David L Perez MD, MMSc
@davidlewisperez.bsky.social
Clinician-Scientist, Neurologist-Psychiatrist at Harvard Medical School | Chief, Mass General Brigham Division of Behavioral Neurology | Director, FND Unit & Research Group | Views My Own
https://connects.catalyst.harvard.edu/Profiles/display/Person/8655
https://connects.catalyst.harvard.edu/Profiles/display/Person/8655
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Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
Registration is open for our #HarvardMedicalSchool course Brain Medicine: Integrating the Clinical Neurosciences.
Goes live February 6th 2026 - with 30 days of on-demand viewing. Bridging neurology, psychiatry, neuropsychology, & interventional neuropsychiatry!
learn.hms.harvard.edu/programs/bra...
Goes live February 6th 2026 - with 30 days of on-demand viewing. Bridging neurology, psychiatry, neuropsychology, & interventional neuropsychiatry!
learn.hms.harvard.edu/programs/bra...
Reposted by David L Perez MD, MMSc
Good to have Mr M safely home from Scotland. Photos from a very wet wander in #HamsterleyForest this afternoon. Misty, murky, mossy, muddy, loved it. 😊
February 6, 2026 at 8:56 PM
Good to have Mr M safely home from Scotland. Photos from a very wet wander in #HamsterleyForest this afternoon. Misty, murky, mossy, muddy, loved it. 😊
Reposted by David L Perez MD, MMSc
Age and duration of illness are important to consider in developmental models of major depression.
Major Depressive Disorder in Youth and Adults: A Quantitative Whole-Brain Meta-Analysis of Functional Magnetic Resonance Imaging Studies
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder with limited treatment success in both youth and adults. Functional magnetic resonance imaging (fMRI) studies have reported…
www.biologicalpsychiatrycnni.org
February 5, 2026 at 1:02 PM
Age and duration of illness are important to consider in developmental models of major depression.
Reposted by David L Perez MD, MMSc
One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
January 29, 2026 at 2:15 PM
One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Check out this 2024 talk on Balancing the Anxious Self: Navigating the Interoceptive and Digital Realms by Sahib Khalsa (@skhalsa.bsky.social) youtu.be/fWUpcjWVMfQ?...
Semel Grand Rounds, 2024-02-20, Dr. Sahib Khalsa
YouTube video by Semel Audio Visual AV
youtu.be
January 30, 2026 at 4:36 PM
Check out this 2024 talk on Balancing the Anxious Self: Navigating the Interoceptive and Digital Realms by Sahib Khalsa (@skhalsa.bsky.social) youtu.be/fWUpcjWVMfQ?...
One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
January 29, 2026 at 2:15 PM
One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Reposted by David L Perez MD, MMSc
Just over 2 weeks left to submit your abstracts to the @fndsociety.bsky.social for the biannual FND international conference in Baltimore!
Do come & support this new society for what must be medicine’s oldest & most enigmatic disorder!
@https://www.fndsociety.org/biennial-meeting/2026/abstract
Do come & support this new society for what must be medicine’s oldest & most enigmatic disorder!
@https://www.fndsociety.org/biennial-meeting/2026/abstract
January 26, 2026 at 8:25 PM
Just over 2 weeks left to submit your abstracts to the @fndsociety.bsky.social for the biannual FND international conference in Baltimore!
Do come & support this new society for what must be medicine’s oldest & most enigmatic disorder!
@https://www.fndsociety.org/biennial-meeting/2026/abstract
Do come & support this new society for what must be medicine’s oldest & most enigmatic disorder!
@https://www.fndsociety.org/biennial-meeting/2026/abstract
Reposted by David L Perez MD, MMSc
Do you know all the updates on restless legs syndrome (RLS) 2026? Are we getting the diagnosis right and the treatment smarter. Spoiler alert: ‘Gabapentenoids’ now take center stage.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
January 26, 2026 at 2:24 PM
Do you know all the updates on restless legs syndrome (RLS) 2026? Are we getting the diagnosis right and the treatment smarter. Spoiler alert: ‘Gabapentenoids’ now take center stage.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by David L Perez MD, MMSc
Over 125 years ago, Cécile & Oskar Vogt began assembling an extensive collection of brain histological sections and related documents. Katrin Amunts explores how digitizing these materials will create a valuable resource for modern neuroscience. shorturl.at/RaMw8
January 23, 2026 at 3:02 PM
Over 125 years ago, Cécile & Oskar Vogt began assembling an extensive collection of brain histological sections and related documents. Katrin Amunts explores how digitizing these materials will create a valuable resource for modern neuroscience. shorturl.at/RaMw8
Reposted by David L Perez MD, MMSc
This is great - a really nice overview of recent FND network studies, and a friendly introduction to predictive processing theory in FND 🙌
Findings in this @biologicalpsych.bsky.social CNNI paper are complementary to other results published using graph theory metrics in @braincomms.bsky.social.
