Bornberglab
@bornberglab.bsky.social
Molecular evolution and bioinformatics at Uni Muenster, Germany. Protein evolution | domains | de novo genes | comparative evolutionary genomics
http://bornberglab.org/
http://bornberglab.org/
molecules that might help fight African Sleeping sickness by targeting the ERK8 protein, looking for molecules that were preferentially bound by the human or parasite ortholog. Sildenafil, aka viagra, showed some selectivity (among others). (2/2)
September 16, 2025 at 12:57 PM
molecules that might help fight African Sleeping sickness by targeting the ERK8 protein, looking for molecules that were preferentially bound by the human or parasite ortholog. Sildenafil, aka viagra, showed some selectivity (among others). (2/2)
Her project aimed to understand ancient enzymes that may have helped the origin of life by catalyzing the conversion of NMPs to NTPs. Now she is off to new adventures, doing her master thesis at the German Aerospace Center (DLR). 🚀(2/2)
July 22, 2025 at 1:48 PM
Her project aimed to understand ancient enzymes that may have helped the origin of life by catalyzing the conversion of NMPs to NTPs. Now she is off to new adventures, doing her master thesis at the German Aerospace Center (DLR). 🚀(2/2)
Reposted by Bornberglab
We also just posted to @biorxiv-genetic.bsky.social a new manuscript led by our superb staff scientist Dr. Prajal Patel in collaboration with @lacholt.bsky.social from @bornberglab.bsky.social. We explored the functionality of orphan gene orthologs in D. melanogaster.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Orthologs of an essential orphan gene vary in their capacities for function and subcellular localization in Drosophila melanogaster
The rapidly evolving nature of orphan genes raises questions about whether their activities remain conserved or evolve uniquely across species. We explore this issue using goddard ( gdrd ), an orphan ...
www.biorxiv.org
May 8, 2025 at 2:04 AM
We also just posted to @biorxiv-genetic.bsky.social a new manuscript led by our superb staff scientist Dr. Prajal Patel in collaboration with @lacholt.bsky.social from @bornberglab.bsky.social. We explored the functionality of orphan gene orthologs in D. melanogaster.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We found that neORFs exhibit greater expression divergence between populations, but less sex-biased expression compared to protein-coding genes or ncRNAs. Notably, the majority of sex-biased neORFs were found in whole-body samples, possibly due to the presence of gonads. (2/2)
April 22, 2025 at 10:02 AM
We found that neORFs exhibit greater expression divergence between populations, but less sex-biased expression compared to protein-coding genes or ncRNAs. Notably, the majority of sex-biased neORFs were found in whole-body samples, possibly due to the presence of gonads. (2/2)