Susan Kilgas
@susankilgas.bsky.social
Postdoc at Dana-Farber Cancer Institute in the Chowdhury lab | Interested in genome stability 🧬
Reposted by Susan Kilgas
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28
probe, alongside a control compound and an inhibitor-resistant mutant. They show that
USP28 inhibition mimics p53 path...
www.cell.com
September 2, 2025 at 5:04 PM
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
August 20, 2025 at 4:30 PM
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
Reposted by Susan Kilgas
Thank you to @chowdhurylab.bsky.social (@danafarber.bsky.social) for joining us for a fantastic #WednedsayLectureSeries on "DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab. #SciSky #ResearchSky
May 14, 2025 at 6:40 PM
Thank you to @chowdhurylab.bsky.social (@danafarber.bsky.social) for joining us for a fantastic #WednedsayLectureSeries on "DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab. #SciSky #ResearchSky
Reposted by Susan Kilgas
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
May 22, 2025 at 9:30 PM
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!