Check out this 20 minute lecture by Christi Westlin that connects the two papers! 8/8
youtu.be/0Zjs-7lf6fA
academic.oup.com/braincomms/a...
Check out this 20 minute lecture by Christi Westlin that connects the two papers! 8/8
youtu.be/0Zjs-7lf6fA
academic.oup.com/braincomms/a...
Inside the Predictive Brain: Neuroimaging Insights into Brain Circuitry in FND
YouTube video by David L Perez
youtu.be
January 22, 2026 at 3:27 AM
This is great - a really nice overview of recent FND network studies, and a friendly introduction to predictive processing theory in FND 🙌
Thank you @mayoclinic.org for a wonderful two days as a visiting professor with you all! Great opportunity to trade notes on how healthcare systems can be optimized to better assess & manage patients with functional neurological disorder. Also, pleased to share some of our latest rs-fMRI findings.
January 21, 2026 at 1:15 AM
Thank you @mayoclinic.org for a wonderful two days as a visiting professor with you all! Great opportunity to trade notes on how healthcare systems can be optimized to better assess & manage patients with functional neurological disorder. Also, pleased to share some of our latest rs-fMRI findings.
Reposted by David L Perez MD, MMSc
Sharing @biologicalpsych.bsky.social CNNI study: Westlin et al. gradient mapping paper in 187 subjects [64 FND, 62 PCs, 61 HCs]. New mechanistic insights delineated in the paper - as well as summarized here 1/n
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
January 13, 2026 at 1:18 PM
Sharing @biologicalpsych.bsky.social CNNI study: Westlin et al. gradient mapping paper in 187 subjects [64 FND, 62 PCs, 61 HCs]. New mechanistic insights delineated in the paper - as well as summarized here 1/n
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
Sharing @biologicalpsych.bsky.social CNNI study: Westlin et al. gradient mapping paper in 187 subjects [64 FND, 62 PCs, 61 HCs]. New mechanistic insights delineated in the paper - as well as summarized here 1/n
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
January 13, 2026 at 1:18 PM
Sharing @biologicalpsych.bsky.social CNNI study: Westlin et al. gradient mapping paper in 187 subjects [64 FND, 62 PCs, 61 HCs]. New mechanistic insights delineated in the paper - as well as summarized here 1/n
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
@yutakatsumi.bsky.social @mgbresearch.bsky.social
sciencedirect.com/science/arti...
Changes in PTSD Symptoms With Integrative Psychotherapy for Functional Neurological Symptom Disorder | The Journal of Neuropsychiatry and Clinical Neurosciences. Study likely worth another good look for those in the #FND field - some interesting results. psychiatryonline.org/doi/10.1176/...
Changes in Posttraumatic Stress Disorder Symptoms With Integrative Psychotherapy for Functional Neurological Symptom Disorder | The Journal of Neuropsychiatry and Clinical Neurosciences
Objective:Patients with functional neurological symptom disorder (FNSD) report high rates of
traumatization and have high levels of posttraumatic stress disorder (PTSD) symptoms.
Psychotherapy is a ma...
psychiatryonline.org
January 10, 2026 at 1:40 PM
Changes in PTSD Symptoms With Integrative Psychotherapy for Functional Neurological Symptom Disorder | The Journal of Neuropsychiatry and Clinical Neurosciences. Study likely worth another good look for those in the #FND field - some interesting results. psychiatryonline.org/doi/10.1176/...
