David Zappulla
@dczapp.bsky.social
Biomedical researcher & professor studying telomerase RNP, telomeres, lncRNAs, & senescence. Opinions are my own, not necessarily those of my employer. (He/him)
Pinned
David Zappulla
@dczapp.bsky.social
· Feb 23
In a preprint published today, we are excited to report the secondary structure of the 1212 nt fission-yeast S. pombe telomerase RNA, TER1, and its roles in the physicofunctional organization of this massive, flexible enzymatic RNP complex.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
“Put another way, punishing campuses by cutting health research funding would destroy the equivalent of one-quarter of annual gross domestic product in the US.”
June 2, 2025 at 10:46 AM
“Put another way, punishing campuses by cutting health research funding would destroy the equivalent of one-quarter of annual gross domestic product in the US.”
Reposted by David Zappulla
Reposted by David Zappulla
"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger”
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...
May 30, 2025 at 11:43 PM
"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger”
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...
Reposted by David Zappulla
A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-relea...
amazon.com/gp/new-relea...
May 27, 2025 at 10:27 PM
A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-relea...
amazon.com/gp/new-relea...
Reposted by David Zappulla
In St. Louis, the sirens to warn people of a tornado threat were not activated by the City Emergency Management Agency before a deadly tornado hit on Friday, and a backup to activate the mechanism that is operated by the Fire Department was broken.
Warning Sirens Were Silent Ahead of Deadly Tornado in St. Louis, City Says
www.nytimes.com
May 22, 2025 at 1:47 AM
In St. Louis, the sirens to warn people of a tornado threat were not activated by the City Emergency Management Agency before a deadly tornado hit on Friday, and a backup to activate the mechanism that is operated by the Fire Department was broken.
Reposted by David Zappulla
More context:
Our tracker (grant-watch.us) currently lists 877 terminated NIH grants. We have 820 rows in the tracker, but some rows list multiple grants.
As of yesterday, NIH RePORTER listed 807 NIH grants specifically at Harvard.
So we're looking at over 1600 formally terminated NIH grants now.
Our tracker (grant-watch.us) currently lists 877 terminated NIH grants. We have 820 rows in the tracker, but some rows list multiple grants.
As of yesterday, NIH RePORTER listed 807 NIH grants specifically at Harvard.
So we're looking at over 1600 formally terminated NIH grants now.
May 16, 2025 at 1:07 PM
More context:
Our tracker (grant-watch.us) currently lists 877 terminated NIH grants. We have 820 rows in the tracker, but some rows list multiple grants.
As of yesterday, NIH RePORTER listed 807 NIH grants specifically at Harvard.
So we're looking at over 1600 formally terminated NIH grants now.
Our tracker (grant-watch.us) currently lists 877 terminated NIH grants. We have 820 rows in the tracker, but some rows list multiple grants.
As of yesterday, NIH RePORTER listed 807 NIH grants specifically at Harvard.
So we're looking at over 1600 formally terminated NIH grants now.
Reposted by David Zappulla
The USFWS has announced that it killed the breeding male of the Hail Canyon pack in New Mexico. The wolf, a 5 yr old dad named Viento, was the breeding male of a family of wolves that includes Slides - the Mexican gray wolf fostered from the WCC into the wild in 2023.
Government Kills Another Endangered Mexican Wolf at the Behest of the Livestock Industry
Just days after admitting that it killed the wrong Mexican wolf in Arizona, the U.S. Fish and Wildlife Service has announced that it also killed the breeding male of the Hail Canyon pack in New Mexico...
nywolf.org
April 28, 2025 at 8:15 PM
The USFWS has announced that it killed the breeding male of the Hail Canyon pack in New Mexico. The wolf, a 5 yr old dad named Viento, was the breeding male of a family of wolves that includes Slides - the Mexican gray wolf fostered from the WCC into the wild in 2023.
Reposted by David Zappulla
Measles in the US, update
—712 cases, 11% hospitalized, 3 deaths, 97% cases are unvaccinated
—Now in 24 states
—Actual cases must be multiple thousand to align with the number of hospitalizations and deaths reported
www.cdc.gov/measles/data...
www.cbsnews.com/news/measles...
—712 cases, 11% hospitalized, 3 deaths, 97% cases are unvaccinated
—Now in 24 states
—Actual cases must be multiple thousand to align with the number of hospitalizations and deaths reported
www.cdc.gov/measles/data...
www.cbsnews.com/news/measles...
April 12, 2025 at 3:12 PM
Measles in the US, update
—712 cases, 11% hospitalized, 3 deaths, 97% cases are unvaccinated
—Now in 24 states
—Actual cases must be multiple thousand to align with the number of hospitalizations and deaths reported
www.cdc.gov/measles/data...
www.cbsnews.com/news/measles...
—712 cases, 11% hospitalized, 3 deaths, 97% cases are unvaccinated
—Now in 24 states
—Actual cases must be multiple thousand to align with the number of hospitalizations and deaths reported
www.cdc.gov/measles/data...
www.cbsnews.com/news/measles...
Reposted by David Zappulla
Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out!
meetings.cshl.edu/courses.aspx...
meetings.cshl.edu/courses.aspx...
April 2, 2025 at 3:45 PM
Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out!
meetings.cshl.edu/courses.aspx...
meetings.cshl.edu/courses.aspx...
