Bong-Ihn Koh
@bikohcello.bsky.social
Assistant Professor @Yale School of Medicine/former musician/scientist/ultra-foodie/Peyton Manning mega-fan
Pinned
Bong-Ihn Koh
@bikohcello.bsky.social
· Jun 26
I am extremely grateful and tremendously excited to share that I've accepted a tenure-track Assistant Professor position at the Yale Stem Cell Center and Department of Comparative Medicine at the Yale University School of Medicine this coming fall!! Can't wait to do awesome science with my own lab!!
November 4, 2025 at 4:03 AM
Reposted by Bong-Ihn Koh
A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).
1/4
1/4
Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow
Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...
doi.org
October 10, 2025 at 2:45 PM
A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).
1/4
1/4
Reposted by Bong-Ihn Koh
Giraffes, long considered a single species, are in fact four. https://scim.ag/4n2po6f
Giraffes are four distinct species, major report confirms
The revised classification will help ensure different giraffe populations are adequately protected, conservationists say
scim.ag
August 31, 2025 at 7:32 PM
Giraffes, long considered a single species, are in fact four. https://scim.ag/4n2po6f
Today, I officially said farewell to my second post-doc lab. I am ever so grateful to my amazing mentor
@ralfhadams.bsky.social for his exceptional and unwavering support. Words do not suffice in expressing my true appreciation and gratitude toward my fellow colleagues:
@ralfhadams.bsky.social for his exceptional and unwavering support. Words do not suffice in expressing my true appreciation and gratitude toward my fellow colleagues:
August 27, 2025 at 8:07 PM
Today, I officially said farewell to my second post-doc lab. I am ever so grateful to my amazing mentor
@ralfhadams.bsky.social for his exceptional and unwavering support. Words do not suffice in expressing my true appreciation and gratitude toward my fellow colleagues:
@ralfhadams.bsky.social for his exceptional and unwavering support. Words do not suffice in expressing my true appreciation and gratitude toward my fellow colleagues:
I just said farewell to the very first restaurant in Münster, Germany that welcomed me 5.5 years ago...Thank you, Hotel Bakenhof, for taking me in during the first COVID lockdown!!
August 26, 2025 at 8:40 PM
I just said farewell to the very first restaurant in Münster, Germany that welcomed me 5.5 years ago...Thank you, Hotel Bakenhof, for taking me in during the first COVID lockdown!!
Reposted by Bong-Ihn Koh
The August issue is live www.nature.com/nbt/volumes/...
The cover shows human pluripotent stem cell–derived embryoid bodies differentiating in vitro into hematopoietic stem cells and, after transplantation in mice, into blood cell lineages go.nature.com/3XeDg1Q
The cover shows human pluripotent stem cell–derived embryoid bodies differentiating in vitro into hematopoietic stem cells and, after transplantation in mice, into blood cell lineages go.nature.com/3XeDg1Q
August 12, 2025 at 4:28 PM
The August issue is live www.nature.com/nbt/volumes/...
The cover shows human pluripotent stem cell–derived embryoid bodies differentiating in vitro into hematopoietic stem cells and, after transplantation in mice, into blood cell lineages go.nature.com/3XeDg1Q
The cover shows human pluripotent stem cell–derived embryoid bodies differentiating in vitro into hematopoietic stem cells and, after transplantation in mice, into blood cell lineages go.nature.com/3XeDg1Q
Reposted by Bong-Ihn Koh
We discovered that the skull bone marrow has direct connections to the brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies.
Kolabas…Ertürk, Cell (2023):
www.cell.com/cell/pdf/S00...
Our Tech: www.biorxiv.org/content/10.1...
bit.ly/3PQuymm
Kolabas…Ertürk, Cell (2023):
www.cell.com/cell/pdf/S00...
Our Tech: www.biorxiv.org/content/10.1...
bit.ly/3PQuymm
August 13, 2025 at 11:04 AM
We discovered that the skull bone marrow has direct connections to the brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies.