Reposted by David L Perez MD, MMSc
One month out from our @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. Registration open! A great lineup of speakers across psychiatry, neurology, neuropsychology & brain research. @massgeneralbrigham.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
January 6, 2026 at 3:06 PM
One month out from our @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. Registration open! A great lineup of speakers across psychiatry, neurology, neuropsychology & brain research. @massgeneralbrigham.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
One month out from our @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. Registration open! A great lineup of speakers across psychiatry, neurology, neuropsychology & brain research. @massgeneralbrigham.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
January 6, 2026 at 3:06 PM
One month out from our @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. Registration open! A great lineup of speakers across psychiatry, neurology, neuropsychology & brain research. @massgeneralbrigham.bsky.social
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
New @neuroimageeic.bsky.social structural brain MRI study in functional cognitive disorder - a collaboration with #NoahSilverberg & colleagues - led by Christi Westlin. Structural brain alterations & predictors of clinical improvement in #FCD after concussion.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
January 5, 2026 at 9:43 PM
New @neuroimageeic.bsky.social structural brain MRI study in functional cognitive disorder - a collaboration with #NoahSilverberg & colleagues - led by Christi Westlin. Structural brain alterations & predictors of clinical improvement in #FCD after concussion.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
Reposted by David L Perez MD, MMSc
FND: an evolutionary perspective
A short piece exploring an evolutionary perspective, specifically survival responses, to FND.
These are not new ideas, but thank you to Akiriho Nishi for suggesting a short, standalone article to encourage wider debate
academic.oup.com/emph/article...
A short piece exploring an evolutionary perspective, specifically survival responses, to FND.
These are not new ideas, but thank you to Akiriho Nishi for suggesting a short, standalone article to encourage wider debate
academic.oup.com/emph/article...
Functional neurological disorder: an evolutionary perspective
Functional neurological disorder (FND) is among the commonest disorders in neurological practice with an estimated prevalence of 80–140 per 100 000 individ
academic.oup.com
January 5, 2026 at 9:10 PM
FND: an evolutionary perspective
A short piece exploring an evolutionary perspective, specifically survival responses, to FND.
These are not new ideas, but thank you to Akiriho Nishi for suggesting a short, standalone article to encourage wider debate
academic.oup.com/emph/article...
A short piece exploring an evolutionary perspective, specifically survival responses, to FND.
These are not new ideas, but thank you to Akiriho Nishi for suggesting a short, standalone article to encourage wider debate
academic.oup.com/emph/article...
In 2025 - grateful that our Functional Neurological Disorder Unit & Research Group has diligently work across the 4 pillars of our mission: clinical care, program development, research & education. Making progress - with much more to do!
giving.massgeneral.org/donate?fnd=1...
giving.massgeneral.org/donate?fnd=1...
December 31, 2025 at 3:12 PM
In 2025 - grateful that our Functional Neurological Disorder Unit & Research Group has diligently work across the 4 pillars of our mission: clinical care, program development, research & education. Making progress - with much more to do!
giving.massgeneral.org/donate?fnd=1...
giving.massgeneral.org/donate?fnd=1...
Reposted by David L Perez MD, MMSc
#1 Friedman & Robbins: The role of prefrontal cortex in cognitive control & executive function (2022)
This review explores cognitive control & executive function, their relationships with goal-directed behavior versus habits, & related brain regions
www.nature.com/artic...
6/6
This review explores cognitive control & executive function, their relationships with goal-directed behavior versus habits, & related brain regions
www.nature.com/artic...
6/6
The role of prefrontal cortex in cognitive control and executive function
Neuropsychopharmacology - The role of prefrontal cortex in cognitive control and executive function
www.nature.com
December 29, 2025 at 6:58 PM
#1 Friedman & Robbins: The role of prefrontal cortex in cognitive control & executive function (2022)
This review explores cognitive control & executive function, their relationships with goal-directed behavior versus habits, & related brain regions
www.nature.com/artic...
6/6
This review explores cognitive control & executive function, their relationships with goal-directed behavior versus habits, & related brain regions
www.nature.com/artic...
6/6
Reposted by David L Perez MD, MMSc
#3 Kredlow...Phelps: Prefrontal cortex, amygdala, & threat processing: implications for PTSD (2022)
This review covers threat or fear learning processes in nonhuman animals, healthy humans & patients with PTSD, through the lens of the PFC
www.nature.com/artic...
4/6
This review covers threat or fear learning processes in nonhuman animals, healthy humans & patients with PTSD, through the lens of the PFC
www.nature.com/artic...
4/6
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Neuropsychopharmacology - Prefrontal cortex, amygdala, and threat processing: implications for PTSD
www.nature.com
December 29, 2025 at 6:58 PM
#3 Kredlow...Phelps: Prefrontal cortex, amygdala, & threat processing: implications for PTSD (2022)
This review covers threat or fear learning processes in nonhuman animals, healthy humans & patients with PTSD, through the lens of the PFC
www.nature.com/artic...
