Reposted by Lars Eicholt
The Max Planck Institute for Evolutionary Biology in Plön, Germany, seeks expressions of interest for open Max Planck Director positions. For details: http://www.evolbio.mpg.de/3856225/Directors. #job
Directors
www.evolbio.mpg.de
January 18, 2026 at 9:27 AM
The Max Planck Institute for Evolutionary Biology in Plön, Germany, seeks expressions of interest for open Max Planck Director positions. For details: http://www.evolbio.mpg.de/3856225/Directors. #job
Reposted by Lars Eicholt
I'm recruiting 1-2 grad students through the AITHYRA-CeMM PhD program! Applications are due January 30th. This is a fully-funded PhD program, combining AI and biology to advance biological discovery. Please forward to anyone who may be interested! You can apply here: apply.cemm.at
Fullfabric :: AITHYRA-CeMM PhD
apply.cemm.at
January 8, 2026 at 10:48 AM
I'm recruiting 1-2 grad students through the AITHYRA-CeMM PhD program! Applications are due January 30th. This is a fully-funded PhD program, combining AI and biology to advance biological discovery. Please forward to anyone who may be interested! You can apply here: apply.cemm.at
Reposted by Lars Eicholt
Alan's elegant work on evolutionary contrastive learning for understanding promoter regulatory logic out in @GeneticsGSA! academic.oup.com/genetics/art... Was really fun having him visit my lab for his sabbatical & work on this. New bucket list item: write a first-author paper as a PI!
Inferring fungal cis-regulatory networks from genome sequences via unsupervised and interpretable representation learning
Abstract. Gene expression patterns are determined to a large extent by transcription factor (TF) binding to noncoding regulatory regions in the genome. How
academic.oup.com
January 7, 2026 at 9:35 PM
Alan's elegant work on evolutionary contrastive learning for understanding promoter regulatory logic out in @GeneticsGSA! academic.oup.com/genetics/art... Was really fun having him visit my lab for his sabbatical & work on this. New bucket list item: write a first-author paper as a PI!
Reposted by Lars Eicholt
Erich traveled to Berlin for the Schering Prize award ceremony, where he delivered the laudatio for Agnes Toth-Petroczy, this year’s recipient of the Schering Young Investigator Award. Warm congratulations to her!
Photo credits: Schering Stiftung/Michael Setzpfandt
Photo credits: Schering Stiftung/Michael Setzpfandt
December 12, 2025 at 10:43 AM
Erich traveled to Berlin for the Schering Prize award ceremony, where he delivered the laudatio for Agnes Toth-Petroczy, this year’s recipient of the Schering Young Investigator Award. Warm congratulations to her!
Photo credits: Schering Stiftung/Michael Setzpfandt
Photo credits: Schering Stiftung/Michael Setzpfandt
Reposted by Lars Eicholt
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
December 13, 2025 at 8:09 AM
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
Reposted by Lars Eicholt
Postdoctoral Research Associates are sought for the GEvol project on evolutionary genomics. Candidates should have programming and data analysis skills. More info: https://g-evol.uni-muenster.de/open-positions/ #postdoc
Open Positions – GEvol – DFG SPP 2349
Open Positions – GEvol – DFG SPP 2349
g-evol.uni-muenster.de
December 3, 2025 at 3:32 PM
Postdoctoral Research Associates are sought for the GEvol project on evolutionary genomics. Candidates should have programming and data analysis skills. More info: https://g-evol.uni-muenster.de/open-positions/ #postdoc
Reposted by Lars Eicholt
Ending my PhD with a bang:
Face-to-face histones are important organizers of archaeal chromatin alongside classical histones.
www.biorxiv.org/content/10.6...
Face-to-face histones are important organizers of archaeal chromatin alongside classical histones.
www.biorxiv.org/content/10.6...
December 8, 2025 at 8:01 AM
Ending my PhD with a bang:
Face-to-face histones are important organizers of archaeal chromatin alongside classical histones.
www.biorxiv.org/content/10.6...
Face-to-face histones are important organizers of archaeal chromatin alongside classical histones.
www.biorxiv.org/content/10.6...
Reposted by Lars Eicholt
Grandchamp, @drdomain.bsky.social et al. publish a new Review on commonly used methods for de novo gene detection, address the limitations of nomenclature and detection methods, and establish a de novo gene annotation format to standardize reporting
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
November 19, 2025 at 11:48 AM
Grandchamp, @drdomain.bsky.social et al. publish a new Review on commonly used methods for de novo gene detection, address the limitations of nomenclature and detection methods, and establish a de novo gene annotation format to standardize reporting
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
Reposted by Lars Eicholt
🚀We’re excited to share our new paper in Bioinformatics!
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
November 12, 2025 at 12:41 PM
🚀We’re excited to share our new paper in Bioinformatics!
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.
Reposted by Lars Eicholt
Join us tomorrow! Joana Pereira is talking about AI-powered classification and discovery across the protein universe. @joanampereira.bsky.social
5PM CET, link in the post and in our bio.
5PM CET, link in the post and in our bio.