Kolabas…Ertürk, Cell (2023):
www.cell.com/cell/pdf/S00...
Our Tech: www.biorxiv.org/content/10.1...
bit.ly/3PQuymm
Kolabas…Ertürk, Cell (2023):
www.cell.com/cell/pdf/S00...
Our Tech: www.biorxiv.org/content/10.1...
bit.ly/3PQuymm
Reposted by Bong-Ihn Koh
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd
August 13, 2025 at 4:18 PM
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd
Reposted by Bong-Ihn Koh
🍹 @ninacabezas.bsky.social & co combine #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, #aging and #leukemia, finding a role for choline and showing that supplementation enhances stemness.
bit.ly/3H98V0U
bit.ly/3H98V0U
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology
Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...
bit.ly
August 13, 2025 at 8:12 PM
🍹 @ninacabezas.bsky.social & co combine #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, #aging and #leukemia, finding a role for choline and showing that supplementation enhances stemness.
bit.ly/3H98V0U
bit.ly/3H98V0U
Please consider contributing to this collection! Looking forward to working with all of you to share with the rest of world how you get those beautiful images!!!
app.jove.com/methods-coll...
app.jove.com/methods-coll...
August 9, 2025 at 1:19 PM
Please consider contributing to this collection! Looking forward to working with all of you to share with the rest of world how you get those beautiful images!!!
app.jove.com/methods-coll...
app.jove.com/methods-coll...
Reposted by Bong-Ihn Koh
1/3 The science and discussions at the Angiogenesis GRS this year were 🔥🔥🔥. Grateful to have had a chance to co-chair it this year together with @bikohcello.bsky.social after attending every single meeting since I was a Graduate Student in 2015!
July 27, 2025 at 9:20 PM
1/3 The science and discussions at the Angiogenesis GRS this year were 🔥🔥🔥. Grateful to have had a chance to co-chair it this year together with @bikohcello.bsky.social after attending every single meeting since I was a Graduate Student in 2015!
Reposted by Bong-Ihn Koh
Now online! A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
Meningeal mast cells, via the receptor Mrgprb2/X2, orchestrate brain inflammation after stroke by recruiting and promoting the transfer of skull bone marrow neutrophils into the brain, highlighting these mast cells as key regulators of brain immunity and of the skull bone marrow-meningeal-brain network.
dlvr.it
July 24, 2025 at 2:59 PM
Now online! A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
One week until the GRC lobster dinner!! See you all this weekend! #GRCAngiogenesis @karinayaniv.bsky.social @AnneEichmann @brisapalikuqilab.bsky.social and so many others!
July 24, 2025 at 3:40 PM
One week until the GRC lobster dinner!! See you all this weekend! #GRCAngiogenesis @karinayaniv.bsky.social @AnneEichmann @brisapalikuqilab.bsky.social and so many others!
Reposted by Bong-Ihn Koh
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and mouse EAE and contribute to EAE chronicity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 23, 2025 at 8:06 PM
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and mouse EAE and contribute to EAE chronicity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Less than a week away! The amazing 2025 #GRSAngiogenesis and #GRCAngiogenesis with a fantastic lineup of awesome speakers and phenomenal attendees!! And let's not forget the heavenly venue in Newport! See you soon!! @karinayaniv.bsky.social @AnneEichmann @brisapalikuqilab.bsky.social
July 20, 2025 at 12:08 PM
Less than a week away! The amazing 2025 #GRSAngiogenesis and #GRCAngiogenesis with a fantastic lineup of awesome speakers and phenomenal attendees!! And let's not forget the heavenly venue in Newport! See you soon!! @karinayaniv.bsky.social @AnneEichmann @brisapalikuqilab.bsky.social
Reposted by Bong-Ihn Koh
Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity #stemcells
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity
Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They identify non-canonical functions for Dnmt3a in the regulation of telomere length and genome stability that restrict the functional potential of HSCs.
dlvr.it
July 17, 2025 at 4:00 PM
Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity #stemcells
Reposted by Bong-Ihn Koh
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
We are looking for a #Postdoc with a great interest in biological robustness to lead a project investigating the self-correction capabilities of the developing nervous system. Join us at the @rocha-lab.bsky.social Rocha lab @mpi-muenster.bsky.social!
jobs.mpi-muenster.mpg.de/jobposting/0...
jobs.mpi-muenster.mpg.de/jobposting/0...
