Bergeron lab
@bergeronlab.bsky.social
Structural biology, and beer. Not necessarily in that order.
Pinned
Bergeron lab
@bergeronlab.bsky.social
· Jul 30
The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension - Nature Communications
The Tad pilus is involved in the formation of antibiotic-resistant biofilms in many bacteria, including the human pathogen Pseudomonas aeruginosa. The authors report the structure of the Tad pilus pro...
www.nature.com
The peer-reviewed version of Sash and Iryna’s paper on the Tad pilus is out:
I probably shouldn’t comment on how amazing and transformative I think this work is, since I’m examining the thesis of its first author in a few weeks. So I’m not going to.
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 7:46 PM
I probably shouldn’t comment on how amazing and transformative I think this work is, since I’m examining the thesis of its first author in a few weeks. So I’m not going to.
Reposted by Bergeron lab
@kingscollegelondon.bsky.social spin-out company Prosemble, co-founded by @bergeronlab.bsky.social has been awarded @innovateuk.bsky.social funding as part of the Biomedical Catalyst to transform cancer care with cutting-edge nanoparticle and AI technologies. Read more: www.kcl.ac.uk/news/kings-s...
King's spin-out company awarded Innovate UK Biomedical Catalyst funding | King's College London
King's College London spin-out company Prosemble, co-founded by Dr Julien Bergeron, has been awarded Innovate UK funding as part of the Biomedical Catalyst to transform cancer care with cutting-edge n...
www.kcl.ac.uk
October 15, 2025 at 2:14 PM
@kingscollegelondon.bsky.social spin-out company Prosemble, co-founded by @bergeronlab.bsky.social has been awarded @innovateuk.bsky.social funding as part of the Biomedical Catalyst to transform cancer care with cutting-edge nanoparticle and AI technologies. Read more: www.kcl.ac.uk/news/kings-s...
😬
Yikes! In this paper the AlphaFold model of human plasminogen (PDB-8uq6) has been refined into noise (EMD-42462) using Phenix & ISOLDE. For some reason the authors even interpret side-chain interactions:
#cryoEM
#cryoEM
October 13, 2025 at 12:46 PM
😬
That is very cool.
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
September 1, 2025 at 12:33 PM
That is very cool.
Reposted by Bergeron lab
The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension pubmed.ncbi.nlm.nih.gov/40730569/ #cryoem
July 30, 2025 at 12:55 PM
The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension pubmed.ncbi.nlm.nih.gov/40730569/ #cryoem
The peer-reviewed version of Sash and Iryna’s paper on the Tad pilus is out:
The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension - Nature Communications
The Tad pilus is involved in the formation of antibiotic-resistant biofilms in many bacteria, including the human pathogen Pseudomonas aeruginosa. The authors report the structure of the Tad pilus pro...
www.nature.com
July 30, 2025 at 8:27 AM
The peer-reviewed version of Sash and Iryna’s paper on the Tad pilus is out:
Hmmmm… there’s a, let’s call it “interesting” new sculpture at the entrance of the @crick.ac.uk . I’m curious to hear what this is meant to illustrate.
July 16, 2025 at 10:13 PM
Hmmmm… there’s a, let’s call it “interesting” new sculpture at the entrance of the @crick.ac.uk . I’m curious to hear what this is meant to illustrate.
Superb work from our lab neighbours!
Excited to see our @natcomms.nature.com paper out! #Cryo-EM reveals a #microtubule stimulated ADP-release transition state of #kinesin 1. The auto-inhibitory tail has no affect on motor domain conformations. Focussed subunit processing helps! #cryoEM #microtubules
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail - Nature Communications
Kinesin-1 utilizes ATP-driven conformational changes to transport vital intracellular cargoes along microtubules. The authors use cryo-EM to reveal a missing structural transition state of the kinesin...
www.nature.com
July 8, 2025 at 12:50 AM
Superb work from our lab neighbours!
Reposted by Bergeron lab
In a new study, @bergeronlab.bsky.social have used the world’s most advanced electron microscope to reveal the complete architecture of the bacterial flagellum - a molecular machine essential for bacteria to cause infection, that could also be a target for antibiotics ⬇️ www.kcl.ac.uk/news/scienti...
Scientists target 'molecular machine' in the war against antimicrobial resistance
Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance.
www.kcl.ac.uk
July 7, 2025 at 10:00 AM
In a new study, @bergeronlab.bsky.social have used the world’s most advanced electron microscope to reveal the complete architecture of the bacterial flagellum - a molecular machine essential for bacteria to cause infection, that could also be a target for antibiotics ⬇️ www.kcl.ac.uk/news/scienti...