The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven)
🗓️ November 11th, 5pm CET
Registration is now open: tinyurl.com/prose-seminar2
Please share!
🗓️ November 11th, 5pm CET
Registration is now open: tinyurl.com/prose-seminar2
Please share!
November 10, 2025 at 2:00 PM
Join us tomorrow! Joana Pereira is talking about AI-powered classification and discovery across the protein universe. @joanampereira.bsky.social
5PM CET, link in the post and in our bio.
5PM CET, link in the post and in our bio.
Reposted by Lars Eicholt
New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
Modulation of archaeal hypernucleosome structure and stability by Mg2+
DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …
www.sciencedirect.com
November 6, 2025 at 7:53 AM
New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).
www.sciencedirect.com/science/arti...
Reposted by Lars Eicholt
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
November 5, 2025 at 12:57 PM
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp!
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
November 3, 2025 at 7:47 PM
The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp!
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
Reposted by Lars Eicholt
Looking for a PostDoc in Origins? The Wisconsin Center for Origins Research might be the right place for you!
Apply here:
wicor.wisc.edu/postdoc/
Apply here:
wicor.wisc.edu/postdoc/
November 3, 2025 at 5:49 PM
Looking for a PostDoc in Origins? The Wisconsin Center for Origins Research might be the right place for you!
Apply here:
wicor.wisc.edu/postdoc/
Apply here:
wicor.wisc.edu/postdoc/
Reposted by Lars Eicholt
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Reposted by Lars Eicholt
Ancient amino acid sets enable stable protein folds https://www.biorxiv.org/content/10.1101/2025.10.29.685319v1
October 30, 2025 at 2:47 AM
Ancient amino acid sets enable stable protein folds https://www.biorxiv.org/content/10.1101/2025.10.29.685319v1
Reposted by Lars Eicholt
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Join our next ProSe seminar 11th November 5PM CET and follow us @proteinstructure.bsky.social!
The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven)
🗓️ November 11th, 5pm CET
Registration is now open: tinyurl.com/prose-seminar2
Please share!
🗓️ November 11th, 5pm CET
Registration is now open: tinyurl.com/prose-seminar2
Please share!
October 28, 2025 at 8:13 PM
Join our next ProSe seminar 11th November 5PM CET and follow us @proteinstructure.bsky.social!
Reposted by Lars Eicholt
Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT.
Sign-Up: tinyurl.com/prose-seminar2
Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.
Sign-Up: tinyurl.com/prose-seminar2
Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.
October 25, 2025 at 9:23 PM
Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT.
Sign-Up: tinyurl.com/prose-seminar2
Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.
Sign-Up: tinyurl.com/prose-seminar2
Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.
Reposted by Lars Eicholt
We need to have a conversation about random seeds. Don't use 42.
blog.genesmindsmachines.com/p/if-your-ra...
blog.genesmindsmachines.com/p/if-your-ra...
If your random seed is 42 I will come to your office and set your computer on fire🔥
Figuratively. More likely you'll get a stern talking to.
blog.genesmindsmachines.com
October 22, 2025 at 12:49 PM
We need to have a conversation about random seeds. Don't use 42.
blog.genesmindsmachines.com/p/if-your-ra...
blog.genesmindsmachines.com/p/if-your-ra...
Reposted by Lars Eicholt
A fun little side project I've been working on with @stepadenisov.bsky.social , Mato Lagator, and Andreas Wagner: "Strong promoters are mutationally robust". Briefly...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Strong promoters are mutationally robust
Mutational robustness is the persistence of a phenotype upon mutation. It facilitates molecular evolution and has been characterized in a variety of biological systems, but studies of prokaryotic prom...
www.biorxiv.org
October 21, 2025 at 8:02 AM
A fun little side project I've been working on with @stepadenisov.bsky.social , Mato Lagator, and Andreas Wagner: "Strong promoters are mutationally robust". Briefly...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lars Eicholt
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
October 20, 2025 at 6:14 PM
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
Reposted by Lars Eicholt
How does catalysis emerge from non-catalytic domains?
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
@claudele.bsky.social et al. studied the fundamental question of how enzymatic activity emerges by focusing on type B dihydrofolate reductases, suggesting DfrB domains evolved rudimentary catalysis from a binding capacity.
🔗 doi.org/10.1093/molbev/msaf215
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf215
#evobio #molbio
From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance
Abstract. How does enzymatic activity emerge? To shed light on this fundamental question, we study type B dihydrofolate reductases (DfrB), which were disco
doi.org
October 8, 2025 at 2:32 PM
How does catalysis emerge from non-catalytic domains?
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
Join us Tuesday for the next Protein Structure Evolution Seminar (ProSe Seminar) with Stephen Fried!
The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2
October 12, 2025 at 6:50 PM
Join us Tuesday for the next Protein Structure Evolution Seminar (ProSe Seminar) with Stephen Fried!
Reposted by Lars Eicholt
Never thought I would say this, but I need a Dane.. novonordiskfonden.dk/grant/postdo...
Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden
novonordiskfonden.dk
October 2, 2025 at 5:11 PM
Never thought I would say this, but I need a Dane.. novonordiskfonden.dk/grant/postdo...