David Gleich
@dgleich.bsky.social
Purdue CS. I like matrices, graphs, networks, tensors if they fit, energy efficient stuff, Julia (I’m ex-Matlab), Laura (my wife), data, clean air, 3D printing, vaccines (especially for kids), cooking, hiking, skiing. I’m quiet so I don’t say too much.
How is MS Teams so bad at large video calls? Can’t they just copy zoom??
January 21, 2026 at 3:31 PM
How is MS Teams so bad at large video calls? Can’t they just copy zoom??
Reposted by David Gleich
Just beautiful! Photos Capture the Breathtaking Scale of China’s Wind and Solar Buildout - Yale E360
January 15, 2026 at 10:09 PM
Reposted by David Gleich
Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
🧪🧠Cell www.cell.com/cell/fulltex...
🧪🧠Cell www.cell.com/cell/fulltex...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple
sclerosis, with T cell responses against ANO2 occurring in over half of patients.
These ANO2-specific T cells shar...
www.cell.com
January 15, 2026 at 1:41 AM
Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
🧪🧠Cell www.cell.com/cell/fulltex...
🧪🧠Cell www.cell.com/cell/fulltex...
I can’t wait to see what software looks like 5-10 years from now. LLMs will change how we do software as there are so many new opportunities. So much of UI design and software is to enable things LLMs can now trivially write. But there are some hard problems we still need to solve regarding access
January 14, 2026 at 3:29 PM
I can’t wait to see what software looks like 5-10 years from now. LLMs will change how we do software as there are so many new opportunities. So much of UI design and software is to enable things LLMs can now trivially write. But there are some hard problems we still need to solve regarding access
Ugh… not digging GPT 5.2 for simple material. It’s like someone trained it to be super duper anal.
January 14, 2026 at 3:27 PM
Ugh… not digging GPT 5.2 for simple material. It’s like someone trained it to be super duper anal.
So much tedium to write good code is just gone with Claude. Still lots for humans to manage though! Our jobs just move to the more interesting parts of development
Most programmers are too lazy and stupid to actually follow known dev practices that result in good code, but Claude will happily spend hours writing tests and iterating to cover every edge case in a way humans just won’t
January 9, 2026 at 12:58 PM
So much tedium to write good code is just gone with Claude. Still lots for humans to manage though! Our jobs just move to the more interesting parts of development
Reposted by David Gleich
Most programmers are too lazy and stupid to actually follow known dev practices that result in good code, but Claude will happily spend hours writing tests and iterating to cover every edge case in a way humans just won’t
January 9, 2026 at 12:42 PM
Most programmers are too lazy and stupid to actually follow known dev practices that result in good code, but Claude will happily spend hours writing tests and iterating to cover every edge case in a way humans just won’t
Reposted by David Gleich
Callenson had the courage and conviction to stay with the scene and keep filming. Not to run away, but instead to follow the scene. To continue documenting what was unfolding.
I'd like to think I'd have done the same. I'm not sure at all that I would have.
daringfireball.net/2026/01/le...
I'd like to think I'd have done the same. I'm not sure at all that I would have.
daringfireball.net/2026/01/le...
Let’s Call a Murder a Murder
Caitlin Callenson’s courage in the face of insane danger is just remarkable.
daringfireball.net
January 8, 2026 at 9:29 PM
Callenson had the courage and conviction to stay with the scene and keep filming. Not to run away, but instead to follow the scene. To continue documenting what was unfolding.
I'd like to think I'd have done the same. I'm not sure at all that I would have.
daringfireball.net/2026/01/le...
I'd like to think I'd have done the same. I'm not sure at all that I would have.
daringfireball.net/2026/01/le...
Reposted by David Gleich
We saw Jan 6, 2021 and Jan 7, 2026 with our own eyes.
This is not Orwell's 1984.
This is not Orwell's 1984.
January 8, 2026 at 8:12 PM
We saw Jan 6, 2021 and Jan 7, 2026 with our own eyes.
This is not Orwell's 1984.
This is not Orwell's 1984.
The weather looks a little warm for ice to be causing school cancelations in Minneapolis.
January 8, 2026 at 8:00 PM
The weather looks a little warm for ice to be causing school cancelations in Minneapolis.
Democracy in America is worth reading to understand our current moment better. (Which is probably true of most good histories)
really appreciated this from @lioneltrolling.bsky.social on the importance of voluntary associations, even if for no purpose greater than making life livable in a time of increasing nightmares and a shrinking public square www.unpopularfront.news/p/living-in-...
January 8, 2026 at 2:22 PM
Democracy in America is worth reading to understand our current moment better. (Which is probably true of most good histories)
Reposted by David Gleich
really appreciated this from @lioneltrolling.bsky.social on the importance of voluntary associations, even if for no purpose greater than making life livable in a time of increasing nightmares and a shrinking public square www.unpopularfront.news/p/living-in-...