4/6
This review covers threat or fear learning processes in nonhuman animals, healthy humans & patients with PTSD, through the lens of the PFC
www.nature.com/artic...
4/6
Looking for options on how to use CME funds as we approach the end of the year? Consider signing up for our @harvardmed.bsky.social #BrainMedicine course at the intersection of neurology, psychiatry, neurorehabilitation, & clinical neuroscience listed below:
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
December 26, 2025 at 6:10 PM
Looking for options on how to use CME funds as we approach the end of the year? Consider signing up for our @harvardmed.bsky.social #BrainMedicine course at the intersection of neurology, psychiatry, neurorehabilitation, & clinical neuroscience listed below:
learn.hms.harvard.edu/programs/bra...
learn.hms.harvard.edu/programs/bra...
Reposted by David L Perez MD, MMSc
Long-term visual-to-tactile stimulation induces functional reorganization of thalamic pathways to achieve visual perception https://www.sciencedirect.com/science/article/pii/S105381192500655X using haptic sensory substitution; #bci #neurotech #blindness #neuroscience […]
[Original post on mas.to]
[Original post on mas.to]
December 18, 2025 at 7:37 AM
Long-term visual-to-tactile stimulation induces functional reorganization of thalamic pathways to achieve visual perception https://www.sciencedirect.com/science/article/pii/S105381192500655X using haptic sensory substitution; #bci #neurotech #blindness #neuroscience […]
[Original post on mas.to]
[Original post on mas.to]
apnews.com/press-releas... issues new guideline for the management of functional seizures
AAN issues new guideline for the management of functional seizures
Highlights: A new guideline by the American Academy of Neurology says psychological interventions are possibly effective in helping people achieve freedom from functional seizures.
apnews.com
December 22, 2025 at 4:44 PM
apnews.com/press-releas... issues new guideline for the management of functional seizures
Reposted by David L Perez MD, MMSc
New @aanmember.bsky.social guidelines for the management of functional seizures led by Ben Tolchin. A landmark for people with FND worldwide.
✅Rigorous evidence-based process
✅Consensus practical recommendations
✅Endorsed by @fndsociety.bsky.social
www.neurology.org/doi/10.1212/...
✅Rigorous evidence-based process
✅Consensus practical recommendations
✅Endorsed by @fndsociety.bsky.social
www.neurology.org/doi/10.1212/...
December 13, 2025 at 5:33 PM
New @aanmember.bsky.social guidelines for the management of functional seizures led by Ben Tolchin. A landmark for people with FND worldwide.
✅Rigorous evidence-based process
✅Consensus practical recommendations
✅Endorsed by @fndsociety.bsky.social
www.neurology.org/doi/10.1212/...
✅Rigorous evidence-based process
✅Consensus practical recommendations
✅Endorsed by @fndsociety.bsky.social
www.neurology.org/doi/10.1212/...
Reposted by David L Perez MD, MMSc
How gratifying that this is finally out!
And what a pleasure to colllaborate on this.
I hope it’s a real step forward for clinical care of people w func seizures.
Also a wonderful learning experience for me personally - extremely rigorous methodology thnx to Maryam Oskoui and co-authors
And what a pleasure to colllaborate on this.
I hope it’s a real step forward for clinical care of people w func seizures.
Also a wonderful learning experience for me personally - extremely rigorous methodology thnx to Maryam Oskoui and co-authors
Four yrs in the making, @greenjournal.bsky.social Practice Guideline Executive Summary on the Management of Functional Seizures. First @aanmember.bsky.social published guideline on any #FND variant. Brilliantly led by #BenTolchin. @fndportal.bsky.social
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Neurology® Journals
www.neurology.org
December 12, 2025 at 1:32 PM
How gratifying that this is finally out!
And what a pleasure to colllaborate on this.
I hope it’s a real step forward for clinical care of people w func seizures.
Also a wonderful learning experience for me personally - extremely rigorous methodology thnx to Maryam Oskoui and co-authors
And what a pleasure to colllaborate on this.
I hope it’s a real step forward for clinical care of people w func seizures.
Also a wonderful learning experience for me personally - extremely rigorous methodology thnx to Maryam Oskoui and co-authors