Ed Huttlin
@edhuttlin.bsky.social
I'm a scientist at Harvard Medical School and I specialize in mass spectrometry, proteomics, and bioinformatics. I spend most of my time thinking about protein-protein interactions!
Reposted by Ed Huttlin
#HUPO2025 I Our CTDP poster was very well-received! Thank you all for coming! It is free to join CTDP! If you are interested in learning more about #topdownproteomics, please join our talks tomorrow 😀❤️ @proteoforms.bsky.social @nlkproteomics.bsky.social @edhuttlin.bsky.social
November 11, 2025 at 1:34 AM
#HUPO2025 I Our CTDP poster was very well-received! Thank you all for coming! It is free to join CTDP! If you are interested in learning more about #topdownproteomics, please join our talks tomorrow 😀❤️ @proteoforms.bsky.social @nlkproteomics.bsky.social @edhuttlin.bsky.social
Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!
November 9, 2025 at 6:03 PM
Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!
I’m at the airport a and ready to fly to Toronto for this year’s HUPO conference. I’m looking forward to talking about AP-MS tips and tricks at tomorrow’s pre-conference workshop on protein-protein interactions and sharing our latest BioPlex results in a poster on Wednesday!
November 8, 2025 at 5:32 PM
I’m at the airport a and ready to fly to Toronto for this year’s HUPO conference. I’m looking forward to talking about AP-MS tips and tricks at tomorrow’s pre-conference workshop on protein-protein interactions and sharing our latest BioPlex results in a poster on Wednesday!
We are ready for Halloween!
October 31, 2025 at 2:30 AM
We are ready for Halloween!
Check out this thread from @haopengxiao.bsky.social on his recent paper! I’m happy I was able to help out on what has turned out to be a really cool story.
We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 18, 2025 at 8:43 PM
Check out this thread from @haopengxiao.bsky.social on his recent paper! I’m happy I was able to help out on what has turned out to be a really cool story.
Hey @haopengxiao.bsky.social - it’s great to see you on BlueSky!
Could your new account be a sign you might have something cool to announce soon???? ;-)
Could your new account be a sign you might have something cool to announce soon???? ;-)
September 1, 2025 at 4:01 PM
Hey @haopengxiao.bsky.social - it’s great to see you on BlueSky!
Could your new account be a sign you might have something cool to announce soon???? ;-)
Could your new account be a sign you might have something cool to announce soon???? ;-)
Reposted by Ed Huttlin
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Post-Translational Modifications Remodel Proteome-Wide Ligandability
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
www.biorxiv.org
August 3, 2025 at 2:36 PM
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Reposted by Ed Huttlin
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
July 29, 2025 at 4:00 PM
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
Reposted by Ed Huttlin
Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.
July 18, 2025 at 3:39 PM
Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.
If you’re at #ASMS2025, stop by the Protein-protein and Protein-ligand Interactions section this afternoon and hear how we are leveraging our BioPlex network and AlphaFold structural models for drug discovery!
June 3, 2025 at 1:11 PM
If you’re at #ASMS2025, stop by the Protein-protein and Protein-ligand Interactions section this afternoon and hear how we are leveraging our BioPlex network and AlphaFold structural models for drug discovery!
If you're going to #ASMS2025, don't miss these Gygi lab presentations! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging BioPlex interactions for drug discovery, new instrumentation, and more! @amandalsmythers.bsky.social @asms.org @harvardcellbio.bsky.social
May 30, 2025 at 6:06 PM
If you're going to #ASMS2025, don't miss these Gygi lab presentations! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging BioPlex interactions for drug discovery, new instrumentation, and more! @amandalsmythers.bsky.social @asms.org @harvardcellbio.bsky.social
#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how BioPlex is enhancing drug discovery!
May 30, 2025 at 6:01 PM
#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how BioPlex is enhancing drug discovery!
Reposted by Ed Huttlin
Harvard's president tells NPR he finds Trump's recent measures "perplexing."
"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX
"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX
May 28, 2025 at 9:04 PM
Harvard's president tells NPR he finds Trump's recent measures "perplexing."
"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX
"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX
Reposted by Ed Huttlin
New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
www.nature.com
May 28, 2025 at 3:52 PM
New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
Reposted by Ed Huttlin
NIH's work saves lives—& Trump is gutting it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
May 2, 2025 at 9:04 PM
NIH's work saves lives—& Trump is gutting it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Reposted by Ed Huttlin
Multimodal cell maps as a foundation for structural and functional genomics @nature.com @edhuttlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:51 PM
Multimodal cell maps as a foundation for structural and functional genomics @nature.com @edhuttlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This essay from @erinbakerims.bsky.social does a good job summarizing the challenges facing scientists in the current climate and is well worth reading.
theanalyticalscientist.com/business-edu...
theanalyticalscientist.com/business-edu...
A Bleak Future?
Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science
theanalyticalscientist.com
March 7, 2025 at 4:57 PM
This essay from @erinbakerims.bsky.social does a good job summarizing the challenges facing scientists in the current climate and is well worth reading.
theanalyticalscientist.com/business-edu...
theanalyticalscientist.com/business-edu...
It’s always fun to open up JASMS and see a familiar face. This time it’s my friend and colleague Jose Navarrete-Perea! @asms.org pubs.acs.org/doi/10.1021/...
Faces of Mass Spectrometry/Jose Navarrete-Perea
pubs.acs.org
February 24, 2025 at 9:41 PM
It’s always fun to open up JASMS and see a familiar face. This time it’s my friend and colleague Jose Navarrete-Perea! @asms.org pubs.acs.org/doi/10.1021/...
Welcome to Bluesky, @coonlab.bsky.social!
December 18, 2024 at 7:32 PM
Welcome to Bluesky, @coonlab.bsky.social!
Reposted by Ed Huttlin
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
December 9, 2024 at 11:19 PM
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
Congratulations to all of the 2025 @us-hupo.bsky.social award winners!
🎉 Huge congratulations to the four incredible winners of the 2025 US HUPO Association Awards! 🏆 We're so excited to celebrate your achievements at US HUPO 2025 in Philadelphia! #USHUPO2025 #USHUPO
December 3, 2024 at 6:13 PM
Congratulations to all of the 2025 @us-hupo.bsky.social award winners!
I’m really a trombone player, but every year at about this time I think I should pick up a euphonium and play in a Tuba Christmas….
December 1, 2024 at 4:25 PM
I’m really a trombone player, but every year at about this time I think I should pick up a euphonium and play in a Tuba Christmas….
Reposted by Ed Huttlin
Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.
November 30, 2024 at 2:00 PM
Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.
I’m looking forward to presenting our latest work combining our BioPlex interaction network with AlphaFold at today’s @ludwigcancer.bsky.social retreat at Harvard and learning more about the great science being done by its members!
November 25, 2024 at 1:54 PM
I’m looking forward to presenting our latest work combining our BioPlex interaction network with AlphaFold at today’s @ludwigcancer.bsky.social retreat at Harvard and learning more about the great science being done by its members!