Courtney Hanna
@cwhanna.bsky.social
Sir Henry Dale Fellow/Group Leader, Centre for Trophoblast Research, University of Cambridge, interested in trophoblast, epigenetics and developmental biology
Reposted by Courtney Hanna
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 8:34 AM
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
Reposted by Courtney Hanna
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
Reposted by Courtney Hanna
I didn't think I could admire Azim Surani more than I already did
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
An interview with Azim Surani
Professor Azim Surani is the Director of Epigenomics and Germline Imprinting at the Gurdon Institute in Cambridge, UK. He is this year's recipient of both the prestigious Kyoto Prize and the Paul Ehrl...
journals.biologists.com
October 3, 2025 at 11:35 AM
I didn't think I could admire Azim Surani more than I already did
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Courtney Hanna
An insight into advances in the field of placental biology and their importance: www.nature.com/articles/d41...
The mini placentas and ovaries revealing the basics of women’s health
Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.
www.nature.com
September 23, 2025 at 8:24 PM
An insight into advances in the field of placental biology and their importance: www.nature.com/articles/d41...
Reposted by Courtney Hanna
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Reposted by Courtney Hanna
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
August 15, 2025 at 4:16 PM
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Congrats to @clairesimon.bsky.social and @niakanlab.bsky.social! We were happy to contribute to this great project investigating FGF/ERK signalling in human embryogenesis. @georgiaplea.bsky.social
Delighted to see this out! Human embryos depend on FGF/ERK signalling to specify epiblast versus primitive endoderm cells. Well done Claire Simon and the lab for their contributions! Many thanks to Mary Herbert @josh-brickman.bsky.social @cwhanna.bsky.social labs for brilliant contributions!
Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Nature Communications - The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic...
rdcu.be
August 14, 2025 at 1:53 PM
Congrats to @clairesimon.bsky.social and @niakanlab.bsky.social! We were happy to contribute to this great project investigating FGF/ERK signalling in human embryogenesis. @georgiaplea.bsky.social
Reposted by Courtney Hanna
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature
A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.
www.nature.com
May 14, 2025 at 4:01 PM
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
@c-jake-harris.bsky.social looking forward to reading this!
Very interesting epigenome editing work on the effect of K4me3 on both gene expression and recombination in plants!
Well done @c-jake-harris.bsky.social & co!
Well done @c-jake-harris.bsky.social & co!
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1
February 10, 2025 at 11:14 AM
@c-jake-harris.bsky.social looking forward to reading this!
Reposted by Courtney Hanna
Registration open for this year's Young Embryologist Network meeting
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
YEN 2025 Conference: Registration is open! - the Node
Register now for the Young Embryologist Network meeting - Monday 19 May 2025 at the Francis Crick Institute. Are you an early career researcher in
thenode.biologists.com
February 3, 2025 at 2:35 PM
Registration open for this year's Young Embryologist Network meeting
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
Reposted by Courtney Hanna
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
qmul-jobs.tal.net
January 21, 2025 at 9:33 AM
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …
tinyurl.com
January 8, 2025 at 4:21 PM
Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
www.nature.com
December 6, 2024 at 9:42 AM