Christian Staehr
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chrstaehr.bsky.social
Christian Staehr
@chrstaehr.bsky.social
MD, PhD. Postdoc studying cerebral circulation, neurovascular coupling. Dad of three amazing kids.
Pinned
I am very excited to share our new paper in #JCBFM (journals.sagepub.com/doi/10.1177/...)! We show that targeting Na,K-ATPase-dependent #Src kinase activation can prevent cerebral hypoperfusion and ⬆️ (video) #neurovascular coupling in a 🐭model of familial hemiplegic #migraine.

Here is a summary 🧵
Reposted by Christian Staehr
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
Reposted by Christian Staehr
Thrilled to share that our work is now published in Science! ✨

We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭

www.science.org/doi/10.1126/...

🧵1/
September 11, 2025 at 8:14 PM
Reposted by Christian Staehr
🚨CALL FOR PAPERS🚨
For our "Integrative physiological considerations of the human vasculature system" #SpecialIssue, which will showcase further insights into vascular haemodynamics and multi-organ diseases, as well as the technology used to monitor and treat cardiovascular disease.
🔗 buff.ly/HN7wlPr
June 25, 2025 at 4:26 PM
Reposted by Christian Staehr
🔗 Full Open Access manuscript: link.springer.com/article/10.1...
👇 Curious to hear more about #PrecapillarySphincters?
Check out these threads about the subject:
Characterization: x.com/SorenGrubb/s...
Ultrastructure: x.com/SorenGrubb/s...
Brain precapillary sphincters modulate myogenic tone in adult and aged mice - GeroScience
Brain precapillary sphincters, which are surrounded by contractile pericytes and are located at the junction of penetrating arterioles and first-order capillaries, can increase their diameter by ~ 30%...
link.springer.com
June 10, 2025 at 7:38 PM
Fantastic study shedding new light on regulation of cerebral microcirculation 👇👇👇
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
June 11, 2025 at 5:32 AM
Reposted by Christian Staehr
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
March 19, 2025 at 7:40 AM
Reposted by Christian Staehr
Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
doi.org
January 6, 2025 at 3:35 PM
Reposted by Christian Staehr
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
fluidsbarrierscns.biomedcentral.com
May 6, 2025 at 6:21 PM
Excited to share our new paper in @acta_physiol: SorCS2—involved in trafficking and synaptic signaling—is important for neurovascular coupling: doi.org/10.1111/apha...

Whisker stim in Sorcs2 KO 🐭 led to ⬇️NVC, ⬇️astrocyte Ca²⁺ signals & disrupted glutamate receptor trafficking.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12…
May 21, 2025 at 5:02 PM
🇦🇺🦘Just wrapped up 6 incredible weeks of science, collaboration at the University of the Sunshine Coast.
Thanks to Vicki Hinkley for such a productive partnership—I’m excited to continue this collaboration across 🇩🇰 and 🇦🇺. I’m also grateful to the USC CONNECT Programme for the funding 🙏
May 16, 2025 at 3:41 AM
🦒🫀Measuring hemodynamics in awake giraffes sounds like a wild challenge 🤯.
New paper by Christian Aalkjaer et al in @actaphysiologica.bsky.social 🔓: onlinelibrary.wiley.com/doi/full/10....
🦒 While drinking🚰:
⬇️ Heart rate
➡️ Arterial blood pressure
➡️ Carotid blood flow
⬆️ CSF pressure 🧠
May 4, 2025 at 11:17 AM
Reposted by Christian Staehr
Come join us at the Bioinformatics Research Centre at Aarhus University. Tenure track/associate professor position available with application deadline June 1, 2025. Application details here: international.au.dk/about/profil...
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
international.au.dk
May 4, 2025 at 9:26 AM
Reposted by Christian Staehr
Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology!
We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social
📢 Free for NorDoc PhD students, but open to all! Apply now!
lnkd.in/dU_fxqqu
March 18, 2025 at 5:46 PM
Reposted by Christian Staehr
Amazing work out by Hirase Lab 🤩
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
March 19, 2025 at 1:18 PM
Reposted by Christian Staehr
Oral Glycine supplementation (DT-109 Gly-Gly-Leu) ⏬#Atherosclerosis & lesional #Calcification in ♂️Monkeys

A potential role of Glycine in GSH antioxidant & #Inflammasome in #SmoothMuscleCell

#SignalTransductTargetTher 2025
www.nature.com/articles/s41...
April 19, 2025 at 12:19 PM
Reposted by Christian Staehr
#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...).
A powerful step toward automated and scalable morphology analysis.
#AI #neuroimmunology #cardiacarrest
April 16, 2025 at 11:32 AM
#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...).
A powerful step toward automated and scalable morphology analysis.
#AI #neuroimmunology #cardiacarrest
April 16, 2025 at 11:32 AM
Reposted by Christian Staehr
Vascular Tone of pressurized🐭distal MCA (sham & #IschemicStroke)⏫by BKCa inhibitor

Brain Arterial #EndothelialCell BKca & TRPV4 (immunofluorescence)⏫by acute (0.5~2 h) #Hypoxia or #Stroke across🐁🐀🐖🚶‍♂️

@chrstaehr.bsky.social #ActaPhysiol 2025
onlinelibrary.wiley.com/doi/10.1111/...
April 2, 2025 at 11:44 AM
Reposted by Christian Staehr
Futile reperfusion of ischemic tissue after #stroke increases the risk of death and disabilities. Spatial transcriptomics provides new insights into the vascular alterations that drive this process.

#BBB #cerebrovascular #neurosky #emedsky #medsky
🧪
#SpatialTranscriptomics #Proteomics acute stage of #IschemicStroke (🐭tMCAO 24h)

Molecular drivers of mural cell hyperconstriction & BBB disintegration in post-stroke futile reperfusion?
A dual non-neuronal role of Calcineurin?

@chrstaehr.bsky.social #Stroke 2025
www.ahajournals.org/doi/10.1161/...
March 29, 2025 at 10:15 AM
Reposted by Christian Staehr
Changes in endothelial cell large conductance calcium-activated potassium channels (BKCa) after #hypoxia may explain the altered myogenic tone which impacts blood flow following ischemic #stroke.

#ionchannels #vascularbiology #physiology #cerebrovascular #endothelium #neurosky #emedsky #medsky
🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.
March 29, 2025 at 10:19 AM
Reposted by Christian Staehr
#SpatialTranscriptomics #Proteomics acute stage of #IschemicStroke (🐭tMCAO 24h)

Molecular drivers of mural cell hyperconstriction & BBB disintegration in post-stroke futile reperfusion?
A dual non-neuronal role of Calcineurin?

@chrstaehr.bsky.social #Stroke 2025
www.ahajournals.org/doi/10.1161/...
March 28, 2025 at 11:50 AM
🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.
March 25, 2025 at 3:45 PM
Reposted by Christian Staehr
Hello All Scientists! We are the Microcirculatory Society and we are excited to join the community here at BlueSky! Follow us for fun updates happening in the microvascular community and the amazing science being done by our scientists!
#microcirculation #science
February 12, 2025 at 2:31 PM
Reposted by Christian Staehr
Is this real? I published it again on Brain @brain1878.bsky.social 😆

Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇

The blood–brain barrier: a help & a hindrance

#Aging #Stroke #Neurodegeneration

Crossing #BBB 😎

academic.oup.com/brain/advanc...
February 21, 2025 at 1:15 PM
Reposted by Christian Staehr
New review from our lab in
@brain1878.bsky.social

We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more!

academic.oup.com/brain/advanc...
February 21, 2025 at 12:25 AM