Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos?

I’m @amichaut.bsky.social, and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

Here is what I have been up to in the lab of @stephangrill.bsky.social together with @neipel.bsky.social and many others.
Intrigued by avian left right symmetry breaking we found that a tissue-scale active torque drives chiral flow and requires mechanical coupling to the underlying tissue.

🏳️‍🌈Our editor @slefkopoulos.bsky.social discussed with @jzylicz.bsky.social about the importance of celebrating Pride, representation in science, and more! Happy Pride!
Read here: rdcu.be/ewfba
bit.ly/3Uc72TO

Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!

🚨 A very interesting conference on gastrulation coming up soon 🚨 Don't miss the chance to interact with these renowned speakers! Early bird deadline: July 15th

🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at ‪
‪ @institutcurie.bsky.social

🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)

Very happy to share our latest lab publication!
The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators!
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...

The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play!

www.biorxiv.org/content/10.1...

🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...

🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics

ICYMI: Commentary on "mechanism" in dev bio

Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level

journals.biologists.com/dev/article/...

Announcing this upcoming conference:

GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan

Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!

📅 14–17 October 2025
📍 Paris, France