Wolfgang Hess
@cyanolab.bsky.social
Interested in comparative & functional microbial genomics, RNA biology, native CRISPR systems, cyanobacteria, plant evolution & regulation of photosynthesis
Riding a train in China, returning from the ISPP 2025 and the Green Carbon conference.
September 26, 2025 at 4:03 PM
Riding a train in China, returning from the ISPP 2025 and the Green Carbon conference.
„RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ rdcu.be/eImcr : 11 authors from 3 labs. Many thanks to all for making this possible!
RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics datasets
Nature Communications - RNA-binding proteins play key roles in post-transcriptional gene regulation. Here, Hemm et al. developed RAPDOR, a widely applicable tool based on Jensen-Shannon Distance...
rdcu.be
September 26, 2025 at 3:55 PM
„RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ rdcu.be/eImcr : 11 authors from 3 labs. Many thanks to all for making this possible!
How to search for unknown RNA-binding proteins? We did GradR in the cyanobacterium Synechocystis 6803. And now our paper „RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ is finally out in Nature Communications, here: rdcu.be/eImcr .
RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics datasets
Nature Communications - RNA-binding proteins play key roles in post-transcriptional gene regulation. Here, Hemm et al. developed RAPDOR, a widely applicable tool based on Jensen-Shannon Distance...
rdcu.be
September 26, 2025 at 3:51 PM
How to search for unknown RNA-binding proteins? We did GradR in the cyanobacterium Synechocystis 6803. And now our paper „RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ is finally out in Nature Communications, here: rdcu.be/eImcr .
Riding a train in Lithuania.
August 14, 2025 at 8:00 AM
Riding a train in Lithuania.
RNA-binding proteins and photosynthesis: The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins | PNAS www.pnas.org/doi/10.1073/...
June 26, 2025 at 1:59 PM
RNA-binding proteins and photosynthesis: The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins | PNAS www.pnas.org/doi/10.1073/...
Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria - Kurkela - New Phytologist - Wiley Online Library nph.onlinelibrary.wiley.com/doi/10.1111/...
Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria
Cyanobacterial growth depends on inorganic carbon (Ci; CO2 and bicarbonate) concentration, but mechanism(s) adjusting photosynthesis and growth according to Ci remain unclear. ΔrpoZ cells lacking th...
nph.onlinelibrary.wiley.com
June 26, 2025 at 1:53 PM
Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria - Kurkela - New Phytologist - Wiley Online Library nph.onlinelibrary.wiley.com/doi/10.1111/...
How are fully submerged algae efficiently fixing carbon?
All organisms performing oxygenic photosynthesis fix CO2 in
the Calvin–Benson–Bassham cycle using RubisCO. But aquatic organisms have a challenge.
All organisms performing oxygenic photosynthesis fix CO2 in
the Calvin–Benson–Bassham cycle using RubisCO. But aquatic organisms have a challenge.
June 23, 2025 at 8:04 AM
How are fully submerged algae efficiently fixing carbon?
All organisms performing oxygenic photosynthesis fix CO2 in
the Calvin–Benson–Bassham cycle using RubisCO. But aquatic organisms have a challenge.
All organisms performing oxygenic photosynthesis fix CO2 in
the Calvin–Benson–Bassham cycle using RubisCO. But aquatic organisms have a challenge.
Reposted by Wolfgang Hess
Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
May 13, 2025 at 7:41 AM
Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
cell.com/molecular-ce...
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
Reposted by Wolfgang Hess
Just three days left for the deadline for oral abstract submissions for the 15th Workshop on Cyanobacteria at Vanderbilt University (Nashville, TN, USA) - don't miss out!
Workshop dates: 4-7th June 2025. More information: web.cvent.com/event/3d0bd3.... Please share widely!
Workshop dates: 4-7th June 2025. More information: web.cvent.com/event/3d0bd3.... Please share widely!
15th Workshop on Cyanobacteria. Online registration by Cvent
web.cvent.com
March 18, 2025 at 6:00 PM
Just three days left for the deadline for oral abstract submissions for the 15th Workshop on Cyanobacteria at Vanderbilt University (Nashville, TN, USA) - don't miss out!
Workshop dates: 4-7th June 2025. More information: web.cvent.com/event/3d0bd3.... Please share widely!
