Chad Weldy, MD, PhD
@chadweldy.bsky.social
Cardiologist and physician-scientist @Stanford | Instructor of Medicine | working to accelerate precision medicine through epigenetics and RNA editing
https://profiles.stanford.edu/chad-weldy
https://profiles.stanford.edu/chad-weldy
Pinned
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Nature Cardiovascular Research - Weldy et al. show that smooth muscle expression of the RNA editing enzyme ADAR1 regulates activation of the double-stranded RNA sensor MDA5 in a novel mechanism of...
rdcu.be
Hard to understate how wonderful it is to see our manuscript in print today @natcardiovascres.nature.com. We discover ADAR1 to control dsRNA sensor MDA5 in atherosclerosis, creating a new paradigm of endogenous dsRNA sensing as a causal mechanism of disease. Let's get into it 👇 #RNAsky rdcu.be/eGEyu
Super excited we made the cover of @natcardiovascres.nature.com! Work represents ADAR1 RNA editing within the vascular wall
October 15, 2025 at 1:38 PM
Super excited we made the cover of @natcardiovascres.nature.com! Work represents ADAR1 RNA editing within the vascular wall
Reposted by Chad Weldy, MD, PhD
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
September 18, 2025 at 4:14 PM
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
Hard to understate how wonderful it is to see our manuscript in print today @natcardiovascres.nature.com. We discover ADAR1 to control dsRNA sensor MDA5 in atherosclerosis, creating a new paradigm of endogenous dsRNA sensing as a causal mechanism of disease. Let's get into it 👇 #RNAsky rdcu.be/eGEyu
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Nature Cardiovascular Research - Weldy et al. show that smooth muscle expression of the RNA editing enzyme ADAR1 regulates activation of the double-stranded RNA sensor MDA5 in a novel mechanism of...
rdcu.be
September 16, 2025 at 12:48 PM
Hard to understate how wonderful it is to see our manuscript in print today @natcardiovascres.nature.com. We discover ADAR1 to control dsRNA sensor MDA5 in atherosclerosis, creating a new paradigm of endogenous dsRNA sensing as a causal mechanism of disease. Let's get into it 👇 #RNAsky rdcu.be/eGEyu
I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci | Molecular Systems Biology
imageimageVascular sites have distinct susceptibility to disease. Here, through single cell epigenomic profiling and predictive machine learning modeling, this study revealed that regulatory enhancers are vascular site specific, providing insight ...
www.embopress.org
September 10, 2025 at 3:54 PM
I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Chad Weldy, MD, PhD
www.cbsnews.com/video/saving.... This video shows the real and devastating impact of the cuts to the NIH funding. My heart aches from hearing the story of Natalie Phelps who has stage 4 colorectal cancer and how she and her family are being impacted.
Saving money vs. saving lives
Scientists conducting medical research are facing an existential crisis: Layoffs and budget cuts pushed by President Trump that, they say, jeopardize finding a cure for cancer. They tell "Sunday Morni...
www.cbsnews.com
June 29, 2025 at 10:25 PM
www.cbsnews.com/video/saving.... This video shows the real and devastating impact of the cuts to the NIH funding. My heart aches from hearing the story of Natalie Phelps who has stage 4 colorectal cancer and how she and her family are being impacted.
Reposted by Chad Weldy, MD, PhD
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 9:08 PM
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Reposted by Chad Weldy, MD, PhD
This is the stupidity of it all—carve outs for AK make no sense for the people of Alaska when the UW/Harborview/Seattle Children’s system is the referral destination for anything too complicated for Anchorage
Today I held a press call to make clear GOP health care cuts hitting hospitals in WA state will also hurt people in WY, AK, MT, & ID.
Because hospitals in our state provide essential, high-level specialty care to people across the entire Mountain West.
Because hospitals in our state provide essential, high-level specialty care to people across the entire Mountain West.
Murray, UW Medicine & Harborview CEOs Sound Alarm on How Republican Medicaid Cuts Will Devastate Hospitals, Threaten Specialty Care People in Washington, Alaska, Montana, Idaho, Wyoming Rely on - Sena...
Hospitals in WA provide essential, high-level specialty care to people across the entire Mountain West and Alaska WA hospitals will lose $662 million in Medicaid revenue every year, 400,000 people in ...
www.murray.senate.gov
July 19, 2025 at 3:18 AM
This is the stupidity of it all—carve outs for AK make no sense for the people of Alaska when the UW/Harborview/Seattle Children’s system is the referral destination for anything too complicated for Anchorage
Reposted by Chad Weldy, MD, PhD
National Science Foundation staff were notified that their office space will be taken over by Department of Housing and Urban Development. It's unclear where the 1,800+ NSF employees will work. Renovation plans apparently include a personal gym for the HUD secretary & family eos.org/research-and...
National Science Foundation Staff Booted From Headquarters - Eos
Staff at the National Science Foundation (NSF) were notified on 25 June that the agency’s office space, located in Alexandria, Va., will be taken over by Department of Housing and Urban Development (H...
eos.org
June 26, 2025 at 1:19 AM
National Science Foundation staff were notified that their office space will be taken over by Department of Housing and Urban Development. It's unclear where the 1,800+ NSF employees will work. Renovation plans apparently include a personal gym for the HUD secretary & family eos.org/research-and...
Reposted by Chad Weldy, MD, PhD
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
June 14, 2025 at 6:35 PM
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
Reposted by Chad Weldy, MD, PhD
If you weren't angry enough already, here are the rates of non-competitive renewals through May.
4008 Non-competitive renewals were due to be funded in May.
The total funded was 99!
Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments.
1/2
4008 Non-competitive renewals were due to be funded in May.
The total funded was 99!
Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments.
1/2
June 9, 2025 at 1:22 PM
If you weren't angry enough already, here are the rates of non-competitive renewals through May.
4008 Non-competitive renewals were due to be funded in May.
The total funded was 99!
Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments.
1/2
4008 Non-competitive renewals were due to be funded in May.
The total funded was 99!
Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments.
1/2
Reposted by Chad Weldy, MD, PhD
The NIH represents incredible value for the US economy and for the people of the world. We need to safeguard its future and that of our students and trainees.
@rachelkeranen.bsky.social and I share our thoughts in today’s LA Times.
www.latimes.com/opinion/stor...
@rachelkeranen.bsky.social and I share our thoughts in today’s LA Times.
www.latimes.com/opinion/stor...
Contributor: Slashing NIH research guarantees a less healthy, less wealthy America
The administration's cuts at the National Institutes of Health will obliterate billions in economic gains, America's scientific predominance and untold human lives.
www.latimes.com
May 29, 2025 at 2:05 AM
The NIH represents incredible value for the US economy and for the people of the world. We need to safeguard its future and that of our students and trainees.
@rachelkeranen.bsky.social and I share our thoughts in today’s LA Times.
www.latimes.com/opinion/stor...
@rachelkeranen.bsky.social and I share our thoughts in today’s LA Times.
www.latimes.com/opinion/stor...
Reposted by Chad Weldy, MD, PhD
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
May 23, 2025 at 8:53 PM
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
Reposted by Chad Weldy, MD, PhD
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️
Dissecting regulatory syntax in human development with scalable multiomics and deep learning
Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...
www.biorxiv.org
May 3, 2025 at 6:27 PM
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️
Reposted by Chad Weldy, MD, PhD
Even as someone who has followed everything going on at the NIH very closely, this story made my heart sink. I hope Americans watch this and see the impact of shutting down science. This effects everyone.
“This doesn't feel like a strategic plan to reorganize and make the NIH better and more efficient. It feels like a wrecking ball,” says an NIH insider, who asked 60 Minutes to protect his identity due to his concern about reprisal. https://cbsn.ws/3EKcER9
April 28, 2025 at 2:33 AM
Even as someone who has followed everything going on at the NIH very closely, this story made my heart sink. I hope Americans watch this and see the impact of shutting down science. This effects everyone.
Tons of fun at our annual #MyHeartCounts 5K! Amazing event and the one time a year I remember that racing a 5K is….hard, lol. Hit my goal time and looking forward to next year! @stanfordmedicine.bsky.social
April 28, 2025 at 2:10 AM
Tons of fun at our annual #MyHeartCounts 5K! Amazing event and the one time a year I remember that racing a 5K is….hard, lol. Hit my goal time and looking forward to next year! @stanfordmedicine.bsky.social
Reposted by Chad Weldy, MD, PhD
Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social !
Register here: tinyurl.com/yhcdr68a
Register here: tinyurl.com/yhcdr68a
April 23, 2025 at 2:21 AM
Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social !
Register here: tinyurl.com/yhcdr68a
Register here: tinyurl.com/yhcdr68a
Reposted by Chad Weldy, MD, PhD
Here is the formal announcement. Jay Bhattacharya and RFK Jr. need to explain. Who exactly are they trying to "make healthy?"
www.whi.org/md/news/whi-...
www.whi.org/md/news/whi-...
April 22, 2025 at 6:56 PM
Here is the formal announcement. Jay Bhattacharya and RFK Jr. need to explain. Who exactly are they trying to "make healthy?"
www.whi.org/md/news/whi-...
www.whi.org/md/news/whi-...
Happy to be part of this NAVBO Symposium on precision genomics (Tues, April 29, 2025). Excited to present on the epigenomic landscape of single vascular cells-ranging from single cell, regulatory networks, and ML prediction of variant effect, so much to talk about!
members.navbo.org/calendar-of-...
members.navbo.org/calendar-of-...
Symposium: Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology
NAVBO Symposium: Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology
Speakers:
“Integrated transcriptomics of human blood vessels”Aaron James, Johns Hopkins University School...
members.navbo.org
April 22, 2025 at 3:59 PM
Happy to be part of this NAVBO Symposium on precision genomics (Tues, April 29, 2025). Excited to present on the epigenomic landscape of single vascular cells-ranging from single cell, regulatory networks, and ML prediction of variant effect, so much to talk about!
members.navbo.org/calendar-of-...
members.navbo.org/calendar-of-...
Reposted by Chad Weldy, MD, PhD
Sigh. This study claiming a lack of association between ApoB & plaque has blown up in the media with the typical podcaster/youtuber grifters jumping on it. Beyond the obvious (small N, non-randomized), here are a few reasons the study doesn't show what people claim 🧵:
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial
www.jacc.org
April 9, 2025 at 7:55 PM
Sigh. This study claiming a lack of association between ApoB & plaque has blown up in the media with the typical podcaster/youtuber grifters jumping on it. Beyond the obvious (small N, non-randomized), here are a few reasons the study doesn't show what people claim 🧵:
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Reposted by Chad Weldy, MD, PhD
Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human
genomic loci linked to coronary artery disease susceptibility. Among these genomic
regions, the most i...
www.ahajournals.org
March 30, 2025 at 8:15 PM
Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Reposted by Chad Weldy, MD, PhD
From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.
The Trump Administration Accidentally Texted Me Its War Plans
U.S. national-security leaders included me in a group chat about upcoming military strikes in Yemen. I didn’t think it could be real. Then the bombs started falling.
www.theatlantic.com
March 24, 2025 at 8:13 PM
From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.
Reposted by Chad Weldy, MD, PhD
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Yeah nice work @shoaclarke.bsky.social and team! Great to see this out in print!
Most hearts have right dominant coronary anatomy but some have left. Why? Is it random? When/how is dominance established?
Now out in @cellpress.bsky.social, the 1st GWAS of coronary dominance + experiments implicating CXCL12 as a driver of human coronary patterning!
www.cell.com/cell/fulltex...
Now out in @cellpress.bsky.social, the 1st GWAS of coronary dominance + experiments implicating CXCL12 as a driver of human coronary patterning!
www.cell.com/cell/fulltex...
March 5, 2025 at 7:45 PM
Yeah nice work @shoaclarke.bsky.social and team! Great to see this out in print!
Reposted by Chad Weldy, MD, PhD
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 2, 2025 at 1:57 PM
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
Reposted by Chad Weldy, MD, PhD
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...