Shoa Clarke
@shoaclarke.bsky.social
Assistant Professor, Stanford University // Preventive cardiologist for adults & children // https://clarkelab.stanford.edu 🧬🫀💻
Pinned
Shoa Clarke
@shoaclarke.bsky.social
· Nov 21
By request, here is a longer explanation of how the CardioSky feed works. I created the feed so I could have one place to see cardiology related activity on Bluesky beyond just the #CardioSky hashtag. Below are the details, some considerations, and some caveats.
bsky.app/profile/did:...
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bsky.app/profile/did:...
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Reposted by Shoa Clarke
We are excited to announce EchoPrime is published in Nature. EchoPrime is the first echocardiography AI model capable of evaluating a full transthoracic echocardiogram study, identify the most relevant videos, and produce a comprehensive interpretation!
November 17, 2025 at 2:38 AM
We are excited to announce EchoPrime is published in Nature. EchoPrime is the first echocardiography AI model capable of evaluating a full transthoracic echocardiogram study, identify the most relevant videos, and produce a comprehensive interpretation!
Reposted by Shoa Clarke
After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership.
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
November 11, 2025 at 7:50 PM
After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership.
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
Reposted by Shoa Clarke
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Shoa Clarke
🚨 #AI-based #ECG analysis significantly improved #STEMI detection, reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways. https://bit.ly/4hopPpT
#TCT2025 #JACCINT #CardioSky
#TCT2025 #JACCINT #CardioSky
October 28, 2025 at 10:00 PM
🚨 #AI-based #ECG analysis significantly improved #STEMI detection, reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways. https://bit.ly/4hopPpT
#TCT2025 #JACCINT #CardioSky
#TCT2025 #JACCINT #CardioSky
Reposted by Shoa Clarke
New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
October 24, 2025 at 9:05 PM
New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
Reposted by Shoa Clarke
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
October 2, 2025 at 12:57 AM
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
ENDORSE! Please can we make MOC make sense?
Physician certification should not be an ordeal; it is in vast need of improvement.
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...
Rethinking Physician Certification: A Call for a Modern, Meaningful Standard
www.jacc.org
October 6, 2025 at 5:25 PM
ENDORSE! Please can we make MOC make sense?
Reposted by Shoa Clarke
We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 .
med.stanford.edu/hypertension/e…
-Jehan Zahid Bahrainwala
HTN Fellowship Program Director
med.stanford.edu/hypertension/e…
-Jehan Zahid Bahrainwala
HTN Fellowship Program Director
https://med.stanford.edu/hypertension/e…
September 25, 2025 at 8:02 AM
We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 .
med.stanford.edu/hypertension/e…
-Jehan Zahid Bahrainwala
HTN Fellowship Program Director
med.stanford.edu/hypertension/e…
-Jehan Zahid Bahrainwala
HTN Fellowship Program Director
Reposted by Shoa Clarke
Quality measurement was once a breakthrough.
But today it’s too slow, too costly, and too disconnected from daily care.
It’s time to reinvent it.
🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....
@jaccjournals.bsky.social @yalemed.bsky.social
But today it’s too slow, too costly, and too disconnected from daily care.
It’s time to reinvent it.
🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....
@jaccjournals.bsky.social @yalemed.bsky.social
Computable Quality
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www.jacc.org
September 23, 2025 at 7:17 PM
Quality measurement was once a breakthrough.
But today it’s too slow, too costly, and too disconnected from daily care.
It’s time to reinvent it.
🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....
@jaccjournals.bsky.social @yalemed.bsky.social
But today it’s too slow, too costly, and too disconnected from daily care.
It’s time to reinvent it.
🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....
@jaccjournals.bsky.social @yalemed.bsky.social
Reposted by Shoa Clarke
Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!!
www.nytimes.com/2025/09/11/h...
www.nytimes.com/2025/09/11/h...
Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers
www.nytimes.com
September 11, 2025 at 6:00 PM
Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!!
www.nytimes.com/2025/09/11/h...
www.nytimes.com/2025/09/11/h...
Reposted by Shoa Clarke
I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci | Molecular Systems Biology
imageimageVascular sites have distinct susceptibility to disease. Here, through single cell epigenomic profiling and predictive machine learning modeling, this study revealed that regulatory enhancers are vascular site specific, providing insight ...
www.embopress.org
September 10, 2025 at 3:54 PM
I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Promoting fads and infusing more money into the >$6 trillion wellness industry is not how to make America healthy.
www.nytimes.com/2025/09/10/o...
www.nytimes.com/2025/09/10/o...
Opinion | It’s Not You. It’s the Food.
www.nytimes.com
September 10, 2025 at 4:54 PM
Promoting fads and infusing more money into the >$6 trillion wellness industry is not how to make America healthy.
www.nytimes.com/2025/09/10/o...
www.nytimes.com/2025/09/10/o...
Reposted by Shoa Clarke
I’m hiring in statistical genetics—senior scientist role but it’s the skills that matter—so earlier career folks with the right experience & interest should apply!
There may also be multiple positions — so please RT & share w/ your network
cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...
There may also be multiple positions — so please RT & share w/ your network
cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...
Senior Scientist I
Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibi...
cytokinetics.wd1.myworkdayjobs.com
September 9, 2025 at 1:52 PM
I’m hiring in statistical genetics—senior scientist role but it’s the skills that matter—so earlier career folks with the right experience & interest should apply!
There may also be multiple positions — so please RT & share w/ your network
cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...
There may also be multiple positions — so please RT & share w/ your network
cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...
Reposted by Shoa Clarke
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
September 8, 2025 at 8:58 PM
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Jay will be remembered for crying, "Censorship!" when the science community rejected his unfounded claims, gaining power by bowing to Trump, and then leading the most insane scientific censorship campaign in US history.
www.wsj.com/health/scien...
www.wsj.com/health/scien...
The Words Scientists Are Changing to Scrub Diversity from Research Grants
Researchers are amending descriptions of their work to keep federal funding and avoid getting flagged in the Trump administration’s push against DEI.
www.wsj.com
August 23, 2025 at 3:51 PM
Jay will be remembered for crying, "Censorship!" when the science community rejected his unfounded claims, gaining power by bowing to Trump, and then leading the most insane scientific censorship campaign in US history.
www.wsj.com/health/scien...
www.wsj.com/health/scien...
Reposted by Shoa Clarke
The people dominating our political landscape, culture, and economy are just so stupid and full of shit it's almost impossible to describe
August 18, 2025 at 10:42 PM
The people dominating our political landscape, culture, and economy are just so stupid and full of shit it's almost impossible to describe
Reposted by Shoa Clarke
I’m not gonna QT the article baiting engagement but more posting doesn’t make a place great. Maybe people grew up & stopped wasting their time on debate bros, social media norms moved from conversation to broadcast, many explanations for fewer posts besides “people don’t actually like the platform”
The idea that more posts = better engagement 🧐. I am old enough to remember days on Twitter when I spent all day wasting energy debating misogynists, I prob posted a hundred posts in those arguments some days. Their followers probably send me 100 violent replies. Was all that posting better? Lol no.
August 7, 2025 at 5:30 PM
I’m not gonna QT the article baiting engagement but more posting doesn’t make a place great. Maybe people grew up & stopped wasting their time on debate bros, social media norms moved from conversation to broadcast, many explanations for fewer posts besides “people don’t actually like the platform”
100% the absolute wrong interpretation of these observations. I thought economists were supposed to understand confounding and causal inference 🤦🏻♂️. People do not randomly move between institutions.
The mantra “location, location, location” isn’t just about real estate. For life scientists, more than 50% of their productivity can be attributed to the institution where they work, according to a new study. scim.ag/4kKs1YO
Large study of scientists who move their labs reveals how location drives productivity
Concentrating funding at high-powered universities can maximize output, paper argues, but may sacrifice broader benefits
scim.ag
July 17, 2025 at 2:54 PM
100% the absolute wrong interpretation of these observations. I thought economists were supposed to understand confounding and causal inference 🤦🏻♂️. People do not randomly move between institutions.
Science. We had a good run...
July 3, 2025 at 6:47 PM
Science. We had a good run...