Workshop dates: 4-7th June 2025. More information: web.cvent.com/event/3d0bd3.... Please share widely!
TIGR-Tas: A new family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses: www.science.org/doi/10.1126/...
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses
RNA-guided systems provide remarkable versatility, enabling diverse biological functions. Through iterative structural and sequence homology-based mining starting with a guide RNA-interaction domain o...
www.science.org
March 3, 2025 at 1:24 PM
TIGR-Tas: A new family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses: www.science.org/doi/10.1126/...
Reposted by Wolfgang Hess
🚨 New #Breakthrough article from @holmqvist-lab.bsky.social: "ProQ prevents mRNA degradation through inhibition of poly(A) polymerase" #RNA #Stability #Degredation #mRNA 📖 Read the full article here: https://doi.org/10.1093/nar/gkaf103
February 27, 2025 at 10:00 AM
🚨 New #Breakthrough article from @holmqvist-lab.bsky.social: "ProQ prevents mRNA degradation through inhibition of poly(A) polymerase" #RNA #Stability #Degredation #mRNA 📖 Read the full article here: https://doi.org/10.1093/nar/gkaf103
Why did chloroplasts retain some genes from their free-living ancestors rather than transferring all of them to the nucleus following endosymbiosis? We suggest that mRNA targeting might play a role.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Does mRNA targeting explain gene retention in chloroplasts?
During their evolution from cyanobacteria, plastids have relinquished most of their genes to the host cell nucleus, but have retained a core set of ge…
www.sciencedirect.com
February 6, 2025 at 10:36 AM
Why did chloroplasts retain some genes from their free-living ancestors rather than transferring all of them to the nucleus following endosymbiosis? We suggest that mRNA targeting might play a role.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Wolfgang Hess
Would you expect that Bacteria use an archaellum for swimming? We didn't, but we found that some Chloroflexota do! Find the story here: www.biorxiv.org/content/10.1...
A little thread below 1/n
A little thread below 1/n
Horizontal gene transfer of the functional archaellum machinery to Bacteria
Motility in Archaea is driven by a nanomachinery called the archaellum. So far, archaella have been exclusively described for the archaeal domain; however, a recent study reported the presence of arch...
www.biorxiv.org
February 3, 2025 at 10:09 AM
Would you expect that Bacteria use an archaellum for swimming? We didn't, but we found that some Chloroflexota do! Find the story here: www.biorxiv.org/content/10.1...
A little thread below 1/n
A little thread below 1/n
Reposted by Wolfgang Hess
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 25, 2025 at 5:33 PM
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
Multicellularity is a key feature of complex life, but how to study multicellularity in bacteria and at the single cell level? Use advanced microscopy, MS imaging, flow cytometry, spatial and single-cell transcriptomics, advanced microfluidics and more. See here: journals.asm.org/doi/10.1128/...
Resolving spatiotemporal dynamics in bacterial multicellular populations: approaches and challenges | Microbiology and Molecular Biology Reviews
SUMMARYThe development of multicellularity represents a key evolutionary transition that
is crucial for the emergence of complex life forms. Although multicellularity has
traditionally been studied in...
journals.asm.org
January 26, 2025 at 1:46 PM
Multicellularity is a key feature of complex life, but how to study multicellularity in bacteria and at the single cell level? Use advanced microscopy, MS imaging, flow cytometry, spatial and single-cell transcriptomics, advanced microfluidics and more. See here: journals.asm.org/doi/10.1128/...
Reposted by Wolfgang Hess
Mark your calendars for next Tuesday: Tel Aviv University's Prof. Eilon Shani will present a #CRISPR -based toolkit that targets multiple genes at a genome-wide scale, addressing functional overlap in genetic systems and to uncover hidden mechanisms behind hormone transport.
kurzlinks.de/fprn
kurzlinks.de/fprn
January 10, 2025 at 10:18 AM
Mark your calendars for next Tuesday: Tel Aviv University's Prof. Eilon Shani will present a #CRISPR -based toolkit that targets multiple genes at a genome-wide scale, addressing functional overlap in genetic systems and to uncover hidden mechanisms behind hormone transport.
kurzlinks.de/fprn
kurzlinks.de/fprn
The conformational space of RNase P RNA in solution using atomic force microscopy: www.nature.com/articles/s41...
