Csaba Orban
@csabaorban.bsky.social
neuroscience, physiology, resting state fMRI
Reposted by Csaba Orban
How do internal bodily rhythms influence #brain activity & motor function? @tahnee-engelen.bsky.social &co show that #cardiac, #respiratory & #gastric rhythms independently modulate motor excitability, revealing distinct #interoceptive profiles across individuals @plosbiology.org 🧪 plos.io/4nMtpLT
November 13, 2025 at 10:17 AM
How do internal bodily rhythms influence #brain activity & motor function? @tahnee-engelen.bsky.social &co show that #cardiac, #respiratory & #gastric rhythms independently modulate motor excitability, revealing distinct #interoceptive profiles across individuals @plosbiology.org 🧪 plos.io/4nMtpLT
Reposted by Csaba Orban
Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT
go.nature.com/3Ln1gh6
go.nature.com/3Ln1gh6
Adenosine signalling drives antidepressant actions of ketamine and ECT - Nature
Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine exhibit improved antidepressant efficacy with reduced side effects.
go.nature.com
November 7, 2025 at 6:27 PM
Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT
go.nature.com/3Ln1gh6
go.nature.com/3Ln1gh6
Reposted by Csaba Orban
Preprint is now published! doi.org/10.1002/hbm....
Thanks to co-authors @chen-zhang.bsky.social @anlijuncn.bsky.social @csabaorban.bsky.social
Thanks to co-authors @chen-zhang.bsky.social @anlijuncn.bsky.social @csabaorban.bsky.social
November 4, 2025 at 12:35 AM
Preprint is now published! doi.org/10.1002/hbm....
Thanks to co-authors @chen-zhang.bsky.social @anlijuncn.bsky.social @csabaorban.bsky.social
Thanks to co-authors @chen-zhang.bsky.social @anlijuncn.bsky.social @csabaorban.bsky.social
Reposted by Csaba Orban
Preprint is now published: doi.org/10.1002/hbm....
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
November 4, 2025 at 12:32 AM
Preprint is now published: doi.org/10.1002/hbm....
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Reposted by Csaba Orban
Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date.
We're very happy to announce that we are able to reduce the APC to $1400.
Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
We're very happy to announce that we are able to reduce the APC to $1400.
Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
September 5, 2025 at 2:59 AM
Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date.
We're very happy to announce that we are able to reduce the APC to $1400.
Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
We're very happy to announce that we are able to reduce the APC to $1400.
Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
Reposted by Csaba Orban
This looks pretty cool: ultrasound can now see through the skull! 🧠🔊
The skull has long been a barrier to ultrasound. This reprint shows how to make it quickly transparent → enabling full-depth, high-res fUSI in mice (& humans! 🤯🤯)
Huge congrats to the authors!!!
www.biorxiv.org/content/10.1...
The skull has long been a barrier to ultrasound. This reprint shows how to make it quickly transparent → enabling full-depth, high-res fUSI in mice (& humans! 🤯🤯)
Huge congrats to the authors!!!
www.biorxiv.org/content/10.1...
September 3, 2025 at 1:35 PM
This looks pretty cool: ultrasound can now see through the skull! 🧠🔊
The skull has long been a barrier to ultrasound. This reprint shows how to make it quickly transparent → enabling full-depth, high-res fUSI in mice (& humans! 🤯🤯)
Huge congrats to the authors!!!
www.biorxiv.org/content/10.1...
The skull has long been a barrier to ultrasound. This reprint shows how to make it quickly transparent → enabling full-depth, high-res fUSI in mice (& humans! 🤯🤯)
Huge congrats to the authors!!!
www.biorxiv.org/content/10.1...
Reposted by Csaba Orban
What started as a journal club on layer decoding turned into a project thanks to @karolisdegutis.bsky.social. Our preprint challenges a widespread assumption in the field: MVPA is not immune to vascular confounds in laminar GE-BOLD decoding, as shown using a mechanistic laminar response model.
Happy to see this out: our new preprint shows that laminar GE-BOLD fMRI decoding isn’t immune to vascular draining biases. Simulations reveal false positives due to multivariate signal spread across layers, but oversampling + deconvolution can (sometimes) improve specificity.
Vascular draining confounds laminar decoding in fMRI https://www.biorxiv.org/content/10.1101/2025.08.26.672278v1
August 30, 2025 at 2:58 PM
What started as a journal club on layer decoding turned into a project thanks to @karolisdegutis.bsky.social. Our preprint challenges a widespread assumption in the field: MVPA is not immune to vascular confounds in laminar GE-BOLD decoding, as shown using a mechanistic laminar response model.
Reposted by Csaba Orban
Longitudinal neuroimaging of participants with planned arm amputations shows that the cortical body map remains stable after amputation. The findings, published in Nature Neuroscience, challenge long-standing theories of brain remapping after limb loss. go.nature.com/4oLSyYO 🧪 #Neuroscience
August 25, 2025 at 1:22 PM
Longitudinal neuroimaging of participants with planned arm amputations shows that the cortical body map remains stable after amputation. The findings, published in Nature Neuroscience, challenge long-standing theories of brain remapping after limb loss. go.nature.com/4oLSyYO 🧪 #Neuroscience
Reposted by Csaba Orban
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
August 22, 2025 at 2:21 PM
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
Reposted by Csaba Orban
Now out in @natneuro.nature.com
What happens to the brain’s body map when a body-part is removed?
Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation
www.nature.com/articles/s41593-025-02037-7
🧵1/18
What happens to the brain’s body map when a body-part is removed?
Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation
www.nature.com/articles/s41593-025-02037-7
🧵1/18
August 21, 2025 at 9:20 AM
Now out in @natneuro.nature.com
What happens to the brain’s body map when a body-part is removed?
Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation
www.nature.com/articles/s41593-025-02037-7
🧵1/18
What happens to the brain’s body map when a body-part is removed?
Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation
www.nature.com/articles/s41593-025-02037-7
🧵1/18
Reposted by Csaba Orban
Great write up of our @nature.com study by @claudia-lopez.bsky.social
When powering fMRI studies, sample size is king, but scan duration can also be a powerful tool, improving phenotypic prediction and cost-efficiency, a new analysis shows
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/fmri/longer-...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/fmri/longer-...
Longer fMRI brain scans boost reliability—but only to a point
Around 30 minutes of imaging per person seems to be the “sweet spot” for linking functional connectivity differences to traits in an accurate and cost-effective way.
www.thetransmitter.org
August 21, 2025 at 1:22 PM
Great write up of our @nature.com study by @claudia-lopez.bsky.social
Reposted by Csaba Orban
I still get chills
Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts
Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE
see videos, read paper, follow thread
doi.org/10.31234/osf...
Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts
Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE
see videos, read paper, follow thread
doi.org/10.31234/osf...
August 10, 2025 at 6:23 PM
I still get chills
Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts
Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE
see videos, read paper, follow thread
doi.org/10.31234/osf...
Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts
Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE
see videos, read paper, follow thread
doi.org/10.31234/osf...
Reposted by Csaba Orban
🚨 New Preprint 🚨
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
August 5, 2025 at 3:31 PM
🚨 New Preprint 🚨
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects
By Cyr et al.
***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?
A: Yes!
🧵:
Reposted by Csaba Orban
Did you know that seeing virtual avatars with coughs or rashes can trigger your brain's immune response? Read more in this fascinating Nature Neuroscience paper @natureportfolio.nature.com 🧪 www.nature.com/articles/s41...
Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience
Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...
www.nature.com
July 31, 2025 at 7:03 PM
Did you know that seeing virtual avatars with coughs or rashes can trigger your brain's immune response? Read more in this fascinating Nature Neuroscience paper @natureportfolio.nature.com 🧪 www.nature.com/articles/s41...
Reposted by Csaba Orban
I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health
Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...
www.nature.com
July 30, 2025 at 10:25 AM
I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
Reposted by Csaba Orban
For me, this work is a classic @ohbmofficial.bsky.social story: In 2023 I wasn't working with @bttyeo.bsky.social but I overheard him at his poster pointing to some accuracy curves saying "I don't why they have this particular shape". That kicked off the collab that led to these results.
3/11 Tom's model explains empirical prediction accuracies well across 76 phenotypes from 9 resting-fMRI & task-fMRI datasets (R2 = 0.89), spanning many scanners, acquisitions, racial groups, disorders & ages.
Does this mean that we should collect large datasets with short scans?
Does this mean that we should collect large datasets with short scans?
July 17, 2025 at 6:34 AM
For me, this work is a classic @ohbmofficial.bsky.social story: In 2023 I wasn't working with @bttyeo.bsky.social but I overheard him at his poster pointing to some accuracy curves saying "I don't why they have this particular shape". That kicked off the collab that led to these results.
Reposted by Csaba Orban
🚨Thrilled to share our latest work just published in @nature.com where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS) 🧠⏱️! Full thread below👇:
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
July 17, 2025 at 2:22 AM
🚨Thrilled to share our latest work just published in @nature.com where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS) 🧠⏱️! Full thread below👇:
Reposted by Csaba Orban
Super thankful to @bttyeo.bsky.social @csabaorban.bsky.social and @shaoshiz.bsky.social for pouring in all the effort to make this work possible!
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
July 17, 2025 at 2:14 AM
Super thankful to @bttyeo.bsky.social @csabaorban.bsky.social and @shaoshiz.bsky.social for pouring in all the effort to make this work possible!
Reposted by Csaba Orban
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
July 17, 2025 at 1:36 AM
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
Reposted by Csaba Orban
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
June 26, 2025 at 1:29 PM
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
Reposted by Csaba Orban
Our new preprint is out!
doi.org/10.1101/2025...
How do brain networks and cognition co-evolve as children enter adolescence?
doi.org/10.1101/2025...
How do brain networks and cognition co-evolve as children enter adolescence?
Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
How brain networks and cognition co-evolve during development remains poorly understood. Using longitudinal data collected at baseline and Year 2 from 2,949 individuals (ages 8.9-13.5) in the Adolesce...
doi.org
June 8, 2025 at 2:52 PM
Our new preprint is out!
doi.org/10.1101/2025...
How do brain networks and cognition co-evolve as children enter adolescence?
doi.org/10.1101/2025...
How do brain networks and cognition co-evolve as children enter adolescence?
Reposted by Csaba Orban
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
Autonomic physiological coupling of the global fMRI signal
Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
rdcu.be
May 7, 2025 at 1:42 PM
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
Reposted by Csaba Orban
While the world burns, we cook up a new preprint! doi.org/10.1101/2025...
Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
April 11, 2025 at 1:35 AM
While the world burns, we cook up a new preprint! doi.org/10.1101/2025...
Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
Reposted by Csaba Orban
New paper in Imaging Neuroscience by Ian D. Driver, Michael Germuska, et al:
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
doi.org/10.1162/imag...
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
doi.org/10.1162/imag...
March 19, 2025 at 6:46 AM
New paper in Imaging Neuroscience by Ian D. Driver, Michael Germuska, et al:
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
doi.org/10.1162/imag...
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
doi.org/10.1162/imag...