Chiara Masnovo
@chiaramasnovophd.bsky.social
Genomic instability | New Postdoc in the @ChowdhuryLab at DFCI/Harvard Medical School | Ph.D. from the Mirkin Lab at Tufts. 🇮🇹
Congrats to @susankilgas.bsky.social and all other authors on this fantastic publication! Make sure to check it out.
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28
probe, alongside a control compound and an inhibitor-resistant mutant. They show that
USP28 inhibition mimics p53 path...
www.cell.com
September 2, 2025 at 5:07 PM
Congrats to @susankilgas.bsky.social and all other authors on this fantastic publication! Make sure to check it out.
Reposted by Chiara Masnovo
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
August 20, 2025 at 4:30 PM
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
Reposted by Chiara Masnovo
Terminations of active NSF grants have overwhelmingly targeted STEM education specifically.
May 22, 2025 at 3:59 PM
Terminations of active NSF grants have overwhelmingly targeted STEM education specifically.
This is terrifying.
But also they really killed it with the graphics 🤣
But also they really killed it with the graphics 🤣
🧪 Detailed data viz NYT article, out today, on the extent of funding cuts at the National Science Foundation.
This "broken pie chart" is neat & new to me: Powerfully shows the slowdown in new NSF awards across areas.
www.nytimes.com/interactive/...
This "broken pie chart" is neat & new to me: Powerfully shows the slowdown in new NSF awards across areas.
www.nytimes.com/interactive/...
May 22, 2025 at 9:38 PM
This is terrifying.
But also they really killed it with the graphics 🤣
But also they really killed it with the graphics 🤣
📣 New paper from the lab 📣 showing how the CST complex inhibits end resection during DNA double-strand break repair! Congrats to all authors.
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
May 22, 2025 at 9:34 PM
📣 New paper from the lab 📣 showing how the CST complex inhibits end resection during DNA double-strand break repair! Congrats to all authors.
I spoke with @aniloza.bsky.social at @statnews.com about how it feels to see opportunities shrink after finding out that the HGF HHMI postdoctoral competition has been canceled this year.
Have a read here.
www.statnews.com/2025/05/19/h...
Have a read here.
www.statnews.com/2025/05/19/h...
Private funder HHMI pauses postdoc fellowship
As HHMI pauses Hanna Gray fellowship applications, opportunities for young scientists shrink further, making them look overseas.
www.statnews.com
May 20, 2025 at 2:24 PM
I spoke with @aniloza.bsky.social at @statnews.com about how it feels to see opportunities shrink after finding out that the HGF HHMI postdoctoral competition has been canceled this year.
Have a read here.
www.statnews.com/2025/05/19/h...
Have a read here.
www.statnews.com/2025/05/19/h...
Reposted by Chiara Masnovo
My friend and fellow Swiftie @chiaramasnovophd.bsky.social's story:
"Molecular biologist Chiara Masnovo spent weeks filling out an application for a research fellowship earlier this year — taking it over the finish line as she was 38 weeks pregnant and starting a new job."
"Molecular biologist Chiara Masnovo spent weeks filling out an application for a research fellowship earlier this year — taking it over the finish line as she was 38 weeks pregnant and starting a new job."
May 20, 2025 at 1:29 AM
My friend and fellow Swiftie @chiaramasnovophd.bsky.social's story:
"Molecular biologist Chiara Masnovo spent weeks filling out an application for a research fellowship earlier this year — taking it over the finish line as she was 38 weeks pregnant and starting a new job."
"Molecular biologist Chiara Masnovo spent weeks filling out an application for a research fellowship earlier this year — taking it over the finish line as she was 38 weeks pregnant and starting a new job."
In other news, officially got hooded today! Thank you to my advisor Sergei Mirkin and all my other mentors and mentees.
Baby’s first doctoral hooding too!
Baby’s first doctoral hooding too!
May 17, 2025 at 10:00 PM
In other news, officially got hooded today! Thank you to my advisor Sergei Mirkin and all my other mentors and mentees.
Baby’s first doctoral hooding too!
Baby’s first doctoral hooding too!
Reposted by Chiara Masnovo
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
I am SO GOOD at this “taking it easier” thing!
Jokes aside starting next week my WFH time will massively increase because my body is toast and this baby needs rest.
Jokes aside starting next week my WFH time will massively increase because my body is toast and this baby needs rest.
April 29, 2025 at 6:02 PM
I am SO GOOD at this “taking it easier” thing!
Jokes aside starting next week my WFH time will massively increase because my body is toast and this baby needs rest.
Jokes aside starting next week my WFH time will massively increase because my body is toast and this baby needs rest.
Before being pregnant I had never realized how much of an active job being a bench scientist is 😂
April 29, 2025 at 12:43 PM
Before being pregnant I had never realized how much of an active job being a bench scientist is 😂
Reposted by Chiara Masnovo
The Department of Human Genetics at the University of Utah is sponsoring the Rising Stars in Genetics and Genomics symposium!
