preprint, authored by former group/ @gevol.bsky.social member Anna Grandchamp, alongside Marie and Elias.
🚨 New preprint alert! 🚨
🔬 Ever wondered how new genes emerge from scratch? Meet DESwoMAN, a fully automated pipeline to detect and analyze newly expressed ORFs (neORFs) from transcriptome data — giving us a window into the earliest stages of de novo gene emergence!
(Thread 🧵👇)
🔬 Ever wondered how new genes emerge from scratch? Meet DESwoMAN, a fully automated pipeline to detect and analyze newly expressed ORFs (neORFs) from transcriptome data — giving us a window into the earliest stages of de novo gene emergence!
(Thread 🧵👇)
June 12, 2025 at 10:38 AM
Looking to detect newly expressed ORFs (neORFs) in your transcriptomes? Check out the DESwoMAN preprint, authored by former group/ @gevol.bsky.social member Anna Grandchamp, alongside Marie and Elias.
Reposted by Bornberglab
We also just posted to @biorxiv-genetic.bsky.social a new manuscript led by our superb staff scientist Dr. Prajal Patel in collaboration with @lacholt.bsky.social from @bornberglab.bsky.social. We explored the functionality of orphan gene orthologs in D. melanogaster.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Orthologs of an essential orphan gene vary in their capacities for function and subcellular localization in Drosophila melanogaster
The rapidly evolving nature of orphan genes raises questions about whether their activities remain conserved or evolve uniquely across species. We explore this issue using goddard ( gdrd ), an orphan ...
www.biorxiv.org
May 8, 2025 at 2:04 AM
We also just posted to @biorxiv-genetic.bsky.social a new manuscript led by our superb staff scientist Dr. Prajal Patel in collaboration with @lacholt.bsky.social from @bornberglab.bsky.social. We explored the functionality of orphan gene orthologs in D. melanogaster.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bornberglab
📢Last Chance: @eseb2025.bsky.social in Barcelona🏖️-->Abstract submission deadline Mai 5th. Please submit a abstract to our symposium #29 Genomic Basis of evolutionary Innovation eseb2025.com/list-of-symp.... With our invited speaker @rmwaterhouse.bsky.social and @ahuylmans.bsky.social.
April 30, 2025 at 7:52 AM
📢Last Chance: @eseb2025.bsky.social in Barcelona🏖️-->Abstract submission deadline Mai 5th. Please submit a abstract to our symposium #29 Genomic Basis of evolutionary Innovation eseb2025.com/list-of-symp.... With our invited speaker @rmwaterhouse.bsky.social and @ahuylmans.bsky.social.
Reposted by Bornberglab
Excited to announce the EMBO Conference: Molecular Biology of Archaea (MBoA) 2026!
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated entirely to Archaea.
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated entirely to Archaea.
April 22, 2025 at 8:26 AM
Excited to announce the EMBO Conference: Molecular Biology of Archaea (MBoA) 2026!
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated entirely to Archaea.
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated entirely to Archaea.
New Paper Alert! Together with the Parsch lab, we investigated the expression of neORFs (newly evolved expressed open reading frames, identified in a previous study) in Drosophila populations using publicly available RNA-seq data. (1/2)
doi.org/10.1002/jez....
doi.org/10.1002/jez....
Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster
We show that newly-evolved, expressed open reading frames (neORFs) identified in a set of inbred Drosophila melanogaster lines are also expressed in multiple tissues and developmental stages of poole...
doi.org
April 22, 2025 at 10:02 AM
New Paper Alert! Together with the Parsch lab, we investigated the expression of neORFs (newly evolved expressed open reading frames, identified in a previous study) in Drosophila populations using publicly available RNA-seq data. (1/2)
doi.org/10.1002/jez....
doi.org/10.1002/jez....
Reposted by Bornberglab
www.biorxiv.org/content/10.1... why are protein fitness landscapes often very rugged and what does this mean for evolution and engineering? We have been interested in this for a while - in this paper (led by Matt Spence) we look at it quantitatively using eg spectral graph theory.
Fitness Landscape Ruggedness Arises from Biophysical Complexity
Epistasis, in which the effect of a mutation depends on the genetic background it is introduced into, drives protein evolution and design by shaping the fitness landscape. Quantifying how constrained ...
www.biorxiv.org
April 15, 2025 at 1:21 AM
www.biorxiv.org/content/10.1... why are protein fitness landscapes often very rugged and what does this mean for evolution and engineering? We have been interested in this for a while - in this paper (led by Matt Spence) we look at it quantitatively using eg spectral graph theory.
Reposted by Bornberglab
biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
March 26, 2025 at 5:13 AM
biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
Reposted by Bornberglab
Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing
More details about the project including how to apply in the link below. Deadline April 9 2025
candidate.hr-manager.net/ApplicationI...
More details about the project including how to apply in the link below. Deadline April 9 2025
candidate.hr-manager.net/ApplicationI...
March 22, 2025 at 7:16 PM
Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing
More details about the project including how to apply in the link below. Deadline April 9 2025
candidate.hr-manager.net/ApplicationI...
More details about the project including how to apply in the link below. Deadline April 9 2025
candidate.hr-manager.net/ApplicationI...
Check out DeNoFo Toolkit to annotate, convert and compare the methodology used in studies on de novo emerged genes! @drdomain.bsky.social @margaubel.bsky.social @lacholt.bsky.social and more!
De novo genes research community 🧬 - please consider using for your future or past work our new methodology annotation format for better comparability of studies and higher reproducibility. (1/3)
DeNoFo: a file format and toolkit for standardised, comparable de novo gene annotation https://www.biorxiv.org/content/10.1101/2025.03.31.644673v1
April 3, 2025 at 3:45 PM
Check out DeNoFo Toolkit to annotate, convert and compare the methodology used in studies on de novo emerged genes! @drdomain.bsky.social @margaubel.bsky.social @lacholt.bsky.social and more!