Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social

looking to hire 2 postdocs to join us in this endeavor.

more details can be found here: sites.google.com/uw.edu/statp...

Babies who are threat to DHS = 0

DHS teargas grenades thrown at babies = More than 0

(Before anyone blames adults for bringing baby there, video shows woman pull baby from her obstructed car to escape area. No indication she was there for a protest.)

www.nytimes.com/2025/09/29/u...

Trying to log into Eduroam

There is no world in which masked and armed agents of the state running down delivery drivers makes us safer. That our information environment and political leaders have convinced people otherwise is a massive failure.

I finished my estimate on required compute to make an atomic-resolution virtual cell: 10^38 FLOPs to simulate a human cell for 1 day. We should be able to do this simulation in 2074 using 200 TW of power. 1/3

Excited to share my new work on using AI and measured transcriptional responses to gene perturbations (knockdowns for example) to predict which sets of genes cause/mitigate complex disease phenotypes like cancer metastasis, IBD, or asthma, out now in PNAS! www.pnas.org/doi/full/10....

A whistleblower complaint says that the personal data of over 300 million Americans was copied to a private cloud account to allow access by members of the Department of Government Efficiency team.

This is not just HHMI. All Chan Zuckerberg Initiative funding calls are CLOSED. The Gates Foundation has no Grand Challenges funding opportunities. I've never seen anything like this. Private foundations have just decided to stop supporting biomedical research.

A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine

I don’t have a problem with someone evaluating my science abilities if I have the ability to examine theirs.

Let’s do televised qualifying exams for all the political appointees who will be evaluating science grants and proposals. Let’s start with directors of institutes and cabinet secretaries.

How challenging is the prediction of transcriptional responses to CRISPR gene perturbations ?

A simple model, just scaling RNA correlation vectors, results in accurate predictions for many perturbations.

The model is intuitive & grounded in a simple approximation.

1/2

Paper in Nature 150 years ago. Beats reading any single-cell experiment…

"Grant cancellations and budget reductions at the National Institutes of Health have put millions of dollars in research for promising new cancer treatments, tuberculosis therapies, and much more in jeopardy."
www.scientificamerican.com/article/atta...

Under Trump, NOAA ran the most recent competition for their highly prestigious postdoc program in climate and global change — but funded no one, wasting huge amounts of applicant and reviewer time.

It gets a lot worse. Now current postdocs in the program are going unpaid.

Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h
www.cell.com/cell-systems...

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw