Ashley Holloway
@ashleyholloway.bsky.social
Neuroscientist interested in all things glia and dopamine
Reposted by Ashley Holloway
NIH grant applicants:
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
grants.nih.gov
November 14, 2025 at 8:45 PM
NIH grant applicants:
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
Reposted by Ashley Holloway
Book launch day is here 🚀
How to Change a Memory, in physical and audio form: www.amazon.com/How-Change-M...
and here's a preview of one of the book's central themes: memories change and, as a result, we change too🧠.
www.statnews.com/2025/11/04/a...
How to Change a Memory, in physical and audio form: www.amazon.com/How-Change-M...
and here's a preview of one of the book's central themes: memories change and, as a result, we change too🧠.
www.statnews.com/2025/11/04/a...
How to Change a Memory: One Neuroscientist’s Quest to Alter the Past
Buy How to Change a Memory: One Neuroscientist’s Quest to Alter the Past on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
November 4, 2025 at 2:33 PM
Book launch day is here 🚀
How to Change a Memory, in physical and audio form: www.amazon.com/How-Change-M...
and here's a preview of one of the book's central themes: memories change and, as a result, we change too🧠.
www.statnews.com/2025/11/04/a...
How to Change a Memory, in physical and audio form: www.amazon.com/How-Change-M...
and here's a preview of one of the book's central themes: memories change and, as a result, we change too🧠.
www.statnews.com/2025/11/04/a...
Reposted by Ashley Holloway
Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males https://www.biorxiv.org/content/10.1101/2025.11.10.687736v1
November 12, 2025 at 10:16 AM
Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males https://www.biorxiv.org/content/10.1101/2025.11.10.687736v1
Reposted by Ashley Holloway
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Nature Neuroscience - Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the...
rdcu.be
November 10, 2025 at 3:43 PM
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Reposted by Ashley Holloway
Spoke recently to the great folks at the science foundation on their efforts to fund curiosity-driven science. They have a new RFA out for catalytic awards (up to $10K).
Take a look if you’re itching to expand or try out a new idea.
science-foundation.org
Take a look if you’re itching to expand or try out a new idea.
science-foundation.org
Public Science, Public Good – Public Science, Public Good
science-foundation.org
November 4, 2025 at 12:33 AM
Spoke recently to the great folks at the science foundation on their efforts to fund curiosity-driven science. They have a new RFA out for catalytic awards (up to $10K).
Take a look if you’re itching to expand or try out a new idea.
science-foundation.org
Take a look if you’re itching to expand or try out a new idea.
science-foundation.org
Reposted by Ashley Holloway
BOSTON (AP) — Judges order the federal government to use contingency funds for SNAP food aid payments during the shutdown.
October 31, 2025 at 6:07 PM
BOSTON (AP) — Judges order the federal government to use contingency funds for SNAP food aid payments during the shutdown.
October 31, 2025 at 2:09 PM
Reposted by Ashley Holloway
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience
A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...
recruiting.paylocity.com
October 29, 2025 at 4:03 PM
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Did not have 'apex predator rat' on my bingo card. Go little guy, go!!
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 27, 2025 at 11:32 PM
Did not have 'apex predator rat' on my bingo card. Go little guy, go!!
Reposted by Ashley Holloway
The ex-prosecutor also said this:
“I have a lot of close contacts in law enforcement, and almost to a person, none of them support these actions. As a lawyer, someone who adamantly believes in the rule of law, watching it in open sight in front of my house just be completely eroded…it’s upsetting.”
“I have a lot of close contacts in law enforcement, and almost to a person, none of them support these actions. As a lawyer, someone who adamantly believes in the rule of law, watching it in open sight in front of my house just be completely eroded…it’s upsetting.”
October 26, 2025 at 1:12 AM
The ex-prosecutor also said this:
“I have a lot of close contacts in law enforcement, and almost to a person, none of them support these actions. As a lawyer, someone who adamantly believes in the rule of law, watching it in open sight in front of my house just be completely eroded…it’s upsetting.”
“I have a lot of close contacts in law enforcement, and almost to a person, none of them support these actions. As a lawyer, someone who adamantly believes in the rule of law, watching it in open sight in front of my house just be completely eroded…it’s upsetting.”
Reposted by Ashley Holloway
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 25, 2025 at 1:42 PM
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
Reposted by Ashley Holloway
WOW: The White House says the president's MAIN PRIORITY is his BALLROOM. SNAP is ending. Subsidies for health care are gong to double and in some instances quadruple plan premiums. The government is shut down. The cost of living is through the roof. And his priority is his ballroom.
October 23, 2025 at 6:46 PM
WOW: The White House says the president's MAIN PRIORITY is his BALLROOM. SNAP is ending. Subsidies for health care are gong to double and in some instances quadruple plan premiums. The government is shut down. The cost of living is through the roof. And his priority is his ballroom.
Reposted by Ashley Holloway
The Cummings Lab is hiring a postdoc to work in the areas of reward and addiction! Please see the ad below:
October 23, 2025 at 6:22 PM
The Cummings Lab is hiring a postdoc to work in the areas of reward and addiction! Please see the ad below:
Reposted by Ashley Holloway
mRNA vaccines seem to work synergistically w/ cancer immunotherapy.
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
A surprise bonus from COVID-19 vaccines: bolstering cancer treatment
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
www.science.org
October 22, 2025 at 3:14 PM
mRNA vaccines seem to work synergistically w/ cancer immunotherapy.
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
Reposted by Ashley Holloway
Check out this exciting new tool from @ajboender.bsky.social - An aav based CRISPR-Cas9 strategy to knockdown dopamine receptors. Works in mice, voles and hamsters. It was a fun collaboration. www.biorxiv.org/content/10.1...