July 10, 2025 at 12:10 PM
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
Reposted by Bong-Ihn Koh
Pan-cancer human brain metastases atlas at single-cell resolution
Pan-cancer human brain metastases atlas at single-cell resolution
Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. The study also identifies several novel cell states and subsets that are strongly enriched in BrM across different lineages, suggesting them as potential therapeutic targets for future investigations.
dlvr.it
July 14, 2025 at 6:51 PM
Pan-cancer human brain metastases atlas at single-cell resolution
Reposted by Bong-Ihn Koh
A speedy imaging method can map the nerves running from a mouse’s brain and spinal cord to the rest of its body at micrometre-scale resolution
go.nature.com/3Il0e3x
go.nature.com/3Il0e3x
Giant map details nerves across a mouse's body: see stunning pics
Nature - High-resolution imaging method could lead to wiring diagram for the whole body.
go.nature.com
July 12, 2025 at 3:07 PM
A speedy imaging method can map the nerves running from a mouse’s brain and spinal cord to the rest of its body at micrometre-scale resolution
go.nature.com/3Il0e3x
go.nature.com/3Il0e3x
Reposted by Bong-Ihn Koh
Replacing defective microglia with wild-type microglia using microglia replacement by bone marrow transplantation halts the progression of microgliopathy in mice and human www.science.org/doi/10.1126/... #NBThighlight
Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...
www.science.org
July 11, 2025 at 3:37 PM
Replacing defective microglia with wild-type microglia using microglia replacement by bone marrow transplantation halts the progression of microgliopathy in mice and human www.science.org/doi/10.1126/... #NBThighlight
Reposted by Bong-Ihn Koh
Excited to share our latest review on biomechanical forces shape endothelial plasticity and morphogenesis! We delve into dynamic feedback between mechanical cues & molecular pathways that drive two key processes: endothelial-to-hematopoietic & -mesenchymal transition.
doi.org/10.1016/j.se...
doi.org/10.1016/j.se...
July 11, 2025 at 4:31 PM
Excited to share our latest review on biomechanical forces shape endothelial plasticity and morphogenesis! We delve into dynamic feedback between mechanical cues & molecular pathways that drive two key processes: endothelial-to-hematopoietic & -mesenchymal transition.
doi.org/10.1016/j.se...
doi.org/10.1016/j.se...
Reposted by Bong-Ihn Koh
“This is a once-in-a-hundred-years discovery.” scim.ag/4lPz3MX
Pterosaur died with belly full of plants—a fossil first
New discovery confirms the long-debated hypothesis that the ancient winged reptiles ate plants
scim.ag
July 10, 2025 at 2:00 PM
“This is a once-in-a-hundred-years discovery.” scim.ag/4lPz3MX
Reposted by Bong-Ihn Koh
Germany digs reveal a large-scale operation 100,000 years earlier than oldest known fat rendering by modern humans
https://go.nature.com/3Gv861V
https://go.nature.com/3Gv861V
Neanderthals boiled bones in 'fat factories' to enrich their lean diet
Germany digs reveal a large-scale operation 100,000 years earlier than oldest known fat rendering by modern humans.
go.nature.com
July 3, 2025 at 5:15 PM
Germany digs reveal a large-scale operation 100,000 years earlier than oldest known fat rendering by modern humans
https://go.nature.com/3Gv861V
https://go.nature.com/3Gv861V
Reposted by Bong-Ihn Koh
Nature research paper: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
https://go.nature.com/4knEz8q
https://go.nature.com/4knEz8q
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature
A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.
go.nature.com
July 3, 2025 at 4:36 PM
Nature research paper: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
https://go.nature.com/4knEz8q
https://go.nature.com/4knEz8q