- We are seeking nominations bu June 1.
- September 18-19, 2025
- Please share with the star postdocs that you know.
docs.google.com/forms/d/e/1F...
- We are seeking nominations bu June 1.
- September 18-19, 2025
- Please share with the star postdocs that you know.
docs.google.com/forms/d/e/1F...
April 28, 2025 at 5:20 PM
The Department of Human Genetics at the University of Utah is sponsoring the Rising Stars in Genetics and Genomics symposium!
- We are seeking nominations bu June 1.
- September 18-19, 2025
- Please share with the star postdocs that you know.
docs.google.com/forms/d/e/1F...
- We are seeking nominations bu June 1.
- September 18-19, 2025
- Please share with the star postdocs that you know.
docs.google.com/forms/d/e/1F...
Taking a small break from bench work because my feet hurt — I guess that’s what being 35 weeks pregnant will do to you!
Reading a great review on replication stress response by @albertociccia.bsky.social and @vindignilab.bsky.social ✨
Reading a great review on replication stress response by @albertociccia.bsky.social and @vindignilab.bsky.social ✨
April 28, 2025 at 8:20 PM
Taking a small break from bench work because my feet hurt — I guess that’s what being 35 weeks pregnant will do to you!
Reading a great review on replication stress response by @albertociccia.bsky.social and @vindignilab.bsky.social ✨
Reading a great review on replication stress response by @albertociccia.bsky.social and @vindignilab.bsky.social ✨
Reposted by Chiara Masnovo
How do so many students get to grad school without a reference manager? I am an unabashed @zotero.org zealot. Students are practically sobbing tears of joy when they find that there is a FREE tool that will organize and label PDFs, allow markup, and insert bibliographies!
February 26, 2025 at 6:34 PM
How do so many students get to grad school without a reference manager? I am an unabashed @zotero.org zealot. Students are practically sobbing tears of joy when they find that there is a FREE tool that will organize and label PDFs, allow markup, and insert bibliographies!
Reposted by Chiara Masnovo
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
DNA replication and genome maintenance: from basic biology to disease
www.embl.org
February 26, 2025 at 3:22 PM
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Sometimes while I am on the bus getting to work I wonder why on earth I’m hearing so many ambulances and then I realize I work by 4 major hospitals 😅
February 25, 2025 at 1:04 PM
Sometimes while I am on the bus getting to work I wonder why on earth I’m hearing so many ambulances and then I realize I work by 4 major hospitals 😅
The learning curve AND imposter syndrome at the start of a postdoc are not a joke!
Any advice on how to navigate them?
Any advice on how to navigate them?
February 25, 2025 at 12:42 PM
The learning curve AND imposter syndrome at the start of a postdoc are not a joke!
Any advice on how to navigate them?
Any advice on how to navigate them?
Reposted by Chiara Masnovo
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
January 21, 2025 at 5:26 PM
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Reposted by Chiara Masnovo
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...
jobs.virginia.edu
January 16, 2025 at 8:35 PM
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Reposted by Chiara Masnovo
Golgi is the post office of the cell.
January 16, 2025 at 5:26 PM
Golgi is the post office of the cell.
Writing two proposals on two things at the same time is quite the trip.
January 12, 2025 at 9:33 PM
Writing two proposals on two things at the same time is quite the trip.
What’s your first experiment of 2025?
January 6, 2025 at 9:31 PM
What’s your first experiment of 2025?
Julia and I’s review on triplex H-DNA is out! Head there to learn more about this fantastic structure. Thank you Sergei for your guidance.
Best holiday present: Our comprehensive review of triplex H-DNA has just come out in NAR Mol Medicine. I am indebted to two outstanding graduate students: Julia Hisey and Chiara Masnovo, whose enthusiasm, dedication and hard work made this review possible! academic.oup.com/narmolmed/ad...
Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease
Abstract. H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from chara
academic.oup.com
December 24, 2024 at 12:48 PM
Julia and I’s review on triplex H-DNA is out! Head there to learn more about this fantastic structure. Thank you Sergei for your guidance.
🌟 I am beyond excited to share that this week I have started a new chapter as a Post-doctoral Research Fellow at the Dana-Farber Cancer Institute / Harvard Medical School, working in Dipanjan Chowdhury's lab!
To more genome maintenance research!
Stay tuned for a lab Bluesky account 🧬
To more genome maintenance research!
Stay tuned for a lab Bluesky account 🧬
December 6, 2024 at 10:55 PM
🌟 I am beyond excited to share that this week I have started a new chapter as a Post-doctoral Research Fellow at the Dana-Farber Cancer Institute / Harvard Medical School, working in Dipanjan Chowdhury's lab!
To more genome maintenance research!
Stay tuned for a lab Bluesky account 🧬
To more genome maintenance research!
Stay tuned for a lab Bluesky account 🧬