Ben Kuznets-Speck
@biophysben.bsky.social
Biophysicist working at the edge of single cell biology, machine learning, and statistical-mechanics. Postdoc in Yogesh Goyal's lab at Northwestern; PhD in biophysics, UC Berkeley; BS in math and physics, CWRU.
Researchers usually target genes that are highly over or under expressed in variant (disease) cells relative to baseline. We go beyond such differential expression analysis to probabilistically match perturbation-induced transcriptional shifts to measured changes from healthy and diseased tissue.
September 23, 2025 at 2:12 PM
Researchers usually target genes that are highly over or under expressed in variant (disease) cells relative to baseline. We go beyond such differential expression analysis to probabilistically match perturbation-induced transcriptional shifts to measured changes from healthy and diseased tissue.
Reposted by Ben Kuznets-Speck
This is not just HHMI. All Chan Zuckerberg Initiative funding calls are CLOSED. The Gates Foundation has no Grand Challenges funding opportunities. I've never seen anything like this. Private foundations have just decided to stop supporting biomedical research.
August 9, 2025 at 4:50 PM
This is not just HHMI. All Chan Zuckerberg Initiative funding calls are CLOSED. The Gates Foundation has no Grand Challenges funding opportunities. I've never seen anything like this. Private foundations have just decided to stop supporting biomedical research.
That's an interesting question! At this stage we focused on RNAseq data but it would be a cool next step to incorporate information about chromatin state!
July 12, 2025 at 5:20 PM
That's an interesting question! At this stage we focused on RNAseq data but it would be a cool next step to incorporate information about chromatin state!