Jeremy Day
@daylab.bsky.social
Neuroscientist at UAB interested in molecular and genetic mechanisms in brain function. Director, UAB Comprehensive Neuroscience Center.
Great talk from @sj-marzi.bsky.social for the UAB Biochemistry and Molecular Genetics seminar series - lots of cool results on chromatin modifications linking human gene variation to neurodegenerative disease risk. Supports what seems to be an emerging consensus of a major role for microglia.
February 11, 2026 at 5:20 PM
Great talk from @sj-marzi.bsky.social for the UAB Biochemistry and Molecular Genetics seminar series - lots of cool results on chromatin modifications linking human gene variation to neurodegenerative disease risk. Supports what seems to be an emerging consensus of a major role for microglia.
Reposted by Jeremy Day
Happy to share the newest study from our lab, led by superstar postdoc Dr. Rodrigo Campos Cardoso, where we resolve the infralimbic cortex GABAergic circuits of fear extinction: tinyurl.com/38vvr2my
February 10, 2026 at 12:44 PM
Happy to share the newest study from our lab, led by superstar postdoc Dr. Rodrigo Campos Cardoso, where we resolve the infralimbic cortex GABAergic circuits of fear extinction: tinyurl.com/38vvr2my
Reposted by Jeremy Day
Very happy to share a new paper in
@npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.
@npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.
February 6, 2026 at 7:46 PM
Very happy to share a new paper in
@npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.
@npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.
Reposted by Jeremy Day
Stunning art installation at BHM (the airport). Can’t tell if it’s permanent or up for BHM (the month) but it really is quite striking.
February 6, 2026 at 5:11 PM
Stunning art installation at BHM (the airport). Can’t tell if it’s permanent or up for BHM (the month) but it really is quite striking.
Reposted by Jeremy Day
These are the curves for new and competitive renewal grants.
The number of new awards is increasing slightly, but only slightly.
17 out of 25 institutes and centers with funding authority have now made awards.
3/4
The number of new awards is increasing slightly, but only slightly.
17 out of 25 institutes and centers with funding authority have now made awards.
3/4
February 4, 2026 at 3:35 PM
These are the curves for new and competitive renewal grants.
The number of new awards is increasing slightly, but only slightly.
17 out of 25 institutes and centers with funding authority have now made awards.
3/4
The number of new awards is increasing slightly, but only slightly.
17 out of 25 institutes and centers with funding authority have now made awards.
3/4
Reposted by Jeremy Day
PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬
www.eneuro.org/content/13/2...
www.eneuro.org/content/13/2...
A Common Iba1 Antibody Labels Vasopressin Neurons in Mice
There are a wide variety of commercially available antibodies for labeling microglial cells based on different protein targets, as well as antibodies for the same protein target made in different spec...
www.eneuro.org
February 3, 2026 at 9:36 PM
PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬
www.eneuro.org/content/13/2...
www.eneuro.org/content/13/2...
Reposted by Jeremy Day
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
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www.biorxiv.org
February 2, 2026 at 1:12 PM
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
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Reposted by Jeremy Day
🧵Good news out of #NIH today.
(1) NIH is extending #ESI and #K99/R00 eligibility to accommodate researchers whose eligibility would have ended during the previous shutdown. Take a look at NOT-OD-26-020. If your ESI status would have ended in 2025, you get an automatic extension through 2026/03/31.
(1) NIH is extending #ESI and #K99/R00 eligibility to accommodate researchers whose eligibility would have ended during the previous shutdown. Take a look at NOT-OD-26-020. If your ESI status would have ended in 2025, you get an automatic extension through 2026/03/31.
NOT-OD-26-020: Notice of Temporary Extension to Early-Stage Investigator (ESI) Eligibility Period
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Temporary Extension to Early-Stage Investigator (ESI) Eligibility Period NOT-OD-26-020. OD
grants.nih.gov
January 30, 2026 at 7:34 PM
Reposted by Jeremy Day
We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867
January 24, 2026 at 1:14 PM
We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867
Reposted by Jeremy Day
Now out in @nature.com: Biological insights into schizophrenia from ancestrally diverse populations.
@sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators
Read: rdcu.be/eZ7he
@sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators
Read: rdcu.be/eZ7he
Biological insights into schizophrenia from ancestrally diverse populations
Nature - Genome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied...
rdcu.be
January 21, 2026 at 6:58 PM
Now out in @nature.com: Biological insights into schizophrenia from ancestrally diverse populations.
@sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators
Read: rdcu.be/eZ7he
@sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators
Read: rdcu.be/eZ7he
Reposted by Jeremy Day
The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau https://www.biorxiv.org/content/10.64898/2026.01.21.700770v1
January 21, 2026 at 11:15 PM
The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau https://www.biorxiv.org/content/10.64898/2026.01.21.700770v1
Reposted by Jeremy Day
Drug discovery for nervous system disorders is really challenging. We think early/rapid in vivo testing with zebrafish will accelerate the drug development cycle for conserved targets. Check out our proof-of-principle pilot study and virtual drug discovery pipeline (tinyurl.com/3whr23hs). #Skytorial
January 21, 2026 at 2:47 PM
Drug discovery for nervous system disorders is really challenging. We think early/rapid in vivo testing with zebrafish will accelerate the drug development cycle for conserved targets. Check out our proof-of-principle pilot study and virtual drug discovery pipeline (tinyurl.com/3whr23hs). #Skytorial
Reposted by Jeremy Day
I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Addiction Neuroscience | Dopamine circuitry and heterogeneity in addiction | ScienceDirect.com by Elsevier
The heterogeneity of midbrain dopamine neurons is coming into focus. Distinct subtypes of dopamine neurons can be identified across the ventral tegmental area (VTA) and substantia nigra pars compacta ...
www.sciencedirect.com
January 19, 2026 at 2:11 PM
I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Honored to have made the frontal cortex (cingulate?) of @npp-journal.bsky.social reviewers this year!
January 16, 2026 at 9:26 PM
Honored to have made the frontal cortex (cingulate?) of @npp-journal.bsky.social reviewers this year!
Reposted by Jeremy Day
TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread
January 15, 2026 at 12:32 PM
TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread
Reposted by Jeremy Day
Check out the preprint: doi.org/10.64898/202... and the TF-MINDI package: github.com/aertslab/TF-MINDI. With @lukasmahieu.bsky.social ’s help this has become an amazing and user-friendly package, please give it a try and provide feedback.
System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development
The genomic cis-regulatory code (CRC) underlies spatiotemporal specificity of gene expression. While sequence-to-function (S2F) models can accurately encode the CRC of transcriptional enhancers, decod...
doi.org
January 15, 2026 at 11:57 AM
Check out the preprint: doi.org/10.64898/202... and the TF-MINDI package: github.com/aertslab/TF-MINDI. With @lukasmahieu.bsky.social ’s help this has become an amazing and user-friendly package, please give it a try and provide feedback.
Don’t know what was more thrilling, the Atlantis water slides #ACNP2026 or the high-speed Bahamian roundabouts on the way to and from the airport. Great meeting with great people and I’m already excited for next year.
January 15, 2026 at 11:51 PM
Don’t know what was more thrilling, the Atlantis water slides #ACNP2026 or the high-speed Bahamian roundabouts on the way to and from the airport. Great meeting with great people and I’m already excited for next year.
Reposted by Jeremy Day
Congrats to the new @acnporg.bsky.social Fellows! #ACNP2026
January 15, 2026 at 1:28 PM
Congrats to the new @acnporg.bsky.social Fellows! #ACNP2026
Reposted by Jeremy Day
Banned from travel to #ACNP2026 at the last minute, the NIH Institute Directors will join the meeting via remote. Koob, Volkow and Acting Director Beckel-Mitchener for NIAAA, NIDA and NIMH.
January 12, 2026 at 6:04 PM
Banned from travel to #ACNP2026 at the last minute, the NIH Institute Directors will join the meeting via remote. Koob, Volkow and Acting Director Beckel-Mitchener for NIAAA, NIDA and NIMH.
Reposted by Jeremy Day
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 6, 2026 at 11:29 PM
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
Reposted by Jeremy Day
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
December 9, 2025 at 7:20 PM
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
Reposted by Jeremy Day
The first one is not a test of replicability. It is a test of generalization. It is important to stop conflating these.
Just had a meeting yesterday with a team (2 labs) where team 1 tried to first replicate findings of team 2 but used different systems and couldn't do it. Then they used the same system and replicated the original finding beautifully. But now we're curious about why the other systems are different
December 3, 2025 at 4:08 PM
The first one is not a test of replicability. It is a test of generalization. It is important to stop conflating these.
Reposted by Jeremy Day
Department of Psychological & Brain Sciences at Johns Hopkins is inviting applications for 3 open-rank tenured/tenure-track positions in (1) Behavioral Neuroscience, (2) Cognitive Neuroscience, and (3) Cognitive Psychology.
pbs.jhu.edu/about/jobs/
pbs.jhu.edu/about/jobs/
Jobs | Psychological & Brain Sciences
Tenured/Tenure-track position in Cognitive Psychology Open Date Dec 01, 2025 Salary Range or Pay Grade The expected academic base salary range for this position is $110,000- $144,500 (Assistant Profes...
pbs.jhu.edu
December 2, 2025 at 12:00 AM
Department of Psychological & Brain Sciences at Johns Hopkins is inviting applications for 3 open-rank tenured/tenure-track positions in (1) Behavioral Neuroscience, (2) Cognitive Neuroscience, and (3) Cognitive Psychology.
pbs.jhu.edu/about/jobs/
pbs.jhu.edu/about/jobs/
New computational paper from the lab! Thanks to the reviewers for helping us improve this paper from the preprint version and Nucleic Acids Research for a smooth publication process.
Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Validate User
doi.org
November 26, 2025 at 6:15 PM
New computational paper from the lab! Thanks to the reviewers for helping us improve this paper from the preprint version and Nucleic Acids Research for a smooth publication process.
Reposted by Jeremy Day
So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking
Ventral tegmental area GABA neurons integrate positive and negative valence - Nature Communications
The role of ventral tegmental area GABA neurons in behavior is unclear. Here, authors show that VTA GABA but not dopamine neurons integrate positive and negative valence to encode motivational conflic...
www.nature.com
November 24, 2025 at 4:18 PM
So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking