Both papers in #NatureCom reveal therapeutic potential of CT-179 in Medulloblastoma recurrence by targeting OLIG-2. Blocking this protein reduced tumour formation and increased survival in mice by preventing dormant stem cells from being activated and proliferating. #MedSky #OncSky #Medulloblastoma

Interesting read from @natureportfolio.nature.com
📉 PhD enrolments are dropping due to high living costs, low stipends & job insecurity. Many are stuck in a cycle of cheap labor with little mentorship. Is academia failing its future researchers? 🤔
#AcademicSky #Research #Science #PhD #AcademicLife

First FDA-approved drug targeting fusions in paediatric gliomas! 🎉
This is a big step, BRAF::KIAA1549 is the most common molecular alteration in PLGG.
While OS is high, these patients face low PFS, long-term treatments, and a need for deeper research.💪🔬
#PediatricGlioma #FDAApproval #MedSky

While the Imaging mass spectrometry (IMS)-based is defined as Top-down proteomics analysing intact proteins, while bottom-up proteomics digests proteins into peptides before analysis.
But I do agree with you, also when we say pixel we all intuitively think imaging.

This figure is from a paper [source in the alt text] where they combine LC-MS/MS with with micro-manipulation techniques, such as laser capture microdissection (LCM) and that can be done on ROI or pixel by pixel level

🌍 Let’s dive into #spatial #proteomics! 🧪🔬

Spatial proteomics is revolutionising how we map #proteins in cells and tissues, giving us crucial insights into their roles in both health and disease. 🧬

When choosing the right technology, here are three key factors to consider:
#AcademicSky #Science

Hi bsky! I’m a PhD student exploring treatment impact on tumor development using #spatial #proteomics. Excited to join the scientific community. A year ago I made the jump from wet to dry lab and looking to connect with fellow peers. #Bioinformatics #academia #CancerResearch #Biology