The conformational space of RNase P RNA in solution - Nature
Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.
www.nature.com
December 20, 2024 at 7:32 AM
The conformational space of RNase P RNA in solution using atomic force microscopy: www.nature.com/articles/s41...
Not all bacteria, even of a single species, are created equal. Nor are they always unicellular. Some cyanobacteria develop heterocysts and fix nitrogen. GradR/R-DeeP analysis identified new RNA-binding proteins. Some were previously known for other functions. Others were completely uncharacterized.
December 19, 2024 at 5:03 PM
Not all bacteria, even of a single species, are created equal. Nor are they always unicellular. Some cyanobacteria develop heterocysts and fix nitrogen. GradR/R-DeeP analysis identified new RNA-binding proteins. Some were previously known for other functions. Others were completely uncharacterized.
R-DeeP/TripepSVM identifies the RNA-binding OB-fold-like protein PatR as regulator of heterocyst patterning. academic.oup.com/nar/advance-...
R-DeeP/TripepSVM identifies the RNA-binding OB-fold-like protein PatR as regulator of heterocyst patterning
Abstract. RNA-binding proteins (RBPs) are central components of gene regulatory networks. The differentiation of heterocysts in filamentous cyanobacteria i
academic.oup.com
December 19, 2024 at 4:49 PM
R-DeeP/TripepSVM identifies the RNA-binding OB-fold-like protein PatR as regulator of heterocyst patterning. academic.oup.com/nar/advance-...
Reposted by Wolfgang Hess
We are looking for a new colleague :)
Please spread the word!
Please spread the word!
📢 Job Alert! The Faculty of #Biology of the @uni-freiburg.de is seeking for a researcher with a competitive, internationally visible profile in #ChemicalBiology focusing on #BiologicalSignallingResearch.
Join us and apply by 28 February, 25!
More info: uni-freiburg.de/stellenangeb...
Join us and apply by 28 February, 25!
More info: uni-freiburg.de/stellenangeb...
December 17, 2024 at 2:04 PM
We are looking for a new colleague :)
Please spread the word!
Please spread the word!
ISPP-18, the "International Symposium on Phototrophic Prokaryotes" will take place September 8-12, 2025. This is the best conference in the world to learn about recent research in photosynthetic prokaryotes. Only every 3 years. Registration for ISPP-18 is now open.
ispp2025-qingdao.com
ispp2025-qingdao.com
ispp2025-qingdao.com
December 14, 2024 at 1:23 PM
ISPP-18, the "International Symposium on Phototrophic Prokaryotes" will take place September 8-12, 2025. This is the best conference in the world to learn about recent research in photosynthetic prokaryotes. Only every 3 years. Registration for ISPP-18 is now open.
ispp2025-qingdao.com
ispp2025-qingdao.com
How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress: onlinelibrary.wiley.com/doi/10.1002/...
How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress
Cyanobacteria are powered by oxygenic photosynthesis located in extensive internal membrane systems, the thylakoids. Using carboxysomes, they assimilate organic from inorganic carbon. The integration...
onlinelibrary.wiley.com
December 13, 2024 at 1:09 PM
How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress: onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Wolfgang Hess
Reposted by Wolfgang Hess
Integration of horizontally acquired light-harvesting genes into an ancestral regulatory network in the cyanobacterium Acaryochloris marina MBIC11017 | mBio journals.asm.org/doi/10.1128/...
Integration of horizontally acquired light-harvesting genes into an ancestral regulatory network in the cyanobacterium Acaryochloris marina MBIC11017 | mBio
Horizontal gene transfer, the asymmetric movement of genetic information between donor and recipient organisms, is an important mechanism for acquiring new traits. In order for newly acquired gene content to be retained, it must be integrated into the ...
journals.asm.org
December 11, 2024 at 7:18 PM
Integration of horizontally acquired light-harvesting genes into an ancestral regulatory network in the cyanobacterium Acaryochloris marina MBIC11017 | mBio journals.asm.org/doi/10.1128/...
Reposted by Wolfgang Hess
I love this tradition at @biologyunifreiburg.bsky.social, every December the student representatives visit each floor and sing Christmas carols for us.
December 9, 2024 at 12:12 PM
I love this tradition at @biologyunifreiburg.bsky.social, every December the student representatives visit each floor and sing Christmas carols for us.