Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01279-1Intracellular bacteria in cancer cells promote the recruitment of neutrophils and their polarization towards an immunosuppressive phenotype via a cGAS-STING-dependent pathway.

Cytosolic nucleic acid sensors contribute to pathogenic and autoinflammatory inflammation; however, little is known about the metabolic adaptations that they induce. Dunphy et al. find that these pathways induce type I interferon-dependent metabolic changes in macrophages, characterized by a decrease in mitochondrial membrane potential and increased mitochondrial fission, promoting efferocytosis, while restraining ISG induction to promote the resolution of inflammation.

CLIM-TIME provides a high-throughput perturbation-mapping platform that links tumor suppressor gene loss to spatially defined metastatic niches and immune responses, identifying LOXL2 as a key modulator of suppressive metastatic environments. Inhibition of LOXL2 restores T cell infiltration into tumors and improves the efficacy of therapy.

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In the triple-negative breast cancer ecosystem, sensory neurons activate cancer-associated fibroblasts to secrete collagen, thus stimulating a dense extracellular matrix that drives immune exclusion.

Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

Metastasis is the leading cause of cancer deaths. To develop strategies for intercepting metastatic progression, a better understanding of how tumor cells adapt to vastly different organ contexts is needed. To investigate this question, a single-cell transcriptomic atlas of primary tumor and diverse …

Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) imm…

One-shot tissue dynamics reconstruction can infer changes in tissue composition over time, from single-time-point spatial proteomics of human cancers.