Reposted by Bergeron lab
#NewResearch
🚨Out now!
Structural analyses of the extracellular flagellum shows mechanism for flagellin incorporation
#MicroSky 🦠
www.nature.com/articles/s41...
🚨Out now!
Structural analyses of the extracellular flagellum shows mechanism for flagellin incorporation
#MicroSky 🦠
www.nature.com/articles/s41...
The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation - Nature Microbiology
Cryo-electron microscopy analysis of the extracellular flagellum structure, including the hook–filament junction and filament cap complex, reveals mechanisms of flagellin incorporation into the growin...
www.nature.com
July 1, 2025 at 3:15 PM
#NewResearch
🚨Out now!
Structural analyses of the extracellular flagellum shows mechanism for flagellin incorporation
#MicroSky 🦠
www.nature.com/articles/s41...
🚨Out now!
Structural analyses of the extracellular flagellum shows mechanism for flagellin incorporation
#MicroSky 🦠
www.nature.com/articles/s41...
A lovely write-up from Kings about our latest paper, and its role in combating antibiotic resistance:
Scientists target 'molecular machine' in the war against antimicrobial resistance
Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance.
www.kcl.ac.uk
July 1, 2025 at 7:56 PM
A lovely write-up from Kings about our latest paper, and its role in combating antibiotic resistance:
The peer-reviewed version of our article on the flagellum filament assembly is out!
A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.
A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.
The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation - Nature Microbiology
Cryo-electron microscopy analysis of the extracellular flagellum structure, including the hook–filament junction and filament cap complex, reveals mechanisms of flagellin incorporation into the growin...
www.nature.com
July 1, 2025 at 10:38 AM
The peer-reviewed version of our article on the flagellum filament assembly is out!
A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.
A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.
Reposted by Bergeron lab
When they go low, you go high, said a very wise woman
Just goes to show how pathetic Europe is exactly 💪🏻🧪
(Well done European Commission and ERC)
Just goes to show how pathetic Europe is exactly 💪🏻🧪
(Well done European Commission and ERC)
March 25, 2025 at 11:10 PM
When they go low, you go high, said a very wise woman
Just goes to show how pathetic Europe is exactly 💪🏻🧪
(Well done European Commission and ERC)
Just goes to show how pathetic Europe is exactly 💪🏻🧪
(Well done European Commission and ERC)
Reposted by Bergeron lab
A family of bacterial actin homologs forms a three-stranded tubular structure pubmed.ncbi.nlm.nih.gov/40073056/ #cryoem
March 13, 2025 at 1:27 PM
A family of bacterial actin homologs forms a three-stranded tubular structure pubmed.ncbi.nlm.nih.gov/40073056/ #cryoem
Latest paper from the lab: the Cryo-EM structure of BeeR! (Yes we did name the protein. No it’s not a coincidence)
A family of bacterial actin homologs forms a three-stranded tubular structure | PNAS
The cytoskeleton is crucial for cell organization and movement. In Eukaryotes, it
largely consists of the protein actin, that forms a double-strand...
www.pnas.org
March 13, 2025 at 10:17 AM
Latest paper from the lab: the Cryo-EM structure of BeeR! (Yes we did name the protein. No it’s not a coincidence)
Reposted by Bergeron lab
Curvature generation and engineering principles from Shewanella oneidensis multi-flagellin flagellum www.biorxiv.org/content/10.1101/2025.02.07.637127v1 #cryoem
February 9, 2025 at 3:50 PM
Curvature generation and engineering principles from Shewanella oneidensis multi-flagellin flagellum www.biorxiv.org/content/10.1101/2025.02.07.637127v1 #cryoem
Reposted by Bergeron lab
We are a little behind schedule, but the line up for the Next Great Wall Symposium in Sicily in September is coming together more soon. Get ready for those applications for abstracts!!!
thegreatwall-symposium.org
thegreatwall-symposium.org
The Greatwall-symposium
The Great Wall Symposium will take place from 18th to 20th September 2023 at the venue in The Vila Galé Sintra Hotel, in Portugal.
thegreatwall-symposium.org
January 7, 2025 at 3:27 PM
We are a little behind schedule, but the line up for the Next Great Wall Symposium in Sicily in September is coming together more soon. Get ready for those applications for abstracts!!!
thegreatwall-symposium.org
thegreatwall-symposium.org
Reposted by Bergeron lab
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com
PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com
www.findaphd.com
January 6, 2025 at 9:14 PM
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239