Chris McGann
@chrismcgann.bsky.social
Postdoctoral Research Fellow, Harvard Medical School & Dana-Farber Cancer Institute
Reposted by Chris McGann
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...
us-hupo.org/Distinguishe...
US HUPO - Distinguished Contribution Award
us-hupo.org
November 12, 2025 at 5:12 PM
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...
us-hupo.org/Distinguishe...
Reposted by Chris McGann
Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...
us-hupo.org/Computationa...
US HUPO - Computational Proteomics Award
us-hupo.org
November 12, 2025 at 5:14 PM
Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...
us-hupo.org/Computationa...
Reposted by Chris McGann
More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1...
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
November 6, 2025 at 5:34 PM
More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1...
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Reposted by Chris McGann
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Carafe enables high quality in silico spectral library generation for data-independent acquisition proteomics - Nature Communications
Accurate spectral libraries are essential for analyzing data-independent acquisition (DIA) proteomics data. Here, the authors present Carafe, which trains on DIA data to build experiment-specific spec...
www.nature.com
November 6, 2025 at 3:49 PM
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris McGann
Excited to see this published in JPR. For years I've wanted a simple way to standardize the signal between instruments. We use the precision of an intraspectrum ratio to assess the relationship between the reported signal and the number of ions. pubs.acs.org/doi/10.1021/...
Evaluation of a Prototype Orbitrap Astral Zoom Mass Spectrometer for Quantitative Proteomics─Beyond Identification Lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...
pubs.acs.org
October 22, 2025 at 3:32 PM
Excited to see this published in JPR. For years I've wanted a simple way to standardize the signal between instruments. We use the precision of an intraspectrum ratio to assess the relationship between the reported signal and the number of ions. pubs.acs.org/doi/10.1021/...
Reposted by Chris McGann
Can nanoparticles help us probe the glycoproteome?
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
September 24, 2025 at 7:04 AM
Can nanoparticles help us probe the glycoproteome?
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
Reposted by Chris McGann
Reposted by Chris McGann
Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!:
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
September 8, 2025 at 11:05 PM
Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!:
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
After five great years, my journey in the Schweppe Lab and at UW has come to a close. Huge thanks to @dschweppe.bsky.social and all the amazing labmates for making graduate school such a wonderful experience. Extremely grateful for the memories and all the help I received along the way.
September 5, 2025 at 3:56 PM
After five great years, my journey in the Schweppe Lab and at UW has come to a close. Huge thanks to @dschweppe.bsky.social and all the amazing labmates for making graduate school such a wonderful experience. Extremely grateful for the memories and all the help I received along the way.
Reposted by Chris McGann
(JASMS) [ASAP] Dynamic Quadrupole Selection to Associate Precursor Masses with MS/MS Products in Data-Independent Acquisition: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00110 (RSS) #MassSpecRSS #JASMS
[ASAP] Dynamic Quadrupole Selection to Associate Precursor Masses with MS/MS Products in Data-Independent Acquisition
Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00110
dlvr.it
August 9, 2025 at 8:05 PM
(JASMS) [ASAP] Dynamic Quadrupole Selection to Associate Precursor Masses with MS/MS Products in Data-Independent Acquisition: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00110 (RSS) #MassSpecRSS #JASMS
Reposted by Chris McGann
News in Proteomics Research blog post | Nova! Build all the mass spec tools! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
July 24, 2025 at 2:00 PM
News in Proteomics Research blog post | Nova! Build all the mass spec tools! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
Reposted by Chris McGann
"I invite all researchers to enter the glycoproteomics field and join the battle.”
With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.
Learn more about Tim & read our discussion: bit.ly/3IXpo8B
With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.
Learn more about Tim & read our discussion: bit.ly/3IXpo8B
Thousands of forms, one protein: how Tim Veth is deciphering the complex language of Glycans
Tim Veth, a postdoctoral researcher working with Prof. Nicholas M.
bit.ly
July 23, 2025 at 2:32 AM
"I invite all researchers to enter the glycoproteomics field and join the battle.”
With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.
Learn more about Tim & read our discussion: bit.ly/3IXpo8B
With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.
Learn more about Tim & read our discussion: bit.ly/3IXpo8B
Reposted by Chris McGann
Nova: A Library for Rapid Development of Mass Spectrometry Software Applications pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
July 22, 2025 at 3:41 PM
Nova: A Library for Rapid Development of Mass Spectrometry Software Applications pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Chris McGann
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization
Experimental evolution is a powerful method for studying the relationship between genotype and phenotype by observing how populations genetically adapt to controlled selective pressures. In educationa...
www.biorxiv.org
July 22, 2025 at 12:53 PM
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
Reposted by Chris McGann
If you asked me 5 years ago if it would be possible to use a de novo tool on DIA data, I would have thought it would only exist in science fiction. Love being proved wrong. Great work from Justin Sanders. #proteomics #massspectrometry
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data - Nature Methods
Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a...
www.nature.com
July 2, 2025 at 5:19 PM
If you asked me 5 years ago if it would be possible to use a de novo tool on DIA data, I would have thought it would only exist in science fiction. Love being proved wrong. Great work from Justin Sanders. #proteomics #massspectrometry
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks so much @dschweppe.bsky.social!!! Couldn’t ask for a better place to do graduate school than the Schweppe Lab!
Huge congratulations to @chrismcgann.bsky.social who passed his PhD dissertation defense yesterday with flying colors!!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
June 26, 2025 at 3:52 PM
Thanks so much @dschweppe.bsky.social!!! Couldn’t ask for a better place to do graduate school than the Schweppe Lab!
Reposted by Chris McGann
Huge congratulations to @chrismcgann.bsky.social who passed his PhD dissertation defense yesterday with flying colors!!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
June 26, 2025 at 3:30 PM
Huge congratulations to @chrismcgann.bsky.social who passed his PhD dissertation defense yesterday with flying colors!!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
Dr. McGann was the lab’s first PhD student and now first graduate! So excited and proud of all of the things he’s accomplished!
Reposted by Chris McGann
Comet's open-source Fragment-Ion Indexing work is live at JPR (@acs.org). @chrismcgann.bsky.social, Jimmy Eng and Erik Bergstrom showed how Comet could be dramatically sped up to keep pace with modern instrumentation and increasing sample sizes:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
June 17, 2025 at 8:57 PM
Comet's open-source Fragment-Ion Indexing work is live at JPR (@acs.org). @chrismcgann.bsky.social, Jimmy Eng and Erik Bergstrom showed how Comet could be dramatically sped up to keep pace with modern instrumentation and increasing sample sizes:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Chris McGann
Assessing error control is fundamental in mass spectrometry-based proteomics. @bo-wen.bsky.social @maccoss.bsky.social @urikeich.bsky.social et al introduce a theoretical foundation for entrapment along with a method for more accurate evaluation of FDR control.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Assessment of false discovery rate control in tandem mass spectrometry analysis using entrapment - Nature Methods
A theoretical foundation for entrapment methods is presented, along with a method that enables more accurate evaluation of false discovery rate (FDR) control in proteomics mass spectrometry analysis p...
www.nature.com
June 16, 2025 at 4:46 PM
Assessing error control is fundamental in mass spectrometry-based proteomics. @bo-wen.bsky.social @maccoss.bsky.social @urikeich.bsky.social et al introduce a theoretical foundation for entrapment along with a method for more accurate evaluation of FDR control.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris McGann
Congrats to @chrismcgann.bsky.social (and the other awardees) for receiving an @asms.org Graduate Student Travel Award!!
Photo credit to Katarina for capturing the moment!
Photo credit to Katarina for capturing the moment!
June 4, 2025 at 9:56 PM
Congrats to @chrismcgann.bsky.social (and the other awardees) for receiving an @asms.org Graduate Student Travel Award!!
Photo credit to Katarina for capturing the moment!
Photo credit to Katarina for capturing the moment!
Reposted by Chris McGann
Thanks to everyone who came out to the Real time MS bioinformatics hub yesterday! Great to chat about current and new directions! Here’s some action shots of Mathieu and Mike leading the discussion.
June 3, 2025 at 3:29 PM
Thanks to everyone who came out to the Real time MS bioinformatics hub yesterday! Great to chat about current and new directions! Here’s some action shots of Mathieu and Mike leading the discussion.
Reposted by Chris McGann
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
June 2, 2025 at 11:55 AM
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
Reposted by Chris McGann
Nova: A library for rapid development of mass spectrometry software applications www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
May 12, 2025 at 9:20 AM
Nova: A library for rapid development of mass spectrometry software applications www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted by Chris McGann
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data
A core computational challenge in the analysis of mass spectrometry data is the de novo sequencing problem, in which the generating amino acid sequence is inferred directly from an observed fragmentat...
www.biorxiv.org
April 22, 2025 at 11:03 PM
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...