Reposted by David Zappulla
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
March 20, 2025 at 5:35 PM
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
Reposted by David Zappulla
Reposted by David Zappulla
Looking at grant funding time for all years from 2015-2025
Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_
1/2
Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_
1/2
April 7, 2025 at 11:26 PM
Looking at grant funding time for all years from 2015-2025
Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_
1/2
Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_
1/2
Reposted by David Zappulla
I don’t think the country understands the nuclear bomb that has hit and destroyed Americas future. Our competitiveness globally was threatened - it is now guaranteed to dwindle to irrelevance. The future is based on science and technology. By the time they realize the damage, it will be too late. AR
April 2, 2025 at 12:02 PM
I don’t think the country understands the nuclear bomb that has hit and destroyed Americas future. Our competitiveness globally was threatened - it is now guaranteed to dwindle to irrelevance. The future is based on science and technology. By the time they realize the damage, it will be too late. AR
Reposted by David Zappulla
Tragic, infuriating news. Mexican gray wolf Ella, whose travels captivated a nation just last week, was found dead in New Mexico.
The U.S. Fish and Wildlife Service has indicated that the cause of Ella’s death is under investigation.
The U.S. Fish and Wildlife Service has indicated that the cause of Ella’s death is under investigation.
Wandering Wolf “Ella” Found Deceased in New Mexico
The Mexican gray wolf who just last week was located north of Interstate 40 near Mount Taylor in New Mexico was found dead on Sunday, March 30, 2025. The U.S. Fish and Wildlife Service has indicated t...
nywolf.org
March 31, 2025 at 9:42 PM
Tragic, infuriating news. Mexican gray wolf Ella, whose travels captivated a nation just last week, was found dead in New Mexico.
The U.S. Fish and Wildlife Service has indicated that the cause of Ella’s death is under investigation.
The U.S. Fish and Wildlife Service has indicated that the cause of Ella’s death is under investigation.
Reposted by David Zappulla
🧪⚛️ If you want to sign a petition to protect the NIST Atomic Spectroscopy Group, here's an opportunity: www.change.org/p/oppose-the...
Hat tip to @nanoscaleviews.bsky.social for sharing this.
Hat tip to @nanoscaleviews.bsky.social for sharing this.
March 30, 2025 at 10:54 PM
🧪⚛️ If you want to sign a petition to protect the NIST Atomic Spectroscopy Group, here's an opportunity: www.change.org/p/oppose-the...
Hat tip to @nanoscaleviews.bsky.social for sharing this.
Hat tip to @nanoscaleviews.bsky.social for sharing this.
Reposted by David Zappulla
The destruction of American science continues apace. Early career people are the most likely to be seeking to leave. One of my about-to-graduate PhDs is seriously considering a job offer in Germany, even though it would involve lower pay. www.nature.com/articles/d41...
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
March 31, 2025 at 2:55 AM
The destruction of American science continues apace. Early career people are the most likely to be seeking to leave. One of my about-to-graduate PhDs is seriously considering a job offer in Germany, even though it would involve lower pay. www.nature.com/articles/d41...
Reposted by David Zappulla
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Reposted by David Zappulla
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
March 22, 2025 at 5:14 PM
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
Reposted by David Zappulla
Texas measles update today
309 cases; 40 have been hospitalized (<-which means there are far more than 300 cases diagnosed)
www.dshs.texas.gov/news-alerts/...
309 cases; 40 have been hospitalized (<-which means there are far more than 300 cases diagnosed)
www.dshs.texas.gov/news-alerts/...
Measles Outbreak – March 21, 2025 | Texas DSHS
www.dshs.texas.gov
March 21, 2025 at 4:08 PM
Texas measles update today
309 cases; 40 have been hospitalized (<-which means there are far more than 300 cases diagnosed)
www.dshs.texas.gov/news-alerts/...
309 cases; 40 have been hospitalized (<-which means there are far more than 300 cases diagnosed)
www.dshs.texas.gov/news-alerts/...
Reposted by David Zappulla
ATTENTION
If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me.
THANK YOU!
If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me.
THANK YOU!
stan marsh from south park says see that 's what happened to me !
ALT: stan marsh from south park says see that 's what happened to me !
media.tenor.com
March 21, 2025 at 1:34 PM
ATTENTION
If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me.
THANK YOU!
If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me.
THANK YOU!
Reposted by David Zappulla
New SGD paper!
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements
Abstract. Budding yeast (Saccharomyces cerevisiae) is the most extensively characterized eukaryotic model organism and has long been used to gain insight i
academic.oup.com
March 19, 2025 at 5:32 PM
New SGD paper!
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...
Reposted by David Zappulla
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
www.sciencefriday.com
March 16, 2025 at 2:09 PM
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
Reposted by David Zappulla
THIS IS INCREDIBLE! Cohen Children’s Medical Center has confirmed that it has successfully ELIMINATED sickle cell disease from Sebastien Beauzile, using the groundbreaking genetic treatment Lyfgenia. He has made HISTORY by becoming the FIRST in New York to be CURED of sickle cell anemia! 🧪🧵⬇️
March 15, 2025 at 4:00 PM
THIS IS INCREDIBLE! Cohen Children’s Medical Center has confirmed that it has successfully ELIMINATED sickle cell disease from Sebastien Beauzile, using the groundbreaking genetic treatment Lyfgenia. He has made HISTORY by becoming the FIRST in New York to be CURED of sickle cell anemia! 🧪🧵⬇️
Reposted by David Zappulla
We have a winner...
March 8, 2025 at 1:09 AM
We have a winner...
Reposted by David Zappulla
Stand Up For Science 2025 in Philadelphia Pennsylvania
March 7, 2025 at 4:50 PM
Stand Up For Science 2025 in Philadelphia Pennsylvania