January 8, 2026 at 1:54 PM
really appreciated this from @lioneltrolling.bsky.social on the importance of voluntary associations, even if for no purpose greater than making life livable in a time of increasing nightmares and a shrinking public square www.unpopularfront.news/p/living-in-...
Reposted by David Gleich
I've often joked that as faculty I program in a high-level language called "graduate student". Having tried out Claude Code this morning, I (i) feel extremely at home, (ii) am realizing that research-by-graduate-student is perhaps the original vibe-coding. 1/2
January 8, 2026 at 12:24 PM
I've often joked that as faculty I program in a high-level language called "graduate student". Having tried out Claude Code this morning, I (i) feel extremely at home, (ii) am realizing that research-by-graduate-student is perhaps the original vibe-coding. 1/2
Put another way: Stop with the 2nd order effect analysis and promote the first order effect!
Also I'm sorry but if you're focused on whether your niche social media site can grow instead of posting for the love of the game, you're doing it wrong. Ego scribo, ergo sum, or something.
January 5, 2026 at 10:07 PM
Put another way: Stop with the 2nd order effect analysis and promote the first order effect!
Reposted by David Gleich
Also I'm sorry but if you're focused on whether your niche social media site can grow instead of posting for the love of the game, you're doing it wrong. Ego scribo, ergo sum, or something.
January 5, 2026 at 10:02 PM
Also I'm sorry but if you're focused on whether your niche social media site can grow instead of posting for the love of the game, you're doing it wrong. Ego scribo, ergo sum, or something.
The best thing about communication is that it takes two to fail and one to succeed.
January 4, 2026 at 8:27 PM
The best thing about communication is that it takes two to fail and one to succeed.
Reposted by David Gleich
It’s so fun to get the little print newsletter!
December 30, 2025 at 7:57 PM
It’s so fun to get the little print newsletter!
It isn’t waiting in line… but you should really sign up for @yesplz.coffee so you can read tonx’s lines each week. Oh. The coffee is good too!
December 30, 2025 at 6:23 PM
It isn’t waiting in line… but you should really sign up for @yesplz.coffee so you can read tonx’s lines each week. Oh. The coffee is good too!
Regarding @yesplz.coffee and the lack of Instagram posts waiting in line… I’ll try and remember to take a selfie the next time I check when my yesplz is going to be delivered! (Just got some today so I missed the chance)
December 30, 2025 at 6:20 PM
Regarding @yesplz.coffee and the lack of Instagram posts waiting in line… I’ll try and remember to take a selfie the next time I check when my yesplz is going to be delivered! (Just got some today so I missed the chance)
The detailed specs are key. Even before llms… The part of coding I loved the most was setting up abstractions and figuring out state. The implementation was just mechanical exercise I can now outsource with detailed description of what I want.
In essence a language model changes you from a programmer who writes lines of code, to a programmer that manages the context the model has access to, prunes irrelevant things, adds useful material to context, and writes detailed specifications. If that doesn't sound fun to you, you won't enjoy it.
December 30, 2025 at 1:51 AM
The detailed specs are key. Even before llms… The part of coding I loved the most was setting up abstractions and figuring out state. The implementation was just mechanical exercise I can now outsource with detailed description of what I want.
Replaced a 2nd gen nest with an ecobee… I forgot how awesome the nest was! I’m sad to bid it fairwell. Got this before the Google acquisition.
December 27, 2025 at 7:20 PM
Replaced a 2nd gen nest with an ecobee… I forgot how awesome the nest was! I’m sad to bid it fairwell. Got this before the Google acquisition.
Has anyone made a cut of home alone 2 without trump?
December 25, 2025 at 11:08 PM
Has anyone made a cut of home alone 2 without trump?
Reposted by David Gleich
But there's an observation selection effect here. Even if there is no correlation between lab size and academic success or prestige, bigger labs just produce more students.
So, akin to the strong friendship paradox, most of us trained in larger labs than we run ourselves. I bet that matters.
(2/2)
So, akin to the strong friendship paradox, most of us trained in larger labs than we run ourselves. I bet that matters.
(2/2)
December 21, 2025 at 9:09 PM
But there's an observation selection effect here. Even if there is no correlation between lab size and academic success or prestige, bigger labs just produce more students.
So, akin to the strong friendship paradox, most of us trained in larger labs than we run ourselves. I bet that matters.
(2/2)
So, akin to the strong friendship paradox, most of us trained in larger labs than we run ourselves. I bet that matters.
(2/2)
I sense a market for high fat cheese wiz…
"Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia."
Results of a 25-year prospective study of ~27,000 participants.
The purported benefit was not linked to APOE4 carriers or low-fat cheese intake
www.neurology.org/doi/full/10....
Results of a 25-year prospective study of ~27,000 participants.
The purported benefit was not linked to APOE4 carriers or low-fat cheese intake
www.neurology.org/doi/full/10....
December 17, 2025 at 11:05 PM
I sense a market for high fat cheese wiz…