Comparative gene editing reduces dopamine receptor levels across rodent species
Translational challenges in neuroscience originate from species-specific differences that limit the generalizability of experimental findings. Comparative approaches can help distinguish conserved fro...
www.biorxiv.org
October 22, 2025 at 3:59 PM
Check out this exciting new tool from @ajboender.bsky.social - An aav based CRISPR-Cas9 strategy to knockdown dopamine receptors. Works in mice, voles and hamsters. It was a fun collaboration. www.biorxiv.org/content/10.1...
Great mentorship is mutually beneficial for mentor and mentee!
October 22, 2025 at 11:53 AM
Great mentorship is mutually beneficial for mentor and mentee!
Reposted by Ashley Holloway
Highly concerning to see such reductions in the training of researchers & leaders in our fields, not just at Harvard, but at many universities across the US.
The targeting of higher ed is purposely eroding futures for individuals & families & the impacts universities can have on society.
The targeting of higher ed is purposely eroding futures for individuals & families & the impacts universities can have on society.
Wow. Harvard nuking its PhD programs
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
www.thecrimson.com
October 21, 2025 at 5:28 PM
Highly concerning to see such reductions in the training of researchers & leaders in our fields, not just at Harvard, but at many universities across the US.
The targeting of higher ed is purposely eroding futures for individuals & families & the impacts universities can have on society.
The targeting of higher ed is purposely eroding futures for individuals & families & the impacts universities can have on society.
Sparsely labeled astrocytes in the VTA expressing a red calcium indicator 😍
October 17, 2025 at 8:44 PM
Sparsely labeled astrocytes in the VTA expressing a red calcium indicator 😍
Reposted by Ashley Holloway
Landmark publication from @junnagai.bsky.social lab!
Incredible work really detailing the neural mechanisms that recruit astrocyte ensembles ! 🤩
www.nature.com/articles/s41...
Incredible work really detailing the neural mechanisms that recruit astrocyte ensembles ! 🤩
www.nature.com/articles/s41...
The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature
Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...
www.nature.com
October 15, 2025 at 3:52 PM
Landmark publication from @junnagai.bsky.social lab!
Incredible work really detailing the neural mechanisms that recruit astrocyte ensembles ! 🤩
www.nature.com/articles/s41...
Incredible work really detailing the neural mechanisms that recruit astrocyte ensembles ! 🤩
www.nature.com/articles/s41...
Reposted by Ashley Holloway
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Reposted by Ashley Holloway
My department at Emory is a hiring a tenure-track neuroscientist!
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 30, 2025 at 6:25 PM
My department at Emory is a hiring a tenure-track neuroscientist!
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Reposted by Ashley Holloway
Our work on mind-boggling CRF-BNST neurons is out! 🥳
🔹Sex & estrous matter: CRF neurons⬇️anxious arousal (yup) after unpredictable fear in diestrus👧not👦
🔹👧show⬆️contextual fear, independent of CRF/estrous
✨Anxiety-potentiated startle🟰👍 readout in🚶♀️&🐀
www.biologicalpsychiatryjournal.com/article/S000...
🔹Sex & estrous matter: CRF neurons⬇️anxious arousal (yup) after unpredictable fear in diestrus👧not👦
🔹👧show⬆️contextual fear, independent of CRF/estrous
✨Anxiety-potentiated startle🟰👍 readout in🚶♀️&🐀
www.biologicalpsychiatryjournal.com/article/S000...
Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner
The prevalence of post-traumatic stress disorder (PTSD) and anxiety disorders is higher
in women than men. The severity of hallmark symptoms including hypervigilance and
fear reactivity to unpredictab...
www.biologicalpsychiatryjournal.com
September 26, 2025 at 7:28 PM
Our work on mind-boggling CRF-BNST neurons is out! 🥳
🔹Sex & estrous matter: CRF neurons⬇️anxious arousal (yup) after unpredictable fear in diestrus👧not👦
🔹👧show⬆️contextual fear, independent of CRF/estrous
✨Anxiety-potentiated startle🟰👍 readout in🚶♀️&🐀
www.biologicalpsychiatryjournal.com/article/S000...
🔹Sex & estrous matter: CRF neurons⬇️anxious arousal (yup) after unpredictable fear in diestrus👧not👦
🔹👧show⬆️contextual fear, independent of CRF/estrous
✨Anxiety-potentiated startle🟰👍 readout in🚶♀️&🐀
www.biologicalpsychiatryjournal.com/article/S000...
Reposted by Ashley Holloway
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.
duunitori.fi/tyopaikat/ty...
duunitori.fi/tyopaikat/ty...
Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori
Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!
duunitori.fi
September 30, 2025 at 8:37 AM
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.
duunitori.fi/tyopaikat/ty...
duunitori.fi/tyopaikat/ty...
Reposted by Ashley Holloway
I was very happy that our lab was able to play a small part in this fantastic new paper from @bradfield-neuro.bsky.social , showing that neuroflammation in the pDMS promotes goal directed behaviour, whereas activation on hM4Di in astrocytes has the opposite effect
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function - Neuropsychopharmacology
Neuropsychopharmacology - Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function
www.nature.com
September 28, 2025 at 3:13 AM
I was very happy that our lab was able to play a small part in this fantastic new paper from @bradfield-neuro.bsky.social , showing that neuroflammation in the pDMS promotes goal directed behaviour, whereas activation on hM4Di in astrocytes has the opposite effect
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ashley Holloway
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
New Tool to Explore NIH Grant Opportunities | Grants & Funding
grants.nih.gov
September 26, 2025 at 2:48 PM
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...