Charbel Machaalani
@charbelmachaalani.bsky.social
Scientist | PhD Candidate @University Children's Hospital of Zurich🇨🇭| Neuro-Oncolgy | Spatial Biology | Transcriptomics | Proteomics
Dear network I am looking for patient advocacy or support groups for patients diagnosed with Kidney cancer [particularly clear cell Renal cell carcinoma]. or patients open to talk to me about life with metastatic cancer and disease monitoring.
(Ideally located in Switzerland)
Thank you 🙏
(Ideally located in Switzerland)
Thank you 🙏
August 16, 2025 at 6:36 PM
Dear network I am looking for patient advocacy or support groups for patients diagnosed with Kidney cancer [particularly clear cell Renal cell carcinoma]. or patients open to talk to me about life with metastatic cancer and disease monitoring.
(Ideally located in Switzerland)
Thank you 🙏
(Ideally located in Switzerland)
Thank you 🙏
Question for Single-cell experts:
I have single nuclei data for different samples from different patients.
would you:
A: Cluster and annotate each sample separately then integrate all of them together (but would need to find the best resolution for all samples)
#MesSky #Science #AcademicSky #GeneSky
I have single nuclei data for different samples from different patients.
would you:
A: Cluster and annotate each sample separately then integrate all of them together (but would need to find the best resolution for all samples)
#MesSky #Science #AcademicSky #GeneSky
May 17, 2025 at 11:53 AM
Question for Single-cell experts:
I have single nuclei data for different samples from different patients.
would you:
A: Cluster and annotate each sample separately then integrate all of them together (but would need to find the best resolution for all samples)
#MesSky #Science #AcademicSky #GeneSky
I have single nuclei data for different samples from different patients.
would you:
A: Cluster and annotate each sample separately then integrate all of them together (but would need to find the best resolution for all samples)
#MesSky #Science #AcademicSky #GeneSky
Reposted by Charbel Machaalani
Happy to give my talk, “Considerations for precision oncology and artificial intelligence for #Indigenous #genomic #data #sovereignty and #health disparities” at the American Association for #Cancer Research #aacr25 in Chicago! #ai
April 30, 2025 at 5:26 PM
Happy to give my talk, “Considerations for precision oncology and artificial intelligence for #Indigenous #genomic #data #sovereignty and #health disparities” at the American Association for #Cancer Research #aacr25 in Chicago! #ai
Very interesting thread
From another side the brain is a muscle, are we really loosing intelligence or not training this muscle enough
Also new times, new skills needed, should we not have new metrics to measure performance other than the traditional ones?
#AcademicSky #AI #SocialSky #ScienceSky
From another side the brain is a muscle, are we really loosing intelligence or not training this muscle enough
Also new times, new skills needed, should we not have new metrics to measure performance other than the traditional ones?
#AcademicSky #AI #SocialSky #ScienceSky
NEW 🧵 Is human intelligence starting to decline?
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
March 18, 2025 at 11:23 AM
Very interesting thread
From another side the brain is a muscle, are we really loosing intelligence or not training this muscle enough
Also new times, new skills needed, should we not have new metrics to measure performance other than the traditional ones?
#AcademicSky #AI #SocialSky #ScienceSky
From another side the brain is a muscle, are we really loosing intelligence or not training this muscle enough
Also new times, new skills needed, should we not have new metrics to measure performance other than the traditional ones?
#AcademicSky #AI #SocialSky #ScienceSky
Both papers in #NatureCom reveal therapeutic potential of CT-179 in Medulloblastoma recurrence by targeting OLIG-2. Blocking this protein reduced tumour formation and increased survival in mice by preventing dormant stem cells from being activated and proliferating. #MedSky #OncSky #Medulloblastoma
March 4, 2025 at 8:37 AM
Both papers in #NatureCom reveal therapeutic potential of CT-179 in Medulloblastoma recurrence by targeting OLIG-2. Blocking this protein reduced tumour formation and increased survival in mice by preventing dormant stem cells from being activated and proliferating. #MedSky #OncSky #Medulloblastoma
Reposted by Charbel Machaalani
“Many say that while they still love their work — and particularly working with students — they don’t know how long they can maintain their current pace. ‘Most of us are working seven days a week just to keep up… That’s not sustainable at all.’”
Higher Education Is Exhausted
Some don’t see a future in a sector battling for its very existence.
www.chronicle.com
February 18, 2025 at 2:34 PM
“Many say that while they still love their work — and particularly working with students — they don’t know how long they can maintain their current pace. ‘Most of us are working seven days a week just to keep up… That’s not sustainable at all.’”
Reposted by Charbel Machaalani
🌟NEW in #NatureMedicine: the longest reported cancer remission after #CARTcell therapy (19 years)! No additional therapy needed. Encouraging news for the ongoing development of #CARTcells in solid tumors
#PedSky #OncSky #MedSky #immunotherapy #neuroblastoma
www.nature.com/articles/s41...
#PedSky #OncSky #MedSky #immunotherapy #neuroblastoma
www.nature.com/articles/s41...
Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma - Nature Medicine
In an extended follow-up of a phase 1 trial evaluating a first-generation GD2-directed CAR-T cell therapy in patients with neuroblastoma, one patient has had a sustained clinical response for over 18 ...
www.nature.com
February 18, 2025 at 10:51 PM
🌟NEW in #NatureMedicine: the longest reported cancer remission after #CARTcell therapy (19 years)! No additional therapy needed. Encouraging news for the ongoing development of #CARTcells in solid tumors
#PedSky #OncSky #MedSky #immunotherapy #neuroblastoma
www.nature.com/articles/s41...
#PedSky #OncSky #MedSky #immunotherapy #neuroblastoma
www.nature.com/articles/s41...
Interesting read from @natureportfolio.nature.com
📉 PhD enrolments are dropping due to high living costs, low stipends & job insecurity. Many are stuck in a cycle of cheap labor with little mentorship. Is academia failing its future researchers? 🤔
#AcademicSky #Research #Science #PhD #AcademicLife
📉 PhD enrolments are dropping due to high living costs, low stipends & job insecurity. Many are stuck in a cycle of cheap labor with little mentorship. Is academia failing its future researchers? 🤔
#AcademicSky #Research #Science #PhD #AcademicLife
February 18, 2025 at 2:21 PM
Interesting read from @natureportfolio.nature.com
📉 PhD enrolments are dropping due to high living costs, low stipends & job insecurity. Many are stuck in a cycle of cheap labor with little mentorship. Is academia failing its future researchers? 🤔
#AcademicSky #Research #Science #PhD #AcademicLife
📉 PhD enrolments are dropping due to high living costs, low stipends & job insecurity. Many are stuck in a cycle of cheap labor with little mentorship. Is academia failing its future researchers? 🤔
#AcademicSky #Research #Science #PhD #AcademicLife
Reposted by Charbel Machaalani
A study in Nature Microbiology demonstrates that phenotypic flexibility allows influenza A virus to rapidly respond to environmental pressures in a way that provides dynamic adaptation potential in changing surroundings. 🧪
Influenza A virus rapidly adapts particle shape to environmental pressures - Nature Microbiology
Quantitative flow virometry assay to measure the shape of viral particles under various conditions reveals that influenza virus infections dynamically tune shape distribution of progeny particles depending on viral efficiency.
go.nature.com
February 17, 2025 at 11:26 PM
A study in Nature Microbiology demonstrates that phenotypic flexibility allows influenza A virus to rapidly respond to environmental pressures in a way that provides dynamic adaptation potential in changing surroundings. 🧪
First FDA-approved drug targeting fusions in paediatric gliomas! 🎉
This is a big step, BRAF::KIAA1549 is the most common molecular alteration in PLGG.
While OS is high, these patients face low PFS, long-term treatments, and a need for deeper research.💪🔬
#PediatricGlioma #FDAApproval #MedSky
This is a big step, BRAF::KIAA1549 is the most common molecular alteration in PLGG.
While OS is high, these patients face low PFS, long-term treatments, and a need for deeper research.💪🔬
#PediatricGlioma #FDAApproval #MedSky
February 17, 2025 at 9:41 AM
First FDA-approved drug targeting fusions in paediatric gliomas! 🎉
This is a big step, BRAF::KIAA1549 is the most common molecular alteration in PLGG.
While OS is high, these patients face low PFS, long-term treatments, and a need for deeper research.💪🔬
#PediatricGlioma #FDAApproval #MedSky
This is a big step, BRAF::KIAA1549 is the most common molecular alteration in PLGG.
While OS is high, these patients face low PFS, long-term treatments, and a need for deeper research.💪🔬
#PediatricGlioma #FDAApproval #MedSky
Fast-forward 100 years from today "Plastic Brain" becomes an official diagnosis.
#Medsky 🧪🧠
#Medsky 🧪🧠
Tiny plastic particles may accumulate at higher levels in the human brain than in the kidney and liver, with greater concentrations detected in postmortem samples from 2024 than in those from 2016, suggests a paper in Nature Medicine. https://go.nature.com/414lf9S #Medsky 🧪
February 15, 2025 at 11:37 AM
Fast-forward 100 years from today "Plastic Brain" becomes an official diagnosis.
#Medsky 🧪🧠
#Medsky 🧪🧠
Reposted by Charbel Machaalani
Measles cases are rising in the US with infections across 5 states - now 48 cases and climbing in Texas alone. With antivax rhetoric from many in government, the world should remember why measles is a "monster"
Great article by @enirenberg.bsky.social
shorturl.at/JMPji #MedSky #measles #vaccinate
Great article by @enirenberg.bsky.social
shorturl.at/JMPji #MedSky #measles #vaccinate
Malicious Measles Myths: Memory-Holing a Monster
Measles is already having a great 2024. We ought to put a stop to that.
deplatformdisease.substack.com
February 15, 2025 at 7:40 AM
Measles cases are rising in the US with infections across 5 states - now 48 cases and climbing in Texas alone. With antivax rhetoric from many in government, the world should remember why measles is a "monster"
Great article by @enirenberg.bsky.social
shorturl.at/JMPji #MedSky #measles #vaccinate
Great article by @enirenberg.bsky.social
shorturl.at/JMPji #MedSky #measles #vaccinate
Nextflow has been a game changer for non-computational biologists analyzing their own data! Excited for this conference! 🚀 #Bioinformatics #Nextflow
🎤Call for Speakers! The @nextflow.io Summit returns to Boston this May!
We’re looking for speakers to showcase groundbreaking research, innovative solutions, and real-world success stories.
👉 Submit your abstract by March 14 to be part of the lineup: hubs.la/Q036sG6T0
We’re looking for speakers to showcase groundbreaking research, innovative solutions, and real-world success stories.
👉 Submit your abstract by March 14 to be part of the lineup: hubs.la/Q036sG6T0
February 13, 2025 at 1:53 PM
Nextflow has been a game changer for non-computational biologists analyzing their own data! Excited for this conference! 🚀 #Bioinformatics #Nextflow
Reposted by Charbel Machaalani
In patients with diffuse intrinsic pontine glioma, a rare, fast-growing and fatal pediatric brain tumor, local delivery of B7-H3 targeting CAR T cells was feasible and well tolerated with a median overall survival of 19.8 months, according to a trial reported in Nature Medicine. #MedSky 🧪
Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial - Nature Medicine
In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients surviving over 40 months from diagnosis.
go.nature.com
January 17, 2025 at 1:21 PM
In patients with diffuse intrinsic pontine glioma, a rare, fast-growing and fatal pediatric brain tumor, local delivery of B7-H3 targeting CAR T cells was feasible and well tolerated with a median overall survival of 19.8 months, according to a trial reported in Nature Medicine. #MedSky 🧪
🌍 Let’s dive into #spatial #proteomics! 🧪🔬
Spatial proteomics is revolutionising how we map #proteins in cells and tissues, giving us crucial insights into their roles in both health and disease. 🧬
When choosing the right technology, here are three key factors to consider:
#AcademicSky #Science
Spatial proteomics is revolutionising how we map #proteins in cells and tissues, giving us crucial insights into their roles in both health and disease. 🧬
When choosing the right technology, here are three key factors to consider:
#AcademicSky #Science
February 12, 2025 at 6:25 PM
🌍 Let’s dive into #spatial #proteomics! 🧪🔬
Spatial proteomics is revolutionising how we map #proteins in cells and tissues, giving us crucial insights into their roles in both health and disease. 🧬
When choosing the right technology, here are three key factors to consider:
#AcademicSky #Science
Spatial proteomics is revolutionising how we map #proteins in cells and tissues, giving us crucial insights into their roles in both health and disease. 🧬
When choosing the right technology, here are three key factors to consider:
#AcademicSky #Science
A friend asked for resources to learn R as biologist
2 years ago I bought courses, most were repetitive “Hello World”
I tried FigOneLab by Dean Lee #NoAd before recommending it
Liked that it’s direct application to actual #bioinformatic use
Any other recommendations for beginners? #academia #biology
2 years ago I bought courses, most were repetitive “Hello World”
I tried FigOneLab by Dean Lee #NoAd before recommending it
Liked that it’s direct application to actual #bioinformatic use
Any other recommendations for beginners? #academia #biology
January 31, 2025 at 9:58 PM
A friend asked for resources to learn R as biologist
2 years ago I bought courses, most were repetitive “Hello World”
I tried FigOneLab by Dean Lee #NoAd before recommending it
Liked that it’s direct application to actual #bioinformatic use
Any other recommendations for beginners? #academia #biology
2 years ago I bought courses, most were repetitive “Hello World”
I tried FigOneLab by Dean Lee #NoAd before recommending it
Liked that it’s direct application to actual #bioinformatic use
Any other recommendations for beginners? #academia #biology
Hi bsky! I’m a PhD student exploring treatment impact on tumor development using #spatial #proteomics. Excited to join the scientific community. A year ago I made the jump from wet to dry lab and looking to connect with fellow peers. #Bioinformatics #academia #CancerResearch #Biology
January 29, 2025 at 2:41 PM
Hi bsky! I’m a PhD student exploring treatment impact on tumor development using #spatial #proteomics. Excited to join the scientific community. A year ago I made the jump from wet to dry lab and looking to connect with fellow peers. #Bioinformatics #academia #CancerResearch #Biology