Christiana Fogg
@cnfogg.bsky.social
Senior Editor at Science Immunology
Interests include #Immunology #Infection #viruses #malaria #vaccines and #cancer. Views are my own.
https://www.science.org/journal/sciimmunol
Also 💙 #trail and #ultrarunning
Interests include #Immunology #Infection #viruses #malaria #vaccines and #cancer. Views are my own.
https://www.science.org/journal/sciimmunol
Also 💙 #trail and #ultrarunning
Reposted by Christiana Fogg
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
www.science.org
October 20, 2025 at 2:42 PM
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Reposted by Christiana Fogg
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!
bit.ly/SciImm_free
bit.ly/SciImm_free
October 9, 2025 at 5:43 PM
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!
bit.ly/SciImm_free
bit.ly/SciImm_free
Reposted by Christiana Fogg
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 3, 2025 at 6:07 PM
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!
Inhibitory immune checkpoints in cancer immunotherapy
Inhibitory immune checkpoints for cancer immunotherapy are reviewed.
www.science.org
September 29, 2025 at 8:50 PM
Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!
That time I was subject of scientific study, and not an editor.....🏃♀️🧪
In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪
September 8, 2025 at 6:22 PM
That time I was subject of scientific study, and not an editor.....🏃♀️🧪
Reposted by Christiana Fogg
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd
August 13, 2025 at 4:18 PM
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd
Reposted by Christiana Fogg
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
May 17, 2025 at 7:50 PM
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
Reposted by Christiana Fogg
This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!
You can submit your abstracts here: iuis2025.org/abstracts/
I hope to see many of you this August in beautiful Vienna!!!
#Immunology #Science2025 #CallForAbstracts #IUIS
You can submit your abstracts here: iuis2025.org/abstracts/
I hope to see many of you this August in beautiful Vienna!!!
#Immunology #Science2025 #CallForAbstracts #IUIS
Abstracts - IUIS 2025
ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...
iuis2025.org
May 5, 2025 at 3:50 PM
This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!
You can submit your abstracts here: iuis2025.org/abstracts/
I hope to see many of you this August in beautiful Vienna!!!
#Immunology #Science2025 #CallForAbstracts #IUIS
You can submit your abstracts here: iuis2025.org/abstracts/
I hope to see many of you this August in beautiful Vienna!!!
#Immunology #Science2025 #CallForAbstracts #IUIS
Happy World #DayofImmunology!
Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!!
First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!
First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression
Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.
www.science.org
April 29, 2025 at 2:33 PM
Happy World #DayofImmunology!
On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses
Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.
www.science.org
April 25, 2025 at 6:16 PM
On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.
Read about this study and more: scim.ag/4j3gx2A
Read about this study and more: scim.ag/4j3gx2A
April 9, 2025 at 2:07 PM
In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.
Read about this study and more: scim.ag/4j3gx2A
Read about this study and more: scim.ag/4j3gx2A
It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
www.science.org
March 24, 2025 at 2:16 PM
It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
scim.ag
March 17, 2025 at 3:29 PM
New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO
Reposted by Christiana Fogg
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
March 14, 2025 at 3:25 PM
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Reposted by Christiana Fogg
This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!
Dynamic STING repression orchestrates immune cell development and function
Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.
www.science.org
March 7, 2025 at 8:32 PM
This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!
The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 7, 2025 at 9:23 PM
The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...
www.science.org
March 7, 2025 at 11:14 AM
Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!
Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy
AAV delivery of antibodies targeting the SIV envelope glycoprotein contains virus replication in macaques after stopping ART.
www.science.org
February 28, 2025 at 9:20 PM
This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!
Reposted by Christiana Fogg
This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!
TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R–BCL6 signaling nexus
TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.
www.science.org
February 15, 2025 at 10:31 AM
This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!
Reposted by Christiana Fogg
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 8, 2025 at 11:39 PM
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Reposted by Christiana Fogg
Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:
Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma
Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.
www.science.org
February 7, 2025 at 8:24 PM
Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:
Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
www.science.org
February 7, 2025 at 7:40 PM
Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
Reposted by Christiana Fogg
Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.
www.science.org
February 6, 2025 at 6:44 PM
Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs
Reposted by Christiana Fogg
This is ... a public ... service ... announcement!
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
February 5, 2025 at 2:48 PM
This is ... a public ... service ... announcement!
Reposted by Christiana Fogg
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...