Courtney Hanna
@cwhanna.bsky.social
Sir Henry Dale Fellow/Group Leader, Centre for Trophoblast Research, University of Cambridge, interested in trophoblast, epigenetics and developmental biology
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August 22, 2025 at 2:26 PM
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July 16, 2025 at 9:59 AM
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Congrats! Really looking forward to reading this!
May 15, 2025 at 12:37 PM
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Compared to early human trophoblast, hTSCs lack DNMT3L expression, which is necessary for PMDs in mouse trophoblast. When we ectopically express DNMT3L in hTSCs, we find placental PMDs are restored, supporting a conserved role for DNMT3L in de novo methylation in trophoblast.
January 8, 2025 at 4:21 PM
Compared to early human trophoblast, hTSCs lack DNMT3L expression, which is necessary for PMDs in mouse trophoblast. When we ectopically express DNMT3L in hTSCs, we find placental PMDs are restored, supporting a conserved role for DNMT3L in de novo methylation in trophoblast.
The placental DNA methylation landscape is unique compared to all other cells of the body, with widespread partially methylated domains (PMDs). hTSCs exhibit widespread loss of PMDs and this pattern is persistent, regardless of cell origin, oxygen levels or culture conditions.
January 8, 2025 at 4:21 PM
The placental DNA methylation landscape is unique compared to all other cells of the body, with widespread partially methylated domains (PMDs). hTSCs exhibit widespread loss of PMDs and this pattern is persistent, regardless of cell origin, oxygen levels or culture conditions.